Bioactivity Screening of Marine and Terrestrial Derived Fungi From Antarctica

Year 2021, , 49 - 53, 31.03.2021

Bülent Gözcelioğlu

https://doi.org/10.17350/HJSE19030000212

Abstract

The Antarctic region is situated in the Southern Hemisphere. The weather in Antarctica can often change dramatically in a short span of time. Due to these sudden changes the organisms and microorganisms which live in Antarctica produce unique metabolites to sur-vive. In the present trial, the marine derived fungi from Antarctica’s coast were researched for their antimicrobial activity. The disk diffusion technique was used to determined an-timicrobial activity of isolated marine-derived fungi extracts. According to the obtained results the Penicillium chrysogenum and P. crustosum extracts were shown higher antibac-terial against Gram positive and Gram negative rather than other extracts. In conclusion, marine derived fungi from Antarctica region produce the structurally novel and interesting bioactive compounds. Some of these fungi species such as Penicillium species are known to produce antimicrobial metabolites, the results obtained in this study also showed that Penicillium species show higher antimicrobial activity than the other species.

Keywords

Antarctica, Antimicrobial activity, Live sources-derived fungi

References

• Corinaldesi C, Barone G, Marcellini F, Dell’Anno A, Danovaro R. Marine Microbial-Derived Molecules and Their Potential Use in Cosmeceutical and Cosmetic Products. Marine Drugs 15 (2017) 118- 139.
• Tripathi VC, Horam S, Singh A, Lata M, Reddy TJ, Arockiaraj J. Pasupuleti M. The diskovery of antioxidants in marine microorganisms and their protective effects on the hepatic cells from chemical-induced oxidative stress. Free Radical Research 54 (2020)150–161.
• Karpiński TM. Marine Macrolides with Antibacterial and/or Antifungal Activity. Marine Drugs 17 (2019) 241- 265.
• El-Hady FKA, Abdel-Aziz MS, Abdou AM, Shaker KH, Ibrahim LS, El-Shahid ZA. In vitro Anti-diabetic and Cytotoxic Effect of the Coral Derived Fungus (Emericella unguis 8429) on Human Colon, Liver, Breast and Cervical carcinoma cell lines.   International Journal of Pharmaceutical Sciences Review and Research 27 (2014) 296-301.
• Xu J, Yi M, Ding L, He S. A Review of Anti-Inflammatory Compounds from Marine Fungi, 2000-2018. Marine Drugs 17 (2019) 636- 660.
• Pontius A, Krick A, Kehraus S, Brun R, König GM. Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp. Journal of Natural Product 71 (2008)1579-1584.
• Luo X, Zhou X, Lin X, Qin X, Zhang T, Wang J, Tu Z, Yang B, Liao S, Tian Y. Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp. Natural Product Research 31 (2017)1958-1962.
• Moghadamtousi SZ, Nikzad S, Kadir HA, Abubakar S, Zandi K. Potential Antiviral Agents from Marine Fungi: An Overview. Marine Drugs13 (2015) 4520-4538.
• Ramos AA, Preta-Sena M, Castro-Carvalho B, Dethoup T, Buttachon S, Kijjoa A, Rocha E. Potential of four marine-derived fungi extracts as anti-proliferative and cell death-inducing agents in seven human cancer cell lines. Asian Pacific Journal of Tropical Medicine 8(2015) 798-806.
• Chavez R. Bioactive Compounds Produced by Antarctic Filamentous Fungi. Fungi of Antarctica (pp.265-283), 2019.
• Gözcelioğlu B. Antioxidant and cytotoxic activity of three Turkish marine-derived fungi. Turkish Journal of Biochemistry. 44 (2019) 554–559.
• Sun Y, Cai Y, Huse SM, Knight R, Farmerie WG, Mai V. A large-scale benchmark study of existing algorithms for taxonomy- independent microbial community analysis. Brief Bioinform.13 (2011) 107- 121.
• Kjer J, Debbab A, Aly AH, Proksch P. Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products. Nature Protocols 5 (2010) 479-490.
• CLSI. Methods for Dilution Antimicrobial Susceptibilit Tests f or Bacteria That Grow Aerobically; Approved St andard 9th Edition. CLSI document M07-A9. Wayne, PA: Clinical and Laboratory Standards Institute; 2012.
• Mondol MA, Shin HJ. Antibacterial and antiyeast compounds from marine-derived bacteria. Marine Drugs. 12(2014) 2913-2921.
• Tian Y, Li YL, Zhao FC. Secondary Metabolites from Polar Organisms. Marine Drugs. 15(2017) 28-58.
• Yang MH, Li TX, Wang Y, Liu RH, Luo J, Kong LY. Antimicrobial metabolites from the plant endophytic fungus Penicillium sp. Fitoterapia. 116 (2017) 72–76.
• Gharaei-Fathabad E, Tajick-Ghanbary MA, Shahrokhi N. Antimicrobial Properties of Penicillium Species Isolated from Agricultural Soils of Northern Iran. Research Journal of Toxins, 6 (2014) 1-7.
• Henríquez M, Vergara K, Norambuena J, Beiza, A, Maza F, Ubilla P, Araya I, Cha´vez R, San-Martı´n A, Darias J, Darias M, Vaca, I. Diversity of cultivable fungi associated with Antarctic marine sponges and screening for their antimicrobial, antitumoral and antioxidant potential. World Journal of Microbiology and Biotechnology, 30(2013) 65–76.
• Albores S, Sanguiñedo P, Held BH, Cerdeiras MP, Blanchette RA. Biodiversity and antimicrobial activity of Antarctic fungi from the Fildes Peninsula, King George Island. Sydowia 70 (2018) 185-191.