Year 2017, Volume 4 , Issue 2, Pages 137 - 144 2017-09-01

Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing

Bengi ÖZKAHRAMAN [1] , Emel TAMAHKAR [2]


The development of the porous, biocompatible and biodegradable hydrogels has been gaining much attention for wound dressing applications. The hydrogels prepared using freeze-thawing method present important properties of high biocompatibility and nontoxicity. The hydrogels that are able to release drugs for prolonged time are widely used biomaterials for wound healing. In this study chitosan CS -based poly-ε-caprolactone PCL hydrogels were prepared using poly vinyl alcohol PVA , poly ethylene glycol PEG and poly vinyl pyrrolidone PVP . PVA-CS-PCL hydrogels only could remain stable at room temperature after synthesis. The properties of the hydrogels were determined with SEM, FTIR, swelling tests and degradation tests. The drugs of ceftazidime CZ as an antibiotic and ketoprofen KP as an analgesic were loaded onto the hydrogels and the loaded hydrogels were used for the drug release studies at pH 5.5 and pH 7.4. All these results suggest that the developed PVA-CS-PCL hydrogels offer significant potential as a wound dressing material.
Chitosan-based hydrogel, Wound dressing, Drug release, Ceftazidime, Ketoprofen.
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Primary Language en
Journal Section Research Article
Authors

Author: Bengi ÖZKAHRAMAN

Author: Emel TAMAHKAR
Institution: Hitit University, Department of Polymer Engineering, Çorum, Turkey

Dates

Application Date : May 6, 2021
Acceptance Date : May 6, 2021
Publication Date : September 1, 2017

Bibtex @ { hjse859993, journal = {Hittite Journal of Science and Engineering}, issn = {}, eissn = {2148-4171}, address = {Hitit Üniversitesi Mühendislik Fakültesi Kuzey Kampüsü Çevre Yolu Bulvarı 19030 Çorum / TÜRKİYE}, publisher = {Hitit University}, year = {2017}, volume = {4}, pages = {137 - 144}, doi = {10.17350/HJSE19030000060}, title = {Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing}, key = {cite}, author = {Özkahraman, Bengi and Tamahkar, Emel} }
APA Özkahraman, B , Tamahkar, E . (2017). Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing . Hittite Journal of Science and Engineering , 4 (2) , 137-144 . DOI: 10.17350/HJSE19030000060
MLA Özkahraman, B , Tamahkar, E . "Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing" . Hittite Journal of Science and Engineering 4 (2017 ): 137-144 <https://dergipark.org.tr/en/pub/hjse/issue/59666/859993>
Chicago Özkahraman, B , Tamahkar, E . "Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing". Hittite Journal of Science and Engineering 4 (2017 ): 137-144
RIS TY - JOUR T1 - Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing AU - Bengi Özkahraman , Emel Tamahkar Y1 - 2017 PY - 2017 N1 - doi: 10.17350/HJSE19030000060 DO - 10.17350/HJSE19030000060 T2 - Hittite Journal of Science and Engineering JF - Journal JO - JOR SP - 137 EP - 144 VL - 4 IS - 2 SN - -2148-4171 M3 - doi: 10.17350/HJSE19030000060 UR - https://doi.org/10.17350/HJSE19030000060 Y2 - 2021 ER -
EndNote %0 Hittite Journal of Science and Engineering Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing %A Bengi Özkahraman , Emel Tamahkar %T Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing %D 2017 %J Hittite Journal of Science and Engineering %P -2148-4171 %V 4 %N 2 %R doi: 10.17350/HJSE19030000060 %U 10.17350/HJSE19030000060
ISNAD Özkahraman, Bengi , Tamahkar, Emel . "Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing". Hittite Journal of Science and Engineering 4 / 2 (September 2017): 137-144 . https://doi.org/10.17350/HJSE19030000060
AMA Özkahraman B , Tamahkar E . Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing. Hittite J Sci Eng. 2017; 4(2): 137-144.
Vancouver Özkahraman B , Tamahkar E . Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing. Hittite Journal of Science and Engineering. 2017; 4(2): 137-144.
IEEE B. Özkahraman and E. Tamahkar , "Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing", Hittite Journal of Science and Engineering, vol. 4, no. 2, pp. 137-144, Sep. 2017, doi:10.17350/HJSE19030000060