Year 2021, Volume 8 , Issue 1, Pages 79 - 83 2021-03-31

Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture

Suzan MURATOĞLU SEVERCAN [1] , Çınar SEVERCAN [2] , Mostafa NORIZADEH TAZEHKAND [3] , Zehra SAFİ ÖZ [4] , Aslıhan GÜRBÜZ [5]


Depression is one of the prevalent psychiatric diseases in Turkey and the world. Fluvoxamine is a strong selective serotonin reuptake inhibitor (SSRI) that is used as an antidepressant. No study investigating the doses of Fluvoxamine treatment that may lead to a disruption in the oxidant-antioxidant balance on the cellular level in addition to its beneficial effects has been found in the literature. For this purpose, by creating Fluvoxamine application groups at the doses of 7.5, 15, 30 and 60 μM and durations of 24 and 48 hours on human lymphocyte cell cultures, we investigated the total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI). According to the results of the study, the TOS levels of all dose groups increased significantly in the 24- and 48-hour applications (p<0.05). While the TAS levels significantly increased in the 24-hour application of the doses of 7.5 and 15 μM and 48-application of the dose of 7.5 μM, they significantly decreased in the 24- and 48-hour applications of the doses of 30 and 60 μM (p<0.05). The OSI level increased significantly in the 24- and 48-hour applications of the doses of 30 and 60 μM. The results of our study demonstrated that, in the 24- and 48-hour applications of the doses of 30 and 60 μM, the antioxidant system could not compensate and the cells exposed to oxidative stress.
Human lymphocyte cell culture, Total oxidant status (TOS), Total antioxidant status (TAS), Oxidative stress index (OSI), Fluvoxamine
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Primary Language en
Subjects Basic Sciences
Journal Section Research Article
Authors

Orcid: 0000-0001-5978-8144
Author: Suzan MURATOĞLU SEVERCAN (Primary Author)
Institution: Ankara University, Institute of Health Sciences, Department of Forensic Chemistry and Forensic Toxicology
Country: Turkey


Orcid: 0000-0002-3806-6406
Author: Çınar SEVERCAN
Institution: Zonguldak Bulent Ecevit University, Faculty of Pharmacy, Department of Biochemistry
Country: Turkey


Orcid: 0000-0002-7688-7467
Author: Mostafa NORIZADEH TAZEHKAND
Institution: Zonguldak Bulent Ecevit University, Faculty of Pharmacy, Department of Pharmaceutical Biotechnology
Country: Turkey


Orcid: 0000-0003-1359-5026
Author: Zehra SAFİ ÖZ
Institution: Zonguldak Bulent Ecevit University, Faculty of Medicine, Department of Medical Biology
Country: Turkey


Orcid: 0000-0002-5089-3965
Author: Aslıhan GÜRBÜZ
Institution: Ankara University, Faculty of Medicine, Department of Biochemistry
Country: Turkey


Dates

Application Date : February 27, 2021
Acceptance Date : March 23, 2021
Publication Date : March 31, 2021

Bibtex @research article { hjse875713, journal = {Hittite Journal of Science and Engineering}, issn = {}, eissn = {2148-4171}, address = {Hitit Üniversitesi Mühendislik Fakültesi Kuzey Kampüsü Çevre Yolu Bulvarı 19030 Çorum / TÜRKİYE}, publisher = {Hitit University}, year = {2021}, volume = {8}, pages = {79 - 83}, doi = {10.17350/HJSE19030000216}, title = {Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture}, key = {cite}, author = {Muratoğlu Severcan, Suzan and Severcan, Çınar and Norızadeh Tazehkand, Mostafa and Safi Öz, Zehra and Gürbüz, Aslıhan} }
APA Muratoğlu Severcan, S , Severcan, Ç , Norızadeh Tazehkand, M , Safi Öz, Z , Gürbüz, A . (2021). Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture . Hittite Journal of Science and Engineering , 8 (1) , 79-83 . DOI: 10.17350/HJSE19030000216
MLA Muratoğlu Severcan, S , Severcan, Ç , Norızadeh Tazehkand, M , Safi Öz, Z , Gürbüz, A . "Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture" . Hittite Journal of Science and Engineering 8 (2021 ): 79-83 <https://dergipark.org.tr/en/pub/hjse/issue/61101/875713>
Chicago Muratoğlu Severcan, S , Severcan, Ç , Norızadeh Tazehkand, M , Safi Öz, Z , Gürbüz, A . "Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture". Hittite Journal of Science and Engineering 8 (2021 ): 79-83
RIS TY - JOUR T1 - Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture AU - Suzan Muratoğlu Severcan , Çınar Severcan , Mostafa Norızadeh Tazehkand , Zehra Safi Öz , Aslıhan Gürbüz Y1 - 2021 PY - 2021 N1 - doi: 10.17350/HJSE19030000216 DO - 10.17350/HJSE19030000216 T2 - Hittite Journal of Science and Engineering JF - Journal JO - JOR SP - 79 EP - 83 VL - 8 IS - 1 SN - -2148-4171 M3 - doi: 10.17350/HJSE19030000216 UR - https://doi.org/10.17350/HJSE19030000216 Y2 - 2021 ER -
EndNote %0 Hittite Journal of Science and Engineering Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture %A Suzan Muratoğlu Severcan , Çınar Severcan , Mostafa Norızadeh Tazehkand , Zehra Safi Öz , Aslıhan Gürbüz %T Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture %D 2021 %J Hittite Journal of Science and Engineering %P -2148-4171 %V 8 %N 1 %R doi: 10.17350/HJSE19030000216 %U 10.17350/HJSE19030000216
ISNAD Muratoğlu Severcan, Suzan , Severcan, Çınar , Norızadeh Tazehkand, Mostafa , Safi Öz, Zehra , Gürbüz, Aslıhan . "Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture". Hittite Journal of Science and Engineering 8 / 1 (March 2021): 79-83 . https://doi.org/10.17350/HJSE19030000216
AMA Muratoğlu Severcan S , Severcan Ç , Norızadeh Tazehkand M , Safi Öz Z , Gürbüz A . Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture. Hittite J Sci Eng. 2021; 8(1): 79-83.
Vancouver Muratoğlu Severcan S , Severcan Ç , Norızadeh Tazehkand M , Safi Öz Z , Gürbüz A . Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture. Hittite Journal of Science and Engineering. 2021; 8(1): 79-83.
IEEE S. Muratoğlu Severcan , Ç. Severcan , M. Norızadeh Tazehkand , Z. Safi Öz and A. Gürbüz , "Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture", Hittite Journal of Science and Engineering, vol. 8, no. 1, pp. 79-83, Mar. 2021, doi:10.17350/HJSE19030000216