Research Article
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Year 2021, Volume 8, Issue 4, 321 - 328, 31.12.2021
https://doi.org/10.17350/HJSE19030000245

Abstract

Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma

Year 2021, Volume 8, Issue 4, 321 - 328, 31.12.2021
https://doi.org/10.17350/HJSE19030000245

Abstract

Pheochromocytoma and Paraganglioma (PCPG) are rare and potentially lethal neuroendocrine tumors. PCPG that predominantly or exclusively produce and secrete DA is rarely seen and it has been known that exclusively dopamine-secreting PCPG is related with advanced malignant features and metastases. Up to the present, little has known about the role of dopamine neurotransmission and dopaminergic system in the initiation and progression of PCPG. The genes with significant expression differences between normal tissue and pheochromocytoma and paraganglioma, survival and correlation analysis, CpG islands prediction, and miRNA-target enrichment analysis were performed by several bioinformatics tools. In the present study, it was determined that COMT gene was significantly less expressed in PCPG than in normal tissue and COMT gene showed a remarkable relationship between differential expression with shorter overall survival among the individuals with PCPG (HR=1, p=0.011). MAOA and COMT gene pair was significantly correlated with PCPG (p=0.012; R=0.19) and hsa-miR-5000-5p regulates the expression of both COMT and MAOA genes (p=0.00215, FDR=0.127). Our findings suppose that COMT may potentially be implicated in tumor suppressive mechanism. The expression values of COMT and MAOA genes, and hsa-miR-5000-5p may have the potential to be used in the genetic evaluation of the pathogenesis and prognosis of PCPG. Further in vitro and in vivo studies are required to clarify the molecular mechanism of dopaminergic system in the pathogenesis and prognosis of PCPG.

Details

Primary Language English
Subjects Basic Sciences
Journal Section Research Articles
Authors

Orçun AVŞAR (Primary Author)
HİTİT ÜNİVERSİTESİ
0000-0003-3556-6218
Türkiye

Publication Date December 31, 2021
Application Date September 7, 2021
Acceptance Date November 17, 2021
Published in Issue Year 2021, Volume 8, Issue 4

Cite

Bibtex @research article { hjse992325, journal = {Hittite Journal of Science and Engineering}, issn = {}, eissn = {2148-4171}, address = {Hitit Üniversitesi Mühendislik Fakültesi Kuzey Kampüsü Çevre Yolu Bulvarı 19030 Çorum / TÜRKİYE}, publisher = {Hitit University}, year = {2021}, volume = {8}, pages = {321 - 328}, doi = {10.17350/HJSE19030000245}, title = {Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma}, key = {cite}, author = {Avşar, Orçun} }
APA Avşar, O. (2021). Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma . Hittite Journal of Science and Engineering , 8 (4) , 321-328 . DOI: 10.17350/HJSE19030000245
MLA Avşar, O. "Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma" . Hittite Journal of Science and Engineering 8 (2021 ): 321-328 <https://dergipark.org.tr/en/pub/hjse/issue/67751/992325>
Chicago Avşar, O. "Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma". Hittite Journal of Science and Engineering 8 (2021 ): 321-328
RIS TY - JOUR T1 - Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma AU - Orçun Avşar Y1 - 2021 PY - 2021 N1 - doi: 10.17350/HJSE19030000245 DO - 10.17350/HJSE19030000245 T2 - Hittite Journal of Science and Engineering JF - Journal JO - JOR SP - 321 EP - 328 VL - 8 IS - 4 SN - -2148-4171 M3 - doi: 10.17350/HJSE19030000245 UR - https://doi.org/10.17350/HJSE19030000245 Y2 - 2021 ER -
EndNote %0 Hittite Journal of Science and Engineering Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma %A Orçun Avşar %T Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma %D 2021 %J Hittite Journal of Science and Engineering %P -2148-4171 %V 8 %N 4 %R doi: 10.17350/HJSE19030000245 %U 10.17350/HJSE19030000245
ISNAD Avşar, Orçun . "Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma". Hittite Journal of Science and Engineering 8 / 4 (December 2021): 321-328 . https://doi.org/10.17350/HJSE19030000245
AMA Avşar O. Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma. Hittite J Sci Eng. 2021; 8(4): 321-328.
Vancouver Avşar O. Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma. Hittite Journal of Science and Engineering. 2021; 8(4): 321-328.
IEEE O. Avşar , "Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma", Hittite Journal of Science and Engineering, vol. 8, no. 4, pp. 321-328, Dec. 2021, doi:10.17350/HJSE19030000245