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Year 2022, Volume 9, Issue 2, 65 - 72, 30.06.2022
https://doi.org/10.17350/HJSE19030000256

Abstract

References

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  • [5] Beasley R, Roche WR, Roberts JA, Holgate ST. Cellular events in the bronchi in mild asthma and after bronchial provocation. American Review of Respiratory Disease 139 (1989) 806.
  • [6] Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z. New insights into the pathogenesis of asthma. The Journal of Clinical Investigation 111 (2003)291- 297.
  • [7] Salomonsson M, Malinovschi A, Kalm-Stephens P, Dahlin JS, Janson C, Alving K, Hallgren J. Circulating mast cell progenitors correlate with reduced lung function in allergic asthma. Clinical Experimental Allergy Abstract,2019.
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  • [9] Köksal B. Astımlı Cocuklarda Serum Angiopoietin-1, Angiopoietin-2, Vascular Endothelial Growth Faktör Tümör Necrosis Faktör-α Düzeylerinin Değerlendirilmesi, Yan Dal Uzmanlık Tezi, Başkent Üniversitesi Sağlık Bilimleri Enstitüsü, Ankara, pp. 1-9,2012.
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  • [11] Kaltalıoğlu K. Trombosit kökenli büyüme faktörü’nün yara dokusu oksidatif olayları üzerine etkileri, Yüksek Lisans Tezi, Gazi Üniversitesi Fen Bilimleri Enstitüsü, Ankara, pp. 32-41,2012.
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  • [14] Casas-Grajales S, Muriel P. Antioxidants in liver health. World J Gastrointest Pharmacol Ther 6 (3) (2015) 59–72.
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  • [18] Temiz Ö. Oreochromis niloticus'un Karaciğerinde Fungisit Propiconazole'un Oksidatif Stres Parametreleri ve Antioksidan Sistem Enzimleri Üzerine Etkileri. J Anatolian Env and Anim Sciences 4(1) (2019) 43-47.
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  • [20] Erge D. Metakolinle Atak Geliştiren Kronik Astımlı BALB/C Farelerde Nebulize Sildenafilin Akciğer Histolojisi, Oksijen Saturasyonu ve Kan Gazi Parametreleri Üzerine Etkileri, Yan Dal Uzmanlık Tezi, Dokuz Eylül Üniversitesi Sağlık Bilimleri Enstitüsü, İzmir,2010.
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Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue

Year 2022, Volume 9, Issue 2, 65 - 72, 30.06.2022
https://doi.org/10.17350/HJSE19030000256

Abstract

Asthma, an important public health problem, is a common, potentially serious, medical condition in children, adults and pregnant women. The aim of this study is to investigate the effects of the combined use of thymoquinone and carob on liver tissue oxidative events, following the experimental asthma model. 18 male albino wistar rats were divided into 3 groups as: the control group, the experimental asthma group and treated group (A+TQ+C). In the asthmatic groups, ovalbumin and alum were given intraperitoneally on the 0 and 14th days, and sensitized by inhalation on the 21st, 22nd and 23rd days. In the next 5 days, thymoquinone and carob were given to the group to be treated by intragastric gavage method. In all experimental groups, glutathione (GSH), ascorbic acid (AA), malondialdehyde (MDA) and nitric oxide (NOx) levels were measured spectrophotometrically to evaluate the oxidant-antioxidant status in the liver tissue of rats. While liver tissue GSH and AA levels increased, NOx levels were found to decrease following thymoquinone and carob administration in the treated group (A+TQ+C) when compared other groups (Control and Asthma). However, MDA levels, which are the indicator of lipid peroxidation, were found to be statistically significantly increased in the treated group (A+TQ+C) (p<0.05) when compared the other groups (Control and Asthma). As a result, the co-administration of thymoquinone and carob has a regulatory effect that eliminates the possible oxidative effects of asthma, giving hope that it may be a new treatment for children, adults and pregnant women.

References

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  • [2] Busse WW. Expert panel report 3 (EPR-3): guidelines for the diagnosis and management of asthma- summary report 2007,National Asthma Education and Prevention Program. Journal Allergy Clinical Immunology 120(5) (2007) 94–138.
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  • [4] Cukic V, Lovre V, Dragisic D, Ustamujic A. Asthma and Chronic Obstructive Pulmonary Disease (COPD) – Differences and Similarities. Mater Sociomed 24(2) (2012) 100–105.
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  • [7] Salomonsson M, Malinovschi A, Kalm-Stephens P, Dahlin JS, Janson C, Alving K, Hallgren J. Circulating mast cell progenitors correlate with reduced lung function in allergic asthma. Clinical Experimental Allergy Abstract,2019.
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  • [23] Klenow SM, Glei R, Owen and B. Pool-Zobel. Carob Fibre compounds modulate parameters of cell growth differently in human HT29 colon adenocarcinoma cell than in LT97colon adenoma cell. Food and Chemical Toxicology 46(4) (2008) 1389-1397.
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  • [35] Farag MA, El-Kersh DM, Ehrlich A, Choucry MA, El-Seedi H, Frolov A, Wessjohann LA. Variation in Ceratonia siliqua pod metabolome in context of its different geographical origin, ripening stage and roasting process. Food Chemistry 283 (2019) 675-687.
  • [36] Christou C, Poulli E, Yiannopoulos S, Agapiou A. GC-MS analysis of D-pinitol in carob: Syrup and fruit (flesh and seed). Journal of chromatography B Analytical technologies in the biomedical and life sciences 1116 (2019) 60-64.
  • [37] Papaefstathiou E, Agapiou A, Giannopoulos S, Kokkinofta R. Nutritional characterization of carobs and traditional carob products. Food Science Nutrition 6(8) (2018) 2151-2161.
  • [38] Fadhil Ahmed A, Coskun Cevher S. The Preventive Effect of Thymoquinone and Ceratonia Siliqua L. in Experimental Asthmatic Pregnant Rats: Histologically and Immunohistochemically Evaluation. Hittite Journal of Science and Engineering 6(3) (2019) 215-222.
  • [39] Moura CTM, Bezerra FC, Moraes IM, Magalhaes PJC, Capaz FR. Increase responsiveness to 5- hydroxytryptamine after antigenic challenge is inhibited by nifedipine and nif lumic acid in rat trachea in vitro. Clin Exp Pharmacol Physiol 32 (2005) 1119–1123.
  • [40] Yang EJ, Lee JS, Song BB, Yun CY, Kim DH, Kim IS. Anti-ınflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice. J Ethnopharmacol 136 (2011) 422–427.
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  • [43] Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5(1) (2001) 62-71.
  • [44] Boskabady MH, Sheiravi N. Inhibitory effect of Nigella sativa on histamine receptors of isolated guinea pig tracheal chains. Pharmaceutical Biology 40(8) (2002) 596-602.
  • [45] Ayaz FA, Torun H, Ayaz S, Correia PJ, Alaiz M, Sanz C, Gruz J, Strand M. Determination of chemical composition of Anatolian carob pod (Ceratonia siliqua L.), Sugars, amino and organic acids, minerals and phenolic compounds. Journal of Food Quality 30 (2007) 1040-1055.
  • [46] Tokeshi I, Yoshimoto T, Muto N, Nakamura S, Ashizawa K, Nakada T, Tatemoto H. Antihyaluronidase action of ellagic acid effectively prevents polyspermy as a result of suppression of the acrosome reaction induced by spermzona interaction during in vitro fertilization of porcine oocytes. The Journal of Reprodaction and Development 53(4) (2007) 755-764.
  • [47] Chekchaki N, Khaldi T, Rouibah Z, Rouag M, Sekiou O, Messarah M, Boumendjel A. Anti-inflammatory and antioxidant effects of two extracts from Pistacia lentiscus in liver and erythrocytes, in an experimental model of asthma. International Journal of Pharmaceutical Sciences Review and Reserch 42(1) (2017) 77– 84.
  • [48] Oskouei Z, Akaberi M, Hosseinzadeh H. A glance at black cumin (Nigella sativa) and its active constituent, thymoquinone, in ischemia: a review. Iranian journal of basic medical sciences 21(12) (2018) 1200- 1209.
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Details

Primary Language English
Subjects Basic Sciences
Journal Section Research Articles
Authors

Özge AKYAZI> (Primary Author)
GAZİ ÜNİVERSİTESİ, FEN BİLİMLERİ ENSTİTÜSÜ, BİYOLOJİ (DR)
0000-0002-4106-1884
Türkiye


Şule Coşkun CEVHER>
GAZI UNIVERSITY, FACULTY OF SCIENCE
0000-0001-6204-2845
Türkiye

Supporting Institution BAP
Project Number 05/2016-22
Publication Date June 30, 2022
Application Date September 25, 2021
Acceptance Date April 9, 2022
Published in Issue Year 2022, Volume 9, Issue 2

Cite

Bibtex @research article { hjse969874, journal = {Hittite Journal of Science and Engineering}, eissn = {2148-4171}, address = {Hitit Üniversitesi Mühendislik Fakültesi Kuzey Kampüsü Çevre Yolu Bulvarı 19030 Çorum / TÜRKİYE}, publisher = {Hitit University}, year = {2022}, volume = {9}, number = {2}, pages = {65 - 72}, doi = {10.17350/HJSE19030000256}, title = {Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue}, key = {cite}, author = {Akyazı, Özge and Cevher, Şule Coşkun} }
APA Akyazı, Ö. & Cevher, Ş. C. (2022). Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue . Hittite Journal of Science and Engineering , 9 (2) , 65-72 . DOI: 10.17350/HJSE19030000256
MLA Akyazı, Ö. , Cevher, Ş. C. "Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue" . Hittite Journal of Science and Engineering 9 (2022 ): 65-72 <https://dergipark.org.tr/en/pub/hjse/issue/70658/969874>
Chicago Akyazı, Ö. , Cevher, Ş. C. "Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue". Hittite Journal of Science and Engineering 9 (2022 ): 65-72
RIS TY - JOUR T1 - Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue AU - Özge Akyazı , Şule Coşkun Cevher Y1 - 2022 PY - 2022 N1 - doi: 10.17350/HJSE19030000256 DO - 10.17350/HJSE19030000256 T2 - Hittite Journal of Science and Engineering JF - Journal JO - JOR SP - 65 EP - 72 VL - 9 IS - 2 SN - -2148-4171 M3 - doi: 10.17350/HJSE19030000256 UR - https://doi.org/10.17350/HJSE19030000256 Y2 - 2022 ER -
EndNote %0 Hittite Journal of Science and Engineering Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue %A Özge Akyazı , Şule Coşkun Cevher %T Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue %D 2022 %J Hittite Journal of Science and Engineering %P -2148-4171 %V 9 %N 2 %R doi: 10.17350/HJSE19030000256 %U 10.17350/HJSE19030000256
ISNAD Akyazı, Özge , Cevher, Şule Coşkun . "Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue". Hittite Journal of Science and Engineering 9 / 2 (June 2022): 65-72 . https://doi.org/10.17350/HJSE19030000256
AMA Akyazı Ö. , Cevher Ş. C. Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue. Hittite J Sci Eng. 2022; 9(2): 65-72.
Vancouver Akyazı Ö. , Cevher Ş. C. Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue. Hittite Journal of Science and Engineering. 2022; 9(2): 65-72.
IEEE Ö. Akyazı and Ş. C. Cevher , "Supplementation of Thymoquinone and Carob Together in the Experimental Rat Asthma Model: Oxidative Effect on the Liver Tissue", Hittite Journal of Science and Engineering, vol. 9, no. 2, pp. 65-72, Jun. 2022, doi:10.17350/HJSE19030000256