Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors

Year 2023, Volume: 10 Issue: 2, 161 - 165, 30.06.2023

Sertan Aytaç

https://doi.org/10.17350/HJSE19030000303

Abstract

In this study, new pyridine-based imine compounds (8-10) were synthesized and docking studies of these compounds against D2 Dopamine receptor (6CM4) were performed. The structures of these compounds, which were synthesized using the microwave method, were determined by 1H-NMR, 13C-NMR and elemental analysis techniques. The binding energy values vary range from -6.79 to -7.07 kcal/mol with D2 Dopamine Receptor/PDB: 6MC4. Compound 10 (-7.07 kcal mol-1) showed better binding energy than 9 (-6.95 kcal mol-1) and 8 (-6.79 kcal/mol).

Keywords

β-Phenylethylamine, Dopamine, Imine, D2 receptor, Molecular docking

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