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Kanserli Hastalarda Tat Alma Değişikliği

Year 2018, , 259 - 266, 10.06.2018
https://doi.org/10.17681/hsp.359196

Abstract

Tat
alma değişikliği kanserli hastalarda görülen en yaygın ve önemli sorunlardan
bir tanesidir. Hastalar tat alma değişimini ağızda metalik, acı ya da kötü bir
tat,  hassasiyet, tatlıya karşı duyarsızlık ve acıya intolerans olarak
tanımlamıştır. Kanserli hastalarda tat alma değişikliğinin nedeni tam
olarak bilinmemektedir. Kanser tedavisi fizyolojik ve psikolojik nedenlerle tat
almayı etkilemektedir. Kanserli hastalarda tat alma değişikliği sonucunda iştah kaybı, bazı yiyeceklerden hoşlanmama, yiyecek
tercihinde değişme, yetersiz beslenme,
yetersiz enerji alımı, kilo kaybı, malnutrisyon, kötü prognoz, yaşam
kalitesinde azalma, stres, depresyon, ağız
kuruluğu, hastanede kalma süresinin uzaması, koku almada bozukluk, immün
sistemde bozulma ve tedaviye uyumda bozulma gelişmektedir. Tat alma değişikliğini değerlendirmek ve
tedavi etmek zordur. Tat alma değişikliğini tanımlamak, sınıflandırmak ve bu
sorunları yönetmek için kanıta dayalı destekleyici stratejilerde yetersizlik
olduğu ve profilaktik tedavilerin başarılı olmadığı belirlenmiştir Bu nedenle
kanserli hastaların bakım ve tedavisinde tat alma değişikliği yönetimi bir
sorun olmaya devam etmektedir.

References

  • 1. Epstein JB, Barasch A. Taste disorders in cancer patients: Pathogenesis, and approach to assessment and management. Oral Oncol 2010;46(2):77–81. 2. Imai H, Soeda H, Komine K, Otsuka K, Shibata H. Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer. BMC Palliat Care [Internet]. 2013;12(1):38. 3. Ravasco P. Aspects of taste and compliance in patients with cancer. Eur J Oncol Nurs. 2005;9(SUPPL. 2):84–91. 4. Zabernigg A, Gamper E-M, Giesinger JM, Rumpold G, Kemmler G, Gattringer K, et al. Taste alterations in cancer patients receiving chemotherapy: a neglected side effect? Oncologist. 2010;15(8):913–20. 5. Rehwaldt M, Wickham R, Purl S, Tariman J, Blendowski C, Shott S. Self-care strategies to cope with taste changes after chemotherapy. Oncol Nurs Forum. 2009;36(2):E47–E56. 6. Speck RM, Demichele A, Farrar JT, Hennessy S, Mao JJ, Stineman MG, et al. Taste alteration in breast cancer patients treated with taxane chemotherapy: Experience, effect, and coping strategies. Support Care Cancer. 2013;21(2):549–55. 7. Hovan AJ, Williams PM, Stevenson-Moore P, Wahlin YB, Ohrn KEO, Elting LS, et al. A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer. 2010;18(8):1081–7. 8. Wismer W V. Assessing alterations in taste and their impact on cancer care. Curr Opin Support Palliat Care [Internet]. 2008;2(4):282–7. 9. Comeau TB, Epstein JB, Migas C. Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge. Support Care Cancer. 2001;9:575–80. 10. Gamper EM, Giesinger JM, Oberguggenberger A, Kemmler G, Wintner LM, Gattringer K, et al. Taste alterations in breast and gynaecological cancer patients receiving chemotherapy: Prevalence, course of severity, and quality of life correlates. Acta Oncol (Madr). 2012;51(4):490–6. 11. Mahmoud FA, Aktas A, Walsh D, Hullihen B. A Pilot study of taste changes among hospice ınpatients with advanced cancer. Am J Hosp Palliat Med [Internet]. 2011;28(7):487–92. 12. Boltong A, Keast R, Aranda S. Talking about taste: how do oncology clinicians discuss and document taste problems? Cancer Forum. 2011;35(2). 13. Brisbois TD, De Kock IH, Watanabe SM, Baracos VE, Wismer WV. Characterization of chemosensory alterations in advanced cancer reveals specific chemosensory phenotypes impacting dietary intake and quality of life. J Pain Symptom Manage [Internet]. 2011;41(4):673–83. 14. Hutton JL, Baracos VE, Wismer W V. Chemosensory dysfunction ıs a primary factor in the evolution of declining nutritional status and quality of life in patients with advanced cancer. J Pain Symptom Manage. 2007;33(2):156–65. 15. Alt-Epping B, Nejad RK, Jung K, Groß U, Nauck F. Symptoms of the oral cavity and their association with local microbiological and clinical findings-a prospective survey in palliative care. Support Care Cancer. 2012;20(3):531–7. 16. Jensen SB, Mouridsen HT, Bergmann OJ, Reibel J, Brünner N, Nauntofte B. Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2008;106(2):217–26. 17. Berteretche M V, Dalix AM, D’Ornano AMC, Bellisle F, Khayat D, Faurion A. Decreased taste sensitivity in cancer patients under chemotherapy. Support care cancer. 2004;12(8):571–6. 18. Sánchez-Lara K, Sosa-Sánchez R, Green-Renner D, Rodríguez C, Laviano A, Motola-Kuba D, et al. Influence of taste disorders on dietary behaviors in cancer patients under chemotherapy. Nutr J [Internet]. 2010;9(1):1–6. 19. Bernhardson B-M, Tishelman C, Rutqvist LE. Self-reported taste and smell changes during cancer chemotherapy. Support Care Cancer [Internet]. 2008 Mar 21;16(3):275–83. 20. Nishijima S, Yanase T, Tsuneki I, Tamura M, Kurabayashi T. Examination of the taste disorder associated with gynecological cancer chemotherapy. Gynecol Oncol [Internet]. 2013;131(3):674–8. 21. Collins JJ, Byrnes ME, Dunkel IJ, Lapin J, Nadel T, Thaler HT, et al. The measurement of symptoms in children with cancer. J Pain Symptom Manage. 2000;19(5):363–77. 22. Huijer A-S, Knar S, Tamim H. Quality of life and symptom prevalence as reported by children with cancer in Lebanon. Eur J Oncol Nurs [Internet]. 2013;17(6):704–10. 23. Karaman N, Sarı N, İlhan İE. Pediatrik onkoloji hastalarında kemoterapiye bağlı tat ve koku değişiklikleri. Turkish J Oncol [Internet]. 2013;28(3):101–4. 24. Yeh CH, Wang CH, Chiang YC, Lin L, Chien LC. Assessment of symptoms reported by 10- to 18-year-old cancer patients in Taiwan. J Pain Symptom Manage [Internet]. 2009;38(5):738–46. 25. Epstein J, Phillips N, Parry J, Epstein M, Nevill T, Stevenson-Moore P. Quality of life, taste, olfactory and oral function following high-dose chemotherapy and allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2002;30:785–92. 26. Boltong A, Keast R. The influence of chemotherapy on taste perception and food hedonics: A systematic review. Cancer Treat Rev [Internet]. 2012;38(2):152–63. 27. Bernhardson BM, Tishelman C, Rutqvist LE. Taste and smell changes in patients receiving cancer chemotherapy: distress, impact on daily life, and self-care strategies. Cancer Nurs [Internet]. 2009;32(1):45–54. 28. Lyckholm L, Heddinger S, Parker G, Coyne P, Ramakrishnan V, Smith T, et al. A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders. J Pain Palliat Care Pharmacother [Internet]. 2012;26(2):111–4. 29. Belqaid K, Tishelman C, McGreevy J, Månsson-Brahme E, Orrevall Y, Wismer W, et al. A longitudinal study of changing characteristics of self-reported taste and smell alterations in patients treated for lung cancer. Eur J Oncol Nurs [Internet]. 2016 Apr [cited 2016 Apr 11];21:232–41. 30. Cohen J, Laing DG, Wilkes FJ, Chan A, Gabriel M, Cohn RJ. Taste and smell dysfunction in childhood cancer survivors. Appetite [Internet]. 2014;75:135–40. 31. Zabernigg A, Gamper E-M, Giesinger JM, Rumpold G, Kemmler G, Gattringer K, et al. Taste alterations in cancer patients receiving chemotherapy: A neglected side effect? Oncologist. 2010;15(8):913–20. 32. McGreevy J, Orrevall Y, Belqaid K, Wismer W, Tishelman C, Bernhardson BM. Characteristics of taste and smell alterations reported by patients after starting treatment for lung cancer. Support Care Cancer. 2014;2635–44. 33. Bernhardson BM, Tishelman C, Rutqvist LE. Chemosensory changes experienced by patients undergoing cancer chemotherapy: A qualitative ınterview study. J Pain Symptom Manage. 2007;34(4):403–12. 34. Kano T, Kanda K. Development and validation of a chemotherapy-induced taste alteration scale. Oncol Nurs Forum [Internet]. 2013;40(2):E79-85. 35. Sherry VW. Taste alterations among patients with cancer. Clin J Oncol Nurs. 2009;6(2):73–7. 36. Wilken MK, Satiroff BA. Pilot study of “miracle fruit” to improve food palatability for patients receiving chemotherapy. Clin J Oncol Nurs. 2012;16(5):173. 37. Mann NM. Management of smell. Cleve Clin J Med. 2002;69(4):329–36. 38. Johnson FM. Alterations in taste sensation: a case presentation of a patient with end-stage pancreatic cancer. Cancer Nurs [Internet]. 2001;24(2):149–55. 39. Skolin I, Wahlin YB, Broman DA, Koivisto Hursti UK, Vikström Larsson M, Hernell O. Altered food intake and taste perception in children with cancer after start of chemotherapy: Perspectives of children, parents and nurses. Support Care Cancer. 2006;14(4):369–78. 40. McCulloch R, Hemsley J, Kelly P. Symptom management during chemotherapy. Paediatr Child Heal (United Kingdom) [Internet]. 2013;24(4):166–71. 41. Steinbach S, Hummel T, Böhner C, Berktold S, Hundt W, Kriner M, et al. Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies. J Clin Oncol. 2009;27(11):1899–905. 42. Hong JH, Omur-Ozbek P, Stanek BT, Dietrich AM, Duncan SE, Lee YW, et al. Taste and odor abnormalities in cancer patients. J Support Oncol. 2009;7(2):58–65. 43. de Vries YC, Helmich E, Karsten MDA, Boesveldt S, Winkels RM, van Laarhoven HWM. The impact of chemosensory and food-related changes in patients with advanced oesophagogastric cancer treated with capecitabine and oxaliplatin: a qualitative study. Support Care Cancer [Internet]. 2016;1–8. 44. Belqaid K, Orrevall Y, McGreevy J, Månsson-Brahme E, Wismer W, Tishelman C, et al. Self-reported taste and smell alterations in patients under investigation for lung cancer. Acta Oncol [Internet]. 2014;53(10):1405–12. 45. Boltong A, Campbell K. “Taste” changes: A problem for patients and their dietitians. Nutr Diet. 2013;70(4):262–9. 46. Sozeri E, Kutluturkan S. Taste Alteration in Patients Receiving Chemotherapy. J Breast Heal [Internet]. 2015;11(2):81–7. 47. Bilsin E. Kanserli Çocuklarda Kemoterapi İle İlişkili Tat Alma Değişikliği Ölçeğinin Geliştirilmesi. Doktora Tezi. Ege Üniversitesi; 2017. 48. Thorne T, Olson K, Wismer W. A state-of-the-art review of the management and treatment of taste and smell alterations in adult oncology patients. Support Care Cancer. 2015;23(9):2843–51. 49. Halyard MY. Taste and smell alterations in cancer patients--real problems with few solutions. J Support Oncol. 2009;7(2):68–9. 50. Heckmann SM, Hujoel P, Habiger S, Friess W, Wichmann M, Heckmann JG, et al. Zinc gluconate in the treatment of dysgeusia - a randomized clinical trial. J Dent Res. 2005;84(1):35–8. 51. Nagraj SK, Naresh S, Srinivas K, George PR, Shrestha A, Levenson D, et al. Interventions for the management of taste disturbances ( Review ). Cochrane Database Syst Rev. 2014;(11). 52. Halyard MY, Jatoi A, Sloan JA, Bearden JD, Vora SA, Atherton PJ, et al. Does zinc sulfate prevent therapy-ınduced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the north Central Cancer Treatment Group (N01C4). Int J Radiat Oncol Biol Phys. 2007;67(5):1318–22. 53. Strasser F, Demmer R, Böhme C, Hsu Schmitz S, Thuerlimann B, Cerny T, et al. Prevention of docetaxel-or paclitaxel-associated taste alterations in cancer patients with oral glutamine: a randomized, placebo-controlled, double-blind study. Oncologist [Internet]. 2008;13:337–46. 54. McLaughlin L, Mahon SM. Understanding taste dysfunction in patients with cancer. [Review]. Clin J Oncol Nurs. 2012;16(2):171–8.

Taste Alteration in Patients With Cancer

Year 2018, , 259 - 266, 10.06.2018
https://doi.org/10.17681/hsp.359196

Abstract

Taste alteration is one of the most common and important problems in
patients with cancer. Some patients were defined taste alteration as metallic,
bitter or bad taste in the mouth, sensitivity, insensitivity to sweet taste and
bitter taste intolerance. The etiologies of taste alteration are not fully
known in patients with cancer. Cancer treatment is influenced taste alteration
by physiological and psychological causes. In patients with cancer, loss of
appetite, dislike of some foods, change in food preferences, inadequate
feeding, inadequate energy intake, weight loss, malnutrition, poor prognosis,
reduced quality of life, stress, depression, dryness of the mouth, prolonged
hospital stay, impaired smell, deterioration of the immune system and reduction
compliance to treatment regimen develops as a result of taste alteration. Taste
alteration are difficult to measure and treat. It has been determined that
there is a lack of supportive strategies based on evidence taste alteration to
describe, classify and manage these problems. It has been determined that
prophylactic treatments are not successful. For this reason, the management of
taste alteration remains a problem in care and t
reatment of patients
with cancer.

References

  • 1. Epstein JB, Barasch A. Taste disorders in cancer patients: Pathogenesis, and approach to assessment and management. Oral Oncol 2010;46(2):77–81. 2. Imai H, Soeda H, Komine K, Otsuka K, Shibata H. Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer. BMC Palliat Care [Internet]. 2013;12(1):38. 3. Ravasco P. Aspects of taste and compliance in patients with cancer. Eur J Oncol Nurs. 2005;9(SUPPL. 2):84–91. 4. Zabernigg A, Gamper E-M, Giesinger JM, Rumpold G, Kemmler G, Gattringer K, et al. Taste alterations in cancer patients receiving chemotherapy: a neglected side effect? Oncologist. 2010;15(8):913–20. 5. Rehwaldt M, Wickham R, Purl S, Tariman J, Blendowski C, Shott S. Self-care strategies to cope with taste changes after chemotherapy. Oncol Nurs Forum. 2009;36(2):E47–E56. 6. Speck RM, Demichele A, Farrar JT, Hennessy S, Mao JJ, Stineman MG, et al. Taste alteration in breast cancer patients treated with taxane chemotherapy: Experience, effect, and coping strategies. Support Care Cancer. 2013;21(2):549–55. 7. Hovan AJ, Williams PM, Stevenson-Moore P, Wahlin YB, Ohrn KEO, Elting LS, et al. A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer. 2010;18(8):1081–7. 8. Wismer W V. Assessing alterations in taste and their impact on cancer care. Curr Opin Support Palliat Care [Internet]. 2008;2(4):282–7. 9. Comeau TB, Epstein JB, Migas C. Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge. Support Care Cancer. 2001;9:575–80. 10. Gamper EM, Giesinger JM, Oberguggenberger A, Kemmler G, Wintner LM, Gattringer K, et al. Taste alterations in breast and gynaecological cancer patients receiving chemotherapy: Prevalence, course of severity, and quality of life correlates. Acta Oncol (Madr). 2012;51(4):490–6. 11. Mahmoud FA, Aktas A, Walsh D, Hullihen B. A Pilot study of taste changes among hospice ınpatients with advanced cancer. Am J Hosp Palliat Med [Internet]. 2011;28(7):487–92. 12. Boltong A, Keast R, Aranda S. Talking about taste: how do oncology clinicians discuss and document taste problems? Cancer Forum. 2011;35(2). 13. Brisbois TD, De Kock IH, Watanabe SM, Baracos VE, Wismer WV. Characterization of chemosensory alterations in advanced cancer reveals specific chemosensory phenotypes impacting dietary intake and quality of life. J Pain Symptom Manage [Internet]. 2011;41(4):673–83. 14. Hutton JL, Baracos VE, Wismer W V. Chemosensory dysfunction ıs a primary factor in the evolution of declining nutritional status and quality of life in patients with advanced cancer. J Pain Symptom Manage. 2007;33(2):156–65. 15. Alt-Epping B, Nejad RK, Jung K, Groß U, Nauck F. Symptoms of the oral cavity and their association with local microbiological and clinical findings-a prospective survey in palliative care. Support Care Cancer. 2012;20(3):531–7. 16. Jensen SB, Mouridsen HT, Bergmann OJ, Reibel J, Brünner N, Nauntofte B. Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2008;106(2):217–26. 17. Berteretche M V, Dalix AM, D’Ornano AMC, Bellisle F, Khayat D, Faurion A. Decreased taste sensitivity in cancer patients under chemotherapy. Support care cancer. 2004;12(8):571–6. 18. Sánchez-Lara K, Sosa-Sánchez R, Green-Renner D, Rodríguez C, Laviano A, Motola-Kuba D, et al. Influence of taste disorders on dietary behaviors in cancer patients under chemotherapy. Nutr J [Internet]. 2010;9(1):1–6. 19. Bernhardson B-M, Tishelman C, Rutqvist LE. Self-reported taste and smell changes during cancer chemotherapy. Support Care Cancer [Internet]. 2008 Mar 21;16(3):275–83. 20. Nishijima S, Yanase T, Tsuneki I, Tamura M, Kurabayashi T. Examination of the taste disorder associated with gynecological cancer chemotherapy. Gynecol Oncol [Internet]. 2013;131(3):674–8. 21. Collins JJ, Byrnes ME, Dunkel IJ, Lapin J, Nadel T, Thaler HT, et al. The measurement of symptoms in children with cancer. J Pain Symptom Manage. 2000;19(5):363–77. 22. Huijer A-S, Knar S, Tamim H. Quality of life and symptom prevalence as reported by children with cancer in Lebanon. Eur J Oncol Nurs [Internet]. 2013;17(6):704–10. 23. Karaman N, Sarı N, İlhan İE. Pediatrik onkoloji hastalarında kemoterapiye bağlı tat ve koku değişiklikleri. Turkish J Oncol [Internet]. 2013;28(3):101–4. 24. Yeh CH, Wang CH, Chiang YC, Lin L, Chien LC. Assessment of symptoms reported by 10- to 18-year-old cancer patients in Taiwan. J Pain Symptom Manage [Internet]. 2009;38(5):738–46. 25. Epstein J, Phillips N, Parry J, Epstein M, Nevill T, Stevenson-Moore P. Quality of life, taste, olfactory and oral function following high-dose chemotherapy and allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2002;30:785–92. 26. Boltong A, Keast R. The influence of chemotherapy on taste perception and food hedonics: A systematic review. Cancer Treat Rev [Internet]. 2012;38(2):152–63. 27. Bernhardson BM, Tishelman C, Rutqvist LE. Taste and smell changes in patients receiving cancer chemotherapy: distress, impact on daily life, and self-care strategies. Cancer Nurs [Internet]. 2009;32(1):45–54. 28. Lyckholm L, Heddinger S, Parker G, Coyne P, Ramakrishnan V, Smith T, et al. A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders. J Pain Palliat Care Pharmacother [Internet]. 2012;26(2):111–4. 29. Belqaid K, Tishelman C, McGreevy J, Månsson-Brahme E, Orrevall Y, Wismer W, et al. A longitudinal study of changing characteristics of self-reported taste and smell alterations in patients treated for lung cancer. Eur J Oncol Nurs [Internet]. 2016 Apr [cited 2016 Apr 11];21:232–41. 30. Cohen J, Laing DG, Wilkes FJ, Chan A, Gabriel M, Cohn RJ. Taste and smell dysfunction in childhood cancer survivors. Appetite [Internet]. 2014;75:135–40. 31. Zabernigg A, Gamper E-M, Giesinger JM, Rumpold G, Kemmler G, Gattringer K, et al. Taste alterations in cancer patients receiving chemotherapy: A neglected side effect? Oncologist. 2010;15(8):913–20. 32. McGreevy J, Orrevall Y, Belqaid K, Wismer W, Tishelman C, Bernhardson BM. Characteristics of taste and smell alterations reported by patients after starting treatment for lung cancer. Support Care Cancer. 2014;2635–44. 33. Bernhardson BM, Tishelman C, Rutqvist LE. Chemosensory changes experienced by patients undergoing cancer chemotherapy: A qualitative ınterview study. J Pain Symptom Manage. 2007;34(4):403–12. 34. Kano T, Kanda K. Development and validation of a chemotherapy-induced taste alteration scale. Oncol Nurs Forum [Internet]. 2013;40(2):E79-85. 35. Sherry VW. Taste alterations among patients with cancer. Clin J Oncol Nurs. 2009;6(2):73–7. 36. Wilken MK, Satiroff BA. Pilot study of “miracle fruit” to improve food palatability for patients receiving chemotherapy. Clin J Oncol Nurs. 2012;16(5):173. 37. Mann NM. Management of smell. Cleve Clin J Med. 2002;69(4):329–36. 38. Johnson FM. Alterations in taste sensation: a case presentation of a patient with end-stage pancreatic cancer. Cancer Nurs [Internet]. 2001;24(2):149–55. 39. Skolin I, Wahlin YB, Broman DA, Koivisto Hursti UK, Vikström Larsson M, Hernell O. Altered food intake and taste perception in children with cancer after start of chemotherapy: Perspectives of children, parents and nurses. Support Care Cancer. 2006;14(4):369–78. 40. McCulloch R, Hemsley J, Kelly P. Symptom management during chemotherapy. Paediatr Child Heal (United Kingdom) [Internet]. 2013;24(4):166–71. 41. Steinbach S, Hummel T, Böhner C, Berktold S, Hundt W, Kriner M, et al. Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies. J Clin Oncol. 2009;27(11):1899–905. 42. Hong JH, Omur-Ozbek P, Stanek BT, Dietrich AM, Duncan SE, Lee YW, et al. Taste and odor abnormalities in cancer patients. J Support Oncol. 2009;7(2):58–65. 43. de Vries YC, Helmich E, Karsten MDA, Boesveldt S, Winkels RM, van Laarhoven HWM. The impact of chemosensory and food-related changes in patients with advanced oesophagogastric cancer treated with capecitabine and oxaliplatin: a qualitative study. Support Care Cancer [Internet]. 2016;1–8. 44. Belqaid K, Orrevall Y, McGreevy J, Månsson-Brahme E, Wismer W, Tishelman C, et al. Self-reported taste and smell alterations in patients under investigation for lung cancer. Acta Oncol [Internet]. 2014;53(10):1405–12. 45. Boltong A, Campbell K. “Taste” changes: A problem for patients and their dietitians. Nutr Diet. 2013;70(4):262–9. 46. Sozeri E, Kutluturkan S. Taste Alteration in Patients Receiving Chemotherapy. J Breast Heal [Internet]. 2015;11(2):81–7. 47. Bilsin E. Kanserli Çocuklarda Kemoterapi İle İlişkili Tat Alma Değişikliği Ölçeğinin Geliştirilmesi. Doktora Tezi. Ege Üniversitesi; 2017. 48. Thorne T, Olson K, Wismer W. A state-of-the-art review of the management and treatment of taste and smell alterations in adult oncology patients. Support Care Cancer. 2015;23(9):2843–51. 49. Halyard MY. Taste and smell alterations in cancer patients--real problems with few solutions. J Support Oncol. 2009;7(2):68–9. 50. Heckmann SM, Hujoel P, Habiger S, Friess W, Wichmann M, Heckmann JG, et al. Zinc gluconate in the treatment of dysgeusia - a randomized clinical trial. J Dent Res. 2005;84(1):35–8. 51. Nagraj SK, Naresh S, Srinivas K, George PR, Shrestha A, Levenson D, et al. Interventions for the management of taste disturbances ( Review ). Cochrane Database Syst Rev. 2014;(11). 52. Halyard MY, Jatoi A, Sloan JA, Bearden JD, Vora SA, Atherton PJ, et al. Does zinc sulfate prevent therapy-ınduced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the north Central Cancer Treatment Group (N01C4). Int J Radiat Oncol Biol Phys. 2007;67(5):1318–22. 53. Strasser F, Demmer R, Böhme C, Hsu Schmitz S, Thuerlimann B, Cerny T, et al. Prevention of docetaxel-or paclitaxel-associated taste alterations in cancer patients with oral glutamine: a randomized, placebo-controlled, double-blind study. Oncologist [Internet]. 2008;13:337–46. 54. McLaughlin L, Mahon SM. Understanding taste dysfunction in patients with cancer. [Review]. Clin J Oncol Nurs. 2012;16(2):171–8.
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Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section REVIEW ARTICLE
Authors

Elif Bilsin

Hatice Bal Yılmaz

Publication Date June 10, 2018
Published in Issue Year 2018

Cite

APA Bilsin, E., & Bal Yılmaz, H. (2018). Kanserli Hastalarda Tat Alma Değişikliği. Sağlık Bilimleri Ve Meslekleri Dergisi, 5(2), 259-266. https://doi.org/10.17681/hsp.359196
AMA Bilsin E, Bal Yılmaz H. Kanserli Hastalarda Tat Alma Değişikliği. HSP. June 2018;5(2):259-266. doi:10.17681/hsp.359196
Chicago Bilsin, Elif, and Hatice Bal Yılmaz. “Kanserli Hastalarda Tat Alma Değişikliği”. Sağlık Bilimleri Ve Meslekleri Dergisi 5, no. 2 (June 2018): 259-66. https://doi.org/10.17681/hsp.359196.
EndNote Bilsin E, Bal Yılmaz H (June 1, 2018) Kanserli Hastalarda Tat Alma Değişikliği. Sağlık Bilimleri ve Meslekleri Dergisi 5 2 259–266.
IEEE E. Bilsin and H. Bal Yılmaz, “Kanserli Hastalarda Tat Alma Değişikliği”, HSP, vol. 5, no. 2, pp. 259–266, 2018, doi: 10.17681/hsp.359196.
ISNAD Bilsin, Elif - Bal Yılmaz, Hatice. “Kanserli Hastalarda Tat Alma Değişikliği”. Sağlık Bilimleri ve Meslekleri Dergisi 5/2 (June 2018), 259-266. https://doi.org/10.17681/hsp.359196.
JAMA Bilsin E, Bal Yılmaz H. Kanserli Hastalarda Tat Alma Değişikliği. HSP. 2018;5:259–266.
MLA Bilsin, Elif and Hatice Bal Yılmaz. “Kanserli Hastalarda Tat Alma Değişikliği”. Sağlık Bilimleri Ve Meslekleri Dergisi, vol. 5, no. 2, 2018, pp. 259-66, doi:10.17681/hsp.359196.
Vancouver Bilsin E, Bal Yılmaz H. Kanserli Hastalarda Tat Alma Değişikliği. HSP. 2018;5(2):259-66.