The bioavailability of ampicillins in some animals

Year 2024, , 1 - 4, 30.04.2024

Kerem Güzelaydın , Murat Yıldırım

https://doi.org/10.30704/http-www-jivs-net.1408540

Abstract

Ampicillin, a partially synthetic derivative of penicillin, has been widely used in both human and veterinary medicine for a long time. As a result of its limited ability to be absorbed into the bloodstream when taken orally by humans, precursor chemicals such bakampicillin, pivampicillin, and talampicillin have been created. Although ampicillin is widely used in veterinary treatment practice, the applications of ampicillin esters in animals have not gone beyond scientific trials and have not found widespread use. Since there are not many antibiotic options authorized for use in poultry, in our review, the pharmacokinetic properties of ampicillins, especially oral bioavailability, in some animal species will be mentioned and the need for studies that will examine the bioavailability of pre-ampicillins will be emphasized.

Keywords

Ampicillins, poultry, pharmacokinetics

References

• Bolme, P., Dahlström, B., Diding, N. Å., Flink, O., & Paalzow, L. (1976). Ampicillin: Comparison of bioavailability and pharmacokinetics after oral and intravenous administration of three brands. European Journal of Clinical Pharmacology, 10, 237-243.
• Çolak, B. (2009). Maleikanhidrit kopolimerinin asetil salisilik asit ile kimyasal modifikasyonu ve kontrollü salımının incelenmesi. Yüksek Lisans Tezi İstanbul Teknik Üniversitesi Fen Bilimleri Enstitüsü, Istanbul, Türkiye.
• Demain, A. L., & Solomon, N. A. (Eds.). (1983). Antibiotics. Handbook of Experimental Pharmacology, Berlin, Heidelberg, Germany: Springer.
• Dorrestein, G. M., Van Gogh, H., Rinzema, J. D., & Buitelaar, M. N. (1987). Comparative study of ampicillin and amoxycillin after intravenous, intramuscular and oral administration in homing pigeons (Columba livia). Research in Veterinary Science, 42(3), 343-348.
• Dürr, A. (1976). Comparison of the pharmacokinetics of penicillin G and ampicillin in the horse. Research in Veterinary Science, 20(1), 24-29. Ensink, J. M., Klein, W. R., Mevius, D. J., Klarenbeek, A., & Vulto, A. G. (1992). Bioavailability of oral penicillins in the horse: a comparison of pivampicillin and amoxicillin. Journal of Veterinary Pharmacology and Therapeutics, 15 (3), 221-230. Ensink, J. M., Vulto, A. G., Van Miert, A. S., Tukker, J. J., Winkel, M. B., & Fluitman, M. A. (1996). Oral bioavailability and in vitro stability of pivampicillin, bacampicillin, talampicillin, and ampicillin in horses. American Jjournal of Veterinary Research, 57(7), 1021-1024.
• Ensley, P. K., & Janssen, D. L. (1981). A Preliminary Study Comparing the Pharmacokinetics of Ampicillin Given Orally and Intramuscularly to Psittacines: Amazon Parrots (Amazond spp.) and Blue-Naped Parrots (Tanygnathus lucionensis). Journal of Zoo Animal Medicine, 12(2), 42-47.
• Goren, E., De Jong, W. A., & Van Solkema, A. (1981). Some pharmacokinetical aspects of ampicillin trihydrate and its therapeutic efficacy in experimental Escherichia coli infection in poultry. Avian Pathology, 10(1), 43-55.
• Gubert, S., Palacin, C., Sacristán, A., & Ortiz, J. A. (1987). Synthesis and oral absorption of hetacillin and hetamoxicillin labile esters. Chemical and pharmaceutical bulletin, 35(6), 2366-2372.
• Horspool, L. J. I., Sarasola, P., & McKellar, Q. A. (1992). Disposition of ampicillin sodium in horses, ponies and donkeys after intravenous administration. Equine Veterinary Journal, 24(S11), 59-61.
• Kandeel, M. (2014). Bioavailability and Pharmacokinetics of Ampicillin in Chicken. International Journal of Pharmacology, 10(6), 340-344.
• Landoni, M. F., & Albarellos, G. (2015). The use of antimicrobial agents in broiler chickens. The Veterinary Journal, 205(1), 21-27.
• Poapolathep, A., Limpoka, M., Tansakul, N., Phaochoosak, N., Klangkaew, N., & Passadurak, W. (2001). Pharmacokinetics and withdrawal times of ampicillin in ducks. Agriculture and Natural Resources, 35(1), 40-45.
• Prescott, J. F., & Baggot, J. D. (1988). Antimicrobial therapy in veterinary medicine : Blackwell scientific publications.
• Sumano Lopez, H., Gutierrez Olivera, L., (2010): Farmacología Clínica en aves comerciales, Fourth Ed. McGraw Hill, Mexico DF, Mexico, pp. 54-196.
• Villa, R., Prandini, E., Montesissa, C., & Carli, S. (1994, August). Serum protein binding of β-lactamine derivatives in farm and domestic animals. In Proceedings of the 6th International Congress of EAVPT (Vol. 7, No. 11).
• Winther, L., Baptiste, K. E., & Friis, C. (2012). Pharmacokinetics in pulmonary epithelial lining fluid and plasma of ampicillin and pivampicillin administered to horses. Research in Veterinary Science, 92(1), 111-115.
• Yıldırım, M. (2008). Veteriner hekimlikte yeni antibiyoterapi yaklaşımları. İstanbul Üniversitesi. Veteriner Fakültesi Dergisi, 34(3), 19-27.
• Ziv, G., Neumann, J., Fridman, J., Ziv, E., Singer, N., & Meshorer, A. (1979, October). Effects of Probenecid on Blood Levels and Tissue Distribution of Ampicillin in Fowls and Turkeys. Avian Diseases, 23(4), 927.