Herbal compounds used in canine cognitive dysfunction
Year 2024,
, 159 - 165, 31.08.2024
Gülşah Emre Mantar
,
Gülcan Demirel
Abstract
The prevalence of chronic diseases in dogs has been increasing due to their longer life spans. One of the diseases developing with age is Canine Cognitive Dysfunction (CCD) and it is a neurodegenerative disease that affects geriatric dogs. In dogs with cognitive dysfunction, behavioral changes such as anxiety, alterations in sleep patterns, and house soiling can be observed. The treatment protocols used for Canine Cognitive Dysfunction focus on alleviating the symptoms of the disease. Since this dysfunction cannot be cured, in addition to medications, lifestyle changes and dietary interventions are used to manage the symptoms. Herbal compounds frequently used in CCD have been the topic of recent studies. This review article presents the herbal compounds that can be used in dogs with CCD and summarizes the findings from studies on these supplements.
References
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Year 2024,
, 159 - 165, 31.08.2024
Gülşah Emre Mantar
,
Gülcan Demirel
References
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- Harvey N. D. (2021). How Old Is My Dog? Identification of Rational Age Groupings in Pet Dogs Based Upon Normative Age-Linked Processes. Frontiers in Veterinary Science, 8, 643085.
- Head E. (2009). Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging. Neurochemical Research, 34(4), 670–678.
- Head, E., Liu, J., Hagen, T. M., Muggenburg, B. A., Milgram, N. W., Ames, B. N., & Cotman, C. W. (2002). Oxidative damage increases with age in a canine model of human brain aging. Journal of Neurochemistry, 82(2), 375–381.
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Head, E., Nukala, V. N., Fenoglio, K. A., Muggenburg, B. A., Cotman, C. W., & Sullivan, P. G. (2009). Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Experimental Neurology, 220(1), 171–176.
- Head, E., Pop, V., Sarsoza, F., Kayed, R., Beckett, T. L., Studzinski, C. M., Tomic, J. L., Glabe, C. G., & Murphy, M. P. (2010). Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. Journal of Alzheimer's Disease, 20(2), 637–646.
- Herholz K. (2008). Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's disease. European Fournal of Nuclear Medicine and Molecular Imaging, 35 Suppl 1, S25–S29.
- Inoue, M., Kwan, N. C. L., & Sugiura, K. (2018). Estimating the life expectancy of companion dogs in Japan using pet cemetery data. The Journal of Veterinary Medical Science, 80(7), 1153–1158.
- Kidd, P. M. (1996). Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Alternative Medicine Review, 1(2), 70-84.
- Koltai, M., Hosford, D., Guinot, P., Esanu, A., & Braquet, P. (1991). Platelet activating factor (PAF). A review of its effects, antagonists and possible future clinical implications (Part I). Drugs, 42(1), 9–29.
- Kuhad, A., Sethi, R., & Chopra, K. (2008). Lycopene attenuates diabetes-associated cognitive decline in rats. Life Sciences, 83(3-4), 128–134.
- Landsberg, G., & Araujo, J. A. (2005). Behavior problems in geriatric pets. The Veterinary clinics of North America. Small Animal Practice, 35(3), 675–698.
- Lee, Mi-Jin, Miey Park, and Hae-Jeung Lee. (2022). "Dietary Supplemented Anthocyanin Reduced Serum Amyloid Beta Oligomers and Improved Cognitive Dysfunction Scores in Elderly Dogs" Applied Sciences 12, no. 23: 12130.
- Liu, J., & Mori, A. (1999). Stress, aging, and brain oxidative damage. Neurochemical research, 24(11), 1479–1497.
- Milgram, N. W., Araujo, J. A., Hagen, T. M., Treadwell, B. V., & Ames, B. N. (2007). Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. FASEB Journal, 21(13), 3756–3762.
- Montoya, M., Morrison, J. A., Arrignon, F., Spofford, N., Charles, H., Hours, M. A., & Biourge, V. (2023). Life expectancy tables for dogs and cats derived from clinical data. Frontiers in Veterinary Science, 10, 1082102.
- Moreta, M. P., Burgos-Alonso, N., Torrecilla, M., Marco-Contelles, J., & Bruzos-Cidón, C. (2021). Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer's Disease. Review of Reviews. Biomedicines, 9(11), 1689.
- Naomi, R., Yazid, M. D., Teoh, S. H., Balan, S. S., Shariff, H., Kumar, J., Bahari, H., & Embong, H. (2023). Dietary Polyphenols as a Protection against Cognitive Decline: Evidence from Animal Experiments; Mechanisms and Limitations. Antioxidants (Basel, Switzerland), 12(5), 1054.
- Okuda, M., Fujita, Y., & Sugimoto, H. (2019). The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice. Biological & Pharmaceutical Bulletin, 42(10), 1694–1706.
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