Is thermography the most effective tool to monitor arthritis in rats?

Year 2021, , 117 - 122, 30.12.2021

Elif Doğan , Azizcan Sezer

https://doi.org/10.30704/http-www-jivs-net.951101

Abstract

In this study, it was aimed to compare the effect of clinical, radiological, and thermographic methods on the diagnosis and prognosis in experimentally rats with arthritis. A total of 24 rats were divided into 2 groups, each consisting of 12 rats. Arthritis was formed by administering 0,1 ml of FCA solution to the left-back extremities of the rats. The first group was called the control group. Cephalexin (60 mg/kg) and Diclofenac Sodium (1mg/kg) were applied to the second group to be the treatment group. From day 1 of the experiment, clinical evaluation and live weight measurements were performed every day. On the 7th, 14th, 21st, 28th days of the experiment, paw edema, radiographic, thermographic measurements were performed. While typical arthritis clinical findings obtain after FCA administration, no statistically significant difference was found when analyzing the changes of live weight measurements and paw edema measurements according to groups and time. The difference in the mean of the thermographic measurements of the arthritis-forming claws was statistically significant. Radiographically, degenerations in the joints and bones were found in the control group compared to the more in the treatment group. As a result, it was concluded that thermography can be a good alternative to clinical findings and radiography in the follow-up of arthritis.

Keywords

Inflammation of joint, monitoring, radiography, thermal camera

Supporting Institution

The authors received no financial support for the research, authorship, and/or publication of this article.

References

• Borojevic, N., Kolaric, D., Grazio, S., Grubisic, F., Antonini, S., Nola, I.A., & Herceg, Z. (2011). Thermography hand temperature distribution in rheumatoid arthritis and osteoarthritis. Periodicum Biologorum, 113(4), 445-448.
• Bumin, A., Temizsoylu, M.D., Kibar, M., & Alkan Z. (2001). Clinical, radiographic and arthroscopic evaluation of purulent arthritis in calves. Veterinary Journal of Ankara University, 48, 183-187.
• Cenesiz, S., Ciftci, G., Gulbahar, M.Y., Yarim, G.F., Nisbet, H., Kabak, Y., & Nisbet, C. (2012). Investigation of the effects of n-acetyl cysteine and resveratrol to acute phase response in rats with experimentally ınduced arthritis. Journal of the Faculty of Veterınary Medıcıne, Kafkas Unıversıty; 18 (6), 991-996.
• Chew, F.S. (2010). Skeletal Radiology, The Bare Bones. 3th ed. Philadelphia, Lip Wil & Wilk.
• Cuevas, I.F., Marins, J.C.B., Lastras, J.A, Carmona, P.M.G., Cano, S.P., Concepcion, M.A.G., & Quintana, M.S. (2015). Classification of factors influencing the use of infrared thermography in humans: a review. Infrared Physics & Technology, 71, 28-55.
• Denoble, A.E., Hall, N., Pieper, C.F., & Kraus, V.B. (2010). Patellar skin surface temperature by thermography refl ects knee osteoarthritis severity. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 3, 69-75.
• Düzgün, D., & Or, M.E. (2009). Application of Thermal Camera on the Medicine and Veterinary. Journal of Tubav Science, 2 (4), 468-475.
• Gertel, S., Serre, G., Shoenfeld, Y., & Amital, H. (2015). Immune tolerance induction with multiepitope peptide derived from citrullinated autoantigens attenuates arthritis manifestations in adjuvant arthritis rats. The Journal of Immunology, 194(12), 5674-5680.
• Gökhan, N., & Öztürk, S. (2016). Evaluation of Clinic, Radiographic, Ultrasonographic and Histopathological Findings of Arthritis Cases in Calves. Journal of Faculty of Veterinary Medicine, Erciyes University, 13 (1), 19-29.
• Hovinen, M., Siivonen, J., Taponen, S., Hanninen, L., Pastell, M., Aisla, A.M., & Pyörala, S. (2008). Detection of clinical mastitis with the help of a thermal camera. Journal of Dairy Science, 91 (12), 4592-4598.
• Jiang, L.J., Ng, E.Y.K., Yeo, A.C.B., Wu, S., Pan, F., Yau, W.Y., Chen, J.H., & Yang Y. (2005). A Perspective on medical infrared imaging. Journal of Medical Engineering Technology, 29(6), 257-267.
• Kerimoğlu, G., Baki, M.E., & Çakıroğlu, K.A. (2017). The effectiveness of intra-articular propolis extract on the treatment of experimental osteoarthritis in rats. Dicle Medical Journal, 44(4), 325-332.
• Laughmiller, J.A., Spire, M.F., Dritz, S.S., Fenwick, B.W., Hosni, M.H., & Hogge, S.B. (2001). Relationship between mean surface temperature measured by use of infrared thermograpy and ambient temperature in clinically normal pigs and pigs inoculated with Antinobacillus Pleuropeumobia. American Journal of Veterinary Research, 62 (5), 676-681.
• Moskowitz, R.W., & Holderbaum, D. (2001). Clinical and laboratory findings in osteoarthritis. Arthritis and allied conditions: a textbook of rheumatology. 14th ed. Philadelphia, Lip Wil and Wilk.
• Naredo, E., Bonilla, G., Gamero, F., Uson, J., & Carmona, L. (2005). Assessment of inflammatory activity in rheumatoid arthritis: a comparative study of clinical evaluation with grey scale and power doppler ultrasonography. Annals Rheumatic Disease, 64(3): 375-381.
• Nipate, S.S., & Bhandarkar, A.A. (2020). Anti-inflammatory, antinociceptive and antiarhritic potential of apis cerana indica bee venom by reducing pain and degeneration of articular cartilage in adjuvant and collagen induced rat models of arthritis. Journal of Orthopedics and Muscular System, 3(1), 1009.
• Öktem, A., Çelik, H.T., Göçer, E., Ceyhan, M., Yiğit, Ş., & Yurdakök, M. (2016). Septic arthritis in newborn: Hacettepe experience and review of the literature. Çocuk Sağlığı ve Hastalıkları Dergisi, 59, 1-13.
• Örgüç Ş. (2014). Romatolojik Hastalıklarda Üst Ekstremite Tutulumu. Türk Radyoloji Derneği Dergisi, 2, 103-117. Özbek, H., & Öztürk A. (2003). The Methods for Measurement of Anti-inflammatory Activity. Van Medical Journal, 10(1), 23-28.
• Öztuna, V. (2010). Septik artrit. Türk Ortopedi ve Travmatoloji Birliği Derneği Dergisi, 9(2), 101-106.
• Rao, M., Nagaraja, B.N., Kumar, S., Vasanth, M.S., & Rao, S. (2020). Incidence and clinical signs associated with septic arthritis in calves, The Pharma Innovation Journal, 9(9), 157-160.
• Samsar, E., & Akın, F. (2003). Genel Cerrahii 2nd ed. Ankara, Medipres Yayınları.
• Sarıerler, M., & Alkan, Z. (2002). The comparison of the clinic radiographic and arthroscopic findings in cattle with arthritis. Veteriner Cerrahi Dergisi, 8(3-4), 41-47.
• Saricaoglu, F., Dal, D., Atilla, P., Iskit, A.B., Tarhan, O., Asan, E., & Aypar, U.A. (2008). Effect of intraarticular injection of lornoxicam on the articular cartilage & synovium in rat. Indian Journal of Medical Research, 127(4), 362.
• Yanık, B., Kurtaiş, Y., & Küçükdeveci, A. (2007). Acute Septic Arthritis in Osteonecrosis of The Knee: Case Report. Turkish Journal of Physical Medicine and Rehabilitation, 53, 124-126.
• Yurdakul, G., & Sarıtaş, Z.K. (2013). Evaluation of Clinic, Radiographic and Some Biochemical Blood Serum and Synovial Fluid Parameters of Arthritis Cases in Calves. Kocatepe Veterinary Journal, 6(2), 13-22.
• Wang, N., Zhao, X., Huai, J., Li, Y., Cheng, C., Bi, K., & Dai, R. (2018). Arachidonic acid metabonomics study for understanding therapeutic mechanism of Huo Luo Xiao Ling Dan on rat model of rheumatoid arthritis. Journal of Ethnopharmacology, 10(217), 205-211.