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Year 2020, Volume: 4 Issue: 3, 136 - 144, 30.12.2020
https://doi.org/10.30704/http-www-jivs-net.811491

Abstract

References

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  • Butler, A. E., Janson, J., Bonner‑Weir, S., Ritzel, R., Rizza, R. A. & Butler, P. C. (2003). Beta‑cell deficit and increased beta‑cell apoptosis in humans with type 2 diabetes. Diabetes, 52, 102–110.
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Ameliorative effects of Allium cepa Linn. scaly leaves extract on reproductive dysfunctions in streptozotocin-induced diabetic Wistar rats

Year 2020, Volume: 4 Issue: 3, 136 - 144, 30.12.2020
https://doi.org/10.30704/http-www-jivs-net.811491

Abstract

Diabetes mellitus, an endocrine and metabolic disorder characterized by hyperglycemia and low blood insulin or target organs insensitivity to insulin affects life quality due to its complications. Infertility is a complication in diabetes. Various agents have been used for research on diabetes-induced infertility globally, but there are little documented treatments for diabetes associated infertility. Allium cepa scaly leaves extract (ACSLE) possess anti-oxidant and anti-diabetic activities. This study investigated the effects of ACSLE on reproductive dysfunctions in male diabetic rats. Twenty eight male rats were assigned to 4 groups (n=7): CT (control); DNT (streptozotocin, 60 mg/kg once, intraperitoneal), DT1 and DT2 (streptozotocin, 60 mg/kg once, intraperitoneal, ACSLE 125 and 250 mg/kg rat/day respectively). Organ samples were obtained after 2 weeks and testicular weights recorded. Fasting blood glucose was determined using a digital glucometer. Sperm count, motility, viability and morphology were assessed microscopically. Testes were histologically evaluated. Glucose levels were reduced in DT1 and DT2 compared with DNT. Testes weights increased in DT1and DT2 compared with DNT. Sperm concentration increased in DT1 and DT2 compared with DNT motility increased in DT1 and DT2 compared with DNT; viability increased significantly in DT1 and DT2 compared with DNT. Abnormal sperm morphology decreased in DT1 and DT2 compared with DNT. Testes showed degenerated cells in DNT and no lesions in DT1 and DT2. Reduced blood glucose, improved testicular functions and morphology showed that ACSLE ameliorated reproductive dysfunctions associated with streptozotocin-induced diabetes in male Wistar rats.

References

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  • Adedara, I. A., Awogbindin, I. O., Anamelechi, J. P. & Farombi, E. O. (2015). Garcinia kola seed ameliorates renal hepatic, and testicular oxidative damage in streptozotocin-induced diabetic rats. Pharmaceutical Biology, 1, 695–704.
  • Afifi, M., Almaghrabi, O. A. & Kadasa, N. M. (2015). Ameliorative effect of zinc oxide nanoparticles on antioxidants and sperm characteristics in streptozotocin- induced diabetic rat testes. Biomedical Research International, 2, 1–6.
  • Agarwal, A., Makker, K. & Sharma, R. (2008). Clinical relevance of oxidative stress in male factor infertility: An update. American Journal of Reproduction and Immunology, 59, 2–11.
  • Agbaje, I. M., Rogers, D. A., McVicar, C. M., McClure, N., Atkinson, A. B., Mallidis, C. & Lewis, S. E. M. (2007). Insulin dependant diabetes mellitus: implications for male reproductive function. Human Reproduction, 22, 1871–7.
  • Akbarzadeh, A., Norouzian, D., Mehrabi, M. R. Jamshidi, Sh., Farhangi, A., Allah Verdi, A., Mofidian, S. M. A. & Lame Rad, B. (2007). Induction of diabetes by streptozotocin in rats. Indian Journal of Clinical Biochemestry, 22 (2), 60-64.
  • Akkati, S., Sam, K. G. & Tungha, G. (2011). Emergence of promising therapies in diabetes mellitus. Journal of Clinical Pharmacology, 51, 796–804.
  • Amaral, S., & Ramalho-Santos, J. (2014). Free radical biology and reproductive health in diabetes. In ‘Systems Biology of Free Radicals and Anti-Oxidants’. (Ed. I. Laher.) pp. 1–24. (Springer–Verlag: Berlin.)
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  • Amidu, N., Owiredu, W. K., Alidu, H., Sarpong, C., Gyasisarpong, C. K. & Quaye, L. (2013). Association between metabolic syndrome and sexual dysfunction among men with clinically diagnosed diabetes. Diabetology and Metabolic Syndrome, 5, 242–250.
  • Baccetti, B., Marca, L. A. & Piomboni, P. (2002). Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality. Human Reproduction, 17, 2673-2677.
  • Bindu, B. & Podikunju, B. (2015). Performance evaluation of onion (Allium Cepa L. Var. Cepa) varieties for their suitability in kollam district. International Journal of Research in Agricultural Science, l (1), 18–20.
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  • Cavallini, G. (2006). Male idiopathic oligoasthenoteratozoospermia. Asian Journal of Andrology. 8, 143–157.
  • Chae, M. R., Kang, S. J., Lee, K. P., Choi, B. R., Kim, H. K., Park, J. K., Kim, C. Y. & Lee, S.W. (2017). Onion (Allium cepa L.) peel extract (OPE) regulates human sperm motility via protein kinase C-mediated activation of the human voltage-gated proton channel. Andrology, 5(5), 979–989.
  • Cooke, D. W. & Plotnick, L. (2008). Type 1 diabetes mellitus in pediatrics. Pediatric Review, 29, 374–384.
  • Coskun, O., Kanter, M., Korkmaz, A. & Oter, S. (2005). Quercetin; a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacology Research, 51, 117-123.
  • de Ancos, B., Colina-Coca, C., Gonzalex-Pena, D. & Sanchez-Moreno, C. (2015). Bioactive compounds from vegetable and fruit by-products. In Biotechnology of Bioactive Compounds. Sources and Applications. Section I, V. K. Gupta and M. G. Tuohy, Eds., pp. 3–36,Wiley Blackwell, 2015.
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  • Edeoga, H. O., Okwu, D. E. & Mbaebie, B. O. (2005). Phytochemical constituents of some Nigerian medicinal plants. African Journal of Biotechnology, 4 (7), 685-688.
  • Eizirik, D. L., Colli, M. L. & Ortis, F. (2009). The role of inflammation in insulitis and beta‑cell loss in type 1 diabetes. Nature Reviews Endocrinology, 5, 219–26.
  • Flesch, F. M. & Gadella, B. M. (2000). Dynamics of the mammalian sperm plasma membrane in the process of fertilization. Biochimica et Biophysica Acta, 1469, 197–235.
  • Folli, F., D. Corradi, P. Fanti, A. Davalli, A. Paez, A. Giaccari, C. Perego & G. Muscogiuri. (2011). The Role of Oxidative Stress in the Pathogenesis of Type 2 Diabetes Mellitus Micro- and Macrovascular Complications: Avenues for a Mechanistic-Based Therapeutic Approach. Current Diabetes Review, 7 (5), 313-324.
  • Freitas, J. P., Filipe, P. M. & Rodrigo, F. G. (1997). Lipid peroxidation intype 2 normolipidemic diabetic patients. Diabetes Research and Clinical Practice, 36, 71–75.
  • Ghanbari, E., Nejati, V., Najafi, G., Khazaei, M. & Babaei, M. (2015). Study on the effect of royal jelly on reproductive parameters in streptozotocin-induced diabetic rats. Internal Journal of Fertility and Sterility, 1, 113–120.
  • Griffiths, G., Trueman, L., Crowther, T., Thomas, B. & Smith, B. (2002). Onions—a global benefit to health. Phytotherapy Research, 16(7), 603–615.
  • Harrison, R. A. & Gadella, B. M. (2005). Bicarbonate‑induced membrane processing in sperm capacitation. Theriogenology, 63, 342–51.
  • Jequier, A. M. (2010). Semen analysis: a new manual and its application to the understanding of semen and its pathology. Asian Journal of Andrology, 12(1), 11–13.
  • Ji, Y. J., Yeni, L., Min, S. M., Ji, Y. K. & Oran, K. (2011). Effect of quercetin derivatives on diabetic animals. Nutrition & Metabolism, 8, 18-25.
  • Kahn, S. E., Hull, R. L. & Utzschneider, K. M. (2006). Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 444, 840–846.
  • Kameswara, R. B., Kesavulu, M. M., Guiri, R. & Apparao, C. H. (1999). Hepatic key enzyme in experimental diabetes. Journal of Ethnopharmacology, 91 (1) , 109-113.
  • Kanter, M., Aktas, C. & Erboga, M. (2013). Curcumin attenuates testicular damage, apoptotic germcell death, and oxidative stress in streptozotocin ‐induced diabetic rats. Molecular Nutrition and Food Research, 57, 1578-1585.
  • Khaki, A., Fathiazad, F., Nouri, M., Maleki, N. A., Khamnei, H. J. & Ahmadi, P. (2010). Beneficial effectsof quercetin on sperm parameters in streptozotocin‐induced diabetic male rats. Phytotherapy Research, 24, 1285-1291.
  • Kilarkaje, N., Al‑Hussaini, H. & Al‑Bader, M. M. (2014). Diabetes‑induced DNA damage and apoptosis are associated with poly (ADP ribose) polymerase 1 inhibition in the rat testis. European Journal of Pharmacology, 737, 29–40.
  • Kim, S. T. & Moley, K. H. (2008). Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression. Reproduction. 136, 313–322.
  • Kobori, M., Masumoto, S., Akimoto, Y. & Takahashi, Y. (2009). Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice. Molecular Nutrition and Food Research, 53, 859-868.
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There are 76 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Research Articles
Authors

Olushola Adeleye 0000-0002-2767-5564

Emmanuel Okoh This is me

Adenike Adeleye This is me

Fakilahyel Musa Mshelbwala This is me

Abiodun Adetomiwa This is me

James Apantaku This is me

Ngozichukwu Aboajah This is me

Ladoke Durotoye This is me

Johnny Olufemi Olukunle This is me

Publication Date December 30, 2020
Published in Issue Year 2020 Volume: 4 Issue: 3

Cite

APA Adeleye, O., Okoh, E., Adeleye, A., Mshelbwala, F. M., et al. (2020). Ameliorative effects of Allium cepa Linn. scaly leaves extract on reproductive dysfunctions in streptozotocin-induced diabetic Wistar rats. Journal of Istanbul Veterinary Sciences, 4(3), 136-144. https://doi.org/10.30704/http-www-jivs-net.811491

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