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MicroRNAs as potential biomarkers in ruminant, avian and porcine

Year 2024, Volume: 8 Issue: 1, 54 - 63, 30.04.2024
https://doi.org/10.30704/http-www-jivs-net.1426005

Abstract

In recent years, studies on microRNAs have increased considerably. miRNAs are small RNA molecules, ranging from 19 to 25 nucleotides in length, that control the suppression of target genes after transcription. MiRNAs serve as fine-tuning factors that influence the expression of up to 60% of all mammalian protein-coding genes. Unlike proteins, miRNA sequences are widely conserved across species. This conservation strongly suggests that miRNAs emerged early in evolution and maintain their functional importance. It has been revealed that these small structures containing a small number of nucleotides can act as critical points in the organism. While traditional cancer biomarkers are mainly produced by tumor tissues or normal embryo tissues, they are absent or present in small amounts in tissue organs and the blood of healthy adults. MiRNAs can be easily detected in the blood, making them selectable candidates as biomarkers for disease. The ruminant family, one of the most diverse subspecies of terrestrial mammals, lives in a wide variety of environments worldwide and is known to have a major impact on various ecosystems and industries, including agriculture, daily activities, and cultures. MiRNAs have a significant impact on the physiology of farm animals, biological development, and cell differentiation. In this review, we will examine miRNAs that have been identified as candidates or potential candidates for the diagnosis and treatment of diseases seen in ruminants, pigs, and avians in recent years. In this way, we will provide a perspective to prevent diseases that can cause great economic losses in veterinary medicine and the production industry.

References

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Year 2024, Volume: 8 Issue: 1, 54 - 63, 30.04.2024
https://doi.org/10.30704/http-www-jivs-net.1426005

Abstract

References

  • Ali, A., Murani, E., Hadlich, F., Liu, X., Wimmers, K., & Ponsuksili, S. (2021a). In utero fetal weight in pigs is regulated by microRNAs and their target genes. Genes, 12(8),1264.
  • Ali, A., Murani, E., Hadlich, F., Liu, X., Wimmers, K., & Ponsuksili, S. (2021b). Prenatal skeletal muscle transcriptome analysis reveals novel microRNA-mRNA networks associated with intrauterine growth restriction in pigs. Cells, 10(5), 1007.
  • Antunes, J., Lee, O., Alizadeh, A. H., LaMarre, J., & Koch, T. G. (2020). Why the hype—What are microRNAs and why do they provide unique investigative, diagnostic, and therapeutic opportunities in veterinary medicine? The Canadian Veterinary Journal, 61(8), 845.
  • Bilinska, A., Pszczola, M., Stachowiak, M., Stachecka, J., Garbacz, F., Aksoy, M. O., & Szczerbal, I. (2023). Droplet digital PCR quantification of selected intracellular and extracellular microRNAs reveals changes in their expression pattern during porcine in vitro adipogenesis. Genes, 14(3).
  • Chakraborty, N., Holmes-Hampton, G. P., Gautam, A., Kumar, R., Hritzo, B., Legesse, B., Dimitrov, G., Ghosh, S. P., & Hammamieh, R. (2023). Early to sustained impacts of lethal radiation on circulating miRNAs in a minipig model. Scientific Reports, 13(1), 18496.
  • Chakraborty, S., Dhama, K., Tiwari, R., Iqbal Yatoo, M., Khurana, S. K., Khandia, R., Munjal, A., Munuswamy, P., Kumar, M. A., & Singh, M. (2019). Technological interventions and advances in the diagnosis of intramammary infections in animals with emphasis on bovine population—a review. Veterinary Quarterly, 39(1), 76-94. Chen, X., Wang, Z., Chen, Y., Akinci, I., Luo, W., Xu, Y., Jebessa, E., Blake, D., Sparks, N., Hanotte, O., & Nie, Q. (2022). Transcriptome analysis of differentially expressed circRNAs miRNAs and mRNAs during the challenge of coccidiosis. Frontiers in Immunology, 13, 910860.
  • Chi, R., Lin, P. Y., Jhuo, Y. S., Cheng, F. Y., & Ho, J. A. (2024, Jan 15). Colorimetric detection of African swine fever (ASF)-associated microRNA based on rolling circle amplification and salt-induced gold nanoparticle aggregation. Talanta, 267, 125159.
  • Ciliberti, M. G., Santillo, A., Sevi, A., Albenzio, M., De Leo, V., Ingrosso, C., Catucci, L., & Caroprese, M. (2023). First insight into extracellular vesicle-miRNA characterization in a sheep in vitro model of inflammation. Frontiers in Veterinary Science, 10.
  • De Los Santos Funes, J. A., Andrade, J. P. N., Berndtson, J., & Parrish, J. (2023). Short communication: profiling the expression of Let-7d-5p microRNA in circulating blood of pregnant and nonpregnant cows. Journal of Animal Science, 101, skad054.
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  • Dlamini, N. H., Nguyen, T., Gad, A., Tesfaye, D., Liao, S. F., Willard, S. T., Ryan, P. L., & Feugang, J. M. (2023). Characterization of extracellular vesicle-coupled miRNA profiles in seminal plasma of boars with divergent semen quality status. International Journal of Molecular Sciences, 24(4). 3194
  • Do, D. N., Dudemaine, P.-L., Fomenky, B. E., & Ibeagha-Awemu, E. M. (2019). Integration of miRNA weighted gene co-expression network and miRNA-mRNA co-expression analyses reveals potential regulatory functions of miRNAs in calf rumen development. Genomics, 111(4), 849-859.
  • Giles, T., van Limbergen, T., Sakkas, P., Quinn, L., Belkhiri, A., Maes, D., Kyriazakis, I., Barrow, P., & Foster, N. (2020). Diagnosis of sub-clinical coccidiosis in fast growing broiler chickens by microRNA profiling. Genomics, 112(5), 3218-3225.
  • Grenier, B., Hackl, M., Skalicky, S., Thamhesl, M., Moll, W.-D., Berrios, R., Schatzmayr, G., & Nagl, V. (2019). MicroRNAs in porcine uterus and serum are affected by zearalenone and represent a new target for mycotoxin biomarker discovery. Scientific Reports, 9(1), 9408.
  • Hamdi, M., Cañon‐Beltrán, K., Mazzarella, R., Cajas, Y. N., Leal, C. L., Gutierrez‐Adan, A., González, E. M., Da Silveira, J. C., & Rizos, D. (2021). Characterization and profiling analysis of bovine oviduct and uterine extracellular vesicles and their miRNA cargo through the estrous cycle. The FASEB Journal, 35(12), e22000.
  • Hou, L., Ji, Z., Wang, G., Wang, J., Chao, T., & Wang, J. (2018). Identification and characterization of microRNAs in the intestinal tissues of sheep (Ovis aries). PLoS One, 13(2), e0193371.
  • Hu, J., Dong, J., Zeng, Z., Wu, J., Tan, X., Tang, T., Yan, J., & Jin, C. (2020). Using exosomal miRNAs extracted from porcine follicular fluid to investigate their role in oocyte development. BMC Veterinary Research, 16(1), 485.
  • Huang, Y., Zhang, C., Wang, Y., & Sun, X. (2022). Identification and analysis of miRNAs in the normal and fatty liver from the Holstein dairy cow. Animal Biotechnology, 33(3), 468-479.
  • Kiss, A., Heber, S., Kramer, A. M., Hackl, M., Skalicky, S., Hallström, S., Podesser, B. K., & Santer, D. (2020). MicroRNA expression profile changes after cardiopulmonary bypass and ischemia/reperfusion-injury in a porcine model of cardioplegic arrest. Diagnostics, 10(4). 240
  • Lai, Y.C., Habiby, G. H., Pathiranage, C. C. J., Rahman, M. M., Chen, H.-W., Husna, A. A., Kubota, C., & Miura, N. (2021). Bovine serum miR-21 expression affected by mastitis. Research in Veterinary Science, 135, 290-292.
  • Lecchi, C., Zamarian, V., Gini, C., Avanzini, C., Polloni, A., Rota Nodari, S., & Ceciliani, F. (2020). Salivary microRNAs are potential biomarkers for the accurate and precise identification of inflammatory response after tail docking and castration in piglets. Journal of Animal Science, 98(5), skaa153.
  • Li, N., Huang, K., Chen, Y., Huang, Z., Zhang, Y., Leng, C., Liu, Y., Shi, J., Xiao, S., & Yao, L. (2021). MicroRNA ssc-miR-124a exhibits antiviral activity against porcine reproductive and respiratory syndrome virus via suppression of host genes CD163. Veterinary Microbiology, 261, 109216.
  • Li, R., Zhang, C.L., Liao, X.X., Chen, D., Wang, W.Q., Zhu, Y.H., Geng, X.H., Ji, D.J., Mao, Y.J., & Gong, Y.C. (2015). Transcriptome microRNA profiling of bovine mammary glands infected with Staphylococcus aureus. International Journal of Molecular Sciences, 16(3), 4997-5013.
  • Li, Y. (2021). Comparing of backfat microRNAomes of Landrace and Neijiang pig by high-throughput sequencing. Genes Genomics, 43(5), 543-551.
  • Liang, G., Malmuthuge, N., McFadden, T. B., Bao, H., Griebel, P. J., Stothard, P., & Guan, L. L. (2014). Potential regulatory role of microRNAs in the development of bovine gastrointestinal tract during early life. PLoS One, 9(3), e92592.
  • Lin, X., Beckers, E., Mc Cafferty, S., Gansemans, Y., Joanna Szymańska, K., Chaitanya Pavani, K., Catani, J. P., Van Nieuwerburgh, F., Deforce, D., & De Sutter, P. (2019). Bovine embryo-secreted microRNA-30c is a potential non-invasive biomarker for hampered preimplantation developmental competence. Frontiers in genetics, 10, 315.
  • Lu, T. X., & Rothenberg, M. E. (2018). MicroRNA. Journal of allergy and clinical immunology, 141(4), 1202-1207. Mahala, S., Kumar, A., Pandey, H. O., Saxena, S., Khanna, S., Kumar, M., Kumar, D., De, U. K., Pandey, A. K., & Dutt, T. (2024). Milk exosomal microRNA profiling identified miR-375 and miR-199-5p for regulation of immune response during subclinical mastitis of crossbred cattle. Molecular Biology Reports, 51(1), 59.
  • Mendes, R. E. (2012). Ruminants: Anatomy, Behavior, and Diseases. Orleans, Santa Catarina State, Brazil: Nova Biomedical.
  • Menezes, E. S., Badial, P. R., El Debaky, H., Husna, A. U., Ugur, M. R., Kaya, A., Topper, E., Bulla, C., Grant, K. E., & Bolden‐Tiller, O. (2020). Sperm miR‐15a and miR‐29b are associated with bull fertility. Andrologia, 52(1), e13412. Miretti, S., Lecchi, C., Ceciliani, F., & Baratta, M. (2020). MicroRNAs as biomarkers for animal health and welfare in livestock. Frontiers in Veterinary Science, 7, 578193.
  • Naylor, D., Sharma, A., Li, Z., Monteith, G., Sullivan, T., Canovas, A., Mallard, B., Baes, C., & Karrow, N. (2020). Characterizing ovine serum stress biomarkers during endotoxemia. Journal of Dairy Science, 103(6), 5501-5508.
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There are 57 citations in total.

Details

Primary Language English
Subjects Veterinary Sciences (Other)
Journal Section Review Articles
Authors

İsmail Bergutay Kalaycılar 0000-0002-8128-2569

Hasret Yardibi 0000-0002-2779-1098

Publication Date April 30, 2024
Submission Date January 27, 2024
Acceptance Date April 16, 2024
Published in Issue Year 2024 Volume: 8 Issue: 1

Cite

APA Kalaycılar, İ. B., & Yardibi, H. (2024). MicroRNAs as potential biomarkers in ruminant, avian and porcine. Journal of Istanbul Veterinary Sciences, 8(1), 54-63. https://doi.org/10.30704/http-www-jivs-net.1426005

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