Review
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Multipl Skleroz Tedavisinde Nanotaşıyıcı Sistemlerin Uygulanması

Year 2024, , 182 - 197, 01.06.2024
https://doi.org/10.52794/hujpharm.1397361

Abstract

Nörodejeneratif hastalıklar arasında kompleks bir immünopatolojiye sahip olan Multipl Skleroz (MS)’un tedavisinde birçok faktörün dikkate alınması gerekmektedir. Bu çok faktörlü hastalıktaki klinik bulgular miyelin kaybının ilerlemesine, enflamasyonun evresine, aksonların durumuna ve oligodendrosit öncü hücrelerinin aktivitesine bağlıdır. Uzun yıllardır süregelen yoğun çalışmalara rağmen hastalığın çok
faktörlü oluşu ve kan-beyin engeli (KBE) gibi ilaçların beyne ulaşmasını engelleyen yapılar nedeniyle henüz kesin bir tedavi bulunamamıştır. Bu durum, bilim insanlarını yeni yaklaşımlar aramaya yönlendirmiştir. Yapılan araştırmalarda genellikle nanotaşıyıcı olarak adlandırılan nano boyuttaki farmasötik taşıyıcıların MS’nin yalnızca teşhisinde değil aynı zamanda tedavisinde de rolüstlenebileceğini göstermiştir. MS’nin tedavisi için klinik öncesi in vitro ve in vivo çalışmalarla başarılı olduğu gösterilen bu sistemlerin klinik uygulamaya geçiş yapabilmesi için çalışmalar yoğun bir şekilde devam etmektedir. Bu derlemede MS tedavisine yönelik nanotaşıyıcılar konusunda literatürde yer alan en güncel gelişmeler değerlendirilmiştir.

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Thanks

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Application of Nanocarrier Systems in the Treatment of Multiple Sclerosis

Year 2024, , 182 - 197, 01.06.2024
https://doi.org/10.52794/hujpharm.1397361

Abstract

Numerous factors need to be taken into consideration in the treatment of Multiple Sclerosis (MS), which has a complex immunopathology among neurodegenerative diseases. Clinical findings in this multifactorial disease depend on the progression of myelin loss, the stage of inflammation, the status of axons, and the activity of oligodendrocyte precursor cells. Despite intensive studies for many years, a definitive treatment has yet to be found due to the multifactorial nature of the disease and structures, such as the blood-brain barrier (BBB) that prevents drugs from reaching the brain. This situation has led scientists to search for new approaches. Studies have shown that nanosized pharmaceutical carriers, often called nanocarriers, might play a role not only in the diagnosis but also in the treatment of MS. Studies are continuing intensively to transition these systems, which have been shown to be successful in preclinical in vitro and in vivo studies for the treatment of MS, to clinical application. In this review, the most current developments in the literature on nanocarriers for MS treatment are evaluated.

Project Number

Yok

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There are 100 citations in total.

Details

Primary Language Turkish
Subjects Pharmaceutical Delivery Technologies
Journal Section Review Articles
Authors

Nihat Kurt 0000-0003-2203-3025

Sibel Bozdağ Pehlivan 0000-0001-5066-2772

Levent Öner 0000-0002-6510-7680

Project Number Yok
Publication Date June 1, 2024
Submission Date November 28, 2023
Acceptance Date December 21, 2023
Published in Issue Year 2024

Cite

Vancouver Kurt N, Bozdağ Pehlivan S, Öner L. Multipl Skleroz Tedavisinde Nanotaşıyıcı Sistemlerin Uygulanması. HUJPHARM. 2024;44(2):182-97.