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Year 2025, Volume: 45 Issue: 2, 188 - 199, 01.06.2025
https://doi.org/10.52794/hujpharm.1486873

Abstract

Project Number

nil

References

  • 1. Kudiyirickal MG, Hollinshead F. Clinical profile of orofacial infections: an experience from two primary care dental practices. Med Oral Patol Oral Cir Bucal. 2012;17(4):e533-7. https://doi.org/10.4317/medoral.17664
  • 2. Igoumenakis D, Gkinis G, Kostakis G, Mezitis M, Rallis G. Severe odontogenic infections: causes of spread and their management. Surg Infect (Larchmt). 2014;15(1):64-8. https://doi.org/10.1089/sur.2012.178
  • 3. Swift JQ, Gulden WS. Antibiotic therapy--managing odontogenic infections. Dent Clin North Am. 2002;46(4):623-33. https://doi.org/10.1016/s0011-8532(02)00031-9
  • 4. Thrum H. Classes of antibiotics and their mechanisms of action. Z Gesamte Inn Med. 1977;32(14):209-14.
  • 5. Brook I. Microbiology and management of endodontic infections in children. J Clin Pediatr Dent. 2003;28(1):13-7. https://doi.org/10.17796/jcpd.28.1.uwjxq61753506255
  • 6. Abbott PV. Selective and intelligent use of antibiotics in endodontics. Aust Endod J. 2000;26(1):30-9. https://doi.org/10.1111/j.1747-4477.2000.tb00149.x
  • 7. Bansal R, Jain A. Overview on the current antibiotic containing agents used in endodontics. N Am J Med Sci. 2014;6(8):351-8. https://doi.org/10.4103/1947-2714.139277
  • 8. Goel D, Goel GK, Chaudhary S, Jain D. Antibiotic prescriptions in pediatric dentistry: A review. J Family Med Prim Care. 2020;9(2):473-480. https://doi.org/10.4103/jfmpc.jfmpc_1097_19
  • 9. Antifungal agents for common pediatric infections. Can J Infect Dis Med Microbiol. 2008;19(1):15-8.
  • 10. American Academy of Pediatric Dentistry. Policy on pediatric dental pain management. The Reference Manual of Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry; 2023:159-61.
  • 11. Cherry WR, Lee JY, Shugars DA, White RP Jr, Vann WF Jr. Antibiotic use for treating dental infections in children: a survey of dentists’ prescribing practices. J Am Dent Assoc. 2012;143(1):31–8. https://doi.org/10.14219/jada.archive.2012.0015
  • 12. Sivaraman SS, Hassan M, Pearson JM. A national survey of pediatric dentists on antibiotic use in children. Pediatr Dent. 2013;35(7):546–9.
  • 13. Dar-Odeh NS, Al-Shayyab M, Obeidat MH, Obeidat H, Kar L, Oa A-H. Prescribing Antibiotics for pediatric dental patients in Jordan; knowledge and attitudes of dentists. Int Arab J Antimicrob Agents. 2013;3(3).
  • 14. Perić M, Perković I, Romić M, Simeon P, Matijević J, Mehičić GP, et al. The pattern of antibiotic prescribing by dental practitioners in Zagreb, Croatia. Cent Eur J Public Health. 2015;23(2):107–13. https://doi.org/10.21101/cejph.a3981
  • 15. Yesudian GT, Gilchrist F, Bebb K, Albadri S, Aspinall A, Swales K, et al. A multicentre, multicycle audit of the prescribing practices of three paediatric dental departments in the North of England. Br Dent J. 2015;218(12):681–5. https://doi.org/10.1038/sj.bdj.2015.440
  • 16. Konde S, Jairam LS, Peethambar P, Noojady SR, Kumar NC. Antibiotic overusage and resistance: A cross-sectional survey among pediatric dentists. J Indian Soc Pedod Prev Dent. 2016;34(2):145–51. https://doi.org/10.4103/0970-4388.180444
  • 17. Ford PJ, Saladine C, Zhang K, Hollingworth SA. Prescribing patterns of dental practitioners in Australia from 2001 to 2012. Antimicrobials. Aust Dent J. 2017;62(1):52–7. https://doi.org/10.1111/adj.12427
  • 18. Al-Johani K, Reddy SG, Al Mushayt AS, El-Housseiny A. Pattern of prescription of antibiotics among dental practitioners in Jeddah, KSA: A cross-sectional survey. Niger J Clin Pract. 2017;20(7):804–10. https://doi.org/10.4103/1119-3077.196072
  • 19. Bhuvaraghan A, King R, Larvin H, Aggarwal VR. Antibiotic use and misuse in dentistry in India—A systematic review. Antibiotics (Basel). 2021;10(12):1459. https://doi.org/10.3390/antibiotics10121459
  • 20. Aidasani B, Solanki M, Khetarpal S, Ravi Pratap S. Antibiotics: their use and misuse in paediatric dentistry. A systematic review. Eur J Paediatr Dent. 2019;20(2):133–8. https://doi.org/10.23804/ejpd.2019.20.02.10
  • 21. Vasudavan S, Grunes B, Mcgeachie J, Sonis AL. Antibiotic prescribing patterns among dental professionals in Massachusetts. Pediatr Dent. 2019;41(1):25–30.
  • 22. Hernández Ceruelos A, Romero-Quezada LC, Ruvalcaba Ledezma JC, López Contreras L. Therapeutic uses of metronidazole and its side effects: an update. Eur Rev Med Pharmacol Sci. 2019;23(1):397–401. https://doi.org/10.26355/eurrev_201901_16788
  • 23. Palmer NOA. Antibiotic prescribing in general dental practice. Prim Dent J. 2014;3(1):52–7. https://doi. org/10.1308/205016814812135878
  • 24. Odonnell KL, Barker D. Metronidazole and tinnitus: A potential side effect? Br Dent J. 2016;220(6). https://doi.org/10.1038/sj.bdj.2016.218
  • 25. Mahmood I. A comparison of different methods for the first-in-pediatric dose selection. J Clin Transl Res. 2022;8(5):369–81.
  • 26. Suda KJ, Calip GS, Zhou J et al Assessment of the Appropriateness of Antibiotic Prescriptions for Infection Prophylaxis Before Dental Procedures, 2011 to 2015. JAMA Netw Open. 2019 May 3;2(5):e193909. https://doi.org/10.1001/jamanet-workopen.2019.3909
  • 27. Baltimore RS, Gewitz M, Baddour LM, Beerman LB, Jackson MA, Lockhart PB, et al. Infective endocarditis in childhood: 2015 update: A scientific statement from the American heart association: A scientific statement from the American heart association. Circulation. 2015;132(15):1487–515. https://doi.org/10.1161/cir.0000000000000298
  • 28. Wilson WR, Gweitz M, Lockhart PB. Prevention of viridans group streptococcal infective endocarditis: A scientific statement from the American Heart Association. Circulation. 2021;143(20):e963–78. https://doi.org/10.1161/cir.0000000000000969
  • 29. Antibiotic pro-phylaxis for dental patients at risk for infection. The Reference Manual of Pediatric Dentistry. American Academy of Pediatric Dentistry. 2022:500–6.
  • 30. Habib G, Hoen B, Tornos P. Guidelines on the prevention, diagnosis, and treatment of infective endo-carditis (new version 2009): The Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Eur Heart J. 2009;30(9):2369–413.
  • 31. Use of anti- biotic therapy for pediatric dental patients. The Reference Manual of Pediatric Dentistry. American Academy of Pediatric Dentistry. 2022:495–9.
  • 32. Gerding DN. The search for good antimicrobial stewardship. Jt Comm J Qual Improv. 2001;27(8):403–4. https://doi.org/10.1016/s1070-3241(01)27034-5

Antimicrobials; Wise Use in Pediatric Dentistry - A Detailed Literature Review

Year 2025, Volume: 45 Issue: 2, 188 - 199, 01.06.2025
https://doi.org/10.52794/hujpharm.1486873

Abstract

In pediatric dentistry, antibiotics are crucial for controlling oral infections and preventing their spread. However, concerns about overuse and inappropriate prescriptions persist. Understanding the complexities of antimicrobial use is vital for optimal oral health outcomes, particularly due to the unique physiology and compliance issues in young patients. This narrative review comprehensively searched peer-reviewed literature, guidelines, and systematic reviews from databases involving PUBMED, Cochrane Library, Google Scholar, Trip Database, Lilacs, ProQuest, and Wiley Library, using keywords related to adverse effects, infection control, pediatric dentistry, and antibiotic use. No publication year restrictions were applied, and references from key papers were reviewed for additional relevant research. Results indicate that while antibiotics can effectively treat bacterial infections in pediatric patients, misuse can lead to adverse outcomes like antimicrobial resistance. Special considerations in pediatric dentistry necessitate tailored antibiotic administration approaches. Adhering to evidence-based guidelines and exercising sound clinical judgment are essential to mitigate the risks of antibiotic overuse. Comprehensive education for dental professionals, caregivers, and young patients is crucial to promote responsible antimicrobial practices and enhance oral health outcomes. A well-rounded strategy for antibiotic use in pediatric dentistry is key to achieving optimal dental health results while minimizing associated risks.

Project Number

nil

References

  • 1. Kudiyirickal MG, Hollinshead F. Clinical profile of orofacial infections: an experience from two primary care dental practices. Med Oral Patol Oral Cir Bucal. 2012;17(4):e533-7. https://doi.org/10.4317/medoral.17664
  • 2. Igoumenakis D, Gkinis G, Kostakis G, Mezitis M, Rallis G. Severe odontogenic infections: causes of spread and their management. Surg Infect (Larchmt). 2014;15(1):64-8. https://doi.org/10.1089/sur.2012.178
  • 3. Swift JQ, Gulden WS. Antibiotic therapy--managing odontogenic infections. Dent Clin North Am. 2002;46(4):623-33. https://doi.org/10.1016/s0011-8532(02)00031-9
  • 4. Thrum H. Classes of antibiotics and their mechanisms of action. Z Gesamte Inn Med. 1977;32(14):209-14.
  • 5. Brook I. Microbiology and management of endodontic infections in children. J Clin Pediatr Dent. 2003;28(1):13-7. https://doi.org/10.17796/jcpd.28.1.uwjxq61753506255
  • 6. Abbott PV. Selective and intelligent use of antibiotics in endodontics. Aust Endod J. 2000;26(1):30-9. https://doi.org/10.1111/j.1747-4477.2000.tb00149.x
  • 7. Bansal R, Jain A. Overview on the current antibiotic containing agents used in endodontics. N Am J Med Sci. 2014;6(8):351-8. https://doi.org/10.4103/1947-2714.139277
  • 8. Goel D, Goel GK, Chaudhary S, Jain D. Antibiotic prescriptions in pediatric dentistry: A review. J Family Med Prim Care. 2020;9(2):473-480. https://doi.org/10.4103/jfmpc.jfmpc_1097_19
  • 9. Antifungal agents for common pediatric infections. Can J Infect Dis Med Microbiol. 2008;19(1):15-8.
  • 10. American Academy of Pediatric Dentistry. Policy on pediatric dental pain management. The Reference Manual of Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry; 2023:159-61.
  • 11. Cherry WR, Lee JY, Shugars DA, White RP Jr, Vann WF Jr. Antibiotic use for treating dental infections in children: a survey of dentists’ prescribing practices. J Am Dent Assoc. 2012;143(1):31–8. https://doi.org/10.14219/jada.archive.2012.0015
  • 12. Sivaraman SS, Hassan M, Pearson JM. A national survey of pediatric dentists on antibiotic use in children. Pediatr Dent. 2013;35(7):546–9.
  • 13. Dar-Odeh NS, Al-Shayyab M, Obeidat MH, Obeidat H, Kar L, Oa A-H. Prescribing Antibiotics for pediatric dental patients in Jordan; knowledge and attitudes of dentists. Int Arab J Antimicrob Agents. 2013;3(3).
  • 14. Perić M, Perković I, Romić M, Simeon P, Matijević J, Mehičić GP, et al. The pattern of antibiotic prescribing by dental practitioners in Zagreb, Croatia. Cent Eur J Public Health. 2015;23(2):107–13. https://doi.org/10.21101/cejph.a3981
  • 15. Yesudian GT, Gilchrist F, Bebb K, Albadri S, Aspinall A, Swales K, et al. A multicentre, multicycle audit of the prescribing practices of three paediatric dental departments in the North of England. Br Dent J. 2015;218(12):681–5. https://doi.org/10.1038/sj.bdj.2015.440
  • 16. Konde S, Jairam LS, Peethambar P, Noojady SR, Kumar NC. Antibiotic overusage and resistance: A cross-sectional survey among pediatric dentists. J Indian Soc Pedod Prev Dent. 2016;34(2):145–51. https://doi.org/10.4103/0970-4388.180444
  • 17. Ford PJ, Saladine C, Zhang K, Hollingworth SA. Prescribing patterns of dental practitioners in Australia from 2001 to 2012. Antimicrobials. Aust Dent J. 2017;62(1):52–7. https://doi.org/10.1111/adj.12427
  • 18. Al-Johani K, Reddy SG, Al Mushayt AS, El-Housseiny A. Pattern of prescription of antibiotics among dental practitioners in Jeddah, KSA: A cross-sectional survey. Niger J Clin Pract. 2017;20(7):804–10. https://doi.org/10.4103/1119-3077.196072
  • 19. Bhuvaraghan A, King R, Larvin H, Aggarwal VR. Antibiotic use and misuse in dentistry in India—A systematic review. Antibiotics (Basel). 2021;10(12):1459. https://doi.org/10.3390/antibiotics10121459
  • 20. Aidasani B, Solanki M, Khetarpal S, Ravi Pratap S. Antibiotics: their use and misuse in paediatric dentistry. A systematic review. Eur J Paediatr Dent. 2019;20(2):133–8. https://doi.org/10.23804/ejpd.2019.20.02.10
  • 21. Vasudavan S, Grunes B, Mcgeachie J, Sonis AL. Antibiotic prescribing patterns among dental professionals in Massachusetts. Pediatr Dent. 2019;41(1):25–30.
  • 22. Hernández Ceruelos A, Romero-Quezada LC, Ruvalcaba Ledezma JC, López Contreras L. Therapeutic uses of metronidazole and its side effects: an update. Eur Rev Med Pharmacol Sci. 2019;23(1):397–401. https://doi.org/10.26355/eurrev_201901_16788
  • 23. Palmer NOA. Antibiotic prescribing in general dental practice. Prim Dent J. 2014;3(1):52–7. https://doi. org/10.1308/205016814812135878
  • 24. Odonnell KL, Barker D. Metronidazole and tinnitus: A potential side effect? Br Dent J. 2016;220(6). https://doi.org/10.1038/sj.bdj.2016.218
  • 25. Mahmood I. A comparison of different methods for the first-in-pediatric dose selection. J Clin Transl Res. 2022;8(5):369–81.
  • 26. Suda KJ, Calip GS, Zhou J et al Assessment of the Appropriateness of Antibiotic Prescriptions for Infection Prophylaxis Before Dental Procedures, 2011 to 2015. JAMA Netw Open. 2019 May 3;2(5):e193909. https://doi.org/10.1001/jamanet-workopen.2019.3909
  • 27. Baltimore RS, Gewitz M, Baddour LM, Beerman LB, Jackson MA, Lockhart PB, et al. Infective endocarditis in childhood: 2015 update: A scientific statement from the American heart association: A scientific statement from the American heart association. Circulation. 2015;132(15):1487–515. https://doi.org/10.1161/cir.0000000000000298
  • 28. Wilson WR, Gweitz M, Lockhart PB. Prevention of viridans group streptococcal infective endocarditis: A scientific statement from the American Heart Association. Circulation. 2021;143(20):e963–78. https://doi.org/10.1161/cir.0000000000000969
  • 29. Antibiotic pro-phylaxis for dental patients at risk for infection. The Reference Manual of Pediatric Dentistry. American Academy of Pediatric Dentistry. 2022:500–6.
  • 30. Habib G, Hoen B, Tornos P. Guidelines on the prevention, diagnosis, and treatment of infective endo-carditis (new version 2009): The Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Eur Heart J. 2009;30(9):2369–413.
  • 31. Use of anti- biotic therapy for pediatric dental patients. The Reference Manual of Pediatric Dentistry. American Academy of Pediatric Dentistry. 2022:495–9.
  • 32. Gerding DN. The search for good antimicrobial stewardship. Jt Comm J Qual Improv. 2001;27(8):403–4. https://doi.org/10.1016/s1070-3241(01)27034-5
There are 32 citations in total.

Details

Primary Language English
Subjects Basic Pharmacology
Journal Section Review Articles
Authors

Prıyanka Balakrıshnan 0000-0002-7838-7992

Daya Srinivasan 0000-0001-5453-4380

Raaja Sreepathy Chandaran Selvaraj 0000-0002-0145-857X

Saravanakumar Mariyappa Subramani 0000-0003-0479-8454

Project Number nil
Publication Date June 1, 2025
Submission Date May 21, 2024
Acceptance Date May 13, 2025
Published in Issue Year 2025 Volume: 45 Issue: 2

Cite

Vancouver Balakrıshnan P, Srinivasan D, Chandaran Selvaraj RS, Mariyappa Subramani S. Antimicrobials; Wise Use in Pediatric Dentistry - A Detailed Literature Review. HUJPHARM. 2025;45(2):188-99.