Design, Development and Evaluation of Etodolac Loaded Chitosan based Nanogel for Topical Drug Delivery

Year 2025, Volume: 45 Issue: 2, 146 - 161, 01.06.2025

Sarika Sanjay Kadam Jameel Ahmed Mulla

https://doi.org/10.52794/hujpharm.1573058

Abstract

Nanogels, sometimes referred to as nanosized hydrogels, are swollen, microscopic particles that can be anywhere between 100 and 400 nm in size. They are composed of hydrophilic or amphiphilic polymer networks that are malleable and can be cross-linked mechanically or chemically. Drugs that are poorly soluble in water can be made more soluble by employing a variety of technologies. Using the spontaneous emulsification method, oleic acid was used as the oil phase while Tween 80 and PEG 400 served as the surfactant and co-surfactant, respectively, to form etodolac nanoemulsion (ETD NE). It was discovered that the ideal zeta potential, PDI, and ETD NE particle size were, respectively, -36.2 mV, 0.363, and 220.0 nm. Particle size, PDI, and zeta potential of the ETD loaded chitosan-based nanogel were found to be 230.4 nm, 0.376, and -37.1 mV, respectively. There were no interactions between the drug and excipients, according to the FTIR spectra. The TEM pictures of the NE and the ETD nanogel show that the oil droplets have a spherical shape. For eight hours, it was discovered that the in-vitro drug release of NE and nanogel was 80.47% and 74.61%, respectively.

Keywords

Nanoemulsion , Nanogel , Particle Size , Zeta Potential , Topical Drug Delivery

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