Vitamin D as an Adjuvant in Rheumatoid Arthritis: A Systematic Review of Existing Literature

Year 2025, Volume: 45 Issue: 3, 255 - 267, 01.09.2025

Mousumi Borgohain Purbajit Chetia , Lakshyajeet Nath Chayanika Kalita

https://doi.org/10.52794/hujpharm.1573889

Abstract

Rheumatoid Arthritis (RA) is a progressive inflammatory complication that negatively affects quality of life by causing the immune system to attack and damage joint cartilage and bones. Several immune illnesses, including RA, have been linked to Vitamin D (Vit D) deficiency. Based on current evidence, this systematic review investigates the connection between RA and blood Vit D levels, as well as the impact of supplementation on disease activity. This systematic review examined research papers in scientific databases from 2018 to 2023. Fourteen publications were chosen for final reporting based on specific inclusion and exclusion criteria. Vit D supplements were linked to positive effects in people with RA, and there is a detrimental correlation between the amount of the Vit D and the development and pathogenesis of the illness. However, none of these publications made any conclusive claims of an extensive cure or remission from RA. Vit D has been found to be moderately correlated with the course and activity of RA, and taking supplements of this vitamin may be advantageous in managing the condition. More diverse cohort studies and randomized controlled trials are needed to corroborate these findings and develop full Vit D recommendations for RA treatment.

Keywords

Vit D , Rheumatoid Arthritis , DAS28 , cytokines , Lymphocytes

Ethical Statement

NA

Supporting Institution

NEMCARE Group of Institutions

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