Streptozotosin ve Nikotinamid/Streptozosin Kullanılarak Sıçanlarda Tip 1 ve Tip 2 Diyabet Geliştirilmesi

Abstract

Diyabet dünya çapında hızla büyüyen bir hastalıktır. Diyabet için geliştirilen deneysel hayvan modelleri hastalığın karmaşık yapısını anlamak için faydalıdır. Bu çalışmanın amacı, sırasıyla streptozotosin ve nikotinamid / streptozotosin kullanarak sıçanlarda tip 1 ve tip 2 diyabet geliştirmektir. Bu çalışmanın sonuçları streptozotosin kullanılarak tip 1 diyabet, ve nikotinamid / streptozotosin kullanarak tip 2 diyabet geliştirildiğini göstermiştir. Tip 1 ve tip 2 diyabet geliştirmek için kullanılan bu yöntemler diyabet ile ilgili çalışmalar da kolaylıkla kullanılabilir.

Keywords

• Tip 1 diyabet,Tip 2 diyabet,streptozotosin,nikotinamid,açlık kan şekeri

Development of Type 1 and Type 2 Diabetes in Rats Using Streptozotocin and Nicotinamide/Streptozotocin

Abstract

Diabetes mellitus is a rapidly growing disease worldwide. Experimental animal models for diabetes mellitus are beneficial for understanding the complex nature of the disease. The purpose of this study was to develop type 1 and type 2 diabetes mellitus in rats using streptozotocin and nicotinamide/streptozotocin, respectively. Results of this study showed that type 1 diabetes was developed using streptozotocin, and type 2 diabetes using nicotinamide/ streptozotocin. These methods used for the development of type 1 and type 2 diabetes can be easily used in the diabetes- related studies.

Keywords

• Type 1 diabetes,Type 2 diabetes,streptozotocin,nicotinamide,fasting blood glucose

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