Year 2018, Volume 38 , Issue 2, Pages 85 - 101 2018-06-15

Nanosuspensions: Preparation Methods and Stability Issue

Adem Eren Bektaş [1] , Afife Büşra Uğur [2] , Meltem Çetin [3]


ABSTRACT

A large proportion of newly discovered active subtances are water insoluble and have

very low bioavailability. One of the different approaches developed to overcome

the issue of low solubility in aqueous media is nanosuspensions and in recent years,

this dosage form has gained popularity in the pharmaceutical area because of their

unique properties. Nanosuspension is nano-sized (<1000 nm, generally, 200-600 nm)

colloidal dispersions of pure active substance particles, which are stabilized by suitable

surfactants and/or polymers. Nanosuspensions are successfully prepared using various

methods such as media milling, high-pressure homogenization and precipitation

techniques etc. This review focus on the properties, stability, advantages and

disadvantages of nanosuspensions, and also, preparation methods for nanosuspensions.

Keywords: Nanosuspensions, preparation methods, stability

ÖZET

Yeni keşfedilen etkin maddelerin büyük bir kısmı suda çözünmez ve biyoyararlanımları

çok düşüktür. Sulu ortamdaki düşük çözünürlük sorununun üstesinden gelmek için

geliştirilen farklı yaklaşımlardan birisi de nanosüspansiyonlardır ve son yıllarda,

bu ilaç şekli, eşsiz özelliklerinden dolayı farmasötik alanda popülerlik kazanmıştır.

Nanosüspansiyon, uygun sürfaktan ve/veya polimerler ile kararlı hale getirilmiş

saf etkin madde partiküllerinin nano-boyutlu (<1000 nm, genellikle, 200-600 nm)

kolloidal dağılımlarıdır. Nanosüspansiyonlar, çeşitli yöntemler (öğütme, yüksek

basınçlı homojenizasyon, çöktürme vb.) kullanılarak başarıyla hazırlanmıştır. Bu

derleme, nanosüspansiyonların özellikleri, kararlılığı, üstünlükleri ve sakıncaları ve

aynı zamanda nanosüspansiyon hazırlama yöntemleri üzerine odaklanmaktadır.

Anahtar Kelimeler: Hazırlama yöntemleri, nanosüspansiyonlar, stabilite

Nanosuspensions, preparation methods
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Primary Language tr
Journal Section Review Articles
Authors

Author: Adem Eren Bektaş
Institution: ATATURK UNIVERSITY
Country: Turkey


Author: Afife Büşra Uğur
Institution: ATATURK UNIVERSITY
Country: Turkey


Author: Meltem Çetin (Primary Author)
Institution: ATATURK UNIVERSITY
Country: Turkey


Dates

Publication Date : June 15, 2018

Bibtex @review { hujpharm500300, journal = {Hacettepe University Journal of the Faculty of Pharmacy}, issn = {}, eissn = {2458-8806}, address = {hujpharm@gmail.com}, publisher = {Hacettepe University}, year = {2018}, volume = {38}, pages = {85 - 101}, doi = {}, title = {Nanosuspensions: Preparation Methods and Stability Issue}, key = {cite}, author = {Bektaş, Adem Eren and Uğur, Afife Büşra and Çetin, Meltem} }
APA Bektaş, A , Uğur, A , Çetin, M . (2018). Nanosuspensions: Preparation Methods and Stability Issue. Hacettepe University Journal of the Faculty of Pharmacy , 38 (2) , 85-101 . Retrieved from https://dergipark.org.tr/en/pub/hujpharm/issue/41389/500300
MLA Bektaş, A , Uğur, A , Çetin, M . "Nanosuspensions: Preparation Methods and Stability Issue". Hacettepe University Journal of the Faculty of Pharmacy 38 (2018 ): 85-101 <https://dergipark.org.tr/en/pub/hujpharm/issue/41389/500300>
Chicago Bektaş, A , Uğur, A , Çetin, M . "Nanosuspensions: Preparation Methods and Stability Issue". Hacettepe University Journal of the Faculty of Pharmacy 38 (2018 ): 85-101
RIS TY - JOUR T1 - Nanosuspensions: Preparation Methods and Stability Issue AU - Adem Eren Bektaş , Afife Büşra Uğur , Meltem Çetin Y1 - 2018 PY - 2018 N1 - DO - T2 - Hacettepe University Journal of the Faculty of Pharmacy JF - Journal JO - JOR SP - 85 EP - 101 VL - 38 IS - 2 SN - -2458-8806 M3 - UR - Y2 - 2017 ER -
EndNote %0 Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi Nanosuspensions: Preparation Methods and Stability Issue %A Adem Eren Bektaş , Afife Büşra Uğur , Meltem Çetin %T Nanosuspensions: Preparation Methods and Stability Issue %D 2018 %J Hacettepe University Journal of the Faculty of Pharmacy %P -2458-8806 %V 38 %N 2 %R %U
ISNAD Bektaş, Adem Eren , Uğur, Afife Büşra , Çetin, Meltem . "Nanosuspensions: Preparation Methods and Stability Issue". Hacettepe University Journal of the Faculty of Pharmacy 38 / 2 (June 2018): 85-101 .
AMA Bektaş A , Uğur A , Çetin M . Nanosuspensions: Preparation Methods and Stability Issue. hujpharm. 2018; 38(2): 85-101.
Vancouver Bektaş A , Uğur A , Çetin M . Nanosuspensions: Preparation Methods and Stability Issue. Hacettepe University Journal of the Faculty of Pharmacy. 2018; 38(2): 101-85.