Yașlılarda İlaç- Besin ve İlaç-Hastalık Etkileșmeleri

Year 2015, Issue: 1, 20 - 41, 01.01.2015

Pınar Erkekoğlu Terken Baydar

Abstract

Dünya genelinde beklenen yaşam süresinin uzadığı ve geriatrik popülasyonunun hızla arttığı bildirilmektedir. Yaşla birlikte birçok hastalık sıklığında artış izlenmekte, bu da polifarmasi uygulamalarının artışını beraberinde getirmektedir. Polifarmasi uygulayan yaşlı bireylerde ilaç-besin ve ilaç-hastalık etkileşmeleri sıklıkla görülmektedir. Besinlerle ilaçların biyotransformasyonları ve etkinliklerinin değişebileceği gibi, ilaçlar da farklı besin öğelerinin biyotransformasyonları ve etkinliklerinin değiştirebilir. Diğer taraftan, var olan hastalık ile ilaç kullanımı sonucu hastalık durumunun kötüleşmesi gibi durumlar ortaya çıkabilir ya da ilaç kullanımı sonucu bazı hastalıkların ortaya çıkış sıklığında artış gözlenebilir. Bu derleme kapsamında ilaç-besin ve ilaç-hastalık etkileşmeleri toksikolojik açıdan değerlendirilecektir.

Keywords

yaşlı, ilaç, etkileşme, gıda, hastalık

Drug-food and drug-disease interactons in the elderly

Abstract

Around the globe, life expectancy is ascending and geriatric population is rapidly increasing. Frequency of several diseases is rising with age and this brings along polypharmacy. Drug-nutrient and drug-disease interactions are often seen in elderly who apply polypharmacy. While nutrients can change the biotransformation and efficacy of drugs, drugs can also alter the biotransformation and efficacy of nutrients. On the other hand, existing disease along with drugs can worsen the course of the disease or drug use can increase the possibility of disease emergence. This review will evaluate drug-nutrient and drug-disease interactions from a toxicological perspective.

Keywords

elder, drug, interaction, food, disease

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