Yașlılıkta Alkol Kullanımına Bağlı İlaç Etkileșmeleri

Year 2015, Issue: 2, 116 - 130, 01.06.2015

Suna Sabuncuoğlu , Hilal Özgüneş

Abstract

İlaç-alkol etkileşmeleri dünya genelinde çok önemli sağlık problemleri arasında yer almaktadır. Yaşlılıkta artan kronik hastalıklara bağlı olarak polifarmasi yaygın olarak görülmektedir. Bunun sonucu olarak da ilaç etkileşmeleri yaşlı populasyonda daha sık ortaya çıkmaktadır. Alkol, bazı ilaçların metabolizmasını enzimlerde inhibisyon veya indüksiyona neden olarak değiştirebilmektedir. Etkileşim, farmakodinamik veya farmakokinetik şekilde görülebilir. Alkol, ilaçlarla ölüm de dahil çok ciddi sağlık problemleri ile sonuçlanacak etkileşimlere neden olabilmektedir. Antidepresanlar, antipsikotikler, antibiyotikler, antidiyabetikler, antihistaminikler, antihipertansifler, non-steroidal antiinflamatuvar ilaçlar, opioidler ve antikoagulanlar gibi pekçok farklı ilaç sınıfı ile alkol etkileşmeleri görülebilmektedir. Bu derlemede, özellikle yaşlılıkta sıklıkla kullanılan ilaçlara bağlı alkol-ilaç etkileşmeleri özetlenmeye çalışılmıştır.

Keywords

yaşlı, alkol, ilaç, etkileşme

Drug-Alcohol Interactions Depending on Consumption of Alcohol in Elderly

Abstract

Drug-alcohol interactions are very improtant worldwilde health problems. Because of the increased chronical diseases, polypharmacy is very common among geriatric people. As a consequence, drug interactions occurs more often in elderly population. Alcohol can effect the metabolisms of some drugs by enzyme inhibition or induction. The interaction can be pharmacodynamic or pharmacokinetic. Alcohol can interact with medications resulting in severe health problems including death. Many different classes of medications can interact with alcohol such as antidepressants, antipsychotics, antibiotics, antidiabetics, antihistamines, antihypertensives, non-steroidal anti-inflammatory agents, opioids, and anticoagulants. In this review, alcohol-drug interactions which are more common in elderly population were summarized.

Keywords

elderly, alcohol, drug, interaction

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