2-Metil-3-Acil-4-Aril-2,6,6 ve/veya 2,7,7-Trimetil-1,4,5,6,7,8-Hekzahidrokinolin Türevlerinin Antimikrobiyal Etkilerinin Araştırılması

Year 2011, Issue: 1, 51 - 58, 01.01.2011

Miyase Gözde Gündüz Melike Ekizoğlu Didem Kart Rahime Şimşek , Cihat Şafak

Abstract

Bu çalışmada metil etil 2,6,6- veya 2,7,7-trimetil-5-okso-4- difluorosübstitüe fenil -1,4,5,6,7,8-hekzahidrokinolin-3-karboksilat ve N,N-dietil-2,6,6- veya 2,7,7-trimetil-5-okso-4- difluorosübstitüe fenil -1,4,5,6,7,8-hekzahidrokinolin-3-karboksamit yapısına sahip otuz bileşiğin antimikrobiyal aktivitesi taranmıştır. Bakteri ve funguslara karşı antimikrobiyal aktiviteleri broth mikrodilüsyon yöntemi kullanılarak minimum inhibitör konsantrasyonu MIC olarak saptanmıştır.

Keywords

1, 4-dihydropyridine, hexahydroquinoline, antimicrobial activity

Antimicrobial Screening of 2-Methyl-3- Acyl-4-Aryl-2,6,6 and / or 2,7,7-Trimethyl1,4,5,6,7,8-Hexahydroquinoline Derivatives

Abstract

In this study, thirty compounds having methyl ethyl 2,6,6- or 2,7,7-trimethyl-5-oxo-4- difluorosubstituted phenyl -1,4,5,6,7,8-hexahydroquinoline- 3-carboxylate and N,N-diethyl-2,6,6- or 2,7,7-trimethyl- 5-oxo-4- difluorosubstituted phenyl -1,4,5,6,7,8-hexahydroquinoline-3- carboxamide structure, have been screened for their antimicrobial activities. Antimicrobial activities were determined as minimum inhibitory concentration MIC values by broth microdilution method against bacteria and fungi.

Keywords

1, 4-dihidropiridin, hekzahidrokinolin, antimikrobiyal aktivite

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