Alcea rosea L. çiçeklerinden Hazırlanan Ekstrelerin Antimikrobiyal ve Sitotoksik Aktiviteleri

Year 2010, Issue: 1, 17 - 24, 01.01.2010

Tuba Mert Tuğçe Fafal , Bijen Kıvçak H. Tansel Öztürk

Abstract

Bu çalışmada, Alcea rosea L.’nin çiceklerinin n-hegzan, metanol, etanol, etil asetat ve su ekstrelerinin, antimikrobiyal ve sitotoksik aktiviteleri değerlendirildi. Ekstrelerin antimikrobiyal aktiviteleri, bakteri olarak Escherichia coli ATCC 29998, Escherichia coli ATCC 25922, ATCC 29213, Staphylococcus epidermidis ATCC 12228, Salmonella thyphimurium CCM 5445, Enterobacter cloacae ATCC 13047, Enterococcus faecalis ATCC 29212, Pseudomonas aeroginosa ATCC 27853 ve mantar olarak Candida albicans ATCC 10239 ’ a karşı disk difüzyon metodu ile tayin edildi. Ekstrelerin sitotoksik aktiviteleri Brine shrimp yöntemiyle değerlendirildi. Etil asetat ekstresi Brine shrimp’e karşı sitotoksik aktivite gösterdi.

Keywords

Alcea rosea L., Malvaceae, sitotoksik aktivite, antimikrobiyal aktivite

Antimicrobial and Cytotoxic Activities of the Extracts Obtained from the Flowers of Alcea Rosea L.

Abstract

The antimicrobial and cytotoxic activities of n-hexane, methanol, ethanol, ethyl acetate and water extracts of Alcea rosea L. flowers were investigated. The antimicrobial activities of the extracts were reported against Escherichia coli ATCC 29998, Escherichia coli ATCC 25922, Escherichia coli ATCC 11230, Staphylococcus aureus ATCC 6538, Staphylococcus aureus ATCC 29213, Staphylococcus epidermidis ATCC 12228, Salmonella thyphimurium CCM 5445, Enterobacter cloacae ATCC 13047, Enterococcus faecalis ATCC 29212, Pseudomonas aeroginosa ATCC 27853 as bacteria and Candida albicans ATCC 10239 as yeastlike fungi by disc diffusion method. These extracts were also tested for cytotoxic activity by brine shrimp assay. Ethyl acetate extract showed cytotoxic activity against brine shrimp.

Keywords

Alcea rosea L., Malvaceae, Cytotoxic activity, Antimicrobial activity

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