Year 2021, Volume 41 , Issue 1, Pages 23 - 34 2021-01-01

Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler
Nanotechnogy Based Drug Delivery Systems in Migraine Treatment

Tuğba ÇOPUR [1] , Sibel BOZDAĞ [2] , Levent ÖNER [3]


Migren, nörolojik semptomların yanı sıra gastrointestinal ve otonomik semptomların da eşlik ettiği sosyo-ekonomik yükü yüksek tekrarlayan baş ağrısı ile karakterize bir hastalıktır. Klinikte profilaktik tedavi ve atak tedavisinde kullanılan ilaçların hiçbiri hastaların % 50'sinde % 50'den daha fazla iyileşme sağlayamamış olup, aynı zamanda ciddi yan etkilere sahiptir. Son zamanlarda migrende spesifik tedavi geliştirmeye yönelik olarak üzerinde en çok çalışılan moleküller 5-HT1F reseptör agonistleri (ditanlar), Kalsitonin geni ilişkili peptit (CGRP) reseptör agonistleri (gepantlar), Anti-kalsitonin geni ilişkili (CGRP) (reseptör) peptit monoklonal antikorları, Anti-hipofiz adenilat siklaz aktive edici polipeptit/hipofiz adenilat siklaz (PACAP/PAC1) monoklonal antikorlarıdır. Migren tedavisinde kullanılan ilaçların kısa yarılanma ömürleri, ilk geçiş etkisine uğramaları, biyoyararlanımlarının düşük olması, sık tekrarlanmalarının gerekmesi ve yan etkileri nedeniyle spesifik tedavi yaklaşımlarına ihtiyaç vardır. Nanoteknoloji temelli ilaç taşıyıcı sistemler ile bilinen anti-migren ilaçların biyoyararlanımının ve beyin hedeflemesinin arttırılmasıyla terapötik etkilerini daha iyi göstermeleri ve yan etkilerinin azalması sağlanabilir. Bu derlemede, literatürde yer alan migren tedavisine yönelik nanoteknoloji temelli ilaç taşıyıcı sistemler değerlendirilmiştir. Daha çok triptanların yer aldığı bu çalışmalarda elde edilen olumlu sonuçların gelecekte migren tedavisi için umut verici tedavilerin ortaya çıkmasına yol açacağı düşünülmektedir.
Migraine is a disease characterized by recurrent headache with high socio-economic burden accompanied by neurological symptoms as well as gastrointestinal and autonomic symptoms. None of the drugs used in the clinic for prophylactic and attack treatment have improved more than 50% in 50% of patients and also have serious side effects. Recently, the most studied molecules for developing specific treatment in migraine are 5-HT1F receptor agonists (ditans), Calcitonin gene related peptide (CGRP) receptor agonists (gepants), Anti-calcitonin gene related (CGRP) (receptor) peptide monoclonal antibodies, Anti-pituitary adenylate cyclase activating polypeptide / pituitary adenylate cyclase (PACAP /PAC1) and monoclonal antibodies. Specific treatment approaches are needed due to the short half-lives, first-pass effects, low bioavailability, frequent application and side effects of the drugs used in migraine treatment. By increasing the bioavailability and brain targeting of anti-migraine drugs with nanotechnology-based drug delivery systems, they can show their therapeutic effects and decrease their side effects. In this review, nanotechnology-based drug delivery systems for migraine treatment in the literature were evaluated. It is thought that the positive results obtained in these studies with mostly triptans will lead to promising results for future migraine treatment in the future.
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Primary Language tr
Subjects Pharmacology and Pharmacy
Journal Section Review Articles
Authors

Author: Tuğba ÇOPUR
Institution: HACETTEPE UNIVERSITY, FACULTY OF PHARMACY, DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY, DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
Country: Turkey


Author: Sibel BOZDAĞ
Institution: HACETTEPE UNIVERSITY, FACULTY OF PHARMACY, DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY, DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
Country: Turkey


Author: Levent ÖNER (Primary Author)
Institution: HACETTEPE UNIVERSITY, FACULTY OF PHARMACY, DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY, DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
Country: Turkey


Dates

Publication Date : January 1, 2021

Bibtex @review { hujpharm769607, journal = {Hacettepe University Journal of the Faculty of Pharmacy}, issn = {}, eissn = {2458-8806}, address = {hujpharm@gmail.com}, publisher = {Hacettepe University}, year = {2021}, volume = {41}, pages = {23 - 34}, doi = {}, title = {Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler}, key = {cite}, author = {Çopur, Tuğba and Bozdağ, Sibel and Öner, Levent} }
APA Çopur, T , Bozdağ, S , Öner, L . (2021). Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler . Hacettepe University Journal of the Faculty of Pharmacy , 41 (1) , 23-34 . Retrieved from https://dergipark.org.tr/en/pub/hujpharm/issue/60867/769607
MLA Çopur, T , Bozdağ, S , Öner, L . "Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler" . Hacettepe University Journal of the Faculty of Pharmacy 41 (2021 ): 23-34 <https://dergipark.org.tr/en/pub/hujpharm/issue/60867/769607>
Chicago Çopur, T , Bozdağ, S , Öner, L . "Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler". Hacettepe University Journal of the Faculty of Pharmacy 41 (2021 ): 23-34
RIS TY - JOUR T1 - Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler AU - Tuğba Çopur , Sibel Bozdağ , Levent Öner Y1 - 2021 PY - 2021 N1 - DO - T2 - Hacettepe University Journal of the Faculty of Pharmacy JF - Journal JO - JOR SP - 23 EP - 34 VL - 41 IS - 1 SN - -2458-8806 M3 - UR - Y2 - 2020 ER -
EndNote %0 Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler %A Tuğba Çopur , Sibel Bozdağ , Levent Öner %T Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler %D 2021 %J Hacettepe University Journal of the Faculty of Pharmacy %P -2458-8806 %V 41 %N 1 %R %U
ISNAD Çopur, Tuğba , Bozdağ, Sibel , Öner, Levent . "Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler". Hacettepe University Journal of the Faculty of Pharmacy 41 / 1 (January 2021): 23-34 .
AMA Çopur T , Bozdağ S , Öner L . Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler. HUJPHARM. 2021; 41(1): 23-34.
Vancouver Çopur T , Bozdağ S , Öner L . Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler. Hacettepe University Journal of the Faculty of Pharmacy. 2021; 41(1): 23-34.
IEEE T. Çopur , S. Bozdağ and L. Öner , "Migren Tedavisinde Nanoteknoloji Temelli İlaç Taşıyıcı Sistemler", Hacettepe University Journal of the Faculty of Pharmacy, vol. 41, no. 1, pp. 23-34, Jan. 2021