Current Approaches in Alzheimer's Disease Treatment
Year 2021,
Volume: 41 Issue: 4, 266 - 280, 01.12.2021
Makbule Dilara Odabaşı
,
Zekiye Tuba Tüylü Küçükkılınç
Abstract
Alzheimer's disease is a disease that causes progressive and irreversible damage to nerve cells, characterized by cognitive and memory impairment. It is the world's leading cause of dementia and the population of Alzheimer's patients is growing rapidly. The reasons such as the etiology of the disease not being determined yet, the increase in the patient population over the years, the lack of a radical treatment, the decrease in the quality of life of the patients increase the importance of the disease and direct the researchers to this field. In this review, general information about Alzheimer's and current treatment approaches that modify and improve the disease are examined.
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Alzheimer Hastalığı Tedavisindeki Güncel Yaklaşımlar
Year 2021,
Volume: 41 Issue: 4, 266 - 280, 01.12.2021
Makbule Dilara Odabaşı
,
Zekiye Tuba Tüylü Küçükkılınç
Abstract
Alzheimer hastalığı bilişsel ve hafıza bozukluğu ile karakterize ilerleyici ve geri dönüşü olmayan sinir hücrelerinin hasarına yol açan bir hastalıktır. Dünyanın önde gelen demans nedenidir ve Alzheimer hastalarının popülasyonu hızla artmaktadır. Hastalığın etiyolojisinin henüz tam olarak belirlenememesi, hasta popülasyonunun yıllar geçtikçe artması, radikal bir tedavinin olmayışı, hastaların yaşam kalitesini oldukça düşürmesi gibi sebepler hastalığın önemini arttırmakta ve araştırmacıları bu alana yönlendirmektedir. Bu derlemede Alzheimer ile ilgili genel bilgiler ve hastalığı modifiye edici, iyileştirici güncel tedavi yaklaşımları incelenmiştir.
References
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- 4. Leinenga G, Koh WK, Götz J. A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse
model of Alzheimer disease. 2021.
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- 6. Biran Y, Masters CL, Barnham KJ, Bush AI, Adlard PA. Pharmacotherapeutic targets in Alzheimer's disease. J Cell Mol Med. 2009;13(1):61-86.
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- 9. Munro KM, Nash A, Pigoni M, Lichtenthaler SF, Gunnersen JM. Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System. J Mol Neurosci. 2016;60(3):305-15.
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- 18. Lichtenthaler SF, Haass C. Amyloid at the cutting edge: activation of α-secretase prevents amyloidogenesis in an Alzheimer disease mouse model. Journal of Clinical Investigation. 2004;113(10):1384-7.
- 19. Mockett BG, Richter M, Abraham WC, Muller UC. Therapeutic Potential of Secreted Amyloid Precursor Protein APPsalpha. Front Mol Neurosci. 2017;10:30.
- 20. Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, et al. Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10. Cell. 2017;171(7):1638-48 e7.
- 21. De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol. 2010;6(2):99-107.
- 22. Liao W, Jin G, Zhao M, Yang H. The effect of genistein on the content and activity of alpha- and beta-secretase and protein kinase C in Abeta-injured hippocampal neurons. Basic Clin Pharmacol Toxicol. 2013;112(3):182-5.
- 23. Khan TK, Wender PA, Alkon DL. Bryostatin and its synthetic analog, picolog rescue dermal fibroblasts from prolonged stress and contribute to survival and rejuvenation of human skin equivalents. J Cell Physiol. 2018;233(2):1523-34.
- 24. Lucke-Wold BP, Turner RC, Logsdon AF, Simpkins JW, Alkon DL, Smith KE, et al. Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration. J Alzheimers Dis. 2015;43(3):711-24.
- 25. Imbimbo BP, Speroni F. β‐Amyloid Therapeutic Strategies for Alzheimer's Disease. Burger's Medicinal Chemistry and Drug Discovery2005.
- 26. Yang HQ, Pan J, Ba MW, Sun ZK, Ma GZ, Lu GQ, et al. New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing alpha-secretase activity. Eur J Neurosci. 2007;26(2):381-91.
- 27. Vellas B, Sol O, Snyder PJ, Ousset PJ, Haddad R, Maurin M, et al. EHT0202 in Alzheimers Disease: A 3-Month, Randomized, Placebo-Controlled, Double-Blind Study. Current Alzheimer Research. 2011;8(2):203-12.
- 28. Tang BL. Enhancing alpha-secretase Processing for Alzheimer's Disease-A View on SFRP1. Brain Sci. 2020;10(2).
- 29. Baptista FI, Henriques AG, Silva AM, Wiltfang J, da Cruz e Silva OA. Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer's disease. ACS Chem Neurosci. 2014;5(2):83-92.
- 30. Frisardi V, Solfrizzi V, Imbimbo BP, Capurso C, D'Introno A, Colacicco AM, et al. Towards Disease-Modifying Treatment of Alzheimers Disease: Drugs Targeting β-Amyloid. Current Alzheimer Research. 2010;7(1):40-55.
- 31. Dos Santos Guilherme M, Stoye NM, Rose-John S, Garbers C, Fellgiebel A, Endres K. The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients. Front Aging Neurosci. 2019;11:182.
- 32. Araki W. Potential repurposing of oncology drugs for the treatment of Alzheimer's disease. BMC Medicine. 2013;11(82).
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