Hot Melt Ekstrüzyonda Son Gelişmeler ve Uygulamaları

Year 2022, Volume: 42 Issue: 1, 31 - 45, 01.03.2022

Ratnaprabha Kinikar Ashwin Kuchekar

https://doi.org/10.52794/hujpharm.961794

Cited By: 1

Abstract

Endüstriyel uyumluluk, üretim süreci, formülasyon ve geliştirmenin sonucuyla birlikte, Hot Melt Ekstrüzyon (HME) de kabulü genişletti. Endüstriyel uyarlanabilirliğin bir sonucu olarak, ilaç araştırma ve geliştirmenin bir parçası olarak geniş bir yelpazede kendini geliştirmiştir. Yeni ilaç varlıkları, zayıf biyofarmasötik özellikler, toksisiteler ve etkinlik eksikliği dahil olmak üzere formülasyon geliştirme sırasında başarısızlıklar veya gecikmelerle karşı karşıyadır. Bu tür engelleri aşmak için en çok tercih edilen HME tekniğidir. Konvansiyonel tekniklerle karşılaştırıldığında, uygun prosesi, solvent içermeyen yapısı, uygun maliyetli ve on-line üretimi nedeniyle kullanımı giderek artmaktadır. Farklı uygulamalar elde etmek için, ekipmanın tasarımı değiştirilerek ve değiştirilmiş bir işleme koşulu uyarlanarak çeşitli dozaj formları üretilebilir

Keywords

Sıcak Eriyik Ekstrüzyon, Vida, Plastifiyan, Çözünürlük, Granüller

Recent Advances in Hot Melt Extrusion and its Applications

Abstract

Over the decades with the outcome of industrial compliance, manufacturing process, formulation and development, Hot Melt Extrusion (HME) has also expanded the acceptance. As a result of industrial adaptability, it has developed itself in a wide range as a part of pharmaceutical research and development. New drug entities face failures or delays during formulation development, including poor biopharmaceutical properties, toxicities and lack of efficacy. To overcome such obstacles, HME technique is most preferred one. In comparison to conventional techniques, its use has been increasing because of its convenient process, solvent free nature, cost effective and on-line manufacturing. For achieving different applications several dosage forms can be produced by altering the design of equipment and adapting a modified processing condition.

Keywords

Melt Extrusion, Screw, Plasticizer, Solubility, Granules

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