COVID-19 Korkusu: Kistik Fibrozisli Hastalarda Psikososyal Faktörler ve Yaşam Kalitesi Üzerine Etkileri

Year 2024, , 21 - 37, 30.04.2024

Elif Kabasakal , Pınar Kaya Ciddi

https://doi.org/10.21020/husbfd.1229482

Abstract

Amaç: Kronik bir hastalık olan Kistik Fibrozis (KF) tanılı bireylerde pandemi sürecinde psikososyal etkiler ortaya konmuş ve tutarsız sonuçlar gözlenmiştir. Bu çalışma, KF'li bireylerde Koronavirüs (COVID-19) pandemisinin anksiyete, depresyon ve yaşam kalitesi (YK) seviyeleri üzerindeki etkilerini araştırdı.
Gereç ve Yöntemler: Çalışmaya dahil edilen tüm katılımcıların verileri, biri KF'li bireyler ve diğeri genel popülasyon (GP) kontrolleri için olmak üzere iki internet tabanlı anket aracılığıyla toplanmıştır. İki anket versiyonunda da araştırmacılar tarafından hazırlanan benzer sorular vardı. KF'li bireyler için olan anket, KF hedefli sorularla zenginleştirildi. Ayrıca her iki ankette de COVID-19 Korkusu Ölçeği, Hastane Anksiyete Depresyon Ölçeği (HADÖ) ve Dünya Sağlık Örgütü YK Ölçeği Kısa Formu (DSÖYK-KF) soru maddeleri yer aldı.
Bulgular: KF'li 64 birey ve 70 GP kontrolü anketleri tamamladı. KF'li bireyler, GP kontrollerine göre COVID-19 korkusu, anksiyete, depresyon ve düşük YK seviyelerine sahipti (p<0,001). KF'li bireylerde COVID-19 korkusunun anksiyete (R2=0,506; p<0,001), depresyon (R2=0,337; p<0,001) ve YK'nin genel sağlık durumu (R2=0,095; p=0,013), fiziksel (R2=0,239; p<0,001), psikolojik (R2=0,275; p<0,001) ve çevresel (R2=0,179; p<0,001) sağlık YK alanları üzerinde önemli etkileri olduğu, ancak sosyal ilişkiler üzerinde (p>0,05) anlamlı etkisi olmadığı görüldü. GP kontrollerinde, COVID-19 korkusunun anksiyete ve depresyon üzerinde anlamlı etkileri vardı (p<0,05), ancak herhangi bir YK alanı üzerinde yoktu (p>0,05).
Sonuç: Çalışmadaki bulgularımıza göre, COVID-19 korkusundaki artışın KF’li bireylerde anksiyete, depresyon ve YK üzerinde olumsuz etkisi vardı. KF'li bireylerdeki psikososyal etkilenimler gelecekteki kesitsel çalışmalarla, olası bir pandemi ve karantina durumunda daha iyi takip edilebileceğini ve önlemlerin alınabileceğini düşünmekteyiz.

Keywords

Anksiyete, COVID-19, Depresyon, Kistik Fibrozis, Yaşam Kalitesi

The Fear of COVID-19: Effects on Psychosocial Factors and Quality of Life in Patients with Cystic Fibrosis

Abstract

Objective: Psychosocial effects have been reported in patients with cystic fibrosis (pwCFs), which is chronic disease, and inconsistent results were observed in pandemic between studies. This study investigated the effects of Coronavirus (COVID-19) pandemic on anxiety, depression and quality of life (QoL) levels among pwCFs.
Material and Methods: The data of all participants included in the study were collected through two web-based questionnaires, one for pwCFs and general population (GP) controls. Two questionnaire versions had similar questions, prepared by the researchers. The pwCFs questionnaire augmented with CF targeted questions. Also, both questionnaires included COVID-19 Fear Scale, Hospital Anxiety Depression Scale (HADS) and World Health Organization QoL Scale Short Form (WHOQOL-Bref) question items.
Results: Sixty-four pwCFs and seventy GP controls completed the questionnairesCompared to GP controls, pwCFs had increased fear of COVID-19, anxiety, depression, and decreased QoL levels (p<0.001). The fear of COVID-19 had significant effects on anxiety (R2=0.506; p<0.001), depression (R2=0.337; p<0.001), and QoL domains of general health status (R2=0.095; p=0.013), physical (R2=0.239; p<0.001) and psychological health (R2=0.275; p<0.001), and environment (R2=0.179; p<0.001), but not on social relationships (p>0.05) in pwCFs. In GP controls, the fear of COVID-19 had significant effects on anxiety and depression (p<0.05), but not on any QoL domains (p>0.05).
Conclusion: According to our study findings, theincrease in fear of COVID-19 had a negative impact on anxiety, depression and QoL in pwCFs.Psychosocial influences in pwCFs need to be further investigated in future cross-sectional studies in case of a possible pandemic and lockdown.

Keywords

Anxiety, COVID-19, Depression, Cystic fibrosis, Quality of Life

References

• Abdelbasset, W.K., Soliman, G.S., Elshehawy, A.A., & Alrawaili, S.M. (2018). Exercise capacity and muscle fatiguability alterations following a progressive maximal exercise of lower extremities in children with cystic fibrosis. African Health Sciences,18(4), 1236-1242. https://doi.org/10.4314/ahs.v18i4.45.
• Ahorsu, D.K., Lin, C.Y., Imani, V., Saffari, M., Griffiths, MD., & Pakpour, A.H. (2020). The Fear of COVID-19 Scale: Development and Initial Validation. International Journal of Mental Health and Addiction, 1(9). https://doi.org/10.1007/s11469-020-00270-8.
• Al-Rahimi, J.S., Nass, N.M., Hassoubah, S.A., Wazqar, D.Y., & Alamoudi, S.A. (2021). Levels and predictors of fear and health anxiety during the current outbreak of COVID-19 in immunocompromised and chronic disease patients in Saudi Arabia: A cross-sectional correlational study. PloS One, 16(4), e0250554. https://doi.org/10.1371/journal.pone.0250554.
• Asmundson, G., &Taylor, S. (2020). Coronaphobia: Fear and the 2019-nCoV outbreak. Journal of Anxiety Disorders, 70(102196). https://doi.org/10.1016/j.janxdis.2020.102196.
• Atzrodt, C.L., Maknojia, I., McCarthy, R., Oldfield, T.M., Po, J., Ta K, et al. (2020). A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2. The FEBS Journal, 287(17), 3633–3650. https://doi.org/10.1111/febs.15375.
• Aydemir, O., Güvenir, T., Küey, L., & Kültür, S. (1997). Hastane Anksiyete ve Depresyon Ölçeği Türkçe Formunun Geçerlilik ve Güvenilirlik Çalışması [Reliability and Validity of the Turkish version of Hospital Anxiety and Depression Scale]. Türk Psikiyatri Dergisi, 8, 280–287.
• Bakioğlu, F., Korkmaz, O., & Ercan, H. (2021). Fear of COVID-19 and Positivity: Mediating Role of Intolerance of Uncertainty, Depression, Anxiety, and Stress. International Journal of Mental Health and Addiction, 19(6),2369–2382. https://doi.org/10.1007/s11469-020-00331-y.
• Bäuerle, A., Teufel, M., Musche, V., Weismüller, B., Kohler H, & Hetkamp, M. (2020). Increased generalized anxiety, depression and distress during the COVID-19 pandemic: a cross-sectional study in Germany. Journal of Public Health, 42(4), 672–678. https://doi.org/10.1093/pubmed/fdaa106.
• Bell, S.C., Mall, M.A., Gutierrez, H., Macek, M., Madge, S., Davies, J.C. (2020). The future of cystic fibrosis care: a global perspective. Lancet Respiratory Medicine, 8(1), 65–124. https://doi.org/10.1016/S2213-2600(19)30337-6.
• Benecke, A. V., Schmidt, K. L., Dinse, H., Schweda, A., Jahre, L., Fink, M., Weismüller, B., Dörrie, N., Welsner, M., Skoda, E. M., Bäuerle, A., Musche, V., & Teufel, M. (2022). Increased Safety Behavior and COVID-19-Related Fear in Adults with Cystic Fibrosis during the Pandemic. Healthcare (Basel, Switzerland), 10(5), 858.
• Ciprandi, R., Bonati, M., Campi, R., Pescini, R., & Castellani, C. (2021). Psychological distress in adults with and without cystic fibrosis during the COVID-19 lockdown. Journal of Cystic Fibrosis, 20(2),198–204. https://doi.org/10.1016/j.jcf.2020.12.016.
• Dogan, R., Kaplan Serin, E., & Bağci, N. (2021). Fear of COVID 19 and social effects in liver transplant patients. Transplant Immunology, 69, 101479. https://doi.org/10.1016/j.trim.2021.101479.
• Ejaz, H., Alsrhani, A., Zafar, A., Javed, H., Junaid, K., Abdalla, A. E. (2020). COVID-19 and comorbidities: Deleterious impact on infected patients. Journal of Infection and Public Health, 13(12), 1833–1839. https://doi.org/10.1016/j.jiph.2020.07.014.
• Eser, S.Y., Fidaner, H., Fidaner, C., Elbi, H. (1999). Measure of quality of life WHOQOL-100 and WHOQOL-Bref. Psychiatry and Clinical Psychopharmacology, 7(2 Suppl.), 5-13.
• Graziano, S., Boldrini, F., Righelli, D., Milo, F., Lucidi, V., Quittner, A. (2021). Psychological interventions during COVID pandemic: Telehealth for individuals with cystic fibrosis and caregivers. Pediatric Pulmonology, 56(7), 1976–1984. https://doi.org/10.1002/ppul.25413.
• Havermans, T., Colpaert, K., & Dupont, L. J. (2008). Quality of life in patients with Cystic Fibrosis: association with anxiety and depression. Journal of cystic fibrosis: official journal of the European Cystic Fibrosis Society, 7(6), 581–584.
• Havermans, T., Houben, J., Vermeulen, F., Boon, M., Proesmans, M., Lorent, N. (2020). The impact of the COVID-19 pandemic on the emotional well-being and home treatment of Belgian patients with cystic fibrosis, including transplanted patients and paediatric patients. Journal of Cystic Fibrosis, 19(6), 880–887. https://doi.org/10.1016/j.jcf.2020.07.022.
• Havermans, T., & Willem, L. (2019). Prevention of anxiety and depression in cystic fibrosis. Current Opinion in Pulmonary Medicine, 25(6), 654–659. https://doi.org/10.1097/MCP.0000000000000617.
• Huang, Y., & Zhao, N. (2020). Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey. Journal of Psychiatry Research, 288,112954. https://doi.org/10.1016/j.psychres.2020.112954.
• Humaj-Grysztar, M., Rachel, M., Śmiech-Michalec, O., Bonior, J. (2022). Mental Health of Cystic Fibrosis Patients and the COVID-19 Pandemic in Poland: A Single-Center Comparative Study. International journal of environmental research and public health, 19(23), 16056. https://doi.org/10.3390/ijerph192316056.
• Korukcu, O., Ozkaya, M., Faruk Boran, O., & Boran, M. (2021). The effect of the COVID-19 pandemic on community mental health: A psychometric and prevalence study in Turkey. Health and Social Care in Community, 29(5), e204–e213. https://doi.org/10.1111/hsc.13270.
• Li, S., Wang, Y., Xue, J., Zhao, N., Zhu, T. (2020). The Impact of COVID-19 Epidemic Declaration on Psychological Consequences: A Study on Active Weibo Users. International Journal of Environmantal Research and Public Health, 17(6),2032. https://doi.org/10.3390/ijerph17062032.
• Luber, R.P., Duff, A., Pavlidis, P., Honap, S., Meade, S., Ray, S. (2022). Depression, anxiety, and stress among inflammatory bowel disease patients during COVID-19: A UK cohort study. Journal of Gastroenterology and Hepatology, 6(1), 76–84. https://doi.org/10.1002/jgh3.12699.
• Mailliez, M., Griffiths, M.D., Carre, A. (2021). Validation of the French Version of the Fear of COVID-19 Scale and Its Associations with Depression, Anxiety, and Differential Emotions. International Journal of Mental Health and Addiction, 1–15. https://doi.org/10.1007/s11469-021-00499-x.
• Parlapani, E., Holeva, V., Voitsidis, P., Blekas, A., Gliatas, I., Porfyri, G.N. (2020). I. Psychological and Behavioral Responses to the COVID-19 Pandemic in Greece. Frontiers in Psychiatry, 11(821). https://doi.org/10.3389/fpsyt.2020.00821.
• Peckham, D., McDermott, MF., Savic, S., & Mehta, A. (2020). COVID-19 meets Cystic Fibrosis: for better or worse?Genes & Immunity,21(4), 260–262. https://doi.org/10.1038/s41435-020-0103-y.
• Radtke, T., Haile, S.R., Dressel, H., & Benden, C. (2020). Recommended shielding against COVID-19 impacts physical activity levels in adults with cystic fibrosis. Journal of Cystic Fibrosis, 19(6), 875–879. https://doi.org/10.1016/j.jcf.2020.08.013.
• Rafeeq, M., & Murad, H. (2017). Cystic fibrosis: current therapeutic targets and future approaches. Journal of Translational Medicine, 15(1), 84. https://doi.org/10.1186/s12967-017-1193-9.
• Rhoads, S., Cooney, K., Banerjee, D. (2021). Emotional Impact of COVID-19 Pandemic on Adults with Cystic Fibrosis. Rhode Island medical journal (2013), 104 (10), 53-55.
• Senkalfa, B.P., SismanlarEyuboglu, T., Aslan, A.T., Ramaslı Gursoy, T., Soysal, A.S., Yapar D. (2022). Effect of the COVID-19 pandemic on anxiety among children with cystic fibrosis and their mothers. Pediatric pulmonology, 55(8), 2128–2134. https://doi.org/10.1002/ppul.24900.
• Simonson, J. L., Esposito, C., Frantzen, T., Henthorne, K., Espinal, A., Romano, S., Ramdeo, R., Trentacoste, J., Tsang, D., LaVecchia, G., Abdullah, R., Berdella, M., Bonitz, L., Condos, R., Constantinescu, A., DeCelie-Germana, J. K., DiMango, E., Draine, M., Gimeli, T., Giusti, R., … Wang, J. (2022). The clinical impact of the Covid-19 pandemic first wave on patients with cystic fibrosis in New York. Journal of cystic fibrosis: official journal of the European Cystic Fibrosis Society, 21(3), e176–e183.
• Smith, B. A., Georgiopoulos, A. M., Mueller, A., Abbott, J., Lomas, P., Aliaj, E., & Quittner, A. L. (2021). Impact of COVID-19 on mental health: Effects on screening, care delivery, and people with cystic fibrosis. Journal of cystic fibrosis: official journal of the European Cystic Fibrosis Society, 20 Suppl 3, 31–38.
• Violant-Holz, V., Gallego-Jiménez, M.G., González-González, C.S., Muñoz-Violant, S., Rodríguez, M.J., Sansano-Nadal, O. (2020). Psychological Health and Physical Activity Levels during the COVID-19 Pandemic: A Systematic Review. International Journal of Environment Research and Public Health, 17(24), 9419. https://doi.org/10.3390/ijerph17249419.
• Voorend, C., Van Oevelen, M., Nieberg, M., Meuleman, Y., Franssen, C., Joosten H. (2021). Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease. BMC geriatrics,21(1), 650. https://doi.org/10.1186/s12877-021-02593-0.
• Wang, H., Li, X., Li, T., Zhang, S., Wang, L., Wu, X. (2020). The genetic sequence, origin, and diagnosis of SARS-CoV-2. European Journal of Clinical Microbiology Infectious Diseases, 39(9), 1629–1635. https://doi.org/10.1007/s10096-020-03899-4.
• Westcott., K.A., Wilkins, F., Chancellor, A., Anderson, A., Doe, S., Echevarria, C. (2021). The impact of COVID-19 shielding on the wellbeing, mental health and treatment adherence of adults with cystic fibrosis. Future Healthcare Journal, 8(1), e47–e49. https://doi.org/10.7861/fhj.2020-0205.
• Zigmond, A.S., & Snaith, R.P. (1983). The Hospital Anxiety and Depression Scale. 64 Acta Psychiatrica Scandinavica, 67(6), 361-370.