Research Article
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Year 2026, Volume: 13 Issue: 1 , 185 - 196 , 30.04.2026
https://doi.org/10.21020/husbfd.1713453
https://izlik.org/JA78TZ42LH

Abstract

References

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  • Bahat, G., Yilmaz, O., Kilic, C., Oren, M., & Karan, M. (2018). Performance of SARC-F in regard to sarcopenia definitions, muscle mass and functional measures. The journal of Nutrition, Health & Aging, 22, 898-903. https://doi.org/10.1007/s12603-018-1067-8
  • Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015). Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimer's & Dementia, 11(6), 718-726. https://doi.org/10.1016/j.jalz.2015.05.016
  • Beaudart, C., Demonceau, C., Reginster, J. Y., Locquet, M., Cesari, M., Cruz Jentoft, A. J., & Bruyère, O. (2023). Sarcopenia and health‐related quality of life: A systematic review and meta‐analysis. Journal of Cachexia, Sarcopenia and Muscle. https://doi.org/10.1002/jcsm.13243
  • Beeri, M. S., Leugrans, S. E., Delbono, O., Bennett, D. A., & Buchman, A. S. (2021). Sarcopenia is associated with incident Alzheimer's dementia, m ild cognitive impairment, and cognitive decline. Journal of the American Geriatrics Society, 69(7), 1826-1835. https://doi.org/10.1111/jgs.17206
  • Bruyère, O., Beaudart, C., Reginster, J.-Y., Buckinx, F., Schoene, D., Hirani, V., Cooper, C., Kanis, J. A., Rizzoli, R., & McCloskey, E. (2016). Assessment of muscle mass, muscle strength and physical performance in clinical practice: an international survey. European Geriatric Medicine, 7(3), 243-246. https://doi.org/10.1016/j.eurger.2015.12.009
  • Chang, K.-V., Hsu, T.-H., Wu, W.-T., Huang, K.-C., & Han, D.-S. (2016). Association between sarcopenia and cognitive impairment: a systematic review and meta-analysis. Journal of the American Medical Directors Association, 17(12), 1164. e1167-1164. e1115. https://doi.org/10.1016/j.jamda.2016.09.013
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  • Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., & Sayer, A. A. (2019). Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing, 48(1), 16-31. https://doi.org/10.1093/ageing/afy169
  • Çebi, M., Babacan, G., Öktem Tanör, Ö., & Gürvit, H. (2020). Discrimination ability of the Short Test of Mental Status (STMS) compared to the Mini Mental State Examination (MMSE) in the spectrum of normal cognition, mild cognitive impairment, and probable Alzheimer’s disease dementia: the Turkish standardization study. Journal of Clinical and Experimental Neuropsychology, 42(5), 450-458. https://doi.org/10.1080/13803395.2020.1758633
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  • Ganmore, I., Elkayam, I., Ravona-Springer, R., Lin, H.-M., Liu, X., Plotnik, M., Buchman, A. S., Berman, Y., Schwartz, J., & Sano, M. (2020). Deterioration in motor function over time in older adults with type 2 diabetes is associated with accelerated cognitive decline. Endocrine Practice, 26(10), 1143-1152. https://doi.org/10.4158/EP-2020-0289
  • Gogtay, N. J., & Thatte, U. M. (2017). Principles of correlation analysis. Journal of the Association of Physicians of India, 65, 78-81.
  • Güngen, C., Ertan, T., Eker, E., Yaşar, R., & Engin, F. (2002). Standardize mini mental test’in Türk toplumunda hafif demans tan› s› nda geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi, 13(4), 273-281.
  • Halil, M., Ulger, Z., Varlı, M., Döventaş, A., Oztürk, G., Kuyumcu, M., Yavuz, B., Yesil, Y., Tufan, F., & Cankurtaran, M. (2014). Sarcopenia assessment project in the nursing homes in Turkey. European Journal of Clinical Nutrition, 68(6), 690-694. https://doi.org/10.1038/ejcn.2014.15
  • Hallgren, M., Herring, M. P., Owen, N., Dunstan, D., Ekblom, Ö., Helgadottir, B., Nakitanda, O. A., & Forsell, Y. (2016). Exercise, physical activity, and sedentary behavior in the treatment of depression: broadening the scientific perspectives and clinical opportunities. Frontiers in Psychiatry, 7, 36. https://doi.org/10.3389/fpsyt.2016.00036
  • Hu, Y., Peng, W., Ren, R., Wang, Y., & Wang, G. (2022). Sarcopenia and mild cognitive impairment among elderly adults: the first longitudinal evidence from CHARLS. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2944-2952. https://doi.org/10.1002/jcsm.13081
  • Huang, C.-Y., Hwang, A.-C., Liu, L.-K., Lee, W.-J., Chen, L.-Y., Peng, L.-N., Lin, M.-H., & Chen, L.-K. (2016). Association of dynapenia, sarcopenia, and cognitive impairment among community-dwelling older Taiwanese. Rejuvenation Research, 19(1), 71-78. https://doi.org/10.1089/rej.2015.1710
  • Jia, X., Wang, Z., Huang, F., Su, C., Du, W., Jiang, H., Wang, H., Wang, J., Wang, F., & Su, W. (2021). A comparison of the Mini-Mental State Examination (MMSE) with the Montreal Cognitive Assessment (MoCA) for mild cognitive impairment screening in Chinese middle-aged and older population: a cross-sectional study. BMC Psychiatry, 21, 1-13. https://doi.org/10.1186/s12888-021-03495-6
  • Kalaria, R. N. (2016). Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease. Acta Neuropathologica, 131(5), 659-685. https://doi.org/10.1007/s00401-016-1571-z
  • Kaplan, H. I., & Sadock, B. J. (1988). Synopsis of psychiatry: Behavioral sciences clinical psychiatry. Williams & Wilkins Co. https://doi.org/10.1097/00004850-198904000-00007
  • Li, X., Peng, A., Li, L., & Chen, L. (2023). Association between walking and square dancing-oriented leisure-time physical activity and cognitive function among middle-aged and elderly people in Southwest China. BMC Geriatrics, 23(1), 28. https://doi.org/10.1186/s12877-023-03737-0
  • Molino, S., Dossena, M., Buonocore, D., & Verri, M. (2016). Sarcopenic obesity: an appraisal of the current status of knowledge and management in elderly people. The Journal of Nutrition, Health and Aging, 20(7), 780-788. https://doi.org/10.1007/s12603-015-0631-8
  • Morley, J. E., Abbatecola, A. M., Argiles, J. M., Baracos, V., Bauer, J., Bhasin, S., Cederholm, T., Coats, A. J. S., Cummings, S. R., & Evans, W. J. (2011). Sarcopenia with limited mobility: an international consensus. Journal of the American Medical Directors Association, 12(6), 403-409. https://doi.org/10.1016/j.jamda.2011.04.014
  • Ogawa, Y., Kaneko, Y., Sato, T., Shimizu, S., Kanetaka, H., & Hanyu, H. (2018). Sarcopenia and muscle functions at various stages of Alzheimer disease. Frontiers in Neurology, 9, 710. https://doi.org/10.3389/fneur.2018.00710
  • Peng, T.-C., Chen, W.-L., Wu, L.-W., Chang, Y.-W., & Kao, T.-W. (2020). Sarcopenia and cognitive impairment: A systematic review and meta-analysis. Clinical Nutrition, 39(9), 2695-2701. https://doi.org/10.1016/j.clnu.2019.12.014
  • Podsiadlo, D., & Richardson, S. (1991). The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. Journal of the American Geriatrics Society, 39(2), 142-148. https://doi.org/10.1111/j.1532-5415.1991.tb01616.x
  • Rosso, A. L., Studenski, S. A., Chen, W. G., Aizenstein, H. J., Alexander, N. B., Bennett, D. A., Black, S. E., Camicioli, R., Carlson, M. C., & Ferrucci, L. (2013). Aging, the central nervous system, and mobility. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 68(11), 1379-1386. https://doi.org/10.1093/gerona/glt089
  • Sahin, U. K., Tozluoglu, E. Y., Durdu, H., Korkmaz, N., Bahar, N. T., & Yavuz, E. (2022). Screening for frailty and sarcopenia in community-dwelling older adults: a cross-sectional study from the Eastern Black Sea region of Turkey. Aging Clinical and Experimental Research, 34(9), 2047-2056. https://doi.org/10.1007/s40520-022-02164-2
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  • Scisciola, L., Fontanella, R. A., Surina, Cataldo, V., Paolisso, G., & Barbieri, M. (2021). Sarcopenia and cognitive function: role of myokines in muscle brain cross-talk. Life, 11(2), 173. https://doi.org/10.3390/life11020173
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Relationship Between Sarcopenia and Cognitive Function in Community-Dwelling Older Adults

Year 2026, Volume: 13 Issue: 1 , 185 - 196 , 30.04.2026
https://doi.org/10.21020/husbfd.1713453
https://izlik.org/JA78TZ42LH

Abstract

Objectives: Sarcopenia, known as muscle bulk and strength loss, along with cognitive impairment, are frequently observed in the aging population. Although both conditions are prevalent, their potential interplay has not yet been clearly defined. It was aimed to explore the link between sarcopenia and cognitive functions in the older adult population.
Materials and Methods: Fifty-five older adults with an average age of 73.34 ± 6.65 participated in the study. While cognitive functions were examined using the Mini-Mental State Examination (MMSE), the risk of sarcopenia was determined using the Sarcopenia Screening Questionnaire (SARC-F). Additionally, functional mobility and hand grip strength were measured using the “Timed Up and Go (TUG)” test and the “Four-Meter Walk Test”.
Results: Of the participants, 56.4% exhibited cognitive impairment, and 52.7% were at risk of sarcopenia. Correlation analysis revealed significant relationships between MMSE scores and SARC-F (r=-0.741), dominant (r=0.577) and non-dominant grip strength (r=0.549), the TUG test (r=-0.714), and the Four-Meter Walk Test (r=-0.752) (p<0.001).
Conclusion: The findings underline the value of incorporating assessments of both sarcopenia and cognitive function in the comprehensive evaluation of older adults.

Ethical Statement

The Declaration of Helsinki conducted the study, and ethical approval was obtained from the Hacettepe University Non-Interventional Ethics Committee with decision number 2022-03/23 and research code GO 22/71.

References

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  • Bahat, G., Yilmaz, O., Kilic, C., Oren, M., & Karan, M. (2018). Performance of SARC-F in regard to sarcopenia definitions, muscle mass and functional measures. The journal of Nutrition, Health & Aging, 22, 898-903. https://doi.org/10.1007/s12603-018-1067-8
  • Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015). Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimer's & Dementia, 11(6), 718-726. https://doi.org/10.1016/j.jalz.2015.05.016
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  • Chen, X., Cao, M., Liu, M., Liu, S., Zhao, Z., & Chen, H. (2022). Association between sarcopenia and cognitive impairment in the older people: a meta-analysis. European Geriatric Medicine, 13(4), 771-787. https://doi.org/10.1007/s41999-022-00661-1
  • Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., & Sayer, A. A. (2019). Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing, 48(1), 16-31. https://doi.org/10.1093/ageing/afy169
  • Çebi, M., Babacan, G., Öktem Tanör, Ö., & Gürvit, H. (2020). Discrimination ability of the Short Test of Mental Status (STMS) compared to the Mini Mental State Examination (MMSE) in the spectrum of normal cognition, mild cognitive impairment, and probable Alzheimer’s disease dementia: the Turkish standardization study. Journal of Clinical and Experimental Neuropsychology, 42(5), 450-458. https://doi.org/10.1080/13803395.2020.1758633
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  • Gogtay, N. J., & Thatte, U. M. (2017). Principles of correlation analysis. Journal of the Association of Physicians of India, 65, 78-81.
  • Güngen, C., Ertan, T., Eker, E., Yaşar, R., & Engin, F. (2002). Standardize mini mental test’in Türk toplumunda hafif demans tan› s› nda geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi, 13(4), 273-281.
  • Halil, M., Ulger, Z., Varlı, M., Döventaş, A., Oztürk, G., Kuyumcu, M., Yavuz, B., Yesil, Y., Tufan, F., & Cankurtaran, M. (2014). Sarcopenia assessment project in the nursing homes in Turkey. European Journal of Clinical Nutrition, 68(6), 690-694. https://doi.org/10.1038/ejcn.2014.15
  • Hallgren, M., Herring, M. P., Owen, N., Dunstan, D., Ekblom, Ö., Helgadottir, B., Nakitanda, O. A., & Forsell, Y. (2016). Exercise, physical activity, and sedentary behavior in the treatment of depression: broadening the scientific perspectives and clinical opportunities. Frontiers in Psychiatry, 7, 36. https://doi.org/10.3389/fpsyt.2016.00036
  • Hu, Y., Peng, W., Ren, R., Wang, Y., & Wang, G. (2022). Sarcopenia and mild cognitive impairment among elderly adults: the first longitudinal evidence from CHARLS. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2944-2952. https://doi.org/10.1002/jcsm.13081
  • Huang, C.-Y., Hwang, A.-C., Liu, L.-K., Lee, W.-J., Chen, L.-Y., Peng, L.-N., Lin, M.-H., & Chen, L.-K. (2016). Association of dynapenia, sarcopenia, and cognitive impairment among community-dwelling older Taiwanese. Rejuvenation Research, 19(1), 71-78. https://doi.org/10.1089/rej.2015.1710
  • Jia, X., Wang, Z., Huang, F., Su, C., Du, W., Jiang, H., Wang, H., Wang, J., Wang, F., & Su, W. (2021). A comparison of the Mini-Mental State Examination (MMSE) with the Montreal Cognitive Assessment (MoCA) for mild cognitive impairment screening in Chinese middle-aged and older population: a cross-sectional study. BMC Psychiatry, 21, 1-13. https://doi.org/10.1186/s12888-021-03495-6
  • Kalaria, R. N. (2016). Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease. Acta Neuropathologica, 131(5), 659-685. https://doi.org/10.1007/s00401-016-1571-z
  • Kaplan, H. I., & Sadock, B. J. (1988). Synopsis of psychiatry: Behavioral sciences clinical psychiatry. Williams & Wilkins Co. https://doi.org/10.1097/00004850-198904000-00007
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  • Molino, S., Dossena, M., Buonocore, D., & Verri, M. (2016). Sarcopenic obesity: an appraisal of the current status of knowledge and management in elderly people. The Journal of Nutrition, Health and Aging, 20(7), 780-788. https://doi.org/10.1007/s12603-015-0631-8
  • Morley, J. E., Abbatecola, A. M., Argiles, J. M., Baracos, V., Bauer, J., Bhasin, S., Cederholm, T., Coats, A. J. S., Cummings, S. R., & Evans, W. J. (2011). Sarcopenia with limited mobility: an international consensus. Journal of the American Medical Directors Association, 12(6), 403-409. https://doi.org/10.1016/j.jamda.2011.04.014
  • Ogawa, Y., Kaneko, Y., Sato, T., Shimizu, S., Kanetaka, H., & Hanyu, H. (2018). Sarcopenia and muscle functions at various stages of Alzheimer disease. Frontiers in Neurology, 9, 710. https://doi.org/10.3389/fneur.2018.00710
  • Peng, T.-C., Chen, W.-L., Wu, L.-W., Chang, Y.-W., & Kao, T.-W. (2020). Sarcopenia and cognitive impairment: A systematic review and meta-analysis. Clinical Nutrition, 39(9), 2695-2701. https://doi.org/10.1016/j.clnu.2019.12.014
  • Podsiadlo, D., & Richardson, S. (1991). The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. Journal of the American Geriatrics Society, 39(2), 142-148. https://doi.org/10.1111/j.1532-5415.1991.tb01616.x
  • Rosso, A. L., Studenski, S. A., Chen, W. G., Aizenstein, H. J., Alexander, N. B., Bennett, D. A., Black, S. E., Camicioli, R., Carlson, M. C., & Ferrucci, L. (2013). Aging, the central nervous system, and mobility. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 68(11), 1379-1386. https://doi.org/10.1093/gerona/glt089
  • Sahin, U. K., Tozluoglu, E. Y., Durdu, H., Korkmaz, N., Bahar, N. T., & Yavuz, E. (2022). Screening for frailty and sarcopenia in community-dwelling older adults: a cross-sectional study from the Eastern Black Sea region of Turkey. Aging Clinical and Experimental Research, 34(9), 2047-2056. https://doi.org/10.1007/s40520-022-02164-2
  • Sakuma, N., Ura, C., Miyamae, F., Inagaki, H., Ito, K., Niikawa, H., Ijuin, M., Okamura, T., Sugiyama, M., & Awata, S. (2017). Distribution of Mini‐Mental State Examination scores among urban community‐dwelling older adults in Japan. International Journal of Geriatric Psychiatry, 32(7), 718-725. https://doi.org/10.1002/gps.4513
  • Scisciola, L., Fontanella, R. A., Surina, Cataldo, V., Paolisso, G., & Barbieri, M. (2021). Sarcopenia and cognitive function: role of myokines in muscle brain cross-talk. Life, 11(2), 173. https://doi.org/10.3390/life11020173
  • Singh-Manoux, A., Dugravot, A., Kauffmann, F., Elbaz, A., Ankri, J., Nabi, H., Kivimaki, M., & Sabia, S. (2011). Association of lung function with physical, mental and cognitive function in early old age. Age, 33, 385-392. https://doi.org/10.1007/s11357-010-9189-x
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There are 43 citations in total.

Details

Primary Language English
Subjects Occupational Therapy
Journal Section Research Article
Authors

Onur Altuntaş 0000-0002-2403-2096

Medine Nur Özata Değerli 0000-0003-4776-3892

Submission Date June 4, 2025
Acceptance Date February 16, 2026
Publication Date April 30, 2026
DOI https://doi.org/10.21020/husbfd.1713453
IZ https://izlik.org/JA78TZ42LH
Published in Issue Year 2026 Volume: 13 Issue: 1

Cite

APA Altuntaş, O., & Özata Değerli, M. N. (2026). Relationship Between Sarcopenia and Cognitive Function in Community-Dwelling Older Adults. Hacettepe University Faculty of Health Sciences Journal, 13(1), 185-196. https://doi.org/10.21020/husbfd.1713453