Coenzyme Q10: Biological Activitiy and Current Approach on the Effect on Health

Year 2019, , 95 - 111, 29.08.2019

Kadriye Toprak , Aylin Ayaz

https://doi.org/10.21020/husbfd.450217

Abstract

Coenzyme Q₁₀
is an endogenously synthesized and lipid-soluble benzoquinone compound. To date
the role in mitochondrial energy production and its antioxidant properties are
the well-known activities of coenzyme Q₁₀. In addition, it is stated
that coenzyme Q₁₀ has important roles in cell growth and in the
control of apoptosis in the case of cellular redox, in which it functions in
cell signaling and gene expression. Because of these biological activities, it
is associated with a number of diseases such as high blood pressure, diabetes,
cancer and cardiovascular disease and also it is effective in the treatment of
some neurodegenerative diseases such as alzheimer and parkinson. It has been reported that the
dietary intake of coenzyme Q₁₀, which decreases especially in
tissues with aging, is inadequate. Experimental and observational studies are
needed to understand the role of vitamin in the pathology of diseases and their
prevention. In this review article, it is aimed to evaluate the health effects
of coenzyme Q₁₀ according to current studies.

Keywords

coenzyme Q10, ubiquinon, energy coupling, lipid soluble antioxidants, mitochondrial diseases

Koenzim Q10 : Biyolojik Aktivitesi ve Sağlık Üzerine Etkisine Güncel Bakış

Abstract

Koenzim Q₁₀, endojen olarak sentezlenen ve yağda
çözünen bir benzokinon bileşiğidir. Mitokondrial enerji üretimindeki görevi ve antioksidan özelliği koenzim Q₁₀’nin
bugüne kadar en iyi bilinen fonksiyonlarıdır.
Ayrıca koenzim Q₁₀’nin
hücre sinyalizasyonunda ve gen ekspresyonunda görev aldığı, hücresel redoks
reaksiyonlarında, hücre büyümesi ve
apoptozisin kontrolünde de önemli görevleri olduğu belirtilmiştir.
Bu biyolojik aktiviteleri nedeniyle
kalp sağlığı, yüksek tansiyon,
diyabet ve kanser gibi hastalıkların tedavisinde yardımcı olarak kullanılmakta,
ayrıca alzheimer ve parkinson gibi bazı nörodejeneratif hastalıkların
tedavisinde de etkili olduğu bildirilmiştir. Özellikle yaşlanma ile beraber
dokularda azalan koenzim Q₁₀ miktarının diyetle birlikte alımının
yetersiz olduğu bildirilmiştir. Hastalıkların
patolojisinde vitaminin rolü ve önlenmesine yönelik mekanizmaların anlaşılması
için deneysel ve gözlemsel çalışmalara ihtiyaç duyulmaktadır. Bu derleme yazıda koenzim Q₁₀’nin
sağlık üzerine etkilerinin güncel çalışmalara göre değerlendirilmesi
amaçlanmıştır.  

Keywords

koenzim Q10, ubikinon, enerji üretimi, mitokondrial hastalıklar

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