Effect of Functional Foods on Cholesterol Metabolism

Abstract

Cholesterol is always an issue because blood total cholesterol and low-density lipoprotein correlate strongly with coronary heart disease. Cholesterol homeostasis is maintained by a complex mechanism of sterol absorption, anabolism, catabolism and excretion. In recent years, nutraceuticals and functional foods have attracted much interest as possible alternative therapies for dyslipidemia. Nutraceuticals and functional foods which lower total cholesterol must affect the genes which regulate cholesterol homeostasis. In general, cholesterol-lowering functional foods and nutraceuticals can be classified into seven types namely intestinal Niemann-Pick C1 like 1 (NPC1L1) competitors, intestinal acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors, 3- hydroxy-3-methylglutaryl (HMG-CoA) reductase inhibitors, LDL receptor up-regulators, bile acid reabsorption inhibitors, plasma cholesteryl ester transporting protein (CETP) inhibitors and cholesterol-7a-hydroxylase (CYP7A1) activators. This review examines some important cholesterol lowering nutraceuticals and functional foods and their cholesterol lowering mechanisms.

Keywords

• Functional foods,Nutraceuticals,Cholesterol

Fonksiyonel Besinlerin Kolesterol Metabolizması Üzerinde Etkisi

Abstract

Total kolesterol ve düşük yoğunluklu lipoprotein, koroner kalp hastalığı ile güçlü ilişki gösterdiğinden dolayı, kolestrol her zaman önemli konulardan biridir. Kolesterol homeostazısı, sterol emilim, biyosentez, katabolizma ve atılımının kompleks bir mekanizması ile sağlanır. Son yıllarda, dislipidemi kontrol ve tedavisini iyileştirmek ve optimize etmek için nutrasötikler ve fonksiyonel besinlerin olası kullanımında, artan bir ilgi olmuştur. Total kolesterolü düşüren nutrasötikler ve fonksiyonel besinler, kolesterol homeostazını düzenleyen genleri etkilemesi gerekmektedir. Genel olarak, kolestrol düşürücü fonksiyonel besinler ve nutrasötikler, intestinal Niemann-Pick C1 benzeri 1 (NPC1L1) rakipleri, asil CoA: kolestrol asiltransferaz (ACAT) inhibitörleri, 3- hidroksi-3-metilglutaril (HMG-CoA) redüktaz inhibitörleri, LDL reseptör aktivatörleri, kolesterol-safra asidi emilim inhibitörleri ve plazma kolesteril ester taşıyan protein (CETP) inhibitörleri, kolesterol-7α-hidroksilaz (CYP7A1) aktivatörleri olarak yedi tipte sınıflandırılabilirler. Bu derlemede, bazı önemli kolestrol düşürücü nutrasötikler ve fonksiyonel besinler ve kolesterol düşürüçü mekanizmalarını incelemektedir.

Keywords

• Fonksiyonel besinler,Nutrasötikler,Kolesterol

References

1. Brown, MS, & Goldstein, JL. (1983). Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic. Journal of Clinical Investigation, 72(3), 743.
2. Bursill, Christina A, Abbey, Mavis, & Roach, Paul D. (2007). A green tea extract lowers plasma cholesterol by inhibiting cholesterol synthesis and upregulating the LDL receptor in the cholesterol-fed rabbit. Atherosclerosis, 193(1), 86-93.
3. Cicero, Arrigo FG, & Colletti, Alessandro. (2016). Role of phytochemicals in the management of metabolic syndrome. Phytomedicine, 23(11), 1134-1144.
4. Cicero, Arrigo FG, Fogacci, Federica, & Colletti, Alessandro. (2017). Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review. British journal of pharmacology, 174(11), 1378-1394.
5. Crouse, John R, Morgan, Timothy, Terry, James G, Ellis, Julie, Vitolins, Mara, & Burke, Gregory L. (1999). A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Archives of internal medicine, 159(17), 2070-2076.
6. Crowe, Kristi M., & Francis, Coni. (2013). Position of the Academy of Nutrition and Dietetics: Functional Foods. Journal of the Academy of Nutrition and Dietetics, 113(8), 1096-1103.
7. Anderson, James W, Allgood, Lisa D, Lawrence, Ann, Altringer, Linda A, Jerdack, George R, Hengehold, David A, & Morel, Jorge G. (2000). Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. The American journal of clinical nutrition, 71(2), 472-479.
8. Anderson, James W, Allgood, Lisa D, Lawrence, Ann, Altringer, Linda A, Jerdack, George R, Hengehold, David A, & Morel, Jorge G. (2000). Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. The American journal of clinical nutrition, 71(2), 472-479.

9. Anderson, James W, Gilinsky, Norman H, Deakins, Dee A, Smith, Sharon F, O'Neal, D Spencer, Dillon, Debra W, & Oeltgen, Peter R. (1991). Lipid responses of hypercholesterolemic men to oat-bran and wheat-bran intake. The American journal of clinical nutrition, 54(4), 678-683.
10. Anderson, James W, Gilinsky, Norman H, Deakins, Dee A, Smith, Sharon F, O'Neal, D Spencer, Dillon, Debra W, & Oeltgen, Peter R. (1991). Lipid responses of hypercholesterolemic men to oat-bran and wheat-bran intake. The American journal of clinical nutrition, 54(4), 678-683.
11. Anderson, James W, Johnstone, Bryan M, & Cook-Newell, Margaret E. (1995). Meta-analysis of the effects of soy protein intake on serum lipids. New England Journal of Medicine, 333(5), 276-282.
12. Anderson, James W, Johnstone, Bryan M, & Cook-Newell, Margaret E. (1995). Meta-analysis of the effects of soy protein intake on serum lipids. New England Journal of Medicine, 333(5), 276-282.
13. Atzel, Amy, & Wetterau, John R. (1993). Mechanism of microsomal triglyceride transfer protein catalyzed lipid transport. Biochemistry, 32(39), 10444-10450.
14. Atzel, Amy, & Wetterau, John R. (1993). Mechanism of microsomal triglyceride transfer protein catalyzed lipid transport. Biochemistry, 32(39), 10444-10450.
15. Berge, Knut E, Tian, Hui, Graf, Gregory A, Yu, Liqing, Grishin, Nick V, Schultz, Joshua, . . . Hobbs, Helen H. (2000). Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science, 290(5497), 1771-1775.
16. Berge, Knut E, Tian, Hui, Graf, Gregory A, Yu, Liqing, Grishin, Nick V, Schultz, Joshua, . . . Hobbs, Helen H. (2000). Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science, 290(5497), 1771-1775.
17. Bisht, Savita, & Maitra, Anirban. (2009). Systemic delivery of curcumin: 21st century solutions for an ancient conundrum. Current drug discovery technologies, 6(3), 192-199.
18. Bisht, Savita, & Maitra, Anirban. (2009). Systemic delivery of curcumin: 21st century solutions for an ancient conundrum. Current drug discovery technologies, 6(3), 192-199.
19. Borradaile, Nica M, WILCOX, Lisa J, EDWARDS, Jane Y, & Murray, W HUFF. (2002). Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms. Biochemical Journal, 366(2), 531-539.
20. Borradaile, Nica M, WILCOX, Lisa J, EDWARDS, Jane Y, & Murray, W HUFF. (2002). Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms. Biochemical Journal, 366(2), 531-539.
21. Brouns, F., Theuwissen, E., Adam, A., Bell, M., Berger, A., & Mensink, R. P. (2011). Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. European Journal of Clinical Nutrition, 66(5), 591-599.
22. Brouns, F., Theuwissen, E., Adam, A., Bell, M., Berger, A., & Mensink, R. P. (2011). Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. European Journal of Clinical Nutrition, 66(5), 591-599.
23. Brown, Lisa, Rosner, Bernard, Willett, Walter W, & Sacks, Frank M. (1999). Cholesterol-lowering effects of dietary fiber: a meta-analysis. The American journal of clinical nutrition, 69(1), 30-42.
24. Brown, Lisa, Rosner, Bernard, Willett, Walter W, & Sacks, Frank M. (1999). Cholesterol-lowering effects of dietary fiber: a meta-analysis. The American journal of clinical nutrition, 69(1), 30-42.
25. Brown, MS, & Goldstein, JL. (1983). Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic. Journal of Clinical Investigation, 72(3), 743.Bursill, Christina A, Abbey, Mavis, & Roach, Paul D. (2007). A green tea extract lowers plasma cholesterol by inhibiting cholesterol synthesis and upregulating the LDL receptor in the cholesterol-fed rabbit. Atherosclerosis, 193(1), 86-93.
26. Caruso, Maria Gabriella, Messa, Caterina, Orlando, Antonella, D'Attoma, Benedetta, & Notarnicola, Maria. (2008). Early induction of LDL receptor gene expression by genistein in DLD-1 colon cancer cell line. Fitoterapia, 79(7), 524-528.
27. Caruso, Maria Gabriella, Messa, Caterina, Orlando, Antonella, D'Attoma, Benedetta, & Notarnicola, Maria. (2008). Early induction of LDL receptor gene expression by genistein in DLD-1 colon cancer cell line. Fitoterapia, 79(7), 524-528.
28. Chen, Zhen-Yu, Jiao, Rui, & Ma, Ka Ying. (2008). Cholesterol-lowering nutraceuticals and functional foods. Journal of Agricultural and Food Chemistry, 56(19), 8761-8773.
29. Chen, Zhen-Yu, Jiao, Rui, & Ma, Ka Ying. (2008). Cholesterol-lowering nutraceuticals and functional foods. Journal of Agricultural and Food Chemistry, 56(19), 8761-8773.
30. Chen, Zhen-Yu, Ma, Ka Ying, Liang, Yintong, Peng, Cheng, & Zuo, Yuanyuan. (2011). Role and classification of cholesterol-lowering functional foods. Journal of Functional Foods, 3(2), 61-69.
31. Chen, Zhen-Yu, Ma, Ka Ying, Liang, Yintong, Peng, Cheng, & Zuo, Yuanyuan. (2011). Role and classification of cholesterol-lowering functional foods. Journal of Functional Foods, 3(2), 61-69.
32. Cheng, Ann-Lii, Hsu, CHIH-HUNG, Lin, Jen-Kun, Hsu, Mow-Ming, Ho, Yunn-Fang, Shen, Tzung-Shiahn, . . . Ming-Shiang, W. (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res, 21(4B), 2895-2900.
33. Cheng, Ann-Lii, Hsu, CHIH-HUNG, Lin, Jen-Kun, Hsu, Mow-Ming, Ho, Yunn-Fang, Shen, Tzung-Shiahn, . . . Ming-Shiang, W. (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res, 21(4B), 2895-2900.
34. Cho, Il Jin, Ahn, Ji Yun, Kim, Suna, Choi, Myung Sook, & Ha, Tae Youl. (2008). Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters. Biochemical and biophysical research communications, 367(1), 190-194.
35. Cho, Il Jin, Ahn, Ji Yun, Kim, Suna, Choi, Myung Sook, & Ha, Tae Youl. (2008). Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters. Biochemical and biophysical research communications, 367(1), 190-194.
36. Cho, Seong-Jun, Juillerat, Marcel A, & Lee, Cherl-Ho. (2007). Cholesterol lowering mechanism of soybean protein hydrolysate. Journal of Agricultural and Food Chemistry, 55(26), 10599-10604.
37. Cho, Seong-Jun, Juillerat, Marcel A, & Lee, Cherl-Ho. (2007). Cholesterol lowering mechanism of soybean protein hydrolysate. Journal of Agricultural and Food Chemistry, 55(26), 10599-10604.
38. Cicero, Arrigo FG, & Colletti, Alessandro. (2016). Role of phytochemicals in the management of metabolic syndrome. Phytomedicine, 23(11), 1134-1144.Cicero, Arrigo FG, Fogacci, Federica, & Colletti, Alessandro. (2017). Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review. British journal of pharmacology, 174(11), 1378-1394.
39. Crouse, John R, Morgan, Timothy, Terry, James G, Ellis, Julie, Vitolins, Mara, & Burke, Gregory L. (1999). A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Archives of internal medicine, 159(17), 2070-2076.Crowe, Kristi M., & Francis, Coni. (2013). Position of the Academy of Nutrition and Dietetics: Functional Foods. Journal of the Academy of Nutrition and Dietetics, 113(8), 1096-1103.
40. Davidson, Michael H, Dugan, Lynn D, Burns, Julie H, Bova, Judith, Story, Kenneth, & Drennan, Kathleen B. (1991). The hypocholesterolemic effects of β-glucan in oatmeal and oat bran: a dose-controlled study. Jama, 265(14), 1833-1839.
41. Davidson, Michael H, Dugan, Lynn D, Burns, Julie H, Bova, Judith, Story, Kenneth, & Drennan, Kathleen B. (1991). The hypocholesterolemic effects of β-glucan in oatmeal and oat bran: a dose-controlled study. Jama, 265(14), 1833-1839.
42. Davis, Harry R, Zhu, Li-ji, Hoos, Lizbeth M, Tetzloff, Glen, Maguire, Maureen, Liu, Jianjun, . . . Lund, Erik G. (2004). Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. Journal of Biological Chemistry, 279(32), 33586-33592.
43. Davis, Harry R, Zhu, Li-ji, Hoos, Lizbeth M, Tetzloff, Glen, Maguire, Maureen, Liu, Jianjun, . . . Lund, Erik G. (2004). Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. Journal of Biological Chemistry, 279(32), 33586-33592.
44. Dhan Prakash, Charu Gupta. (2014). Phytochemicals of nutraceutical importance, In Role of antioxidant polyphenols in nutraceuticals and human health. Wallingford, UK: CABI International Publishers. p.208.
45. Dhan Prakash, Charu Gupta. (2014). Phytochemicals of nutraceutical importance, In Role of antioxidant polyphenols in nutraceuticals and human health. Wallingford, UK: CABI International Publishers. p.208.
46. Drevon, Christian A, Engelhorn, Sheldon C, & Steinberg, Daniel. (1980). Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification. Journal of lipid research, 21(8), 1065-1071.
47. Drevon, Christian A, Engelhorn, Sheldon C, & Steinberg, Daniel. (1980). Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification. Journal of lipid research, 21(8), 1065-1071.
48. Eberlé, Delphine, Hegarty, Bronwyn, Bossard, Pascale, Ferré, Pascal, & Foufelle, Fabienne. (2004). SREBP transcription factors: master regulators of lipid homeostasis. Biochimie, 86(11), 839-848.
49. Eberlé, Delphine, Hegarty, Bronwyn, Bossard, Pascale, Ferré, Pascal, & Foufelle, Fabienne. (2004). SREBP transcription factors: master regulators of lipid homeostasis. Biochimie, 86(11), 839-848.
50. Efsa Panel on Dietetic Products, Nutrition, & Allergies. (2010a). Scientific Opinion on the substantiation of a health claim related to oat beta glucan and lowering blood cholesterol and reduced risk of (coronary) heart disease pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal, 8(12), 1885-n/a.
51. Efsa Panel on Dietetic Products, Nutrition, & Allergies. (2010a). Scientific Opinion on the substantiation of a health claim related to oat beta glucan and lowering blood cholesterol and reduced risk of (coronary) heart disease pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal, 8(12), 1885-n/a.
52. Efsa Panel on Dietetic Products, Nutrition, & Allergies. (2010b). Scientific Opinion on the substantiation of health claims related to pectins and reduction of post-prandial glycaemic responses (ID 786), maintenance of normal blood cholesterol concentrations (ID 818) and increase in satiety leading to a reduction in energy intake (ID 4692) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 8(10), 1747-n/a.
53. Efsa Panel on Dietetic Products, Nutrition, & Allergies. (2010b). Scientific Opinion on the substantiation of health claims related to pectins and reduction of post-prandial glycaemic responses (ID 786), maintenance of normal blood cholesterol concentrations (ID 818) and increase in satiety leading to a reduction in energy intake (ID 4692) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 8(10), 1747-n/a.
54. Erkkilä, Arja T, & Lichtenstein, Alice H. (2006). Fiber and cardiovascular disease risk: how strong is the evidence? Journal of Cardiovascular Nursing, 21(1), 3-8.Expert Panel on, Detection, Evaluation, & and Treatment of High Blood Cholesterol in, Adults. (2001). Executive summary of the third report of the national cholesterol education program (ncep) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel iii). Jama, 285(19), 2486-2497.
55. Erkkilä, Arja T, & Lichtenstein, Alice H. (2006). Fiber and cardiovascular disease risk: how strong is the evidence? Journal of Cardiovascular Nursing, 21(1), 3-8.Expert Panel on, Detection, Evaluation, & and Treatment of High Blood Cholesterol in, Adults. (2001). Executive summary of the third report of the national cholesterol education program (ncep) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel iii). Jama, 285(19), 2486-2497.
56. Ferguson, Jessica JA, Stojanovski, Elizabeth, MacDonald-Wicks, Lesley, & Garg, Manohar L. (2016). Fat type in phytosterol products influence their cholesterol-lowering potential: A systematic review and meta-analysis of RCTs. Progress in lipid research, 64, 16-29.
57. Ferguson, Jessica JA, Stojanovski, Elizabeth, MacDonald-Wicks, Lesley, & Garg, Manohar L. (2016). Fat type in phytosterol products influence their cholesterol-lowering potential: A systematic review and meta-analysis of RCTs. Progress in lipid research, 64, 16-29.
58. Fransen, Heidi P, de Jong, Nynke, Wolfs, Marion, Verhagen, Hans, Verschuren, WM Monique, Lütjohann, Dieter, . . . Mensink, Ronald P. (2007). Customary use of plant sterol and plant stanol enriched margarine is associated with changes in serum plant sterol and stanol concentrations in humans. The Journal of nutrition, 137(5), 1301-1306.
59. Fransen, Heidi P, de Jong, Nynke, Wolfs, Marion, Verhagen, Hans, Verschuren, WM Monique, Lütjohann, Dieter, . . . Mensink, Ronald P. (2007). Customary use of plant sterol and plant stanol enriched margarine is associated with changes in serum plant sterol and stanol concentrations in humans. The Journal of nutrition, 137(5), 1301-1306.
60. Gardner, Christopher D, Newell, Kathryn A, Cherin, Rise, & Haskell, William L. (2001). The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. The American journal of clinical nutrition, 73(4), 728-735.
61. Gardner, Christopher D, Newell, Kathryn A, Cherin, Rise, & Haskell, William L. (2001). The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. The American journal of clinical nutrition, 73(4), 728-735.
62. Gebhardt, Rolf, Beck, Halgund, & Wagner, Karl G. (1994). Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism, 1213(1), 57-62.
63. Gebhardt, Rolf, Beck, Halgund, & Wagner, Karl G. (1994). Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism, 1213(1), 57-62.
64. Gerhardt, Ann L, & Gallo, Noreen B. (1998). Full-fat rice bran and oat bran similarly reduce hypercholesterolemia in humans. The Journal of nutrition, 128(5), 865-869.Glore, Stephen R, Van Treeck, Dianne, Knehans, Allen W, & Guild, Marinell. (1994). Soluble fiber and serum lipids: a literature review. Journal of the American Dietetic Association, 94(4), 425-436.
65. Goodwin, Bryan, Watson, Michael A, Kim, Hwajin, Miao, Ji, Kemper, Jongsook Kim, & Kliewer, Steven A. (2003). Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-α. Molecular endocrinology, 17(3), 386-394.
66. Grieco, Antonio, Miele, Luca, Pompili, Maurizio, Biolato, Marco, Vecchio, Fabio M, Grattagliano, Ignazio, & Gasbarrini, Giovanni. (2009). Acute hepatitis caused by a natural lipid-lowering product: when “alternative” medicine is no “alternative” at all. Journal of hepatology, 50(6), 1273-1277.
67. Grundy, Scott M. (1983). Absorption and metabolism of dietary cholesterol. Annual review of nutrition, 3(1), 71-96.
68. Grundy, Scott M, & Metzger, Allan L. (1972). A physiological method for estimation of hepatic secretion of biliary lipids in man. Gastroenterology, 62(6), 1200-1217.
69. Guan, Lei, Yeung, Sai Ying Venus, Huang, Yu, & Chen, Zhen-Yu. (2006). Both soybean and kudzu phytoestrogens modify favorably the blood lipoprotein profile in ovariectomized and castrated hamsters. Journal of agricultural and food chemistry, 54(13), 4907-4912.
70. Gylling, Helena, Plat, Jogchum, Turley, Stephen, Ginsberg, Henry N, Ellegård, Lars, Jessup, Wendy, . . . Masana, Luis. (2014). Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease. Atherosclerosis, 232(2), 346-360.
71. Han, Kyu-Ho, Iijuka, Miharu, Shimada, Ken-ichiro, Sekikawa, Mitsuo, Kuramochi, Katsuhisa, Ohba, Kiyoshi, . . . Fukushima, Michihiro. (2005). Adzuki resistant starch lowered serum cholesterol and hepatic 3-hydroxy-3-methylglutaryl-CoA mRNA levels and increased hepatic LDL-receptor and cholesterol 7α-hydroxylase mRNA levels in rats fed a cholesterol diet. British Journal of Nutrition, 94(6), 902-908.
72. Harland, Janice I, & Haffner, Tanya A. (2008). Systematic review, meta-analysis and regression of randomised controlled trials reporting an association between an intake of circa 25g soya protein per day and blood cholesterol. Atherosclerosis, 200(1), 13-27.
73. Hasan, ST, Zingg, J-M, Kwan, Paul, Noble, Timothy, Smith, Donald, & Meydani, Mohsen. (2014). Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice. Atherosclerosis, 232(1), 40-51.
74. Jäger, Ralf, Lowery, Ryan P, Calvanese, Allison V, Joy, Jordan M, Purpura, Martin, & Wilson, Jacob M. (2014). Comparative absorption of curcumin formulations. Nutrition journal, 13(1), 11.
75. Jenkins, David JA, Kendall, Cyril WC, Jackson, Chung-Ja C, Connelly, Philip W, Parker, Tina, Faulkner, Dorothea, . . . Josse, Robert G. (2002). Effects of high-and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. The American journal of clinical nutrition, 76(2), 365-372.
76. Jiao, Rui, Zhang, Zesheng, Yu, Hongjian, Huang, Yu, & Chen, Zhen-Yu. (2010). Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by enhancement of bile acid excretion and up-regulation of CYP7A1. The Journal of nutritional biochemistry, 21(11), 1134-1139.
77. Kapoor, Gurpreet S, Atkins, Brett A, & Mehta, Kamal D. (2002). Activation of Raf-1/MEK-1/2/p42/44 MAPK cascade alone is sufficient to uncouple LDL receptor expression from cell growth. Molecular and cellular biochemistry, 236(1), 13-22.
78. Kastelein, John JP. (2007). Refocusing on use of cholesteryl ester transfer protein inhibitors. The American journal of cardiology, 100(11), S47-S52.
79. Katan, Martijn B., Grundy, Scott M., Jones, Peter, Law, Malcolm, Miettinen, Tatu, & Paoletti, Rodolfo. (2003). Efficacy and Safety of Plant Stanols and Sterols in the Management of Blood Cholesterol Levels. Mayo Clinic Proceedings, 78(8), 965-978.
80. Keenan, Joseph M, Goulson, Melanie, Shamliyan, Tatyana, Knutson, Nathan, Kolberg, Lore, & Curry, Leslie. (2007). The effects of concentrated barley β-glucan on blood lipids in a population of hypercholesterolaemic men and women. British Journal of Nutrition, 97(6), 1162-1168.
81. Kerckhoffs, Daniëlle AJM, Brouns, Fred, Hornstra, Gerard, & Mensink, Ronald P. (2002). Effects on the human serum lipoprotein profile of β-glucan, soy protein and isoflavones, plant sterols and stanols, garlic and tocotrienols. The Journal of nutrition, 132(9), 2494-2505.
82. Kim, Hyun Jung, & White, Pamela J. (2009). In vitro bile-acid binding and fermentation of high, medium, and low molecular weight β-glucan. Journal of Agricultural and Food Chemistry, 58(1), 628-634.
83. Kim, Minji, & Kim, Yangha. (2010). Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutrition Research and Practice, 4(3), 191-195.
84. Kirk, Elizabeth A, Sutherland, Phuong, Wang, Shari A, Chait, Alan, & LeBoeuf, Renee C. (1998). Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor–deficient mice. The Journal of nutrition, 128(6), 954-959.
85. Kris-Etherton, PM, Krummel, Debra, Russell, ME, Dreon, D, Mackey, S, Borchers, J, & Wood, PD. (1988). The effect of diet on plasma lipids, lipoproteins, and coronary heart disease. Journal of the American Dietetic Association, 88(11), 1373-1400.
86. Kumar, Pradeep, Malhotra, Pooja, Ma, Ke, Singla, Amika, Hedroug, Omar, Saksena, Seema, . . . Alrefai, Waddah A. (2011). SREBP2 mediates the modulation of intestinal NPC1L1 expression by curcumin. American Journal of Physiology-Gastrointestinal and Liver Physiology, 301(1), G148-G155.
87. KuwABARA, Tomoko, Han, Kyu-Ho, Hashimoto, Naoto, Yamauchi, Hiroaki, Shimada, Ken-Ichiro, Sekikawa, Mitsuo, & Fukushima, Michihiro. (2007). Tartary buckwheat sprout powder lowers plasma cholesterol level in rats. Journal of nutritional science and vitaminology, 53(6), 501-507.
88. Kwon, Myung-Ja, Song, Young-Sun, Choi, Myung-Sook, Park, Sang-Joon, Jeong, Kyu-Shik, & Song, Yeong-Ok. (2003). Cholesteryl ester transfer protein activity and atherogenic parameters in rabbits supplemented with cholesterol and garlic powder. Life sciences, 72(26), 2953-2964.
89. Lam, Cheuk Kai, Chen, Jingnan, Cao, Ying, Yang, Lin, Wong, Yin Mei, Yeung, Sai Ying Venus, . . . Chen, Zhen-Yu. (2008). Conjugated and non-conjugated octadecaenoic acids affect differently intestinal acyl coenzyme A: Cholesterol acyltransferase activity. Atherosclerosis, 198(1), 85-93.
90. Lammi, Carmen, Zanoni, Chiara, Scigliuolo, Graziana M, D’Amato, Alfonsina, & Arnoldi, Anna. (2014). Lupin peptides lower low-density lipoprotein (LDL) cholesterol through an up-regulation of the LDL receptor/sterol regulatory element binding protein 2 (SREBP2) pathway at HepG2 cell line. Journal of Agricultural and Food Chemistry, 62(29), 7151-7159.
91. Largis, EE, Wang, CH, DeVries, VG, & Schaffer, SA. (1989). CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. Journal of lipid research, 30(5), 681-690.
92. Law, Malcolm. (2000). Plant sterol and stanol margarines and health. BMJ: British Medical Journal, 320(7238), 861.
93. Lee, J. Y.; Mitmesser, S. H.; Carr, T. P. . (2004). Regulation of cellular cholesterol. In Molecular Nutrition. CABI Publishing: Wallingford, Oxon, U.K.Lee, Mi-Hye, Lu, Kangmo, Hazard, Star, Yu, Hongwei, Shulenin, Sergey, Hidaka, Hideki, . . . Pegoraro, Rosemary. (2001). Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nature genetics, 27(1), 79.
94. Lee, Sun-Ok, Renouf, Mathieu, Ye, Zhong, Murphy, Patricia A, & Hendrich, Suzanne. (2007). Isoflavone glycitein diminished plasma cholesterol in female golden Syrian hamsters. Journal of agricultural and food chemistry, 55(26), 11063-11067.
95. Letexier, Dominique, Diraison, Frédérique, & Beylot, Michel. (2003). Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans. The American journal of clinical nutrition, 77(3), 559-564.
96. Lichtenstein, Alice H, Jalbert, Susan M, Adlercreutz, Herman, Goldin, Barry R, Rasmussen, Helen, Schaefer, Ernst J, & Ausman, Lynne M. (2002). Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arteriosclerosis, thrombosis, and vascular biology, 22(11), 1852-1858.
97. Lin, Xiao-long, Liu, Mi-Hua, Hu, Hui-Jun, Feng, Hong-ru, Fan, Xiao-Juan, Zou, Wei-wen, . . . Wang, Zuo. (2015). Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRα signaling in THP-1 macrophage-derived foam cells. DNA and cell biology, 34(9), 561-572.Lin, Yuguang, Vermeer, Mario A, & Trautwein, Elke A. (2011). Triterpenic acids present in hawthorn lower plasma cholesterol by inhibiting intestinal ACAT activity in hamsters. Evidence-Based Complementary and Alternative Medicine, 2011.
98. Mann, J. (2007). Dietary carbohydrate: relationship to cardiovascular disease and disorders of carbohydrate metabolism. European Journal of Clinical Nutrition, 61, S100-S111.
99. Mannarino, Massimo R., Ministrini, Stefano, & Pirro, Matteo. (2014). Nutraceuticals for the treatment of hypercholesterolemia. European Journal of Internal Medicine, 25(7), 592-599.
100. Merz-Demlow, Barbara E, Duncan, Alison M, Wangen, Kerry E, Xu, Xia, Carr, Timothy P, Phipps, William R, & Kurzer, Mindy S. (2000). Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. The American journal of clinical nutrition, 71(6), 1462-1469.
101. Mohammadi, Akram, Sahebkar, Amirhossein, Iranshahi, Mehrdad, Amini, Maral, Khojasteh, Roshanak, Ghayour‐Mobarhan, Majid, & Ferns, Gordon A. (2013). Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytotherapy research, 27(3), 374-379.
102. Momtazi, Amir Abbas, Derosa, Giuseppe, Maffioli, Pamela, Banach, Maciej, & Sahebkar, Amirhossein. (2016). Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases. Molecular diagnosis & therapy, 20(4), 335-345.
103. Mullen, Eimear, Brown, Rachel M, Osborne, Timothy F, & Shay, Neil F. (2004). Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells. The Journal of nutrition, 134(11), 2942-2947.
104. Musa-Veloso, Kathy, Poon, Theresa H., Elliot, Julie Ann, & Chung, Catherine. (2011). A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: Results of a meta-analysis of randomized, placebo-controlled trials. Prostaglandins, Leukotrienes and Essential Fatty Acids, 85(1), 9-28.
105. Nijjar, Prabhjot S., Burke, Frances M., Bloesch, Annette, & Rader, Daniel J. (2010). Role of dietary supplements in lowering low-density lipoprotein cholesterol: A review. Journal of Clinical Lipidology, 4(4), 248-258.
106. Owen, Alice J, Roach, Paul D, & Abbey, Mavis. (2004). Regulation of low-density lipoprotein receptor activity by estrogens and phytoestrogens in a HepG2 cell model. Annals of nutrition and metabolism, 48(4), 269-275.
107. Pal, Sebely, Ho, Nerissa, Santos, Carlos, Dubois, Paul, Mamo, John, Croft, Kevin, & Allister, Emma. (2003). Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells. The Journal of nutrition, 133(3), 700-706.
108. Panahi, Yunes, Khalili, Nahid, Hosseini, Mahboobeh Sadat, Abbasinazari, Mohammad, & Sahebkar, Amirhossein. (2014). Lipid-modifying effects of adjunctive therapy with curcuminoids–piperine combination in patients with metabolic syndrome: results of a randomized controlled trial. Complementary therapies in medicine, 22(5), 851-857.
109. Peschel, Dieter, Koerting, Ramona, & Nass, Norbert. (2007). Curcumin induces changes in expression of genes involved in cholesterol homeostasis. The Journal of nutritional biochemistry, 18(2), 113-119.
110. Plat, Jogchum, & Mensink, Ronald P. (2005). Plant stanol and sterol esters in the control of blood cholesterol levels: mechanism and safety aspects. The American journal of cardiology, 96(1), 15-22.
111. Potter, Susan M. (1995). Overview of proposed mechanisms for the hypocholesterolemic. The Journal of nutrition, 125(3), 606S.
112. Pulido-Moran, Mario, Moreno-Fernandez, Jorge, Ramirez-Tortosa, Cesar, & Ramirez-Tortosa, MCarmen. (2016). Curcumin and Health. Molecules, 21(3), 264. Retrieved from http://www.mdpi.com/1420-3049/21/3/264
113. Qin, Yu, Xia, Min, Ma, Jing, Hao, YuanTao, Liu, Jing, Mou, HaiYing, . . . Ling, WenHua. (2009). Anthocyanin supplementation improves serum LDL-and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. The American journal of clinical nutrition, 90(3), 485-492.
114. Ras, Rouyanne T, Geleijnse, Johanna M, & Trautwein, Elke A. (2014). LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies. British Journal of Nutrition, 112(2), 214-219.
115. Ras, Rouyanne T, Hiemstra, Harry, Lin, Yuguang, Vermeer, Mario A, Duchateau, Guus SMJE, & Trautwein, Elke A. (2013). Consumption of plant sterol-enriched foods and effects on plasma plant sterol concentrations–a meta-analysis of randomized controlled studies. Atherosclerosis, 230(2), 336-346.
116. Reiner, Željko, Catapano, Alberico L., De Backer, Guy, Graham, Ian, Taskinen, Marja-Riitta, Wiklund, Olov, . . . Zamorano, Jose Luis. (2011). ESC/EAS Guidelines for the management of dyslipidaemiasThe Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). European Heart Journal, 32(14), 1769-1818.
117. Ripsin, Cynthia M, Keenan, Joseph M, Jacobs, David R, Elmer, Patricia J, Welch, Robert R, Van Horn, Linda, . . . Kestin, Mark. (1992). Oat products and lipid lowering: a meta-analysis. Jama, 267(24), 3317-3325.
118. Roberfroid, Marcel B. (2007). Inulin-type fructans: functional food ingredients. The Journal of nutrition, 137(11), 2493S-2502S.
119. Sahebkar, Amirhossein. (2013). Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome? Biofactors, 39(2), 197-208.
120. Sahebkar, Amirhossein. (2014). A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels. Clinical nutrition, 33(3), 406-414.
121. Sahebkar, Amirhossein, Cicero, Arrigo FG, Simental-Mendía, Luis E, Aggarwal, Bharat B, & Gupta, Subash C. (2016). Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials. Pharmacological research, 107, 234-242.
122. Shaghaghi, Mandana Amir, Abumweis, Suhad S, & Jones, Peter JH. (2013). Cholesterol-lowering efficacy of plant sterols/stanols provided in capsule and tablet formats: results of a systematic review and meta-analysis. Journal of the Academy of Nutrition and Dietetics, 113(11), 1494-1503.
123. Shin, Su‐Kyung, Ha, Tae‐Youl, McGregor, Robin A, & Choi, Myung‐Sook. (2011). Long‐term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism. Molecular nutrition & food research, 55(12), 1829-1840.
124. Sikorski, James A. (2006). Oral cholesteryl ester transfer protein (CETP) inhibitors: a potential new approach for treating coronary artery disease. Journal of medicinal chemistry, 49(1), 1-22.
125. Sirtori, Cesare R., Galli, Claudio, Anderson, James W., Sirtori, Elena, & Arnoldi, Anna. (2009). Functional foods for dyslipidaemia and cardiovascular risk prevention. Nutrition Research Reviews, 22(02), 244.
126. Stark, Aliza H, & Madar, Zecharia. (1993). In vitro production of short-chain fatty acids by bacterial fermentation of dietary fiber compared with effects of those fibers on hepatic sterol synthesis in rats. Journal of Nutrition, 123(12), 2166-2173.
127. Steinberg, Francene M, Guthrie, Nicole L, Villablanca, Amparo C, Kumar, Kavita, & Murray, Michael J. (2003). Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. The American journal of clinical nutrition, 78(1), 123-130.
128. Sung, Jang Hoon, Choi, Seung Jun, Lee, Soon Won, Park, Kwan Hwa, & Moon, Tae Wha. (2004). Isoflavones found in Korean soybean paste as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Bioscience, biotechnology, and biochemistry, 68(5), 1051-1058.
129. Tai, Mi‐Hsueh, Chen, Po‐Kong, Chen, Pei‐Yi, Wu, Ming‐Jiuan, Ho, Chi‐Tang, & Yen, Jui‐Hung. (2014). Curcumin enhances cell‐surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells. Molecular nutrition & food research, 58(11), 2133-2145.
130. Talati, Ripple, Sobieraj, Diana M, Makanji, Sagar S, Phung, Olivia J, & Coleman, Craig I. (2010). The comparative efficacy of plant sterols and stanols on serum lipids: a systematic review and meta-analysis. Journal of the American Dietetic Association, 110(5), 719-726.
131. Tokede, Oluwabunmi A, Onabanjo, Temilola A, Yansane, Alfa, Gaziano, J Michael, & Djoussé, Luc. (2015). Soya products and serum lipids: a meta-analysis of randomised controlled trials. British Journal of Nutrition, 114(6), 831-843.
132. Um, Min Young, Hwang, Kwang Hyun, Ahn, Jiyun, & Ha, Tae Youl. (2013). Curcumin Attenuates Diet‐Induced Hepatic Steatosis by Activating AMP‐Activated Protein Kinase. Basic & clinical pharmacology & toxicology, 113(3), 152-157.
133. Walker, R. . (1994). Hyperlipidaemia. In In R. Walter & C. Edwards (Eds.), Clinical pharmacy and therapeutics . Churchill Livingstone:New York.
134. Wangen, Kerry E, Duncan, Alison M, Xu, Xia, & Kurzer, Mindy S. (2001). Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. The American journal of clinical nutrition, 73(2), 225-231.
135. Weggemans, RM, & Trautwein, EA. (2003). Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis. European Journal of Clinical Nutrition, 57(8), 940-946.
136. Wei, ZH, Wang, H, Chen, XY, Wang, BS, Rong, ZX, Su, BH, & Chen, HZ. (2009). Time-and dose-dependent effect of psyllium on serum lipids in mild-to-moderate hypercholesterolemia: a meta-analysis of controlled clinical trials. European Journal of Clinical Nutrition, 63(7), 821-827.
137. Wong, Julia MW, De Souza, Russell, Kendall, Cyril WC, Emam, Azadeh, & Jenkins, David JA. (2006). Colonic health: fermentation and short chain fatty acids. Journal of clinical gastroenterology, 40(3), 235-243.
138. Yang, Yi‐Sun, Su, Ying‐Fang, Yang, Hui‐Wen, Lee, Yu‐Hsien, Chou, Janet I, & Ueng, Kwo‐Chang. (2014). Lipid‐Lowering Effects of Curcumin in Patients with Metabolic Syndrome: A Randomized, Double‐Blind, Placebo‐Controlled Trial. Phytotherapy research, 28(12), 1770-1777.
139. Zannis, Vassilis I, Chroni, Angeliki, & Krieger, Monty. (2006). Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL. Journal of molecular medicine, 84(4), 276-294.
140. Zhan, Siyan, & Ho, Suzanne C. (2005). Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. The American journal of clinical nutrition, 81(2), 397-408.
141. Zhang, W, Liu, D, Wo, X, Zhang, Y, Jin, M, & Ding, Z. (1999). Effects of Curcuma Longa on proliferation of cultured bovine smooth muscle cells and on expression of low density lipoprotein receptor in cells. Chinese medical journal, 112(4), 308-311.
142. Zhu, Xiulong, Sun, Xiwen, Wang, Maosheng, Zhang, Can, Cao, Yong, Mo, Guanhai, . . . Zhu, Shiming. (2015). Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects. Nutrition, Metabolism and Cardiovascular Diseases, 25(8), 714-723.
143. Zhuo, Xing-Gang, Melby, Melissa K, & Watanabe, Shaw. (2004). Soy isoflavone intake lowers serum LDL cholesterol: a meta-analysis of 8 randomized controlled trials in humans. The Journal of nutrition, 134(9), 2395-2400.
144. Zingg, Jean‐Marc, Hasan, Syeda T, & Meydani, Mohsen. (2013). Molecular mechanisms of hypolipidemic effects of curcumin. Biofactors, 39(1), 101-121.