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İrritabl Bağırsak Sendromu ve Fonksiyonel Dispepsi Tedavisinde Probiyotikler ve Prebiyotikler

Year 2019, Volume: 6 Issue: 2, 178 - 191, 29.08.2019
https://doi.org/10.21020/husbfd.437227

Abstract

Bağırsak florasında yaklaşık 500 mikroorganizma türü olduğu bilinmektedir ve bunların %98’inin yararlı olduğu tespit edilmiştir fakat her bireyin bağırsak florasında farklı mikroorganizmalar bulunabilmektedir. Probiyotiklerin ve prebiyotiklerin bireylerdeki etkilerine bakıldığında bağışıklığı arttırdıkları, inflamasyonu engelleyen sitokinleri uyararak inflamasyonu önledikleri, patojenlerin üremesini ve virüslerin tutulumunu engelledikleri bilinmektedir. İrritabl Bağırsak Sendromu (IBS) ve Fonksiyonel Dispepsi (FD) karın ağrısı, diyare ve/veya konstipasyon, şişkinlik, erken doygunluk, mide bulantısı gibi semptomlara ek olarak üst gastrointestinal sistem semptomlarının eşlik ettiği hastalıklardır. İBS ve FD hastalarında karın ağrıları, karındaki gaz ve gurultu şikayetleri, mide bulantıları ve şişkinlik semptomları tedavisi zor semptomlar olmakla birlikte bireyin sosyal hayatını ve yaşam kalitesini oldukça etkilemektedir. Probiyotiklerin ve prebiyotiklerin bireylerin sağlığına olan olumlu etkileri ile bu semptomlarda etkili olabileceği düşünülmektedir. Bu derlemede İBS ve FD hastalarında probiyotiklerin ve prebiyotiklerin tedavi amaçlı kullanılabilirliğini ve semptomları azaltmadaki etkilerini araştıran yayınlar değerlendirilerek özetlenmiştir.

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Probiotics and Prebiotics in the Treatment of Irrıtable Bowel Syndrome and Functional Dyspepsia

Year 2019, Volume: 6 Issue: 2, 178 - 191, 29.08.2019
https://doi.org/10.21020/husbfd.437227

Abstract



In the
intestinal flora, there seems to be about 500 microorganism species and 98% of
them are found to be useful. However intestinal flora can contain different
microorganisms in each individual. Probiotics and prebiotics might have
beneficial effects such as increasing immunity, preventing inflammation by
stimulating inflammation-inhibiting cytokines, inhibiting the reproduction of
pathogens and the involvement of viruses. Irritable Bowel Syndrome (IBS) and
Functional Dyspepsia (FD) are disorders associated with upper gastrointestinal
system symptoms in addition to symptoms such as abdominal pain, diarrhea and /
or constipation, bloating, early satiety, and nausea. Abdominal pain, gas,
bloating and nausea complaints are common and very difficult to treat in IBS
and FD patients, and may affect the social life and quality of life of the
individual. Probiotics and prebiotics are claimed to be effective in treating
these symptoms with positive effects on the health of the individual. This
review evaluates and summarizes the literature on the use of probiotics and
prebiotics as a treatment and their efficacy in reducing the symptoms in IBS
and FD patients.

References

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  • Gallego, C. G., & Salminen, S. (2016). Novel probiotics and prebiotics: How can they help in human gut microbiota dysbiosis? Applied Food Biotechnology, 3(2), 72-81.
  • Gareau, M. G., Sherman, P. M., & Walker, W. A. (2010). Probiotics and the gut microbiota in intestinal health and disease. Nature Reviews Gastroenterology and Hepatology, 7(9), 503.
  • Geboes, K. (2001). Biological therapies in IBD: an international course. IDrugs, 4(3), 265-267.
  • Gerritsen, J., Smidt, H., Rijkers, G. T., & Vos, W. M. (2011). Intestinal microbiota in human health and disease: the impact of probiotics. Genes & nutrition, 6(3), 209.
  • Göktaş, Z., Köklü, S., Dikmen, D., Öztürk, Ö., Yılmaz, B., Asıl, M. ve diğerleri.(2016). Nutritional habits in functional dyspepsia and its subgroups: a comparative study. Scandinavian journal of gastroenterology, 51(8), 903-907.
  • Guarner, F., & Malagelada, J.-R. (2003). Gut flora in health and disease. The Lancet, 361(9356), 512-519. doi:https://doi.org/10.1016/S0140-6736(03)12489-0
  • Gupta, V., & Garg, R. (2009). Probiotics. Indian journal of medical microbiology, 27(3), 202.
  • Gutiérrez, R. L., Riddle, M. S., & Porter, C. K. (2015). Increased Risk of Functional Gastrointestinal Sequelae After Clostridium difficile Infection Among Active Duty United States Military Personnel (1998–2010). Gastroenterology, 149(6), 1408-1414.
  • Hassanzadeh, S., Saneei, P., Keshteli, A. H., Daghaghzadeh, H., Esmaillzadeh, A., & Adibi, P. (2016). Meal frequency in relation to prevalence of functional dyspepsia among Iranian adults. Nutrition, 32(2), 242-248.
  • Horvath, A., & Szajewska, H. (2013). Probiotics, prebiotics, and dietary fiber in the management of functional gastrointestinal disorders. World Rev Nutr Diet, 108, 40-48. doi:10.1159/000351483
  • Ianiro, G., Pizzoferrato, M., Franceschi, F., Tarullo, A., Luisi, T., & Gasbarrini, G. (2013). Effect of an extra-virgin olive oil enriched with probiotics or antioxidants on functional dyspepsia: a pilot study. Eur Rev Med Pharmacol Sci, 17(15), 2085-2090.
  • Joint, F. (2007). WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food. Guidelines for the evaluation of probiotics in food: report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food, London, Ontario, Canada, April 30 and May 1, 2002. ftp. fao. org/es/esn/food/wgreport2. pdf. Accessed, 16.
  • Jones, M. P., Talley, N. J., Eslick, G. D., Dubois, D., & Tack, J. (2008). Community subgroups in dyspepsia and their association with weight loss. The American journal of gastroenterology, 103(8), 2051-2060.
  • Kajander, K., Hatakka, K., Poussa, T., Farkkila, M., & Korpela, R. (2005). A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. Aliment Pharmacol Ther, 22(5), 387-394. doi:10.1111/j.1365-2036.2005.02579.x
  • Karabulut, S., Karabulut, M., Akarsu, C., Bozkurt, M. A., Bademler, S., Kocataş, A., ve diğerleri.(2015). Araştırmalar. Türk Toplumunda Organik ve Fonksiyonel Dispepsili Hastalarda Etyolojiye Yönelik Analiz. Researches. To investigate possible etiologic factors of organic and functional dyspepsia in Turkey., 11(1), 17-23. doi:10.5350/BTDMJB201511105
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There are 70 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Gözde Ağca This is me

Ece Yalçın This is me 0000-0002-4469-7255

Zeynep Göktaş 0000-0001-7241-8017

Publication Date August 29, 2019
Submission Date June 26, 2018
Published in Issue Year 2019 Volume: 6 Issue: 2

Cite

APA Ağca, G., Yalçın, E., & Göktaş, Z. (2019). İrritabl Bağırsak Sendromu ve Fonksiyonel Dispepsi Tedavisinde Probiyotikler ve Prebiyotikler. Hacettepe University Faculty of Health Sciences Journal, 6(2), 178-191. https://doi.org/10.21020/husbfd.437227