Which one is more dangerous in childhood Rotavirus or Adenovirus?
Year 2024,
, 1 - 12, 31.08.2024
Hakan Onur
,
Arzu Rahmanali Onur
Abstract
Objective: Determination of the frequency of Rotavirus and Adenovirus in patients diagnosed with gastroenteritis in the Pediatric Polyclinic of our hospital by immunochromatographic method and retrospective evaluation of the change in the distribution of the agent according to age, gender and vaccination status.
Method: Those patients with complaints of diarrhea, vomiting, dehydration, and fever as well as those diagnosed with acute gastroenteritis were evaluated by taking fresh stool samples between January 2015 and November 2020. The data were presented using descriptive statistics.
Results: The number of acute gastroenteritis patients included in the study was 1,192. The mean age of the patients was 18±SD months (min: 1 month, max: 180 months). Adenovirus and Rotavirus antigens were detected in 10% of all cases (n=119). Rotavirus antigen was positive in 6.6% (n=78) and Adenovirus antigen was positive in 3.1% (n=38) of all cases. The hospitalization rate was 5.1 times higher in Rotavirus positive cases (p<0.001). It was observed that fever and vomiting were statistically higher in patients with Adenovirus or Rotavirus positive. (p=0.001).
Conclusion: It has been shown that Rotavirus should be kept in mind, especially in children with severe vomiting/diarrhea leading to dehydration. Therefore, Rotavirus vaccination is very important in early childhood.
Ethical Statement
This research was authorized by the Memorial Private Bahçelievler Ethics Committee and was conducted in accordance with the Declaration of Helsinki (Approval date: 08.06.2023 and number: 102).
Thanks
The authors thank all the contributors of this study.
References
- Guarino A, Ashkenazi S, Gendrel D, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr 2014; 59:132.
- Pieścik-Lech M, Shamir R, Guarino A, Szajewska H. Review article: the management of acute gastroenteritis in children. Aliment Pharmacol Ther 2013;37(3):289-303.
- Freedman SB, Ali S, Oleszczuk M, Gouin S, Hartling L. Treatment of acute gastroenteritis in children: an overview of systematic reviews of interventions commonly used in developed countries. Evid Based Child Health 2013;8(4):1123-37.
- Kurugöl Z, Devrim I. Gastrointestinal infections. J Pediatr Inf 2014;8:71-81.
- Paarashar UD, Nelson EA, Kang G. Diagnosis, management, and prevention of rotavirus gastroenteritis in children. BMJ 2013;347:7204.
- Ceyhan M, Alhan E, Salman N et al. Multicenter prospective study on the burden of rotavirus gastroenteritis in Turkey, 2005-2006: a hospital-based study. J Pediatr Inf 2009;200:234-238.
- Chhabra P, Payne DC, Szilagyi PG, Edwards KM, Staat MA, et al. Etiology of viral gastroenteritis in children<5 years of age in the United States, 2008-2009. J Infect Dis. 2013;208(5):790.
- Osborne CM, Montano AC, Robinson CC, Schultz-Cherry S, Dominguez SR. Viral gastroenteritis in children in Colorado 2006-2009. J Med Virol. 2015;87(6):931-9.
- Gastañaduy PA, Curns AT, Parashar UD, Lopman BA. Gastroenteritis hospitalizations in older children and adults in the United States before and after implementation of infant rotavirus vaccination. JAMA. 2013;310(8):851-3.
- Shah MP, Tate JE, Steiner CA, Parashar UD. Decline in Emergency Department Visits for Acute Gastroenteritis Among Children in 10 US States After Implementation of Rotavirus Vaccination, 2003 to 2013. Pediatr Infect Dis J. 2016;35(7):782-6.
- Bozdayi G, Dogan B, Dalgic B, et al. Diversity of human rotavirus G9 among children in Turkey. J Med Virol 2008;80(4):733-740.
- Caneriği FH, Şafak B. Determination and Genotype Distribution of Rotavirus Gastroenteritis in Pediatric Patients Admitted to a Tertiary Care Hospital]. Mikrobiyol Bul 2022;56(2):304-314.
- Akan H, İzbırak G, Gürol Y, et al. Rotavirus and adenovirus frequency among patients with acute gastroenteritis and their relationship to clinical parameters: a retrospective study in Turkey. Asia Pac Fam Med 2009;8(1):8.
- Hallowell BD, Parashar UD, Curns A, et al. Trends in the Laboratory Detection of Rotavirus Before and After Implementation of routine rotavirus vaccination United States, 2000-2018. MMWR Morv Mortal Wkly Rep 2019;68:539.
- Guerrero ML, Noel JS, Mitchell DK, et al. A prospective study of astrovirus diarrhea of infancy in Mexico City. Pediatr Infect Dis J. 1998;17(8):723.
- Robilotti E, Deresinski S, Pinsky BA. Norovirus. Clin Microbiol Rev 2015; 28:134.
- Köhler T, Erben U, Wiedersberg H, Bannert N. Histological findings of the small intestinal mucosa in rotavirus infections in infants and young children. Kinderarztl Prax 1990;58(6):323-7.
- Dennehy PH. Viral gatroenteritis in children. Pediatr Infect Dis J. 2011;30:63-64.
- Ali S, Maki C, Xie J, et al. Characterizing pain in children with acute gastroenteritis who present for emergency care. J Pediatr 2021;231:102-109.
- Corcoran MS, Van Well GT, van Loo IH. Diagnosis of viral gatroenteritis in children: interpretation of real-time PCR results and relation to clinical symptoms. Eur J Clin Microbiol Infect Dis 2014;33:1663.
- Staat MA, Azimi PH, Berke T, et al. Clinical presentations of rotavirus infection among hospitalized children. Pediatr Infect Dis J 2002;21:221.
- Hall AJ, Rosenthal M, Gregoricus N, Greene AS, et al. Incidence of acute gastroenteritis and role of norovirus, Georgia, USA, 2004-2005. Emerg Infect Dis 2011;17(8):1381-1388.
- Troeger C, Blacker BF, Khalil IA, et al. Estimates of the global, regional and national morbidity, mortality, and aetiologiies of diarrhoea in 195 countries: a systematic analysis fort he Global Burden of Disease Study 2016. The Lancet Infect Dis 2018;18:1211-1228.
Year 2024,
, 1 - 12, 31.08.2024
Hakan Onur
,
Arzu Rahmanali Onur
References
- Guarino A, Ashkenazi S, Gendrel D, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr 2014; 59:132.
- Pieścik-Lech M, Shamir R, Guarino A, Szajewska H. Review article: the management of acute gastroenteritis in children. Aliment Pharmacol Ther 2013;37(3):289-303.
- Freedman SB, Ali S, Oleszczuk M, Gouin S, Hartling L. Treatment of acute gastroenteritis in children: an overview of systematic reviews of interventions commonly used in developed countries. Evid Based Child Health 2013;8(4):1123-37.
- Kurugöl Z, Devrim I. Gastrointestinal infections. J Pediatr Inf 2014;8:71-81.
- Paarashar UD, Nelson EA, Kang G. Diagnosis, management, and prevention of rotavirus gastroenteritis in children. BMJ 2013;347:7204.
- Ceyhan M, Alhan E, Salman N et al. Multicenter prospective study on the burden of rotavirus gastroenteritis in Turkey, 2005-2006: a hospital-based study. J Pediatr Inf 2009;200:234-238.
- Chhabra P, Payne DC, Szilagyi PG, Edwards KM, Staat MA, et al. Etiology of viral gastroenteritis in children<5 years of age in the United States, 2008-2009. J Infect Dis. 2013;208(5):790.
- Osborne CM, Montano AC, Robinson CC, Schultz-Cherry S, Dominguez SR. Viral gastroenteritis in children in Colorado 2006-2009. J Med Virol. 2015;87(6):931-9.
- Gastañaduy PA, Curns AT, Parashar UD, Lopman BA. Gastroenteritis hospitalizations in older children and adults in the United States before and after implementation of infant rotavirus vaccination. JAMA. 2013;310(8):851-3.
- Shah MP, Tate JE, Steiner CA, Parashar UD. Decline in Emergency Department Visits for Acute Gastroenteritis Among Children in 10 US States After Implementation of Rotavirus Vaccination, 2003 to 2013. Pediatr Infect Dis J. 2016;35(7):782-6.
- Bozdayi G, Dogan B, Dalgic B, et al. Diversity of human rotavirus G9 among children in Turkey. J Med Virol 2008;80(4):733-740.
- Caneriği FH, Şafak B. Determination and Genotype Distribution of Rotavirus Gastroenteritis in Pediatric Patients Admitted to a Tertiary Care Hospital]. Mikrobiyol Bul 2022;56(2):304-314.
- Akan H, İzbırak G, Gürol Y, et al. Rotavirus and adenovirus frequency among patients with acute gastroenteritis and their relationship to clinical parameters: a retrospective study in Turkey. Asia Pac Fam Med 2009;8(1):8.
- Hallowell BD, Parashar UD, Curns A, et al. Trends in the Laboratory Detection of Rotavirus Before and After Implementation of routine rotavirus vaccination United States, 2000-2018. MMWR Morv Mortal Wkly Rep 2019;68:539.
- Guerrero ML, Noel JS, Mitchell DK, et al. A prospective study of astrovirus diarrhea of infancy in Mexico City. Pediatr Infect Dis J. 1998;17(8):723.
- Robilotti E, Deresinski S, Pinsky BA. Norovirus. Clin Microbiol Rev 2015; 28:134.
- Köhler T, Erben U, Wiedersberg H, Bannert N. Histological findings of the small intestinal mucosa in rotavirus infections in infants and young children. Kinderarztl Prax 1990;58(6):323-7.
- Dennehy PH. Viral gatroenteritis in children. Pediatr Infect Dis J. 2011;30:63-64.
- Ali S, Maki C, Xie J, et al. Characterizing pain in children with acute gastroenteritis who present for emergency care. J Pediatr 2021;231:102-109.
- Corcoran MS, Van Well GT, van Loo IH. Diagnosis of viral gatroenteritis in children: interpretation of real-time PCR results and relation to clinical symptoms. Eur J Clin Microbiol Infect Dis 2014;33:1663.
- Staat MA, Azimi PH, Berke T, et al. Clinical presentations of rotavirus infection among hospitalized children. Pediatr Infect Dis J 2002;21:221.
- Hall AJ, Rosenthal M, Gregoricus N, Greene AS, et al. Incidence of acute gastroenteritis and role of norovirus, Georgia, USA, 2004-2005. Emerg Infect Dis 2011;17(8):1381-1388.
- Troeger C, Blacker BF, Khalil IA, et al. Estimates of the global, regional and national morbidity, mortality, and aetiologiies of diarrhoea in 195 countries: a systematic analysis fort he Global Burden of Disease Study 2016. The Lancet Infect Dis 2018;18:1211-1228.