Comparative Investigation of The Effects of Platelet-Rich Plasma in Sinus Lifting

Abstract

Background: In this study, we aimed to evaluate the produced bone’s quality, quantity, volume and the period of the healing process clinically, radiologically, histologically and histomorphologically after a sinus lifting operation using a natural mineralized bone graft with or without Platelet Rich Plasma (PRP). Material and methods: 22 sinus elevation operations under local anesthesia performed on 16 patients with no systemic illnesses which may affect healing. Before the operations, orthopantomograph and conical beam 3D dental tomographies of all patients were taken. Ten of the sinus lifting operations were performed by using mineralized hydroxyapatite and PRP mixtures produced from the patients’ own blood samples (Group 1); the other 12 sinus lifting operations were performed by using natural mineralized hydroxyapatite (Group 2). Orthopantomograph and computerized tomographies of the first group of patients were taken following a four-month healing period and for the second group following an eight-month healing period. After that, a bone biopsy was taken using trephine burs and dental implants were installed. At the end of the four-month healing period, biopsy samples were taken from two patients in the second group. The samples were evaluated histomorphologically. Results: In the histomorphological evaluation, core biopsies taken from the first group after the fourth month revealed greater bone formation, osteoid tissue and lamellar matrix. But no significant differences were statistically observed between the two groups. Conclusion: Although there were no significant differences in amount of bone healing, the bone healing of the first group was faster than that of the second group

Keywords

• Platelet-Rich Plasma, Maxillary Sinus, Guided tissue regeneration, Bone regeneration

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