A cross sectional study of autoantibodies in children with hepatitis A infection

Year 2011, Volume: 1 Issue: 1, 1 - 7, 01.06.2011

Ayfer Gözü Pırınccıoglu Kendal Yalcın Heybet Tüzün Mustafa Taskesen Salih Adıgüzel Sehmus Sevınc Derya Budak Remzi Bestas

Abstract

Background: Hepatitis A is one of the most frequently reported vaccine-preventable diseases worldwide and
remains endemic in many areas of the world. The study aims to investigate the prevalence of autoantibodies
in patients with acute viral hepatitis A.
Method: A total of 52 patients diagnosed with hepatitis A (HA) were enrolled in this study. The diagnosis of
acute hepatitis A (AHA) was based on negative hepatitis B surface antigen and hepatitis C virus RNA, and
positive immunoglobulin (Ig) M HA antibody. Biochemical parameters and the presence of autoantibodies
were recorded.
Results: Prolonged protrombin time, international normalized ratio corrected with vitamin K and prolonged
activated partial thromboplastin time were seen in 11, 11 and in 12 patients respectively. Total bilirubin
levels were higher than 2 mg/dL in 21 patients and only five of these patients had direct bilirubin higher than
50% of the total bilirubin and serum bilirubin levels were higher than 10 mg/dL during at least 4 weeks.
These 5 patients were evaluated as cholestatic hepatitis. Antinuclear antibodies were detected in four and
anti-liver cytosolic antigen type 1 in one patient.
Conclusion: The early diagnose of any autoimmune disease in patients with HA was found important since it
may help take necessary precautions. In addition, we conclude that further studies in larger populations will
contribute to understanding of the relationship between the autoimmune disease and HA.

Keywords

Seroprevalence, autoantibodies, hepatitis A, infection

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