Does Microalbuminuria has Positive Predictive Value in Patients With Essential Hypertension for Renovascular Hypertension?

Year 2013, Volume: 5 Issue: 1, 16 - 23, 01.06.2013

Zülfükar Yılmaz İdris Oruç Yaşar Yıldırım Fatma Yılmaz Aydın Emre Aydın Ali Kemal Kadiroglu Mehmet Emin Yılmaz

Abstract

Background: Renovascular disease is an important correctable cause of secondary hypertension. We aimed
to research whether microalbuminuria might be an indicator for renovascular hypertension among the
essential hypertensive patients.
Method: 330 essential hypertensive patients were enrolled to the study. Patients were divided into 2 groups:
group 1 (microalbuminuria) and group 2 (normoalbuminuria). Urine albumin concentrations were
measured by nepholometry after 24-hour urine collection. All subjects were examined by renal duplex
doppler ultrasonography and who had renal artery stenosis then MR angiography was performed.
Results: Microalbuminuria was detected in 107 of 330 essential hypertensive patients (32.42%). Mean CrCl
levels (108,14±19,83 vs 116,36±18,62, p=0,002) were significantly lower in the group of patients with
microalbuminuria. 3/107 (2.80%) of the patients had renal artery stenosis in the group of patients with
microalbuminuria and 8/223 (3.58%) of the patients had renal artery stenosis in the group of patients with
normoalbuminuria. This study showed a sensitivity of 2.8%, specificity 96.41%, positive predictive value
27.27%, negative predictive value 67.40%.
Conclusion: We suggest that microalbuminuria isn’t an indicator for renovascular hypertension in patients
with essential hypertension.

Keywords

Renovascular hypertension, essential hypertension, microalbuminuria, renal doppler ultrasonography

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