Review
BibTex RIS Cite

Examination of the obesogenic effects of Bisphenol-A

Year 2018, Volume: 2 Issue: 2, 185 - 194, 15.08.2018

Abstract

The prevalence of obesity among people
has increased dramatically in recent years in all the world. It is not enough
to explain this increasing trend only with people's lifestyle, eating habits
and cultural differences. Some chemicals, which are taken into the human body,
especially through the food chain and are considered to be endocrine
disruptors, affect the frequency of obesity. Endocrine disrupting chemicals
(EDCs) are compounds that cause hormone disruption and elimination of the
functions of these hormones. Bisphenol-A (BPA) is one of the most intensive
chemicals in human life and is generally called 2,2-bis (4-hydroxyphenyl)
propane. 70% of the BPA in the world is used in polycarbonate plastics and 30%
in epoxy resins. Due to the widespread usage of it, BPA reaches solid and
liquid wastes in terrestrial and aquatic ecosystems in large quantities.
Considering the high production capacity of BPA and its different application
areas, it is claimed that significant amount of BPA enters the environment.
Studies show that the rate of being exposed to BPA has an increasing tendency.
In the literature, the rate of availability in drinking water and the data on
the reproductive system were only included in the researches related to BPA.
Therefore, this study aimed to observe the obesogenic role of BPA in the
development of obesity, which is the current health problem of the world. BPA
is an endocrine disrupting chemical known to have in vitro effects on glucose
metabolism and adipose tissue. In a limited number of clinical and
epidemiological studies, BPA has been shown to be associated with diabetes and
obesity. For this purpose, the current literature related to this issue has
been reviewed and the effects of BPA on obesity have been compiled both in the
world and in our country.

References

  • 1. Kim, J.T., H.K. Lee, Childhood obesity and endocrine disrupting chemicals. Annals of Pediatric Endocrinology & Metabolism, 2017. 22(4): p. 219-225.
  • 2. Darbre, P.D., Endocrine disruptors and obesity. Current Obesity Reports, 2017. 6(1): p. 18-27.
  • 3. Newbold, R.R., Impact of environmental endocrine disrupting chemicals on the development of obesity. Hormones, 2010, 9(3): p. 206-217.
  • 4. Zarean, M., P. Poursafa, M.M. Amin, R. Kelishadi, Association of endocrine disrupting chemicals, bisphenol A and phthalates, with childhood obesity: a systematic review. Journal of Pediatrics Review, 2018. 6(1): p. 1-16.
  • 5. Kumar, A., R. Verma, N. K. Agrawal, A study of urinary bisphenol A levels in endocrine disorders. International Journal of Research in Medical Sciences, 2018. 6(2): p. 696-700.
  • 6. Simmons, A.L., J.J. Schlezinger, B.E. Corkey, What are we putting in our food that is making us fat? Food additives, contaminants, and other putative contributors to obesity. Current Obesity Reports, 2014. 3: p. 273-285.
  • 7. Fan, H., K.F. Lee, Bisphenol compounds on human reproduction health. Gynecology and Obstetrics Research, 2017. 4(2): p. 30-35.
  • 8. Li, J., H. Lai, S. Chen, H. Zhu, S. Lai, Gender differences in the associations between urinary bisphenol A and body composition among american children: the national health and nutrition examination survey, 2003-2006. Journal of Epidemiology, 2017. 27: p. 228-234.
  • 9. Verstraete, S.G., J.M. Wojcicki, E.R. Perito, P. Rosenthal, Bisphenol a increases risk for presumed non-alcoholic fatty liver disease in hispanic adolescents in NHANES 2003-2010. Environmental Health, 2018. 17(1): p. 1-8.
  • 10. Galloway, T.S., N. Baglin, B.P. Lee, A.L. Kocur, M.H. Shepherd, A.M. Steele, BPA Schools Study Consortium, L.W. Harries, An engaged research study to assess the effect of a ‘real-world’ dietary intervention on urinary bisphenol A (BPA) levels in teenagers. BMJ Open, 2018. 8: p. 1-8.
  • 11. Al-Daghri, N.M., S.H. Abd-Alrahman, I. Bukhari, A. Panigrahy, M.N.K. Khattak, M. Alokail, BPA exposure is related to metabolic changes in obese Saudi children. International Journal of Clinical and Experimental Pathology, 2017. 10(9): p. 9910-9916.
  • 12. Rubin, B.S., Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects. The Journal of Steroid Biochemistry and Molecular Biology, 2011. 127(1-2): p. 27-34.
  • 13. Rochester, J.R., Bisphenol A, and human health: a review of the literature. Reproductive Toxicology, 2013. 42: p. 132-155.
  • 14. Bramwell, L., S.V. Glinianaia, J. Rankin, M. Rose, A. Fernandes, S. Harrad, T. Pless-Mulolli, Associations between human exposure to polybrominated diphenyl ether flame retardant via diet and indoor dust, and internal dose: a systematic review. Environment International, 2016. 92-93: p. 680-694.
  • 15. Mas, S., J. Egido, E.o González-Parra, en representación del Grupo de Análisis del Papel del Bisfenol A en el Paciente en Hemodiálisis, The importance of bisphenol A, an uraemic toxin from exogenous sources, in haemodialysis patients. Nefrologia, 2017. 37(3):p. 229-234.
  • 16. Valentino, R., V. D’Esposito, F. Ariemma, I. Cimmino, F. Beguinot, P. Formisano, Bisphenol A environmental exposure and the detrimental effects on human metabolic health: Is it necessary to revise the risk assessment in vulnerable population?, Journal of Endocrinological Investigation, 2016. 39: p. 259-263.
  • 17. Caporossi, L., B. Papaleo, Bisphenol A and metabolic diseases: challenges for occupational medicine. International Journal of Environmental Research and Public Health, 2017. 14(9): p. 1-14.
  • 18. Calafat, A.M., Z. Kuklenyik, J.A. Reidy, S.P. Caudill, J. Ekong, L.L. Needham, Urinary concentrations of Bisphenol A and 4-nonylphenol in a human reference population. Environmental Health Perspectives, 2005. 113(4): p. 391-395.
  • 19. Schönfelder, G., W. Wittfoht, H. Hopp, C.E. Talsness, M. Paul, I. Chahoud, Parent bisphenol A accumulation in the maternal-fetal-placental unit, Environmental Health Perspectives, 2004. 110(211): p. 703-707.
  • 20. Ikezuki, Y., O. Tsutsumi, Y. Takai, Y. Kamei, Y. Taketani, Determination of bisphenol A concentration in human biological fluids reveals significant early prenatal exposure. Human Reproduction, 2002. 17: p. 2839-2841.
  • 21. Hunt, P.A., K.E. Koehler, M. Susiarjo, C.A. Hodges, A. Ilagan, R.C. Voigt, S. Thomas, B.F. Thomas, T.J. Hassold, Bisphenol A exposure causes meiotic aneuploidy in the female mouse. Current Biology, 2003. 13: p. 546-553.
  • 22. Wetherill, Y.B., C.E. Petre, K.R. Monk, A. Puga, K.E. Knudsen, The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic sdenocarcinoma cells. Molecular Cancer Therapeutics, 2002. 1(7): p. 515-524.
  • 23. Markey, C.M., E.H. Luque, M.Munoz de Toro, C. Sonnenschein, A.M. Soto, In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biology of Reproduction, 2001. 65(4): p. 1215–1223.
  • 24. Munoz-de-Toro, M., C. M. Markey, P.R. Wadia, E.H. Luque, B.S. Rubin, C. Sonnenschein, A.M. Soto, Perinatal exposure to bisphenol A alters peripubertal mammary gland development in mice. Endocrinology, 2005. 146(9): p. 4138-4147.
  • 25. Tamschick, S., B. Rozenblut-Koscisty, M. Ogielska, D. Kekenj, F. Gajewski, A. Krüger, W. Kloas, M. Stöck, The plasticizer bisphenol A affects somatic and sexual development, but differently in pipid, hylid and bufonid anurans. Environmental Pollution, 2016. 216: p. 282-291.
  • 26. Takeuchi T., O. Tsutsumi, Y. Ikezuki, Y. Takai, Y. Taketani, Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction. Endocrine Journal, 2004. 51(2): p. 165-169.
  • 27. Sugiura-Ogasawara, M., Y. Ozaki, S. Sonta, T. Makino, K. Suzumori, Exposure to bisphenol A is associated with recurrent miscarriage. Human Reproduction, 2005. 20(8): p. 2325-2329.
  • 28. Lang, I.A., T.S. Galloway, A. Scarlett, W.E. Henley, M. Depledge, R.B. Wallace, D. Melzer, Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA, 2008. 300(11): p. 1303-1310.
  • 29. Melzer, D., N.E. Rice, C. Lewis, W.E. Henley, T.S. Galloway, Association of urinary bisphenol A concentration with heart disease: evidence from NHANES 2003/06. PLoS One, 2010. 5(1): p. 1-9.
  • 30. Geyer, N.R., Waist to height ratio is the preferred way to measure the sssociation between obesity and bisphenol a exposure. Current Research in Diabetes & Obesity Journal, 2017. 4(5): p. 1-4.
  • 31. Miyawaki, J., K. Sakayama, H. Kato, H. Yamamoto, H. Masuno, Perinatal and postnatal exposure to bisphenol A increases adipose tissue mass and serum cholesterol level in mice. Journal of Atherosclerosis Thrombosis, 2007. 14(5): p. 245-252.
  • 32. Rubin, B.S., M.K. Murray, D.A. Damassa, J.C. King, A.M. Soto, Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity and plasma LH levels. Environmental Health Perspectives, 2001. 109(7): p. 675-680.
  • 33. Alonso-Magdalena, P., E. Vieira, S. Soriano, L. Menes, D. Burks, I. Quesada, A. Nadal, Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring. Environmental Health Perspectives, 2010. 118(9): p. 1243-1250.
  • 34. Takai, Y., O. Tsutsumi, Y. Ikezuki, Y. Kamei, Y. Osuga, T. Yano, Y. Taketan, Preimplantation exposure to bisphenol A advances postnatal development. Reproductive Toxicology, 2001. 15(1): p. 71-74.
  • 35. Wei, J., Y. Li, C. Ying, J. Chen, L. Song, Z. Zhou, Z. Lv, W. Xia, X. Chen, S. Xu, Perinatal exposure to bisphenol A at reference döşe predisposes offspring to metabolic syndrome in adult rats on a high fat diet. Endocrinology, 2011. 152(8): p. 3049-3061.
  • 36. Trasande, L., T.M. Attina, J. Blustein, Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. JAMA, 2012. 308(11): p. 1113-1121.
  • 37. Shankar. A., S. Teppala, C. Sabanayagam, Urinary bisphenol a levels and measures of obesity: results from the national health and nutrition examination survey 2003-2008. ISRN Endocrinology, 2012. 2012: p. 1-7.
  • 38. Hugo, E., T.D. Brandebourg, J.G. Woo, J. Loftus, J.W. Alexander, N. Ben-Jonathan, Bisphenol A at environmentally relevant doses inhibits adinopectin release from human adipose tissue explants and adipocytes. Environmental Health Perspectives, 2008. 116(12): p. 1642-1647.
  • 39. Masuno, H., T. Kidani, K Sekiya, K. Sakayama, T. Shiosaka, H. Yamamoto, K. Honda, Bisphenol A in combination with insülin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes. Journal of Lipid Research, 2002. 43(5): p. 676-684.
  • 40. Menale, C., A. Grandone, C. Nicolucci, G. Cirillo, S. Crispi, A. Di Sessa, P. Marzuillo, S. Rossi, D.G. Mita, L. Perrone, N. Diano, E.M.D. Giudice, Bisphenol A is associated with insulin resistance and modulates adiponectin and resistin gene expression in obese children. Pediatric Obesity, 2017. 12(5): p. 380-387.
  • 41. Vafeiadi, M., T. Roumeliotaki, A. Myridakis, G. Chalkiadaki, E. Fthenou, E. Dermitzaki, M. Karachaliou, K. Sarri, M. Vassilaki, E.G. Stephanou, M. Kogevinas, L. Chatzi. Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood. Environmental Research, 2016. 146: p.379-387.
  • 42. LaKind J.S., M. Goodman, D.R. Mattison, Bisphenol A and indicators of obesity, glucose metabolism/type 2 diabetes and cardiovascular disease: a systematic review of epidemiologic research. Critical Reviews in Toxicology, 2014. 44(2): p. 121-150.
  • 43. Kelishadi, R., P. Poursafa, F. Jamshidi, Role of environmental chemicals in obesity: a systematic review on the current evidence. Journal of Environmental and Public Health, 2013. 2013: p. 1-9.
  • 44. Sabanayagam, C., S. Teppala, A. Shankar, Relationship between urinary bisphenol A levels and prediabetes among subjects free of diabetes. Acta Diabetologica, 2013. 50(4): p. 625–631.
  • 45. Canesi, L., E. Fabbri, Environmental effects of BPA: focus on aquatic species. Dose-Response: An International Journal, 2015. 2015:1-14.
  • 46. Dehghani, M.H., M. Ghadermazi, A. Bhatnagar, P. Sadighara, G. Jahed-Khaniki, B. Heibati, G. McKay, Adsorptive removal of endocrine disrupting bisphenol A from aqueous solution using chitosan. Journal of Environmental Chemical Engineering 2016. 4: p. 2647–2655
  • 47. Donna, S.E., MD, J.M. Lee, MD, MPH, A. Gebremariam, MS, J.D. Meeker, ScD, K. Peterson, DSc, V. Padmanabhan, PhD, Bisphenol A and chronic disease risk factors in US children. Pediatrics, 2013. 132(3): p. 637-645.
  • 48. Lang, I.A., T.S. Galloway, A. Scarlett, W.E. Henley, M. Depledge, R.B.Wallace, D. Melzer, Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 2008; 300(11): 1303-1310.
  • 49. Hong, S., Y.A. Sung, Y.S. Hong, E. Ha, K. Jeong, H. Chung, H. Lee, Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women. Clinical Endocrinology, 2016, 86(4): p. 506-512.
  • 50. Ning, G., Y. Bi, T. Wang, M. Xu, Y. Xu, Y. Huang, M. Li, X. Li, W. Wang, Y. Chen, Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults: a cross-sectional analysis. Annals of Internal Medicine, 2011. 155(6): p. 368-374.
  • 51. Kim, K., H. Park, Association between urinary concentrations of bisphenol A and type 2 diabetes in Korean adults: a population based cross sectional study. International Journal of Hygiene and Environmental Health, 2013, 216(4): p. 467-471.
  • 52. Savastano, S., G. Tarantino, V. D’Esposito, F. Passaretti, S. Cabaro, A. Liotti, D. Liguoro, G. Perruolo, F. Ariemma, C. Finelli, F. Beguinot , P. Formisano, R. Valentino, Bisphenol A plasma levels are related to inflammatory markers, visceral obesity and insulin-resistance: A cross sectional study on adult male population. Journal of Translational Medicine, 2015, 13: p. 1-7.
  • 53. Melzer, D., P. Gates, N.J. Osborn, W.E. Henley, R. Cipelli, A. Young, C. Money, P. McCormack, P. Schofield, D. Mosedale, D. Grainger, T.S. Galloway, Urinary bisphenol A concentration and angiography-defined coronary artery stenosis. PLoS ONE 2012. 7: p. 1-7.
  • 54. Melzer, D., N.J. Osborne, W.E. Henley, R. Cipelli, A. Young, C. Money, P. McCormack, R. Luben, K. Khaw, N.J. Wareham, T.S. Galloway, Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation, 2012. 125: p. 1482-1490.
  • 55. Song, Y., R. Hauser, F.B. Hu, A.A. Franke, S. Liu, Q. Sun, Urinary concentrations of bisphenol A and phthalate metabolites and weight change: A prospective investigation in US women. International Journal of Obesity, 2014. 38: p. 1532-1537.
  • 56. Shankar, A., S. Teppala, C. Sabanayagam, Bisphenol A and peripheral arterial disease: results from the NHANES. Environmental Health Perspectives, 2012, 120: p. 1297-1300.
  • 57. Rönn, M., L. Lind, J. Örberg, J. Kullberg, S. Söderberg, A. Larsson, L. Johansson, H. Ahlström, P.M. Lind, Bisphenol A is related to circulating levels of adiponectin, leptin and ghrelin, but not to fat mass or fat distribution in humans. Chemosphere, 2014. 112: p. 42-48.
  • 58. Wang, T., M. Li, B. Chen, M. Xu, Y. Xu, Y. Huang, J. Lu, Y. Chen, W. Wang, X. Li, Y. Liu, Y. Bi, S. Lai, G. Ning, Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 2012. 97: p. 223-227.
  • 59. Andra, S.S., K.C. Makris, Association between urinary levels of bisphenol A and its monochlorinated derivative and obesity. Journal of Environmental Science and Health Part A, 2015. 50: p. 1169-1179.
  • 60. Zhao, H.Y., Y.F. Bi, L.Y. Ma, L. Zhao, T.G. Wang, L.Z. Zhang, B. Tao, L.H. Sun, Y.J. Zhao, W.Q. Wang, X.Y. Li, M.Y. Xu, J.L. Chen, G. Ning, J.M. Liu, The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women. Clinical Biochemistry, 2012. 45: p. 1602-1606.
  • 61. Metwally, F.M., M.M. Mohamed, N.E. Sharaf, M.A. Ghazy, A.M. El Mishad, A. Elfiky, The Impact of bisphenol A (BPA) as environmental obesogen on lipids and lipids metabolism. International Journal of Pharmaceutical and Clinical Research, 2016. 8: p. 1323-1330.
  • 62. Mahalingaiah, S., J.D. Meeker, K.R. Pearson, A.M. Calafat, X. Ye, J. Petrozza, R. Hauser, Temporal variability and predictors of urinary bisphenol A concentrations in men and women. Environmental Health Perspectives, 2008. 116: p. 173-178.
  • 63. Liu, B., H.J. Lehmler, Y. Sun, G. Xu, Y. Liu, G. Zong, Q. Sun, F.B. Hu, R.B. Wallace, W. Bao, Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study. Lancet Planet Health, 2017. 1: p. 114–122.
  • 64. Bhandari, R., J. Xiao, A. Shankar, Urinary bisphenol A and obesity in US children. American Journal of Epidemiology, 2013. 177(11): p. 1263-1270.
  • 65. Erkan, T., Yalvac, S., Erginoz, E., Cokugras, F., Kutlu, T., The evaluation of nutritional status of children, by anthropometric measurements, attending the day nursery of Cerrahpasa Medical School. Türk Pediatri Arşivi, 2007. 42: p. 142-147.
  • 66. Akca, S.O., Uysal, G., Buyukgonenc, L.A., Obesitiy in nursery school children in Corum, Turkey. Iranian Red Crescent Medical Journal, 2016. 18: p. 1-6.
  • 67. Karaoglan, D., Tansel, A., Determinants of obesity in Turkey: a quantile regression analysis from a developing country. MPRA, 2017. 16: p. 1-19.
  • 68. Alper, Z., Ercan, İ., Uncu, Y., A meta-analysis and an evaluation of trends in obesity prevalence among children and adolescents in Turkey: 1990 through 2015. Journal Of Clinical Research İn Pediatric Endocrinology, 2018. 10: p. 59-67.
  • 69. Battal, D., Cok, I., Unlusayin, I., Aktas, A., Tunctan, B., Determination of urinary levels of Bisphenol A in a Turkish population. Environmental Monitoring and Assessment, 2014. 186: p. 8443-8452.
  • 70. Öztürk, Y., Etiology and comorbidities of childhood obesity. The Turkish Journal of Gastroenterology, 2017. 28: p. 149-151.
  • 71. Bulus¸ A.D., Aşci, A., Erkekoglu, P., Balci, A., Andiran, N., Koçer-Gümüşel, B., The evaluation of possible role of endocrine disruptors in central and peripheral precocious puberty. Toxicology Mechanisms and Methods, 2016. 26: p. 493-500.
  • 72. Durmaz, E., Asci, A., Erkekoglu, P., Balcı, A., Bircan, I., Koçer-Gumusel, B., Urinary bisphenol A levels in Turkish girls with premature thelarche. Human and Experimental Toxicology, 2018. (article in press).
  • 73. Erem, C., Prevalence of overweight and obesity in Turkey. IJC Metabolic & Endocrine, 2015. 8: p. 38-41.
  • 74. Şenyıldız, M., Karaman, E.F., Baş, S.S., Pirinççi, P.A., Özden, S., Alteration on global and gene-spesific DNA methylation and global histone modifications in HepG2 cells in response to BPA. İstanbul Eczacilık Fakültesi Dergisi, 2016. 46: p. 97-114.
  • 75. Durmaz, E., Aşçı, A., Erkekoğlu, P., Akçurin, S., Koçer Gümüşel, B., Bircan, I., Urinary Bisphenol A levels in girls with idiopathic central precocious puberty. Journal Of Clinical Research İn Pediatric Endocrinology,2014. 6: p. 16-21.
  • 76. Yalçın, S., Yalçın, S.S., Bisphenol A Exposure and anthropometry in Turkish children aged 8-9 years in Konya, in 15th International Conference on Environmental Science and Technology 2017: Rhodes, p. 1-4.
  • 77. Ozcebe, H., Bosi, T.B., Yardim, N., Ertuğrul, Ç., Nermin, Ç., Bekir, K., Seçil, Ö., Türkiye’ de çocuklarda fazla kiloluluk ve şişmanlık prevalansları. TSK Koruyucu Hekimlik Bülteni, 2015. 14: p. 145-152.
  • 78. Topçu, S., Orhon, F.Ş., tayfun, M., Uçaktürk, S.A., Demirel, F., Anxiety, depression and self-esteem levels in obese children: a case-control study. Journal of Pediatric Endocrinology and Metabolism, 2016. 29: p. 357-361.
  • 79. Balcı, A., Erkekoğlu, P., Koçer-Gümüşel, B., Endokrin bozucu kimyasallar ve obezite arasındaki ilişkinin değerlendirilmesi-I: ftalatlar ve Bisfenol A. Eczacılık Bilimleri Dergisi, 2014. 3: p. 1-16.
  • 80. Turhan, E., Tözün, M., Doğanay, S., İzmir’e bağlı dokuz ilçede ilköğretim birinci sınıf öğrencilerinde obezite sıklığı. Journal of Clinical and Analytical Medicine, 2015. 6: p. 755-759.
  • 81. Polat, M., Yıkılkan, H., Aypak, C., Görpelioğlu, S., The relationship between BMI and blood pressure in children aged 7-12 years in Ankara, Turkey. Public Health Nutrition, 2014. 17: p. 2419-2424.
  • 82. Demirci, H., Nuhoglu, C., Ursavas, I.S., Isildak, S., Basaran, E.O., Kilic, M.Y., Obesity and asymptomatic hypertension among children aged 6-13 years living in Bursa, Turkey. Family Practice, 2013. 30: p. 629-633.
  • 83. Kaya, M., Sayan, A., Birinci, M., Yildiz, M., Turkmen, K., The obesity prevalence among students between the ages of 5 and 19 in Kutahya. Turkish Journal of Medical Sciences, 2014. 44: p. 10-15.
  • 84. Özdal, T., Yeşilcubuk, N.Ş., Toxicity of Bisphenol-A: effects on health and regulations. International Journal of Agricultural and Biosystems Engineering, 2014. 8: p. 553-557.
  • 85. Pektas, S.D., Yilmaz, N., Kivrak, I., Increased serum levels of Bisphenol A and Betatrophin in patients with psoriasis. Medicine Science, 2018. (article in press).
  • 86. Nappi, F., Barrea, L., Somma, C.D., Savanelli, M.C., Muscogiuri, G., Orio, F., Savastano, S., Endocrine aspects of environmental “Obesogen” pollutants. International Journal of Environmental Research and Public Health, 2016. 13: p. 1-16.
  • 87. Akın, L., Kendirci, M., Narin, F., Kurtoglu, S., Saraymen, R., Kondolot, M., Koçak, S., Elmalı, F., The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls. Acta Paediatrica, 2015. 104: p. 171-177.
  • 88. Turan, S., Omar, A., Berber, M., Ozen, A., Bereket, A., Effect of socio-economical condition and age on prevalence of obesity, in Proceedings of the IX. National Pediatric Endocrinology Congress 2004: Malatya, p. PP F-2.
  • 89. Turkkahraman, D., Bircan, I., Tosun, O., Saka, O., Prevalence and risk factors of obesity in school children in Antalya, Turkey. Saudi Medical Journal, 2006. 27: p. 1028-1033.
  • 90. Uckun-Kitapci, A., Tezic, T., Firat, S., Sipahi, T., Barrier, R., Edwards, L.J., Calikoglu, A.S., Obesity and type 2 diabetes mellitus: a population-based study of adolescents. Journal of Pediatric Endocrinology and Metabolism, 2004. 17: p. 1633-1640.
  • 91. Krassas, G.E., Tsametis, C., Baleki, V., Constantinidis, T., Unluhizarci, K., Kurtoglu, S., Kelestimut, F., Prevalence of overweight and obesity among children and adolescents in Thessaloniki-Greece and Kayseri-Turkey. Pediatric Endocrinology Reviews, 2004. 1: p. 460-464.
  • 92. Discigil, G., Tekin, N., Soylemez, A., Obesity in Turkish children and adolescents: prevalence and non-nutritional correlates in an urban sample. Child: Care, Health and Development, 2009. 35: p. 153-158.
  • 93. Pirincci, E., Durmus, B., Gundogdu, C., Acik, Y., Prevalence and risk factors of overweight and obesity among urban school children in Elazig city, Eastern Turkey, 2007. Annals of Human Biology, 2010. 37: p. 44-56.
  • 94. Sağlam, H., Tarim, O., Prevalence and correlates of obesity in schoolchildren from the city of Bursa, Turkey. Journal of Clinical Research in Pediatric Endocrinology, 2008. 1: p. 80-88.
  • 95. Simsek, E., Akpinar, S., Bahcebasi, T., Senses, D.A., Kocabay, K., The prevalence of overweight and obese children aged 6-17 years in the West Black Sea region of Turkey. International Journal of Clinical Practice, 2008. 62: p. 1033-1038.
  • 96. Kalkan-Ucar, S., Dizdarer, C., Darcan, S., Korkmaz, S., Ergudenler, Y., Asilsoy, S., Bilgili, G., Ozcan, T., Goksen Simsek, D., Coker, M., Prevalence of obesity and overweight among children in İzmir, Turkey: effects of nutritional and socio-economic factors. Obesity and Metablolism, 2009. 5: p. 99-106.
  • 97. Cizmecioglu, F.M., Etiler, N., Hamzaoglu, O., Hatun, S., Prevalence of metabolic syndrome in schoolchildren and adolescents in Turkey: a population-based study. Journal of Pediatric Endocrinology and Metabolism, 2009. 22: p. 703-714.
  • 98. Dündar, C., Öz, H., Obesity-related factors in Turkish school children. Scientific World Journal, 2012. 2012: p. 353485.
  • 99. Kondolot, M., Balci, E., Ozturk, A., Mazicioglu, M.M., Hatipoglı, N., Kurtoglu, S., Ustunbas, H.B., Body mass index percentiles for Turkish children aged 0-84 months. Annals of Human Biology, 2011. 38: p. 676–680.
  • 100. Yuca, A.S., Yilmaz, C., Cesur, Y., Dogan, M., Kaya, A., Basaranoglu, M., Prevalence of overweight and obesity in children and adolescents in eastern Turkey. Journal of Clinical Research in Pediatric Endocrinology, 2010. 2: p. 159-163.
  • 101. Ercan, S., Dallar, Y.B., Önen, S., Engiz, Ö., Prevalence of obesity and associated risk factors among adolescents in Ankara, Turkey. Journal of Clinical Research in Pediatric Endocrinology, 2012. 4: p. 204-207.
  • 102. Inanç, B.B., Sahin, D.S., Oğuzöncül, A.F., Bindak, R., Mungan, F., Prevalence of obesity in elementary schools inMardin, South-eastern of Turkey: a preliminary study. Balkan Medical Journal, 2012. 29: p. 424-430.
  • 103. Ustu, Y., Uğurlu, M., Aslan, O., Aksoy, Y.M., Kasim, I., Egici, M.T., Sanisoglu, S.Y. High prevalence of obesity in Tokat, a Northern Province of Turkey. Journal of the Pakistan Medical Association, 2012. 62: p. 435-440.
  • 104. Ünal, B., Sözmen, K., Uçku, R., Ergör, G., Soysal, A., Baydur, H., Meseri, R., Şimşek, H., Gerçeklioğlu, G., Doğanay, S., Budak, R., Kiliç, B., Günay, T., Ergör, A., Demiral, Y., Aslan, Ö., Çimrin, D., Akvardar, Y., Tuncel, P., High prevalence of cardiovascular risk factors in a western urban Turkish population: a community-based study. Anadolu Kardiyoloji Dergisi, 2013. 13: p. 9-17.
  • 105. OECD, 2017. [cited 2018 29 May]; Available from: http://www.oecd.org/health/obesity.update.htm
Year 2018, Volume: 2 Issue: 2, 185 - 194, 15.08.2018

Abstract

References

  • 1. Kim, J.T., H.K. Lee, Childhood obesity and endocrine disrupting chemicals. Annals of Pediatric Endocrinology & Metabolism, 2017. 22(4): p. 219-225.
  • 2. Darbre, P.D., Endocrine disruptors and obesity. Current Obesity Reports, 2017. 6(1): p. 18-27.
  • 3. Newbold, R.R., Impact of environmental endocrine disrupting chemicals on the development of obesity. Hormones, 2010, 9(3): p. 206-217.
  • 4. Zarean, M., P. Poursafa, M.M. Amin, R. Kelishadi, Association of endocrine disrupting chemicals, bisphenol A and phthalates, with childhood obesity: a systematic review. Journal of Pediatrics Review, 2018. 6(1): p. 1-16.
  • 5. Kumar, A., R. Verma, N. K. Agrawal, A study of urinary bisphenol A levels in endocrine disorders. International Journal of Research in Medical Sciences, 2018. 6(2): p. 696-700.
  • 6. Simmons, A.L., J.J. Schlezinger, B.E. Corkey, What are we putting in our food that is making us fat? Food additives, contaminants, and other putative contributors to obesity. Current Obesity Reports, 2014. 3: p. 273-285.
  • 7. Fan, H., K.F. Lee, Bisphenol compounds on human reproduction health. Gynecology and Obstetrics Research, 2017. 4(2): p. 30-35.
  • 8. Li, J., H. Lai, S. Chen, H. Zhu, S. Lai, Gender differences in the associations between urinary bisphenol A and body composition among american children: the national health and nutrition examination survey, 2003-2006. Journal of Epidemiology, 2017. 27: p. 228-234.
  • 9. Verstraete, S.G., J.M. Wojcicki, E.R. Perito, P. Rosenthal, Bisphenol a increases risk for presumed non-alcoholic fatty liver disease in hispanic adolescents in NHANES 2003-2010. Environmental Health, 2018. 17(1): p. 1-8.
  • 10. Galloway, T.S., N. Baglin, B.P. Lee, A.L. Kocur, M.H. Shepherd, A.M. Steele, BPA Schools Study Consortium, L.W. Harries, An engaged research study to assess the effect of a ‘real-world’ dietary intervention on urinary bisphenol A (BPA) levels in teenagers. BMJ Open, 2018. 8: p. 1-8.
  • 11. Al-Daghri, N.M., S.H. Abd-Alrahman, I. Bukhari, A. Panigrahy, M.N.K. Khattak, M. Alokail, BPA exposure is related to metabolic changes in obese Saudi children. International Journal of Clinical and Experimental Pathology, 2017. 10(9): p. 9910-9916.
  • 12. Rubin, B.S., Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects. The Journal of Steroid Biochemistry and Molecular Biology, 2011. 127(1-2): p. 27-34.
  • 13. Rochester, J.R., Bisphenol A, and human health: a review of the literature. Reproductive Toxicology, 2013. 42: p. 132-155.
  • 14. Bramwell, L., S.V. Glinianaia, J. Rankin, M. Rose, A. Fernandes, S. Harrad, T. Pless-Mulolli, Associations between human exposure to polybrominated diphenyl ether flame retardant via diet and indoor dust, and internal dose: a systematic review. Environment International, 2016. 92-93: p. 680-694.
  • 15. Mas, S., J. Egido, E.o González-Parra, en representación del Grupo de Análisis del Papel del Bisfenol A en el Paciente en Hemodiálisis, The importance of bisphenol A, an uraemic toxin from exogenous sources, in haemodialysis patients. Nefrologia, 2017. 37(3):p. 229-234.
  • 16. Valentino, R., V. D’Esposito, F. Ariemma, I. Cimmino, F. Beguinot, P. Formisano, Bisphenol A environmental exposure and the detrimental effects on human metabolic health: Is it necessary to revise the risk assessment in vulnerable population?, Journal of Endocrinological Investigation, 2016. 39: p. 259-263.
  • 17. Caporossi, L., B. Papaleo, Bisphenol A and metabolic diseases: challenges for occupational medicine. International Journal of Environmental Research and Public Health, 2017. 14(9): p. 1-14.
  • 18. Calafat, A.M., Z. Kuklenyik, J.A. Reidy, S.P. Caudill, J. Ekong, L.L. Needham, Urinary concentrations of Bisphenol A and 4-nonylphenol in a human reference population. Environmental Health Perspectives, 2005. 113(4): p. 391-395.
  • 19. Schönfelder, G., W. Wittfoht, H. Hopp, C.E. Talsness, M. Paul, I. Chahoud, Parent bisphenol A accumulation in the maternal-fetal-placental unit, Environmental Health Perspectives, 2004. 110(211): p. 703-707.
  • 20. Ikezuki, Y., O. Tsutsumi, Y. Takai, Y. Kamei, Y. Taketani, Determination of bisphenol A concentration in human biological fluids reveals significant early prenatal exposure. Human Reproduction, 2002. 17: p. 2839-2841.
  • 21. Hunt, P.A., K.E. Koehler, M. Susiarjo, C.A. Hodges, A. Ilagan, R.C. Voigt, S. Thomas, B.F. Thomas, T.J. Hassold, Bisphenol A exposure causes meiotic aneuploidy in the female mouse. Current Biology, 2003. 13: p. 546-553.
  • 22. Wetherill, Y.B., C.E. Petre, K.R. Monk, A. Puga, K.E. Knudsen, The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic sdenocarcinoma cells. Molecular Cancer Therapeutics, 2002. 1(7): p. 515-524.
  • 23. Markey, C.M., E.H. Luque, M.Munoz de Toro, C. Sonnenschein, A.M. Soto, In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biology of Reproduction, 2001. 65(4): p. 1215–1223.
  • 24. Munoz-de-Toro, M., C. M. Markey, P.R. Wadia, E.H. Luque, B.S. Rubin, C. Sonnenschein, A.M. Soto, Perinatal exposure to bisphenol A alters peripubertal mammary gland development in mice. Endocrinology, 2005. 146(9): p. 4138-4147.
  • 25. Tamschick, S., B. Rozenblut-Koscisty, M. Ogielska, D. Kekenj, F. Gajewski, A. Krüger, W. Kloas, M. Stöck, The plasticizer bisphenol A affects somatic and sexual development, but differently in pipid, hylid and bufonid anurans. Environmental Pollution, 2016. 216: p. 282-291.
  • 26. Takeuchi T., O. Tsutsumi, Y. Ikezuki, Y. Takai, Y. Taketani, Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction. Endocrine Journal, 2004. 51(2): p. 165-169.
  • 27. Sugiura-Ogasawara, M., Y. Ozaki, S. Sonta, T. Makino, K. Suzumori, Exposure to bisphenol A is associated with recurrent miscarriage. Human Reproduction, 2005. 20(8): p. 2325-2329.
  • 28. Lang, I.A., T.S. Galloway, A. Scarlett, W.E. Henley, M. Depledge, R.B. Wallace, D. Melzer, Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA, 2008. 300(11): p. 1303-1310.
  • 29. Melzer, D., N.E. Rice, C. Lewis, W.E. Henley, T.S. Galloway, Association of urinary bisphenol A concentration with heart disease: evidence from NHANES 2003/06. PLoS One, 2010. 5(1): p. 1-9.
  • 30. Geyer, N.R., Waist to height ratio is the preferred way to measure the sssociation between obesity and bisphenol a exposure. Current Research in Diabetes & Obesity Journal, 2017. 4(5): p. 1-4.
  • 31. Miyawaki, J., K. Sakayama, H. Kato, H. Yamamoto, H. Masuno, Perinatal and postnatal exposure to bisphenol A increases adipose tissue mass and serum cholesterol level in mice. Journal of Atherosclerosis Thrombosis, 2007. 14(5): p. 245-252.
  • 32. Rubin, B.S., M.K. Murray, D.A. Damassa, J.C. King, A.M. Soto, Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity and plasma LH levels. Environmental Health Perspectives, 2001. 109(7): p. 675-680.
  • 33. Alonso-Magdalena, P., E. Vieira, S. Soriano, L. Menes, D. Burks, I. Quesada, A. Nadal, Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring. Environmental Health Perspectives, 2010. 118(9): p. 1243-1250.
  • 34. Takai, Y., O. Tsutsumi, Y. Ikezuki, Y. Kamei, Y. Osuga, T. Yano, Y. Taketan, Preimplantation exposure to bisphenol A advances postnatal development. Reproductive Toxicology, 2001. 15(1): p. 71-74.
  • 35. Wei, J., Y. Li, C. Ying, J. Chen, L. Song, Z. Zhou, Z. Lv, W. Xia, X. Chen, S. Xu, Perinatal exposure to bisphenol A at reference döşe predisposes offspring to metabolic syndrome in adult rats on a high fat diet. Endocrinology, 2011. 152(8): p. 3049-3061.
  • 36. Trasande, L., T.M. Attina, J. Blustein, Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. JAMA, 2012. 308(11): p. 1113-1121.
  • 37. Shankar. A., S. Teppala, C. Sabanayagam, Urinary bisphenol a levels and measures of obesity: results from the national health and nutrition examination survey 2003-2008. ISRN Endocrinology, 2012. 2012: p. 1-7.
  • 38. Hugo, E., T.D. Brandebourg, J.G. Woo, J. Loftus, J.W. Alexander, N. Ben-Jonathan, Bisphenol A at environmentally relevant doses inhibits adinopectin release from human adipose tissue explants and adipocytes. Environmental Health Perspectives, 2008. 116(12): p. 1642-1647.
  • 39. Masuno, H., T. Kidani, K Sekiya, K. Sakayama, T. Shiosaka, H. Yamamoto, K. Honda, Bisphenol A in combination with insülin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes. Journal of Lipid Research, 2002. 43(5): p. 676-684.
  • 40. Menale, C., A. Grandone, C. Nicolucci, G. Cirillo, S. Crispi, A. Di Sessa, P. Marzuillo, S. Rossi, D.G. Mita, L. Perrone, N. Diano, E.M.D. Giudice, Bisphenol A is associated with insulin resistance and modulates adiponectin and resistin gene expression in obese children. Pediatric Obesity, 2017. 12(5): p. 380-387.
  • 41. Vafeiadi, M., T. Roumeliotaki, A. Myridakis, G. Chalkiadaki, E. Fthenou, E. Dermitzaki, M. Karachaliou, K. Sarri, M. Vassilaki, E.G. Stephanou, M. Kogevinas, L. Chatzi. Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood. Environmental Research, 2016. 146: p.379-387.
  • 42. LaKind J.S., M. Goodman, D.R. Mattison, Bisphenol A and indicators of obesity, glucose metabolism/type 2 diabetes and cardiovascular disease: a systematic review of epidemiologic research. Critical Reviews in Toxicology, 2014. 44(2): p. 121-150.
  • 43. Kelishadi, R., P. Poursafa, F. Jamshidi, Role of environmental chemicals in obesity: a systematic review on the current evidence. Journal of Environmental and Public Health, 2013. 2013: p. 1-9.
  • 44. Sabanayagam, C., S. Teppala, A. Shankar, Relationship between urinary bisphenol A levels and prediabetes among subjects free of diabetes. Acta Diabetologica, 2013. 50(4): p. 625–631.
  • 45. Canesi, L., E. Fabbri, Environmental effects of BPA: focus on aquatic species. Dose-Response: An International Journal, 2015. 2015:1-14.
  • 46. Dehghani, M.H., M. Ghadermazi, A. Bhatnagar, P. Sadighara, G. Jahed-Khaniki, B. Heibati, G. McKay, Adsorptive removal of endocrine disrupting bisphenol A from aqueous solution using chitosan. Journal of Environmental Chemical Engineering 2016. 4: p. 2647–2655
  • 47. Donna, S.E., MD, J.M. Lee, MD, MPH, A. Gebremariam, MS, J.D. Meeker, ScD, K. Peterson, DSc, V. Padmanabhan, PhD, Bisphenol A and chronic disease risk factors in US children. Pediatrics, 2013. 132(3): p. 637-645.
  • 48. Lang, I.A., T.S. Galloway, A. Scarlett, W.E. Henley, M. Depledge, R.B.Wallace, D. Melzer, Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 2008; 300(11): 1303-1310.
  • 49. Hong, S., Y.A. Sung, Y.S. Hong, E. Ha, K. Jeong, H. Chung, H. Lee, Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women. Clinical Endocrinology, 2016, 86(4): p. 506-512.
  • 50. Ning, G., Y. Bi, T. Wang, M. Xu, Y. Xu, Y. Huang, M. Li, X. Li, W. Wang, Y. Chen, Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults: a cross-sectional analysis. Annals of Internal Medicine, 2011. 155(6): p. 368-374.
  • 51. Kim, K., H. Park, Association between urinary concentrations of bisphenol A and type 2 diabetes in Korean adults: a population based cross sectional study. International Journal of Hygiene and Environmental Health, 2013, 216(4): p. 467-471.
  • 52. Savastano, S., G. Tarantino, V. D’Esposito, F. Passaretti, S. Cabaro, A. Liotti, D. Liguoro, G. Perruolo, F. Ariemma, C. Finelli, F. Beguinot , P. Formisano, R. Valentino, Bisphenol A plasma levels are related to inflammatory markers, visceral obesity and insulin-resistance: A cross sectional study on adult male population. Journal of Translational Medicine, 2015, 13: p. 1-7.
  • 53. Melzer, D., P. Gates, N.J. Osborn, W.E. Henley, R. Cipelli, A. Young, C. Money, P. McCormack, P. Schofield, D. Mosedale, D. Grainger, T.S. Galloway, Urinary bisphenol A concentration and angiography-defined coronary artery stenosis. PLoS ONE 2012. 7: p. 1-7.
  • 54. Melzer, D., N.J. Osborne, W.E. Henley, R. Cipelli, A. Young, C. Money, P. McCormack, R. Luben, K. Khaw, N.J. Wareham, T.S. Galloway, Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation, 2012. 125: p. 1482-1490.
  • 55. Song, Y., R. Hauser, F.B. Hu, A.A. Franke, S. Liu, Q. Sun, Urinary concentrations of bisphenol A and phthalate metabolites and weight change: A prospective investigation in US women. International Journal of Obesity, 2014. 38: p. 1532-1537.
  • 56. Shankar, A., S. Teppala, C. Sabanayagam, Bisphenol A and peripheral arterial disease: results from the NHANES. Environmental Health Perspectives, 2012, 120: p. 1297-1300.
  • 57. Rönn, M., L. Lind, J. Örberg, J. Kullberg, S. Söderberg, A. Larsson, L. Johansson, H. Ahlström, P.M. Lind, Bisphenol A is related to circulating levels of adiponectin, leptin and ghrelin, but not to fat mass or fat distribution in humans. Chemosphere, 2014. 112: p. 42-48.
  • 58. Wang, T., M. Li, B. Chen, M. Xu, Y. Xu, Y. Huang, J. Lu, Y. Chen, W. Wang, X. Li, Y. Liu, Y. Bi, S. Lai, G. Ning, Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 2012. 97: p. 223-227.
  • 59. Andra, S.S., K.C. Makris, Association between urinary levels of bisphenol A and its monochlorinated derivative and obesity. Journal of Environmental Science and Health Part A, 2015. 50: p. 1169-1179.
  • 60. Zhao, H.Y., Y.F. Bi, L.Y. Ma, L. Zhao, T.G. Wang, L.Z. Zhang, B. Tao, L.H. Sun, Y.J. Zhao, W.Q. Wang, X.Y. Li, M.Y. Xu, J.L. Chen, G. Ning, J.M. Liu, The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women. Clinical Biochemistry, 2012. 45: p. 1602-1606.
  • 61. Metwally, F.M., M.M. Mohamed, N.E. Sharaf, M.A. Ghazy, A.M. El Mishad, A. Elfiky, The Impact of bisphenol A (BPA) as environmental obesogen on lipids and lipids metabolism. International Journal of Pharmaceutical and Clinical Research, 2016. 8: p. 1323-1330.
  • 62. Mahalingaiah, S., J.D. Meeker, K.R. Pearson, A.M. Calafat, X. Ye, J. Petrozza, R. Hauser, Temporal variability and predictors of urinary bisphenol A concentrations in men and women. Environmental Health Perspectives, 2008. 116: p. 173-178.
  • 63. Liu, B., H.J. Lehmler, Y. Sun, G. Xu, Y. Liu, G. Zong, Q. Sun, F.B. Hu, R.B. Wallace, W. Bao, Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study. Lancet Planet Health, 2017. 1: p. 114–122.
  • 64. Bhandari, R., J. Xiao, A. Shankar, Urinary bisphenol A and obesity in US children. American Journal of Epidemiology, 2013. 177(11): p. 1263-1270.
  • 65. Erkan, T., Yalvac, S., Erginoz, E., Cokugras, F., Kutlu, T., The evaluation of nutritional status of children, by anthropometric measurements, attending the day nursery of Cerrahpasa Medical School. Türk Pediatri Arşivi, 2007. 42: p. 142-147.
  • 66. Akca, S.O., Uysal, G., Buyukgonenc, L.A., Obesitiy in nursery school children in Corum, Turkey. Iranian Red Crescent Medical Journal, 2016. 18: p. 1-6.
  • 67. Karaoglan, D., Tansel, A., Determinants of obesity in Turkey: a quantile regression analysis from a developing country. MPRA, 2017. 16: p. 1-19.
  • 68. Alper, Z., Ercan, İ., Uncu, Y., A meta-analysis and an evaluation of trends in obesity prevalence among children and adolescents in Turkey: 1990 through 2015. Journal Of Clinical Research İn Pediatric Endocrinology, 2018. 10: p. 59-67.
  • 69. Battal, D., Cok, I., Unlusayin, I., Aktas, A., Tunctan, B., Determination of urinary levels of Bisphenol A in a Turkish population. Environmental Monitoring and Assessment, 2014. 186: p. 8443-8452.
  • 70. Öztürk, Y., Etiology and comorbidities of childhood obesity. The Turkish Journal of Gastroenterology, 2017. 28: p. 149-151.
  • 71. Bulus¸ A.D., Aşci, A., Erkekoglu, P., Balci, A., Andiran, N., Koçer-Gümüşel, B., The evaluation of possible role of endocrine disruptors in central and peripheral precocious puberty. Toxicology Mechanisms and Methods, 2016. 26: p. 493-500.
  • 72. Durmaz, E., Asci, A., Erkekoglu, P., Balcı, A., Bircan, I., Koçer-Gumusel, B., Urinary bisphenol A levels in Turkish girls with premature thelarche. Human and Experimental Toxicology, 2018. (article in press).
  • 73. Erem, C., Prevalence of overweight and obesity in Turkey. IJC Metabolic & Endocrine, 2015. 8: p. 38-41.
  • 74. Şenyıldız, M., Karaman, E.F., Baş, S.S., Pirinççi, P.A., Özden, S., Alteration on global and gene-spesific DNA methylation and global histone modifications in HepG2 cells in response to BPA. İstanbul Eczacilık Fakültesi Dergisi, 2016. 46: p. 97-114.
  • 75. Durmaz, E., Aşçı, A., Erkekoğlu, P., Akçurin, S., Koçer Gümüşel, B., Bircan, I., Urinary Bisphenol A levels in girls with idiopathic central precocious puberty. Journal Of Clinical Research İn Pediatric Endocrinology,2014. 6: p. 16-21.
  • 76. Yalçın, S., Yalçın, S.S., Bisphenol A Exposure and anthropometry in Turkish children aged 8-9 years in Konya, in 15th International Conference on Environmental Science and Technology 2017: Rhodes, p. 1-4.
  • 77. Ozcebe, H., Bosi, T.B., Yardim, N., Ertuğrul, Ç., Nermin, Ç., Bekir, K., Seçil, Ö., Türkiye’ de çocuklarda fazla kiloluluk ve şişmanlık prevalansları. TSK Koruyucu Hekimlik Bülteni, 2015. 14: p. 145-152.
  • 78. Topçu, S., Orhon, F.Ş., tayfun, M., Uçaktürk, S.A., Demirel, F., Anxiety, depression and self-esteem levels in obese children: a case-control study. Journal of Pediatric Endocrinology and Metabolism, 2016. 29: p. 357-361.
  • 79. Balcı, A., Erkekoğlu, P., Koçer-Gümüşel, B., Endokrin bozucu kimyasallar ve obezite arasındaki ilişkinin değerlendirilmesi-I: ftalatlar ve Bisfenol A. Eczacılık Bilimleri Dergisi, 2014. 3: p. 1-16.
  • 80. Turhan, E., Tözün, M., Doğanay, S., İzmir’e bağlı dokuz ilçede ilköğretim birinci sınıf öğrencilerinde obezite sıklığı. Journal of Clinical and Analytical Medicine, 2015. 6: p. 755-759.
  • 81. Polat, M., Yıkılkan, H., Aypak, C., Görpelioğlu, S., The relationship between BMI and blood pressure in children aged 7-12 years in Ankara, Turkey. Public Health Nutrition, 2014. 17: p. 2419-2424.
  • 82. Demirci, H., Nuhoglu, C., Ursavas, I.S., Isildak, S., Basaran, E.O., Kilic, M.Y., Obesity and asymptomatic hypertension among children aged 6-13 years living in Bursa, Turkey. Family Practice, 2013. 30: p. 629-633.
  • 83. Kaya, M., Sayan, A., Birinci, M., Yildiz, M., Turkmen, K., The obesity prevalence among students between the ages of 5 and 19 in Kutahya. Turkish Journal of Medical Sciences, 2014. 44: p. 10-15.
  • 84. Özdal, T., Yeşilcubuk, N.Ş., Toxicity of Bisphenol-A: effects on health and regulations. International Journal of Agricultural and Biosystems Engineering, 2014. 8: p. 553-557.
  • 85. Pektas, S.D., Yilmaz, N., Kivrak, I., Increased serum levels of Bisphenol A and Betatrophin in patients with psoriasis. Medicine Science, 2018. (article in press).
  • 86. Nappi, F., Barrea, L., Somma, C.D., Savanelli, M.C., Muscogiuri, G., Orio, F., Savastano, S., Endocrine aspects of environmental “Obesogen” pollutants. International Journal of Environmental Research and Public Health, 2016. 13: p. 1-16.
  • 87. Akın, L., Kendirci, M., Narin, F., Kurtoglu, S., Saraymen, R., Kondolot, M., Koçak, S., Elmalı, F., The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls. Acta Paediatrica, 2015. 104: p. 171-177.
  • 88. Turan, S., Omar, A., Berber, M., Ozen, A., Bereket, A., Effect of socio-economical condition and age on prevalence of obesity, in Proceedings of the IX. National Pediatric Endocrinology Congress 2004: Malatya, p. PP F-2.
  • 89. Turkkahraman, D., Bircan, I., Tosun, O., Saka, O., Prevalence and risk factors of obesity in school children in Antalya, Turkey. Saudi Medical Journal, 2006. 27: p. 1028-1033.
  • 90. Uckun-Kitapci, A., Tezic, T., Firat, S., Sipahi, T., Barrier, R., Edwards, L.J., Calikoglu, A.S., Obesity and type 2 diabetes mellitus: a population-based study of adolescents. Journal of Pediatric Endocrinology and Metabolism, 2004. 17: p. 1633-1640.
  • 91. Krassas, G.E., Tsametis, C., Baleki, V., Constantinidis, T., Unluhizarci, K., Kurtoglu, S., Kelestimut, F., Prevalence of overweight and obesity among children and adolescents in Thessaloniki-Greece and Kayseri-Turkey. Pediatric Endocrinology Reviews, 2004. 1: p. 460-464.
  • 92. Discigil, G., Tekin, N., Soylemez, A., Obesity in Turkish children and adolescents: prevalence and non-nutritional correlates in an urban sample. Child: Care, Health and Development, 2009. 35: p. 153-158.
  • 93. Pirincci, E., Durmus, B., Gundogdu, C., Acik, Y., Prevalence and risk factors of overweight and obesity among urban school children in Elazig city, Eastern Turkey, 2007. Annals of Human Biology, 2010. 37: p. 44-56.
  • 94. Sağlam, H., Tarim, O., Prevalence and correlates of obesity in schoolchildren from the city of Bursa, Turkey. Journal of Clinical Research in Pediatric Endocrinology, 2008. 1: p. 80-88.
  • 95. Simsek, E., Akpinar, S., Bahcebasi, T., Senses, D.A., Kocabay, K., The prevalence of overweight and obese children aged 6-17 years in the West Black Sea region of Turkey. International Journal of Clinical Practice, 2008. 62: p. 1033-1038.
  • 96. Kalkan-Ucar, S., Dizdarer, C., Darcan, S., Korkmaz, S., Ergudenler, Y., Asilsoy, S., Bilgili, G., Ozcan, T., Goksen Simsek, D., Coker, M., Prevalence of obesity and overweight among children in İzmir, Turkey: effects of nutritional and socio-economic factors. Obesity and Metablolism, 2009. 5: p. 99-106.
  • 97. Cizmecioglu, F.M., Etiler, N., Hamzaoglu, O., Hatun, S., Prevalence of metabolic syndrome in schoolchildren and adolescents in Turkey: a population-based study. Journal of Pediatric Endocrinology and Metabolism, 2009. 22: p. 703-714.
  • 98. Dündar, C., Öz, H., Obesity-related factors in Turkish school children. Scientific World Journal, 2012. 2012: p. 353485.
  • 99. Kondolot, M., Balci, E., Ozturk, A., Mazicioglu, M.M., Hatipoglı, N., Kurtoglu, S., Ustunbas, H.B., Body mass index percentiles for Turkish children aged 0-84 months. Annals of Human Biology, 2011. 38: p. 676–680.
  • 100. Yuca, A.S., Yilmaz, C., Cesur, Y., Dogan, M., Kaya, A., Basaranoglu, M., Prevalence of overweight and obesity in children and adolescents in eastern Turkey. Journal of Clinical Research in Pediatric Endocrinology, 2010. 2: p. 159-163.
  • 101. Ercan, S., Dallar, Y.B., Önen, S., Engiz, Ö., Prevalence of obesity and associated risk factors among adolescents in Ankara, Turkey. Journal of Clinical Research in Pediatric Endocrinology, 2012. 4: p. 204-207.
  • 102. Inanç, B.B., Sahin, D.S., Oğuzöncül, A.F., Bindak, R., Mungan, F., Prevalence of obesity in elementary schools inMardin, South-eastern of Turkey: a preliminary study. Balkan Medical Journal, 2012. 29: p. 424-430.
  • 103. Ustu, Y., Uğurlu, M., Aslan, O., Aksoy, Y.M., Kasim, I., Egici, M.T., Sanisoglu, S.Y. High prevalence of obesity in Tokat, a Northern Province of Turkey. Journal of the Pakistan Medical Association, 2012. 62: p. 435-440.
  • 104. Ünal, B., Sözmen, K., Uçku, R., Ergör, G., Soysal, A., Baydur, H., Meseri, R., Şimşek, H., Gerçeklioğlu, G., Doğanay, S., Budak, R., Kiliç, B., Günay, T., Ergör, A., Demiral, Y., Aslan, Ö., Çimrin, D., Akvardar, Y., Tuncel, P., High prevalence of cardiovascular risk factors in a western urban Turkish population: a community-based study. Anadolu Kardiyoloji Dergisi, 2013. 13: p. 9-17.
  • 105. OECD, 2017. [cited 2018 29 May]; Available from: http://www.oecd.org/health/obesity.update.htm
There are 105 citations in total.

Details

Primary Language English
Journal Section Review Articles
Authors

Hakan Çelebi

Gülden Gök

Özlem Güllü This is me

Oğuzhan Gök

Publication Date August 15, 2018
Submission Date March 7, 2018
Acceptance Date June 19, 2018
Published in Issue Year 2018 Volume: 2 Issue: 2

Cite

APA Çelebi, H., Gök, G., Güllü, Ö., Gök, O. (2018). Examination of the obesogenic effects of Bisphenol-A. International Advanced Researches and Engineering Journal, 2(2), 185-194.
AMA Çelebi H, Gök G, Güllü Ö, Gök O. Examination of the obesogenic effects of Bisphenol-A. Int. Adv. Res. Eng. J. August 2018;2(2):185-194.
Chicago Çelebi, Hakan, Gülden Gök, Özlem Güllü, and Oğuzhan Gök. “Examination of the Obesogenic Effects of Bisphenol-A”. International Advanced Researches and Engineering Journal 2, no. 2 (August 2018): 185-94.
EndNote Çelebi H, Gök G, Güllü Ö, Gök O (August 1, 2018) Examination of the obesogenic effects of Bisphenol-A. International Advanced Researches and Engineering Journal 2 2 185–194.
IEEE H. Çelebi, G. Gök, Ö. Güllü, and O. Gök, “Examination of the obesogenic effects of Bisphenol-A”, Int. Adv. Res. Eng. J., vol. 2, no. 2, pp. 185–194, 2018.
ISNAD Çelebi, Hakan et al. “Examination of the Obesogenic Effects of Bisphenol-A”. International Advanced Researches and Engineering Journal 2/2 (August 2018), 185-194.
JAMA Çelebi H, Gök G, Güllü Ö, Gök O. Examination of the obesogenic effects of Bisphenol-A. Int. Adv. Res. Eng. J. 2018;2:185–194.
MLA Çelebi, Hakan et al. “Examination of the Obesogenic Effects of Bisphenol-A”. International Advanced Researches and Engineering Journal, vol. 2, no. 2, 2018, pp. 185-94.
Vancouver Çelebi H, Gök G, Güllü Ö, Gök O. Examination of the obesogenic effects of Bisphenol-A. Int. Adv. Res. Eng. J. 2018;2(2):185-94.



Creative Commons License

Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.