Synthesis and stability analysis of folic acid-graphene oxide nanoparticles for drug delivery and targeted cancer therapies

Year 2019, Volume: 3 Issue: 2, 81 - 85, 15.08.2019

Neşe Keklikcioğlu Çakmak , Mustafa Küçükyazıcı Atakan Eroğlu

https://doi.org/10.35860/iarej.411717

Cited By: 11

Abstract

Cancer is the growth and proliferation of damage-ending
cells in an uncontrolled or abnormal way. Today, it takes place among the most
important health problems around the world and in our country. Surgery,
radiotherapy, and chemotherapy are the main treatment methods in cancer
treatment. The development of resistance to chemotherapeutic medicines has led
scientists to investigate this issue as well as the drug’s ability to reach the
targeted tumor site and destroying cancer cells in addition to normal cells.
The production of various nanostructures for anticancer drug development has
been one of the most important areas of nanomedicine. Thus, in the present
research, the improved Hummers’ method was employed for the synthesis of graphene
oxide nanoparticle (NGO), and it was activated by the folic acid (FA) antibody
to increase targeting ability after attachment of the drug to the nanostructure
systems. SEM, FTIR, XRD, UV/Vis spectroscopy, and
zeta potential analysis were performed for characterization of the products.
The highest absorbance of the FA-NGO/DIW nanostructures produced at the
concentration of 0.01 mg/ml-0.05 mg/ml synthesized by the Hummers’ method and in
the UV/Vis spectra, peaks at 232 nm and 270 nm corresponds to NGO-DIW and
FA-NGO/DIW, respectively. The zeta potential value above 35 mV was obtained in
all measurements, and the NGO-DIW and NGO-FA-DIW samples
maintained stability for days. These findings are consistent with the
few studies in the literature, and this study will guide future studies in
which nanoparticle systems will be directed to the target by binding
chemotherapeutic drugs. 

Keywords

Cancer, nano-graphene oxide, folic acid, nano-drug delivery systems, zeta potential

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