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Kök hücreyi tanıyalım

Year 2016, Volume: 1 Issue: 1, 19 - 28, 01.02.2016

Utku Ateş

Abstract

1960’lı yıllarda kemik iliği kök hücreleri ile başlayan kök hücrenin hastalıklarda tedavi amaçlı kullanılma umudu; bugün halen devam etmektedir. Kök hücrelerin uygun uyaranlar altında farklılaşmış hücrelere dönüşebilme yetenekleri bilim dünyası açısından dikkat çekicidir. Pluripotent veya multipotent kök hücreler daha sonra belirli hücre dizilerine farklılaşacak progenitor hücreleri oluştururlar. Kök hücre tipleri ve özellikleri bu yazıda tartışılacaktır.

Keywords

Gelecek kök hücre tedavi

References

  • Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981;292:154-6.
  • Thomson JA, Kalishman J, Golos TG, Durning M, Harris CP, Becker RA, et al. Isolation of a primate embryonic stem cell line. Proc Natl Acad Sci USA 1995;92:7844-8.
  • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7.
  • Martin-Rendon E, Watt SM. Stem cell plasticity. Br J Haematol 2003;122:877-91.
  • Martin-Rendon E, Watt SM. Stem cell plasticity. Br J Haematol 2003;122:877-91.
  • Patapoutian A, Wold BJ, Wagner RA. Evidence for developmentally programmed transdifferentiation in mouse esophageal muscle. Science 1995;270:1818-21.
  • Campbell KH, McWhir J, Ritchie WA, Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature 1996;380:64-6.
  • Amabile G, Meissner A. Induced pluripotent stem cells: current progress and potential for regenerative medicine. Trends Mol Med 2009;15:59-68
  • Wobus AM. Potential of embryonic stem cells. Mol Aspects Med 2001;22:149-64.
  • Trounson A. The production and directed differentiation of human embryonic stem cells. Endocr Rev 2006;27:208-19.
  • Durand C, Dzierzak E. Embryonic beginnings of adult hematopoietic stem cells. Haematologica 2005;90:100-8.
  • Dieterlen-Lièvre F, Pardanaud L, Bollerot K, Jaffredo T. Hemangioblasts and hemopoietic stem cells during ontogeny. C R Biol 2002;325:1013-20.
  • Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7.
  • Reyes M, Dudek A, Jahagirdar B, Koodie L, Marker PH, Verfaillie CM. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest 2002;109:337-46.
  • Can A. Haematopoietic stem cells niches: interrelations between structure and function. Transfus Apher Sci 2008;38:261-8.
  • Ross J, Li L. Recent advances in understanding extrinsic control of hematopoietic stem cell fate. Curr Opin Hematol 2006;13:237-42.
  • Li Z, Li L. Understanding hematopoietic stem-cell microenvironments. Trends Biochem Sci 2006;31:589-95.
  • Mezey E, Key S, Vogelsang G, Szalayova I, Lange GD, Crain B. Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci USA 2003;100:1364-9.
  • Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001;7:430-6.
  • Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 2003;361:45-6.
  • Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003;107:2294-302.
  • Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6:1229-34.
  • Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6:1229-34.
  • Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia A, Jacob J, et al. Hepatocytes from non-hepatic adult stem cells. Nature 2000;406:257.
  • Ianus A, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003;111:843-50.
  • Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-77.
  • Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, et al. Osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Pept 2007;142:16-23.
  • Pansky A, Roitzheim B, Tobiasch E. Differentiation potential of adult human mesenchymal stem cells. Clin Lab 2007;53:81-4.
  • İnan S, Özbilgin K. Kök hücre: Biyolojik ve klinik yaklaşım. Sağlıkta Birikim Dergisi 2009;1:57-65.
  • Caplan AI. Mesenchymal stem cells. J Orthop Res 1991;9:641-50.
  • Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 1992;13:69-80.
  • Erickson GR, Gimble JM, Franklin DM, Rice HE, Awad H, Guilak F. Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Commun 2002;290:763-9.
  • Toma JG, Akhavan M, Fernandes KJ, Barnabé-Heider F, Sadikot A, Kaplan DR, et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001;3:778-84.
  • Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364:149-55.
  • Ünal Ş, Uçkan Çetinkaya D. Mezenkimal kök hücrelerin pediatride klinik uygulama alanları. Turkiye Klinikleri J Hem Onc-Special Topics 2008;1:57-61.
  • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-7.
  • Kim N, Cho SG. Clinical applications of mesenchymal stem cells. Korean J Intern Med 2013;28:387-402.
  • Wang S, Qu X, Zhao RC. Clinical applications of mesenchymal stem cells. J Hematol Oncol 2012;5:19.
  • Ringdén O, Uzunel M, Rasmusson I, Remberger M, Sundberg B, Lönnies H, et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006;81:1390-7.
  • Fang B, Song Y, Liao L, Zhang Y, Zhao RC. Favorable response to human adipose tissue-derived mesenchymal stem cells in steroid-refractory acute graft-versus-host disease. Transplant Proc 2007;39:3358-62.

Year 2016, Volume: 1 Issue: 1, 19 - 28, 01.02.2016

Utku Ateş

Abstract

References

  • Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981;292:154-6.
  • Thomson JA, Kalishman J, Golos TG, Durning M, Harris CP, Becker RA, et al. Isolation of a primate embryonic stem cell line. Proc Natl Acad Sci USA 1995;92:7844-8.
  • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7.
  • Martin-Rendon E, Watt SM. Stem cell plasticity. Br J Haematol 2003;122:877-91.
  • Martin-Rendon E, Watt SM. Stem cell plasticity. Br J Haematol 2003;122:877-91.
  • Patapoutian A, Wold BJ, Wagner RA. Evidence for developmentally programmed transdifferentiation in mouse esophageal muscle. Science 1995;270:1818-21.
  • Campbell KH, McWhir J, Ritchie WA, Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature 1996;380:64-6.
  • Amabile G, Meissner A. Induced pluripotent stem cells: current progress and potential for regenerative medicine. Trends Mol Med 2009;15:59-68
  • Wobus AM. Potential of embryonic stem cells. Mol Aspects Med 2001;22:149-64.
  • Trounson A. The production and directed differentiation of human embryonic stem cells. Endocr Rev 2006;27:208-19.
  • Durand C, Dzierzak E. Embryonic beginnings of adult hematopoietic stem cells. Haematologica 2005;90:100-8.
  • Dieterlen-Lièvre F, Pardanaud L, Bollerot K, Jaffredo T. Hemangioblasts and hemopoietic stem cells during ontogeny. C R Biol 2002;325:1013-20.
  • Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7.
  • Reyes M, Dudek A, Jahagirdar B, Koodie L, Marker PH, Verfaillie CM. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest 2002;109:337-46.
  • Can A. Haematopoietic stem cells niches: interrelations between structure and function. Transfus Apher Sci 2008;38:261-8.
  • Ross J, Li L. Recent advances in understanding extrinsic control of hematopoietic stem cell fate. Curr Opin Hematol 2006;13:237-42.
  • Li Z, Li L. Understanding hematopoietic stem-cell microenvironments. Trends Biochem Sci 2006;31:589-95.
  • Mezey E, Key S, Vogelsang G, Szalayova I, Lange GD, Crain B. Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci USA 2003;100:1364-9.
  • Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001;7:430-6.
  • Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 2003;361:45-6.
  • Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003;107:2294-302.
  • Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6:1229-34.
  • Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6:1229-34.
  • Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia A, Jacob J, et al. Hepatocytes from non-hepatic adult stem cells. Nature 2000;406:257.
  • Ianus A, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003;111:843-50.
  • Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-77.
  • Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, et al. Osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Pept 2007;142:16-23.
  • Pansky A, Roitzheim B, Tobiasch E. Differentiation potential of adult human mesenchymal stem cells. Clin Lab 2007;53:81-4.
  • İnan S, Özbilgin K. Kök hücre: Biyolojik ve klinik yaklaşım. Sağlıkta Birikim Dergisi 2009;1:57-65.
  • Caplan AI. Mesenchymal stem cells. J Orthop Res 1991;9:641-50.
  • Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 1992;13:69-80.
  • Erickson GR, Gimble JM, Franklin DM, Rice HE, Awad H, Guilak F. Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Commun 2002;290:763-9.
  • Toma JG, Akhavan M, Fernandes KJ, Barnabé-Heider F, Sadikot A, Kaplan DR, et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001;3:778-84.
  • Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364:149-55.
  • Ünal Ş, Uçkan Çetinkaya D. Mezenkimal kök hücrelerin pediatride klinik uygulama alanları. Turkiye Klinikleri J Hem Onc-Special Topics 2008;1:57-61.
  • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-7.
  • Kim N, Cho SG. Clinical applications of mesenchymal stem cells. Korean J Intern Med 2013;28:387-402.
  • Wang S, Qu X, Zhao RC. Clinical applications of mesenchymal stem cells. J Hematol Oncol 2012;5:19.
  • Ringdén O, Uzunel M, Rasmusson I, Remberger M, Sundberg B, Lönnies H, et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006;81:1390-7.
  • Fang B, Song Y, Liao L, Zhang Y, Zhao RC. Favorable response to human adipose tissue-derived mesenchymal stem cells in steroid-refractory acute graft-versus-host disease. Transplant Proc 2007;39:3358-62.
There are 40 citations in total.

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Journal Section Articles
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Utku Ateş This is me

Publication Date February 1, 2016
Published in Issue Year 2016 Volume: 1 Issue: 1

Cite

APA Ateş, U. (2016). Kök hücreyi tanıyalım. İstanbul Bilim Üniversitesi Florence Nightingale Transplantasyon Dergisi, 1(1), 19-28. https://doi.org/10.5606/fng.transplantasyon.2016.004
AMA Ateş U. Kök hücreyi tanıyalım. İstanbul Bilim Üniversitesi Florence Nightingale Transplantasyon Dergisi. February 2016;1(1):19-28. doi:10.5606/fng.transplantasyon.2016.004
Chicago Ateş, Utku. “Kök hücreyi tanıyalım”. İstanbul Bilim Üniversitesi Florence Nightingale Transplantasyon Dergisi 1, no. 1 (February 2016): 19-28. https://doi.org/10.5606/fng.transplantasyon.2016.004.
EndNote Ateş U (February 1, 2016) Kök hücreyi tanıyalım. İstanbul Bilim Üniversitesi Florence Nightingale Transplantasyon Dergisi 1 1 19–28.
IEEE U. Ateş, “Kök hücreyi tanıyalım”, İstanbul Bilim Üniversitesi Florence Nightingale Transplantasyon Dergisi, vol. 1, no. 1, pp. 19–28, 2016, doi: 10.5606/fng.transplantasyon.2016.004.
ISNAD Ateş, Utku. “Kök hücreyi tanıyalım”. İstanbul Bilim Üniversitesi Florence Nightingale Transplantasyon Dergisi 1/1 (February 2016), 19-28. https://doi.org/10.5606/fng.transplantasyon.2016.004.
JAMA Ateş U. Kök hücreyi tanıyalım. İstanbul Bilim Üniversitesi Florence Nightingale Transplantasyon Dergisi. 2016;1:19–28.
MLA Ateş, Utku. “Kök hücreyi tanıyalım”. İstanbul Bilim Üniversitesi Florence Nightingale Transplantasyon Dergisi, vol. 1, no. 1, 2016, pp. 19-28, doi:10.5606/fng.transplantasyon.2016.004.
Vancouver Ateş U. Kök hücreyi tanıyalım. İstanbul Bilim Üniversitesi Florence Nightingale Transplantasyon Dergisi. 2016;1(1):19-28.
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