Synthesis and Characterization of Oleic Acid Coated Magnetic Nanoparticles for Hyperthermia Applications

Abstract

In this study, we aimed to synthesize stable dispersions of iron oxide nanoparticles (IONs) coated with different amounts of oleic acid (OA) suitable for magnetic nano hyperthermia applications. For this purpose, bare and different amounts of oleic acid (0.2%, 0.5% and 1.0%, v/v) coated IONs were prepared by co-precipitation method. Then, their structures, morphologies, magnetic properties and heating abilities were characterized by using suitable techniques. IONs+1.0%OA nanoparticles showed low agglomeration with high dispersion capacity. Moreover, 1.0% OA coating showed the highest heating ability with a temperature increase of (25.2 °C) compared to IONs+OA (0.2%, 16.4 °C; 0.5%, 19 °C), but similar with bare IONs (26.7 °C). The specific absorption rate (SAR) values of bare IONs and IONs+OA (0.2%, 0.5%, 1.0% v/v) were found as 39.50, 34.81, 23.36 and 45.98 W/g, respectively. Our results showed that the comparable hyperthermia effect of IONs+1.0%OA with bare IONs was attributable to their uniform dispersion performance along with higher SAR values. We concluded that the dispersion of hydrophobic IONs+OA in an aqueous medium is one of the critical requirements for increasing temperature in magnetic nano hyperthermia applications.

Keywords

• Iron oxide nanoparticles,magnetic hyperthermia,oleic acid coated,co precipitation

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