The Hidden Face of Obesity: The Role of Inflammation

Year 2025, Volume: 3 Issue: 1, 20 - 27, 06.05.2025

Yaren Aray , Gözde Dumlu Bilgin

Abstract

Aim: This study explores the interaction between elevated proinflammatory cytokines, part of the body’s inflammatory response, and obesity, also known as low-grade inflammation. The aim is to clarify whether the increased levels of adipocytokines contribute to the development of obesity or if obesity itself enhances the production of adipocytokines. Understanding the reciprocal relationship between these two factors could facilitate the development of new strategies for preventing and treating obesity-related complications. Results: In people with obesity, changes occur in various metabolic pathways as the body’s energy balance shifts, with inflammation being the primary driver of these alterations. Inflammation influences key adipokines such as adiponectin and leptin and interacts with other biological processes. The literature suggests that a diet rich in complex carbohydrates, high fiber, and low glycemic index foods is linked to reduced proinflammatory cytokines. The Mediterranean and anti-inflammatory diets are clinically recommended for managing inflammation. However, determining the root cause of inflammation requires a detailed exploration of several interconnected mechanisms. Conclusion: Determining the root cause of inflammation requires thorough examination. The ongoing debate is whether increased cytokine inflammatory responses trigger obesity, or whether obesity itself initiates inflammation by amplifying cytokine responses. Further research is needed to clarify the long-term implications of this complex relationship.

Keywords

Adipocytokines , Cytokines , Inflammation , Nutrition , obesity

Obezitenin Gizli Yüzü: İnflamasyonun Rolü

Abstract

Amaç: Bu çalışma, vücudun inflamatuar tepkisinin bir parçası olan yüksek proinflamatuar sitokinler ile düşük dereceli inflamasyon olarak da bilinen obezite arasındaki etkileşimi araştırmaktadır. Amaç, artan adipositokin seviyelerinin obezitenin gelişimine katkıda bulunup bulunmadığını veya obezitenin kendisinin adipositokinlerin üretimini artırıp artırmadığını açıklığa kavuşturmaktır. Bu iki faktör arasındaki karşılıklı ilişkinin anlaşılması, obeziteye bağlı komplikasyonların önlenmesi ve tedavisi için yeni stratejilerin geliştirilmesini kolaylaştırabilir. Bulgular: Obezitesi olan kişilerde, vücudun enerji dengesi değiştikçe çeşitli metabolik yollarda değişiklikler meydana gelir ve bu değişikliklerin birincil itici gücü inflamasyondur. İnflamasyon, adiponektin ve leptin gibi temel adipokinleri etkiler ve diğer biyolojik süreçlerle etkileşime girer. Literatür, kompleks karbonhidratlar, yüksek lif ve düşük glisemik indeksli gıdalar açısından zengin bir diyetin proinflamatuar sitokinlerin azalmasıyla bağlantılı olduğunu göstermektedir. Akdeniz diyeti ve anti-inflamatuar diyetler, inflamasyonu yönetmek için klinik olarak önerilmektedir. Bununla birlikte, inflamasyonun temel nedenini belirlemek, birbirine bağlı çeşitli mekanizmaların ayrıntılı bir şekilde araştırılmasını gerektirir. Sonuç: İnflamasyonun temel nedenini belirlemek kapsamlı bir inceleme gerektirir. Devam eden tartışma, artan sitokin inflamatuar yanıtlarının mı obeziteyi tetiklediği, yoksa obezitenin kendisinin mi sitokin yanıtlarını güçlendirerek inflamasyonu başlattığıdır. Bu konuyu açıklığa kavuşturmak için daha fazla araştırmaya ihtiyaç vardır.

Keywords

Adipositokinler , beslenme , sitokinler , inflamasyon , obezite

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