BENİGN VE MALİGN AKCİĞER HASTALARINDA BRONKOALVEOLAR LAVAJ SIVISI BİYOKİMYASAL PARAMETRELERİNİN TANISAL DEĞERİ

Year 2002, Volume: 16 Issue: 2, 1 - 10, 01.10.2002

Özlem Ediboğlu Fevziye Tuksavul Dilek Kalenci Salih Güçlü Mehmet Gülpek

Abstract

Çalışmada benign ve malign akciğer hastalıklarında BAL sıvısındaki üre, ALP ve LDH'ın tanısal değerinin araştırılması amaçlandı. Çalışmaya toplam 63 hasta alındı. Bunların 25'i periferik akciğer tümörü olup malign grubu; 38'i ise benign grubu oluşturdu. Benign grupta 13 tüberküloz (Tb), 18 pnömoni, 3 kronik obstrüktif akciğer hastalığı (KOAH), 4 interstisyel akciğer hastalığı olgusu yer almaktaydı. Tüm olgulara belirlenen uygun lokalizasyondan BAL yapıldı. Eşzamanlı alınan kanla birlikte BAL sıvısında üre, ALP, LDH parametreleri ölçüldü. Malign grupta üre hem kan, hem BAL sıvısında; benign grupta ALP sadece BAL sıvısında yüksek saptandı. Sonuçlar anlamlıydı (p< 0.05). LDH değerleri iki grup arasında farklı değildi (p> 0.05).LDH değerleri iki grup arasında farklı değildi

Keywords

Bronkoalveolar Lavaj (BAL), Üre, Alkalen Fosfataz (ALP), Laktik Dehidrogenaz (LDH)

THE DIAGNOSTIC VALUE OF BRONCHOALVEOLAR LAVAGE FLUID BIOCHEMICAL MARKERS IN BENIGN AND MALIGN LUNG DISEASES

Abstract

The aim of this study was to examine the diagnostic contribution of the ALP, LDH and urea in BAL of patients with benign and malign lung disease. BAL was obtained from 63 patients. Patients were divided in two groups, according to final diagnosis, 25 patients with peripherally lung tumor, 38 patients with benign lung disease, tuberculosis (n:13), pneumonia (n:18), chronic bronchitis (n:3) , interstitial lung disease (n:4). BAL was performed in all cases according to radiological location. Urea, ALP and LDH were measured both in BAL and serum which was collected syncronically. In malign group urea levels were significantly higher both in serum and BAL, in benign group ALP were significantly higher only in BAL. The results were significante (p0.05).

Keywords

Bronchoalveolar Lavage, Urea, Alchalen Phosphatase, Lactate Dehydrogenase

References

• 1- Numanoğlu N. (Ed) Solunum Sistemi ve Hastalıkları. 1997:496
• 2- Linder J, Rennard SI. Atlas of Bronchoalveolar Lavage. 1988; 6:28
• 3- Rennard S. I, Spurzem J.R Bronchoalveolar Lavage in the Diagnosis of Lung Cancer. Chest 1992;102(2): 331- 32
• 4- Klech H. (Ed), Pohl W. Technical recommendations and guidelines for bronchoalveolar lavage (BAL). Eur. Respir J.1989(2) :561-85
• 5- Rennard S.I, Basset G. Estimation of Volüme of epithelial lining fluid recovered by lavage using urea as marker of dilution. J. Appl. Physiol 1986;60 (2): 532-38
• 6- Olsen G. N., Gangemi J.D. Bronchoalveolar Lavage and the Immunology of Primary Lung Cancer. Chest/ 87/ 5/ May, 1985, 677- 682
• 7- Özyardımcı N. (Ed) Akciğer Hastalıkları El Kitabı. 200l ;2 : 127-39
• 8- Ettensohn D.B., Jankowski M.J. Bronchoalveolar Lavage in the Normal Volunteer Subject. Chest 1988; 94(2): 275-80
• 9- Dwenger A., Schweitzer G. Bronchoalveolar Lavage Fluid and plasma proteins, Chemiluminescence Response and Protein Contents of Polymorphanuclear leukocytes from blood and Lavage Fluid in Traumatized patients. J. Clin. Chem. Clin. Biochem. 1986; 24: 73-88
• 10- Velluti G, Capelli O. Bronchoalveolar Lavage in the Normal Lung. Respiration 1983; 44: 403-10
• 11- Pozzi E.,Rose De V., Rennard S.I., Fabbri L.M. Chronic bronchitis and emphysema. Eur. Respir J 1990; 3(8):959.
• 12-Griffith D.E., Peterson B.T. Rewash Bronchoalveolar Lavage. Am Rev. Respir Dis 1991; 144: 151-55
• 13- Marcy T. W., Merrill W.W. Limitations of Using Urea to Quantifty Epithelial Lining Fluid Recovered by Bronchoalveolar Lavage. Am. Rev. Respir. Dis. 1987;135:1276- 80
• 14- Baldwin D.R., Wise R. Microlavage: A technique for determining the volume of epithelial lining fluid. Thorax 1991; 46: 658-62
• 15- Samara I,Dimadi M. Biochemical markers in Bronchoalveolar lavage and their diagnostic significance. European Respiratory Journal Abstracts ERS Annual Congress,Geneva,Switzerland, 1988; 12:252-3s.
• 16- Dimadi M, Samara I. Common Biochemical markers in Bronchoalveolar lavage and how they are influenced in patients with lung cancer. European Respiratory Journal Abstracts ERS Annual Congress Madrid, Spain, 1999; 2049: 299 s
• 17- Drent M., Cobben N.A.M., Henderson R.F. BAL fluid LDH activity and LDH isoenzyme pattern in lipoid pneumonia caused by an intravenous injection of lamp oil. Eur. Respir. J.1996 ;9: 2416-18.
• 18- Drent M., Cobben N.A.M., Henderson R.F. Usefulness of lactate dehydrogenase and its izoenzymes as indicators of lung damage or inflamation. Eur. Respir. J, 1996 ;9 1736-42
• 19- Smith RL, Ripps CS. Elevated lactate dehydrogenase values in patients with Pneumocystis carinii pneumonia Chest 1988; 93: 987-92
• 20- Bell R. R.,Soliman M. MRT. Selenium and cadmium induced pulmonary functional impairment and cytotoxicity. Toxicology Letters 1997; 90: 107-14