RİFAMPİSİN VE HEPATOTOKSİSİTE

Year 2003, Volume: 17 Issue: 2, 45 - 50, 01.10.2003

Uğur Gönlügür İbrahim Akkurt

Abstract

Safraya yüksek derecede afinite gösteren bir antibiyotik olan rifampisin antitüberküloz tedavide değerli bir ilaçtır. Toksisitesi esas olarak hepatik ve immünolojiktir. Bununla beraber rifampisin nadiren ciddi toksisiteye neden olmaktadır. Bilirubinin karaciğerce alımını ve atılımını bozduğundan, kullanımının ilk 2-3 haftası esnasında plazma konjuge ve ankonjuge bilirubin düzeylerini yükseltebilir. Tedavi başlandığında karaciğer enzimlerinde ve plazma bilirubininde yükseklik meydana gelebilir ancak bunlar çoğunlukla geçici olup ilacın kesilmesini gerektirmez. Biz bu yazımızda rifampisinin neden olduğu hepatotoksisiteyi inceledik.

Keywords

Rifampisin, hepatotoksisite, bilirubin

RIFAMPICIN AND HEPATOTOXICITY

Abstract

Rifampicin, a highly cholephilic antibiotic, is a valuable drug for antituberculous therapy. Its toxicity is predominantly hepatic and immunologic. However, rifampicin rarely causes serious toxicity. It impairs hepatic uptake and excretion of bilirubin; plasma conjugated and unconjugated bilirubin levels may be elevated during the first 2-3 weeks of dosing. Rises in plasma bilirubin and hepatic enzymes may occur when treatment starts but are often transient and not necessarily an indication for stopping the drug. We reviewed rifampicin-induced hepatotoxicity in this paper.

Keywords

Rifampicin, hepatotoxicity, bilirubin

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