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TORAKS BİLGİSAYARLI TOMOGRAFİ EŞLİĞİNDE ANINDA SİTOPATOPLOJİK DEĞERLENDİRME YAPILAN TRANSTORASİK İNCE İĞNE ASPİRASYON BİOPSİSİ SONUÇLARIMIZ

Year 2005, Volume: 19 Issue: 3, 101 - 106, 01.12.2005

Abstract

Bu çalışmanın amacı; akciğer hastalıklarının tanısında sık kullanılan komplikasyon oranı düşük, basit ve etkin bir tanı yöntemi olan “Toraks Bilgisayarlı Tomografisi (BT) klavuzluğunda transtorasik ince iğne aspirasyon biopsisi”nin (TTİİAB) tanısal verimliliğini ortaya koymaktır. 4 yıllık periotta kliniğimizde 110 olguya BT kılavuzluğunda TTİİAB yapıldı. İşlem 22 Gauge iğne kullanılarak ve premedikasyon uygulanmaksızın gerçekleştirildi. İşlemin tekrarına anında sitopatoljik değerlendirme ile karar verildi. Alınan materyal Hemotoksilen-Eozin ile boyanarak ışık mikroskopisinde incelendi. BT'de periferik lezyon oranı %56.4, santral lezyon oranı %43.6 idi. Olguların %67.3'ünde tanı elde edildi. Benign olguların %12.2'sinde kesin tanı koyuldu. Malign sitoloji tesbit edilen olguların %7.24'ünde tip tayini yapılamadı. Lezyon boyutu ve yapısı (nodül, kitle, infiltrasyon) ile tanı koyma oranı arasında anlamlı ilişki saptanmadı (p=0.25, p=0.31). BT'de lezyonun periferik ya da santral olması tanı koyma oranını önemli ölçüde etkilemedi (p=0.35). Malign olgularda tanı koyma oranı anlamlı ölçüde yüksek bulundu (p=0.00). Sekiz olguda (%7.2) pnomotoraks gelişti. BT'de santral lezyonu olan olgularda komplikasyon gelişme oranı daha yüksek bulundu (p=0.07). TTİİAB sayısı ile komplikasyon gelişimi arasında anlamlı ilişki saptanmadı (p=0.73). Tecrübelerimiz bilgisayarlı tomografi kılavuzluğunda ince iğne aspirasyon biyopsisinin güvenilir ve iyi tolere edilebilen tanı değeri yüksek bir işlem olduğunu göstermektedir.

References

  • Austin JH, Cohen MB. Value of having a cytopathologist present during percutaneous fine needle aspiration biopsy of lung:report of 55 cancer patients and metaanalysis of the literature. AJR 1993; 160(1): 175-7.
  • Baysal T, Mızrak B, Soysal Ö ve ark. BT eflliğinde yapılan TTİİAB’de erken sitolojik değerlendirmenin yeri. Tanısal ve Giriflimsel Radyoloji 2002; 8: 206-10.
  • Dash BK, Tripathy SK. Comparison of accuracy and safety of computed tomografhy guided and unguided transthorasic fine needle aspiration biopsy in diagnosis of lung lesions. J Assoc Phsicians India 2001; 49: 9.
  • Santambrogio L, Nosotti M, Belaviti N, et al. CT–guided percutaneous fine-needle aspira- tion cytology of solitary pulmonary nodules: a prospective, randomized study of immediate cytologic evaluation. Chest 1997; 112(2): 5.
  • Yalçınkaya S, Sayınbafl Ö, Erdoğan Ö. Akci- ğer Lezyonlarında Bilgisayarlı Tomografi Eflli- ğinde Transtorasik İnce İğne Aspirasyon Biop- sisi Sonuçlarımız. Akciğer Arflivi 2002; 4: 182-5.
  • Tolunay fi. Akciğer tanısında kullanılan yöntemler ve patolojik evreleme. Engin K ve Özyardımcı N(ed) Akciğer Kanserleri: Tanı ve tedavide temel ilkeler ve uygulamalar. İstanbul: Avrupa Tıp Kitapçılık Ltd. fiti. 2001: 125-32.
  • Di Dona A, Bazzocchi M, Dolcet F, et al. CT- guided transthorasic needle aspiration of solitary lung lesions.Personal experience in cases. Radiol Med 1995; 89(3): 287-94.
  • Bayramgüler B, Yılmaz A, Anla S. Bilgisayarlı Tomografi Eflliğinde yapılan Transtorasik İnce İğne Aspirasyon Biopsisi Sonuçlarımız. Solunum Hastalıkları 2000; 11: 165-8.
  • Khouri NF, Stitik FP, Erozan YS, et al. Trans- thoracic needle aspiration biopsy of benign and malignant lung lesions. AJR Am J Roentgenol 1985;144(2): 281-8.
  • Moulton JS, Moore. Coaxial percutaneous biopsy technique with automated biopsy devices: value in improving accuracy and negative predictive value. Radiology 1993; (2): 515-22.
  • Solak H, Öztafl S, Ağanoğlu S. Diagnostic value of transthoracic fine needle aspiration biopsy in thoracic lesions. Turkish Respiratory Journal 2001; 2:11-5.
  • Gobien RP, Valicenti JF, Paris BS, Daniell C. Thin-needle aspiration biopsy: methods of increasing the accuracy of a negative pre- diction. Radiology 1982; 145(3): 603-5.
  • Swensen Swensen SJ, Jett JR, Payne WS. An integrated approach to evaluation of the solitary pulmonary nodule. Mayo Clin Proc ; 65(2): 173-86. Westcott JL. Percutaneous transthorasic needle biopsy. Radiology 1988;169: 593-601.
  • Fein AM, Feinsilver, SH, Ares CA. The solitary Pulmonary nodule:A systemıc approach. In Fishman AP (ed). Fishman’s Pulmonary Diseases and Disorders. New York: Mc Graw- Hill Book Company; 1998: 1727-37.
  • Diagnosis and Management of Lung Cancer: ACCP Evidence-based guidelines Chest 2003; (1): 1-337.
  • Odell MJ, Reid KR. Does percutaneus Fine- Needle Aspiration Biopsy Aid in the Diagno- sis and Surgical Management of Lung Masses. Can J Surg 1999; 42: 297-301.
  • Regge D, Gallo T, Gali J, et al. Systemic arterial air embolism and tension pneumothorax two complications of transthoracic percutaneous thin-needle biopsy in the same patient. Eur Radiol 1997; 7: 173-5.
  • Wallace MJ, Krishnamurty S, Broemeling LD, Gupa S, et al. CT –guided percutaneous fine- needle aspiration biopsy of small pulmonary lesions. Radiology 2002; 225(3): 823-8.
  • Perlmutt LM, Johston WW,Dunnick NR. Percu- taneos. Percutaneous fine needle aspiration: a rewiev. AJR 1989; 152: 451-5.
  • Layfield LJ, Coogan A, Johnston WW, Patz EF. Transthoracic fine needle aspiration biopsy. Sensitivity in relation to guidance technique and lesion size and location. Acta Cytol ; 40(4): 687-90. Boiselle PM, Shepard JA, Mark EJ, Szyfelbein WM, et al. Routine addition of an automated biopsy device to fine-needle aspiration of the lung: a prospective assessment. AJR Am J Roentgenol 1997; 169(3): 661-6. Yazıflma Adresi: Dr. Aydan ÇAKAN
  • Dr. Suat Seren Göğüs Hastalıkları ve Cerrahisi Eğitim ve Arafltırma Hastanesi Yeniflehir/İZMİR Tel: 433 33 33/139

RESULTS OF COMPUTED TOMOGRAPHY – GUIDED TRANSTHORACIC FINE NEEDLE ASPIRATION BIOPSY ACCOMPANIED WITH RAPID ONSITE EVALUATION

Year 2005, Volume: 19 Issue: 3, 101 - 106, 01.12.2005

Abstract

The aim of this study is to determine the diagnostic value of thorax computed tomography guided transthoracic fine needle aspiration biopsy (FNAB), a simple and effective method with a low complication risk, commonly used in diagnosis of pulmonary diseases In four year duration 110 cases were performed CT-guided FNAB. The procedure was performed by using 22 Gauge needle without premedication. Repeating of the procedure was decided by rapid onsite evaluation. Obtained materials were examined by light microscopy after being coloured with Haemotoxilen-Eosine. Frequency of peripheral lesion was 56.4% and central lesion was 43.6% on CT. Diagnosis could be obtained in 67.3% of cases. 12.2% of benign cases were specific diagnosed. In 7.24% of cases diagnosed as malign, type was unidentified. There was no significant relationship between the dimensions and structure of lesions (nodule, mass, infiltration) and rate of diagnosis (p=0.25, p=0.31). Peripheral or central localization of the lesion did not alter the rate of diagnosis significantly (p=0.35). Rate of diagnosis was significantly high in malign cases (p=0.00). Pneumothorax occurred in 8 cases (7.2%). Complication rate was high in cases having central lesion on CT (p=0.07). No relation was found between FNAB number and complication rate (p=0.73). Our experiences had shown that CT-guided FNAB is a reliable and well tolerated method having a high diagnostic value.

References

  • Austin JH, Cohen MB. Value of having a cytopathologist present during percutaneous fine needle aspiration biopsy of lung:report of 55 cancer patients and metaanalysis of the literature. AJR 1993; 160(1): 175-7.
  • Baysal T, Mızrak B, Soysal Ö ve ark. BT eflliğinde yapılan TTİİAB’de erken sitolojik değerlendirmenin yeri. Tanısal ve Giriflimsel Radyoloji 2002; 8: 206-10.
  • Dash BK, Tripathy SK. Comparison of accuracy and safety of computed tomografhy guided and unguided transthorasic fine needle aspiration biopsy in diagnosis of lung lesions. J Assoc Phsicians India 2001; 49: 9.
  • Santambrogio L, Nosotti M, Belaviti N, et al. CT–guided percutaneous fine-needle aspira- tion cytology of solitary pulmonary nodules: a prospective, randomized study of immediate cytologic evaluation. Chest 1997; 112(2): 5.
  • Yalçınkaya S, Sayınbafl Ö, Erdoğan Ö. Akci- ğer Lezyonlarında Bilgisayarlı Tomografi Eflli- ğinde Transtorasik İnce İğne Aspirasyon Biop- sisi Sonuçlarımız. Akciğer Arflivi 2002; 4: 182-5.
  • Tolunay fi. Akciğer tanısında kullanılan yöntemler ve patolojik evreleme. Engin K ve Özyardımcı N(ed) Akciğer Kanserleri: Tanı ve tedavide temel ilkeler ve uygulamalar. İstanbul: Avrupa Tıp Kitapçılık Ltd. fiti. 2001: 125-32.
  • Di Dona A, Bazzocchi M, Dolcet F, et al. CT- guided transthorasic needle aspiration of solitary lung lesions.Personal experience in cases. Radiol Med 1995; 89(3): 287-94.
  • Bayramgüler B, Yılmaz A, Anla S. Bilgisayarlı Tomografi Eflliğinde yapılan Transtorasik İnce İğne Aspirasyon Biopsisi Sonuçlarımız. Solunum Hastalıkları 2000; 11: 165-8.
  • Khouri NF, Stitik FP, Erozan YS, et al. Trans- thoracic needle aspiration biopsy of benign and malignant lung lesions. AJR Am J Roentgenol 1985;144(2): 281-8.
  • Moulton JS, Moore. Coaxial percutaneous biopsy technique with automated biopsy devices: value in improving accuracy and negative predictive value. Radiology 1993; (2): 515-22.
  • Solak H, Öztafl S, Ağanoğlu S. Diagnostic value of transthoracic fine needle aspiration biopsy in thoracic lesions. Turkish Respiratory Journal 2001; 2:11-5.
  • Gobien RP, Valicenti JF, Paris BS, Daniell C. Thin-needle aspiration biopsy: methods of increasing the accuracy of a negative pre- diction. Radiology 1982; 145(3): 603-5.
  • Swensen Swensen SJ, Jett JR, Payne WS. An integrated approach to evaluation of the solitary pulmonary nodule. Mayo Clin Proc ; 65(2): 173-86. Westcott JL. Percutaneous transthorasic needle biopsy. Radiology 1988;169: 593-601.
  • Fein AM, Feinsilver, SH, Ares CA. The solitary Pulmonary nodule:A systemıc approach. In Fishman AP (ed). Fishman’s Pulmonary Diseases and Disorders. New York: Mc Graw- Hill Book Company; 1998: 1727-37.
  • Diagnosis and Management of Lung Cancer: ACCP Evidence-based guidelines Chest 2003; (1): 1-337.
  • Odell MJ, Reid KR. Does percutaneus Fine- Needle Aspiration Biopsy Aid in the Diagno- sis and Surgical Management of Lung Masses. Can J Surg 1999; 42: 297-301.
  • Regge D, Gallo T, Gali J, et al. Systemic arterial air embolism and tension pneumothorax two complications of transthoracic percutaneous thin-needle biopsy in the same patient. Eur Radiol 1997; 7: 173-5.
  • Wallace MJ, Krishnamurty S, Broemeling LD, Gupa S, et al. CT –guided percutaneous fine- needle aspiration biopsy of small pulmonary lesions. Radiology 2002; 225(3): 823-8.
  • Perlmutt LM, Johston WW,Dunnick NR. Percu- taneos. Percutaneous fine needle aspiration: a rewiev. AJR 1989; 152: 451-5.
  • Layfield LJ, Coogan A, Johnston WW, Patz EF. Transthoracic fine needle aspiration biopsy. Sensitivity in relation to guidance technique and lesion size and location. Acta Cytol ; 40(4): 687-90. Boiselle PM, Shepard JA, Mark EJ, Szyfelbein WM, et al. Routine addition of an automated biopsy device to fine-needle aspiration of the lung: a prospective assessment. AJR Am J Roentgenol 1997; 169(3): 661-6. Yazıflma Adresi: Dr. Aydan ÇAKAN
  • Dr. Suat Seren Göğüs Hastalıkları ve Cerrahisi Eğitim ve Arafltırma Hastanesi Yeniflehir/İZMİR Tel: 433 33 33/139
There are 21 citations in total.

Details

Other ID JA54CK98TB
Journal Section Research Article
Authors

Aydan Çakan This is me

Mithat Gassaloğlu This is me

İşıl Karasu This is me

Ayşe Özsöz This is me

Ömer Soy This is me

Zekiye Aydoğdu Dinç This is me

Publication Date December 1, 2005
Published in Issue Year 2005 Volume: 19 Issue: 3

Cite

APA Çakan, A., Gassaloğlu, M., Karasu, İ., Özsöz, A., et al. (2005). TORAKS BİLGİSAYARLI TOMOGRAFİ EŞLİĞİNDE ANINDA SİTOPATOPLOJİK DEĞERLENDİRME YAPILAN TRANSTORASİK İNCE İĞNE ASPİRASYON BİOPSİSİ SONUÇLARIMIZ. İzmir Göğüs Hastanesi Dergisi, 19(3), 101-106.