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OUR RESULTS OF THE SURGICAL TREATMENT OF SMALL CELL LUNG CANCER

Year 2006, Volume: 20 Issue: 3, 55 - 60, 01.12.2006

Abstract

The sma 11 cell lung cancer (SCLC) constitutes 20-25% of all lung cancers. In the surgical series, this rate is 2-5%. It is expected that chemotherapy and surgical resection modalities provide longer survival and less local recurrence. In spite of treatment modalities, most of the patients die in two years. In this study, survival rate of the patients who were operated for SCLC evaluated retrospectively. Between January 1990 to June 2003, 512 patients with lung cancer were underwent surgical resection and 15 were SCLC. The mean age was 55.67 ± 13.3 (29-68). All of the patients were male and smoker, except one. Surgical resection performed in 13 cases. Other two cases were unresectable (13.3%). We performed pneumonectomy in four (30.7%), lobectomy in seven (53.8%) and bilobectomy in two cases (15.3%). Histopathological stages were Stage La in one (6.6%), Stage Ib in 5 (33.4%), Stage IIb in 3 (20%), Stage IlIa in 3 (20%), and Stage IIIb in 3 (20%) patients. Overall 5 and 10 years survival rates were respectively 39.5% and 26.3%. At the early stages (Stage I and II) 5 and 10 years survival rates were respectively 46.6% and 23.3%. Comparing NO cases with Nl and N2 cases, five years survival rates were respectively 70% to 0%.

References

  • cell lung vancer in whom complete remission
  • was obtained (a non-randomised retrospective
  • study of 124 consecutive patients). Lung Cancer 1995; 13: 129-35.
  • Turrisi AT 3 rd, Kim K, Blum R, et al. Twice
  • daily compared with once-daily thoracic
  • radiotherapy in limited small-cell lung cancer
  • treated concurrently with cisplatin and
  • etoposide. N Engl J Med 1999; 340: 265-71.
  • EF Smit, HJ Groen, W. Timens, et al. Surgical
  • ; 7(1): 95-103. 17. Anraku M, Waddell TK. Surgery for small cell
  • lung cancer. Semin Thorac Cardiovasc Surg
  • Fall; 18(3): 211-3. 18. Shepherd FA, Ginsberg RJ, Patterson GA, et
  • al. A prospective study of adjuvant surgical
  • resection after chemotherapy for limited
  • small cell lung cancer. J Thorac Cardiovasc
  • Surg 1989; 97: 177. 19. Johnson BE, Bridges JD, Sobczeck M, et al.
  • Patients with limited-stage small cell lung
  • cancer treated with concurrent twice-daily
  • chest radiotherapy and etoposide / cisplatin
  • followed by cyclophoshamide, doxorubicin
  • and vincristine. J Clin Oncol 1996; 14: 806-13. 20. Shepherd FA, Ginsberg RJ, Feld R, et al.
  • Surgical Treatment for limited small cell lung
  • cancer. J Thorac Cardiovasc Surg 1991; 101: 385-93. 21. Karner K, Ulsperger E. Surgery for cure
  • followed by chemotherapy in small cell
  • carcinoma of the lung. Acta Oncol 1995; 34: 899-906. 22. Macchiarini P, Hardin M, Basolo F, et al.
  • Surgery plus adjuvant chemotherapy for T1
  • N0M0 small cell lung cancer. Am J Clin
  • Oncol 1991; 14: 218-24. cell lung cancer. Semin Thorac Cardiovasc
  • Surg 1997; 9(1): 101-10. 13. Deslauriers J. Surgery for small cell lung
  • cancer. Lung cancer 17 (Suppl 1). 1997; 591-8. 14. Graham BL, Balducci L, Khansur T, et al.
  • Surgery in small cell lung cancer Ann Thorac
  • Surg 1988; 45: 687-92. 15. Saito Y, Kanna K, Sagowa M, et al. Surgical
  • treatment for small cell lung cancer. Gan To
  • Kagaku Ryoho 24 (Suppl): 1997; 390-7. Yazıflma Adresi: Dr. Soner GÜRSOY
  • /7 Sk. Albatros 10 4 Girifl D: 47 K: 12
  • Maviflehir / Bostanlı / İZMİR
  • GSM: 0 532 353 24 03
  • e-posta: grssoner@gmail.com 60

KÜÇÜK HÜCRELİ AKCİĞER KANSERLERİNDE CERRAHİ TEDAVİ SONUÇLARIMIZ

Year 2006, Volume: 20 Issue: 3, 55 - 60, 01.12.2006

Abstract

Küçük hücreli akciğer kanseri (KHAK), akciğer kanserlerinin %20-25'ini oluşturmaktadır. Cerrahi serilerde bu oran %2-5 arasındadır. Kemoterapi (KT) ve cerrahi rezeksiyon uygulamalarından beklenen; yaşam süresinin uzatılması ve lokal nüksün azaltılmasıdır. Ancak, uygulanan tedavi modalitelerine rağmen, hastaların çoğu iki yıl içinde kaybedilmektedir. Bu çalışmada KHAK nedeniyle öpere edilen olgulann sağkalım sonuçları retrospektif olarak değerlendirilmiştir. Kliniğimizde Ocak 1989-Haziran 2003 tarihleri arasında, öpere edilen 512 akciğer kanseri olgusunun 15 inde KHAK'i saptanmıştır. Yaş ortalaması 55.67±13.3 (29-68) olan olguların biri dışında tamamı erkek ve sigara içicisiydi. 13 olguya rezeksiyon uygulanırken, iki olgu (%13.3) anre-zektabl bulunmuştur. Olguların dördüne pnömo-nektomi (%30.7), yedisine lobektomi (%53.8) ve ikisine bilobektomi (%15.3) uygulanmıştır. Patolojik evrelemelerinde, olguların biri (%6.6) Evre la, beşi (%33.3) Evre Ib, üçü (%20) Evre lib, üçü (%20) Evre Ula ve üçü (%20) Evre IIIb olarak sınıflandı. 5 ve 10 yıllık sağkalım oranları sırasıyla %39.5 ve %26.3 idi. Erken evrede ise (Evre I+II) 5 ve 10 yıllık sağkalım oranları sırasıyla %46.6 ve %23.3 idi. NO olgularla Nl ve N2 tutulumu olan olgular karşılaştırıldığında ise sırasıyla 5 yıllık sağkalım oranları %70 ve %0 olarak saptanmıştır

References

  • cell lung vancer in whom complete remission
  • was obtained (a non-randomised retrospective
  • study of 124 consecutive patients). Lung Cancer 1995; 13: 129-35.
  • Turrisi AT 3 rd, Kim K, Blum R, et al. Twice
  • daily compared with once-daily thoracic
  • radiotherapy in limited small-cell lung cancer
  • treated concurrently with cisplatin and
  • etoposide. N Engl J Med 1999; 340: 265-71.
  • EF Smit, HJ Groen, W. Timens, et al. Surgical
  • ; 7(1): 95-103. 17. Anraku M, Waddell TK. Surgery for small cell
  • lung cancer. Semin Thorac Cardiovasc Surg
  • Fall; 18(3): 211-3. 18. Shepherd FA, Ginsberg RJ, Patterson GA, et
  • al. A prospective study of adjuvant surgical
  • resection after chemotherapy for limited
  • small cell lung cancer. J Thorac Cardiovasc
  • Surg 1989; 97: 177. 19. Johnson BE, Bridges JD, Sobczeck M, et al.
  • Patients with limited-stage small cell lung
  • cancer treated with concurrent twice-daily
  • chest radiotherapy and etoposide / cisplatin
  • followed by cyclophoshamide, doxorubicin
  • and vincristine. J Clin Oncol 1996; 14: 806-13. 20. Shepherd FA, Ginsberg RJ, Feld R, et al.
  • Surgical Treatment for limited small cell lung
  • cancer. J Thorac Cardiovasc Surg 1991; 101: 385-93. 21. Karner K, Ulsperger E. Surgery for cure
  • followed by chemotherapy in small cell
  • carcinoma of the lung. Acta Oncol 1995; 34: 899-906. 22. Macchiarini P, Hardin M, Basolo F, et al.
  • Surgery plus adjuvant chemotherapy for T1
  • N0M0 small cell lung cancer. Am J Clin
  • Oncol 1991; 14: 218-24. cell lung cancer. Semin Thorac Cardiovasc
  • Surg 1997; 9(1): 101-10. 13. Deslauriers J. Surgery for small cell lung
  • cancer. Lung cancer 17 (Suppl 1). 1997; 591-8. 14. Graham BL, Balducci L, Khansur T, et al.
  • Surgery in small cell lung cancer Ann Thorac
  • Surg 1988; 45: 687-92. 15. Saito Y, Kanna K, Sagowa M, et al. Surgical
  • treatment for small cell lung cancer. Gan To
  • Kagaku Ryoho 24 (Suppl): 1997; 390-7. Yazıflma Adresi: Dr. Soner GÜRSOY
  • /7 Sk. Albatros 10 4 Girifl D: 47 K: 12
  • Maviflehir / Bostanlı / İZMİR
  • GSM: 0 532 353 24 03
  • e-posta: grssoner@gmail.com 60
There are 38 citations in total.

Details

Other ID JA74FE59EB
Journal Section Research Article
Authors

Soner Gürsoy This is me

Serkan Yazgan This is me

Sadık Yaldız This is me

Murat Uygar Yapucu This is me

Cemil Kul This is me

Halil Tözün This is me

Oktay Basok This is me

Publication Date December 1, 2006
Published in Issue Year 2006 Volume: 20 Issue: 3

Cite

APA Gürsoy, S., Yazgan, S., Yaldız, S., Yapucu, M. U., et al. (2006). KÜÇÜK HÜCRELİ AKCİĞER KANSERLERİNDE CERRAHİ TEDAVİ SONUÇLARIMIZ. İzmir Göğüs Hastanesi Dergisi, 20(3), 55-60.