KOAH AKUT ATAKTA SERUM ÜRİK ASİT DÜZEYİ VE ÜRİK ASİT/KREATİNİN ORANININ ATAĞIN AĞIRLIĞI VE ARTERYEL KAN GAZLARI İLE İLİŞKİSİ
Abstract
Ürik asit, pürin yıkımında son ürün olup doku hipoksisinde düzeyi artar. Serum ürik asit seviyesi, oksidatif metabolizmadaki bozukluğun belirteci olarak kullanılabilir. Çalışmada 70 KOAH'lı olgunun 74 akut alevlenme nedenli yatışı değerlendirildi. Çalışmamızda KOAH akut atağı (AA) olan hastalarda serum ürik asit düzeyi ve serum ürik asit/kreatinin oranının hipoksemiyi göstermedeki başarısı, spirometri ve arter kan gazı ile ilişkisi araştırılmıştır KOAH AA'lı olguların tedavi öncesi ve sonrası serum ürik asit düzeyleri kontrol grubundan anlamlı olarak yüksekti.
References
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- Erdinç E, Erk M, Tatlıcıoğlu T, Kocabafl A, Süerdem M, Umut S, Mirici A, Yılmaz V, KOAH Çalıflma Grubu. Toraks Derneği Kronik Obstrüktif Akciğer Hastalığı Tanı ve Tedavi Rehberi. İstanbul: Turgut Yayıncılık; 2000; 1: 25.
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- Braghiroli A, Sacco C, Erbetta M, Ruga V, Donner CF. Overnight urinary acid: creatinine ratio for detection of sleep hypoxemia. De Torres JP, Cordoba-Lanus E, Lopez-Aguilar C, Mures de Fuentos M, Montejo de Garcini A, Aguirre-Jaime AA, Celli BR, Casanova C. C-reactive protein levels and clinically impor- tant predictive outcomes in stable COPD patients. Eur Respir J 2006; 27: 902-7.
- Ruggiero C, Cherubini A, Ble A, Bos JGA, Maggio M, Dixit VD, Lauretani F, Bandinelli S, Senin U, Ferrucci L. Uric acid and inflammatory markers. Eur Heart J 2006; 27: 1174-81.
- Hasday JD, Grum CM. Nocturnal increase of urinary uric acid/creatinine ratio: a biochemical correlate of sleepassociated hypoxemia. Am Rev Respir Dis 1987; 135: 534-8.
- Stijn LV, Van Hoeck K, Schrauwen N, Haentjens D, Rooman R, VanGaal L, DeBecker WA, Desager KN. Overweight and Obese Children and Sleep-Disordered Breathing and Uric Acid in Adolescents. Chest 2007; 132: 76-80.
- Dülger H, Uzun K, Özbay B, Erkoç R, Durmufl A . Kronik obstruktif akciğer hastalığında hipoksi göstergesi olarak serum ürik asit düzeyleri. Tıp Arafltırmaları Dergisi 2003; 1: 1-4.
- International Consensus Conferences in Intensive Care Medicine: Noninvaziv Pozitive Pressure Ventilation in acute Respiratory Failure. Am J Respir Crit Care 2001; 163: 91.
- Gosker HR, Bast A, Haenen GR, Fischer MA, van der Vusse GJ, Wouters EF, Schols AM. Altered antioxidant status in peripheral skele- tal muscle of patients with COPD. Respir Med 2005; 99: 118-25.
- Mateos FA, Gomez PF, Puig JG, Jimenez ML, Ramos TH, Mantilla JG. Enhanced adenine nucleotide degradation in chronic obstructive pulmonary disease: the effect of oxygen therapy. Adv Exp Med Biol 1989; 253: 333-8. Yazıflma Adresi: Dr. Hayrettin GÖÇMEN
- İnegöl Devlet Hastanesi, Göğüs Hastalıkları, İnegöl, BURSA Tel : 0 224 443 41 20 e-posta: dr_hayrettin@yahoo.com.au
THE RELATIONSHIP OF SERUM URIC ACID AND URIC ACID TO CREATININE RATIO WITH SEVERITY OF EXACERBATIONS AND ARTERIAL BLOOD GASES IN COPD ACUTE EXACERBATION
Abstract
Serum uric acid (UA) is the final product of purine degradation, its level increases in tissue hypoxemia. Serum UA level may be indicator in evaluation of impaired oxidation. The success in indicating hypoxemia, of serum UA and serum UA/creatinine ratio, in COPD with acute exacerbations and the relationship with spirometry and arterial blood gases were investigated in our study Seventy four hospitalizations due to acute exacerbation of seventy patients with COPD were evaluated. In patients with COPD, pretreatment mean serum UA levels .
References
- Global strategy for the diagnosis, manage- ment and prevention of chronic obstructive pulmonary disease. NHLBI / WHO Workshop Report. Global initiative for chronic obstruc- tive pulmonary disease. National Institutes of Health, 2003: 1-30.
- Erdinç E, Erk M, Tatlıcıoğlu T, Kocabafl A, Süerdem M, Umut S, Mirici A, Yılmaz V, KOAH Çalıflma Grubu. Toraks Derneği Kronik Obstrüktif Akciğer Hastalığı Tanı ve Tedavi Rehberi. İstanbul: Turgut Yayıncılık; 2000; 1: 25.
- Elsayed NM, Nakashima JM, Poslethwait EM. Measurement of uric acid as a marker of oxygen tension in the lung. Arch Biochem Biophys 1993; 302: 228-32.
- Sahebjami H. Changes in urinary uric acid excretion in obstructive sleep apnea before and after therapy with nasal continuous positive airway pressure. Chest 1998; 113: 8.
- Aranzazu RG, Angeles SA, Estefanía LC, Domingo GA, Auxiliadora RF, Bernal CC, Capoteet F. Blood Uric Acid Levels in Patients With Sleep-Disordered Breathing. Arch Bronconeumol 2006; 42: 492-500.
- Braghiroli A, Sacco C, Erbetta M, Ruga V, Donner CF. Overnight urinary acid: creatinine ratio for detection of sleep hypoxemia. De Torres JP, Cordoba-Lanus E, Lopez-Aguilar C, Mures de Fuentos M, Montejo de Garcini A, Aguirre-Jaime AA, Celli BR, Casanova C. C-reactive protein levels and clinically impor- tant predictive outcomes in stable COPD patients. Eur Respir J 2006; 27: 902-7.
- Ruggiero C, Cherubini A, Ble A, Bos JGA, Maggio M, Dixit VD, Lauretani F, Bandinelli S, Senin U, Ferrucci L. Uric acid and inflammatory markers. Eur Heart J 2006; 27: 1174-81.
- Hasday JD, Grum CM. Nocturnal increase of urinary uric acid/creatinine ratio: a biochemical correlate of sleepassociated hypoxemia. Am Rev Respir Dis 1987; 135: 534-8.
- Stijn LV, Van Hoeck K, Schrauwen N, Haentjens D, Rooman R, VanGaal L, DeBecker WA, Desager KN. Overweight and Obese Children and Sleep-Disordered Breathing and Uric Acid in Adolescents. Chest 2007; 132: 76-80.
- Dülger H, Uzun K, Özbay B, Erkoç R, Durmufl A . Kronik obstruktif akciğer hastalığında hipoksi göstergesi olarak serum ürik asit düzeyleri. Tıp Arafltırmaları Dergisi 2003; 1: 1-4.
- International Consensus Conferences in Intensive Care Medicine: Noninvaziv Pozitive Pressure Ventilation in acute Respiratory Failure. Am J Respir Crit Care 2001; 163: 91.
- Gosker HR, Bast A, Haenen GR, Fischer MA, van der Vusse GJ, Wouters EF, Schols AM. Altered antioxidant status in peripheral skele- tal muscle of patients with COPD. Respir Med 2005; 99: 118-25.
- Mateos FA, Gomez PF, Puig JG, Jimenez ML, Ramos TH, Mantilla JG. Enhanced adenine nucleotide degradation in chronic obstructive pulmonary disease: the effect of oxygen therapy. Adv Exp Med Biol 1989; 253: 333-8. Yazıflma Adresi: Dr. Hayrettin GÖÇMEN
- İnegöl Devlet Hastanesi, Göğüs Hastalıkları, İnegöl, BURSA Tel : 0 224 443 41 20 e-posta: dr_hayrettin@yahoo.com.au
There are 14 citations in total.
Details
| Other ID | JA43TC42JR |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | October 1, 2010 |
| Published in Issue | Year 2010 Volume: 24 Issue: 2 |