GEMSİTABİN'E BAĞLI KUTANOZ TOKSİSİTE GELİŞEN KÜÇÜK HÜCRELİ DIŞI AKCİĞER KANSERİ

Year 2011, Volume: 25 Issue: 1, 51 - 55, 01.05.2011

Davut Aydın Muzaffer Sarıaydın Meftun Ünsal

Abstract

Gemsitabin kısmen iyi tolere edilebilen; küçük hücreli dışı akciğer karsinomu, meme, over, pankreas ve baş boyun kanserlerinde yaygın kullanım alanı kazanmış bir ilaçtır. Kemik iliği süpresyonu, bulantı, kusma benzeri semptomlar, alerjik reaksiyonlar gibi sistemik yan etkilerinin yanında yaygın olarak dermatolojik toksisiteler de görülebilir. Alopesi, raş, makülopapüler erüpsiyonlar ve diğer nadir görülen lezyonlar gemsitabin tedavisi sürecinde görülebilmektedir. Çalışmamızda evre 4 akciğer adenokarsinomu tanısıyla, ilk kez gemsitabin içeren ikili kemoterapi aldıktan sonra tüm vücudunda yaygın makülopapüler özellikte döküntüler ortaya çıkan 49 yaşındaki erkek hasta ele alınmıştır.

Keywords

Makulopapüler döküntü, gemsitabin, akciğer kanseri

NON SMALL CELL LUNG CARCINOMA WITH GEMCITABINE INDUCED CUTANEOUS TOXICITY

Abstract

Gemcitabine is considerably well tolerated agent, that is often used for; non small cell lung carcinoma, breast, over, pancreas and head-neck malignancies. It's likely to have dermatologyical reactions, furthermore it has systemic side effects like pancytopenia, nausea, vomitting, flu-like symptoms and allergic reactions. Alopecia, maculopapullar eruptions, erytematous lesions and other derma- tologycal toxicities can occur during gemcitabine treatment. In our study we investigated a fourty nine year old patient with stage 4 lung adeno- carcinoma, that had diffus maculopapullar lesions after his first time combine chemoterapy with gemcitabine.

Keywords

Maculopapullar rush, gemcitabine, lung cancer

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