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NADİR GÖRÜLEN BİR AKCİĞER KARSİNOMU: DEV HÜCRELİ KARSİNOM

Year 2011, Volume: 25 Issue: 2, 63 - 67, 01.10.2011

Abstract

Dünya Sağlık Örgütü (DSÖ), sarkom veya sarkom benzeri komponent içeren tümörleri kapsayan malign epithelial tumor altgrubunu "pleomorfik, sarkomatoid veya sarkomatöz elemanlar içeren karsinomlar" adı altında toplamaktadır (1). Sarkomatoid karsinomlar çok nadir görülen akciğer tümörleridir; tüm akciğer malignitelerinin yaklaşık %0.1-0.4'ünü meydana getirmektedir. Dev hücreli akciğer karsinomu, sarkomatoid karsinomların bir altgrubudur. Solunumsal yakınması olmayan 50 yaşındaki erkek hastanın akciğer radyogramında ve toraks bilgisayarlı tomografisi'nde sağ akciğer üst lobda bir kitle lezyonu saptandı. Tetkikler sonrasında "küçük hücreli dışı akciğer karsinomu" tanısı kondu. Klinik ve radyolojik olarak evre Ib (T2N0M0) olarak evrelenen hastaya sağ üst lobektomi + Mediastinal lenf bezi diseksiyonu + sağ intratorasik tiroidektomi operasyonu uygulandı. Histopatolojik inceleme sonucu "dev hücreli akciğer karsinomu" ile uyumlu bulundu. Hasta, nadir bir akciğer tümörü olan dev hücreli akciğer karsinomu tanısı ile literatür bilgileri eşliğinde sunuldu.

References

  • 1. Travis WB, Brambilla A, Muller Hermelinck HK, Harris CC. World Heath Organization Classification of Tumors. Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Heart. Lyon, IARC Pres, 2004.
  • 2. Miller DL. Rare pulmonary neoplasms. Semin. Respir Crit Care Med 1997; 18: 405-15.
  • 3. Allan JS. Rare solitary benign tumors of the lung. Semin Thorac Cradiovasc Surg 2003; 15: 315-22.
  • 4. Wick MR, Ritter JH, Humphrey PA. Sarcomatoid carcinomas of the lung: a clinicopathologic review. Am J Clin Pathol 1997; 108(1): 40-53.
  • 5. da Matta Abreu M, Marcondes Kozlowski B, de Biasi Cordeiro P, de Sousa A, F Nascimento M, Zamboni M. Primary pleomorphic sarcoma of the lung. Rev Port Pneumol 2008;14(4): 535-9.
  • 6. Xu X, Yin H, Meng K, Zhou X. Pathological study of the pleomorphic carcinoma of the lung Zhonghua Bing Li Xue Za Zhi 2000;29 (6): 424- 7.
  • 7. Venissac N, Pop D, Lassalle S, Berthier F, Hofman P, Mouroux J. Sarcomatoid lung cancer (spindle/giant cells): an aggressive disease? J Thorac Cardiovasc Surg 2007; 134(3): 619-23.
  • 8. Baldassarre E, Maggi P, Ramieri MT, Torino G, Graziano P, Barone M, Siani A. Jejunal perforation secondary to metastatic sarcomatoid carcinoma of the lung. Minerva Gastroenterol Dietol 2008; 54(2): 225-8.
  • 9. Petrov DB, Vlassov VI, Kalaydjiev GT, Plochev MA, Obretenov ED, Stanoev VI, Danon SE. Primary pulmonary sarcomas and carcinosarcomas–postoperative results and comparative survival analysis. Eur J Cardiothorac Surg 2003; 23: 461-6.
  • 10. Davis MP, Eagan RT, Weiland LH, Pairlero PC. Carcinosarcoma of the lung: Mayo Clinic experience and response to chemotherapy. Mayo Clin Proc 1984; 59: 598-603.
  • 11. Koss MN, Hochholzer L, Frommelt RA. Carcinosarcomas of the lung: a clinicopathologic study of 66 patients. Am J Surg Pathol 1999; 23: 1514-26.
  • 12. Huwer H, Kalweit G, Straub U, Feindt P, Volkmer I, Gams E. Pulmonary carcinosarcoma: diagnostic problems and determinants of the prognosis. Eur J Cardiothorac Surg 1996; 10: 403-7.

A RARE PULMONARY CARCINOMA: GIANT CELL CARCINOMA

Year 2011, Volume: 25 Issue: 2, 63 - 67, 01.10.2011

Abstract

World Health Organization classifies malignant epithelial tumors which contain sarcomas as "carcinomas with pleomorphic, sarcomatoid or sarcomatous elements" Sarcomatoid carcinomas are rare pulmonary tumors, composing approximately 0.1-0.4% of all lung malignancies. Giant cell pulmonary carcinoma is a subgroup of sarcomatoid carcinoma. Chest radiogram and thorax Computerized Tomography of a 50-years-old male patient with no pulmonary symptom revealed a mass lesion in right upper lobe. He was diagnosed to have "nonsmall cell lung cancer". He was staged clinically and radiologically as stage Ib (T2N0M0) and right upper lobectomy + Mediastinal lymph node dissection + right intrathoracic thyroidectomy were performed. "Giant cell pulmonary carcinoma" was diagnosed after histopathological examination. The patient was presented in attendance with literature as a rare pulmonary tumor, giant-cell pulmonary carcinoma.

References

  • 1. Travis WB, Brambilla A, Muller Hermelinck HK, Harris CC. World Heath Organization Classification of Tumors. Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Heart. Lyon, IARC Pres, 2004.
  • 2. Miller DL. Rare pulmonary neoplasms. Semin. Respir Crit Care Med 1997; 18: 405-15.
  • 3. Allan JS. Rare solitary benign tumors of the lung. Semin Thorac Cradiovasc Surg 2003; 15: 315-22.
  • 4. Wick MR, Ritter JH, Humphrey PA. Sarcomatoid carcinomas of the lung: a clinicopathologic review. Am J Clin Pathol 1997; 108(1): 40-53.
  • 5. da Matta Abreu M, Marcondes Kozlowski B, de Biasi Cordeiro P, de Sousa A, F Nascimento M, Zamboni M. Primary pleomorphic sarcoma of the lung. Rev Port Pneumol 2008;14(4): 535-9.
  • 6. Xu X, Yin H, Meng K, Zhou X. Pathological study of the pleomorphic carcinoma of the lung Zhonghua Bing Li Xue Za Zhi 2000;29 (6): 424- 7.
  • 7. Venissac N, Pop D, Lassalle S, Berthier F, Hofman P, Mouroux J. Sarcomatoid lung cancer (spindle/giant cells): an aggressive disease? J Thorac Cardiovasc Surg 2007; 134(3): 619-23.
  • 8. Baldassarre E, Maggi P, Ramieri MT, Torino G, Graziano P, Barone M, Siani A. Jejunal perforation secondary to metastatic sarcomatoid carcinoma of the lung. Minerva Gastroenterol Dietol 2008; 54(2): 225-8.
  • 9. Petrov DB, Vlassov VI, Kalaydjiev GT, Plochev MA, Obretenov ED, Stanoev VI, Danon SE. Primary pulmonary sarcomas and carcinosarcomas–postoperative results and comparative survival analysis. Eur J Cardiothorac Surg 2003; 23: 461-6.
  • 10. Davis MP, Eagan RT, Weiland LH, Pairlero PC. Carcinosarcoma of the lung: Mayo Clinic experience and response to chemotherapy. Mayo Clin Proc 1984; 59: 598-603.
  • 11. Koss MN, Hochholzer L, Frommelt RA. Carcinosarcomas of the lung: a clinicopathologic study of 66 patients. Am J Surg Pathol 1999; 23: 1514-26.
  • 12. Huwer H, Kalweit G, Straub U, Feindt P, Volkmer I, Gams E. Pulmonary carcinosarcoma: diagnostic problems and determinants of the prognosis. Eur J Cardiothorac Surg 1996; 10: 403-7.
There are 12 citations in total.

Details

Other ID JA25NY47MY
Journal Section Research Article
Authors

Emel Tellıoqlu This is me

Nur Cabar Yücel This is me

Kenan Can Ceylan This is me

Rıfat Özacar This is me

Publication Date October 1, 2011
Published in Issue Year 2011 Volume: 25 Issue: 2

Cite

APA Tellıoqlu, E., Yücel, N. C., Ceylan, K. C., Özacar, R. (2011). NADİR GÖRÜLEN BİR AKCİĞER KARSİNOMU: DEV HÜCRELİ KARSİNOM. İzmir Göğüs Hastanesi Dergisi, 25(2), 63-67.