Periferik eozinofili ve akciğerde infiltrasyonun bulunması eozinofilik akciğer hastalıkları başlığı altında incelenir. Atopi, parazitler, ilaçlar, vaskülitler başta olmak üzere bir çok sebep eozinofili yapar. Aspergillomanın eozinofiliye sebep olması nadir bir durumdur. Bu olgu sunumunda hemogramda eozinofili, yüksek çözünürlüklü bilgisayarlı tomografide infiltrasyon, bronşektazi ve kaviter lezyon ile aspergilloma saptanan otuz yedi yaşında erkek hasta sunuldu. Yapılan ayrıntılı incelemelerde eozinofili yapan herhangi bir neden bulunamadı. Tanı aşamasında eozinofilik akciğer hastalığı ayırıcı tanısına giren hastalıklar için ayrı ayrı değerlendirildi. Aspergilloma tedavisi olarak yapılan lobektomi neticesinde eozinofilinin düzeldiği gözlendi. Bu olgu eozinofilik akciğer hastalığı ayırıcı tanısında nadir de olsa aspergillomanın bulunması gerektiğini belirtmek amacıyla sunuldu.
1. Rochester CL. The eosinophilic pneumonias.
In: Fishman AP. Fishman’s Pulmonary Diseases
and Disorders. Mc Graw-Hill Company, New
York 2002; 1133-1150.
2. Teo CG, Singh M, Ting WC, Ong YW and Seet
LC. Evaluation of the common conditions
associated with eosinophilia. J Clin Pathol
1985; 38: 305-8.
3. Cheng WH, Shih CL, Jen CC, Hong WG,
Yeung LC. Complex Pulmonary Aspergilloma: A
Case Report. J Med Sci 2001; 21(6): 301-4.
4. Sharma OP, Bethlem EP: The pulmonary
infiltration with eosinophilia syndrome. Curr
Opin Pulm Med 1996; 2: 380-9.
5. Weller PF. Causes of pulmonary eosinophilia.
In UpToDate. Rose BD (Ed). Wellesley, MA:
UpToDate, 2003.
6. Allen JN, Davis WB. Eosinophilic lung diseases.
Am J Respir Crit Care Med 1994; 150: 1423-38.
7. Weller PF. Parasitic pneumonias. In Respiratory
Infections: Diagnosis and Management, 3rd
ed. Pennington JE (Ed). New York: Raven
Press; 1994: 695.
8. Goetz EJ, Luce JM. Eosinophilic lung diseases.
In: Murray JF, Nadel JA; eds. Textbook of
Respiratory Medicine. 3td ed. Philadelphia:
W.B. Saunders Company; 2000: 1757-1773.
9. Goetzl EJ, Luce MJ. Eosinophilic lung diseases.
In: Murray JF, Nadel JA, Mason RJ, Boushey HA,
eds. Textbook of Respiratory Medicine. 3rd
ed. Philadelphia: WB Saunders Company,
2000; 1767.
10. Philit F, Etienne-Mastroianni B, Parrot A, et al.
Idiopathic acute eosinophilic pneumonia: A
study of 22 patients. Am J Respir Crit Care
Med 2002; 166: 1235-9.
14. Vlahakis N, Aksamit T. Diagnosis and treatment
of allergic bronchopulmonary aspergillosis.
Mayo Clin Proc 2001; 76: 930-8.
15. Scott SM, Takaro T. Thoracic Infections Caused
by Actinomycetes, Fungi, Opportunistic
Organisms, an Echinococcus. in Baue AA,
Geha AS, Hammond GL, et al (eds). Glenn's
Thoracic and Cardiovascular Surgery, 5th
ed, Prentice Hail International Inc, 1991:
273-275.
16. Scott SM, Takara T, Varkey B, et al. Thoracic
mycotic and actinomycotic infections in
General Thoracic Surgery: Ed: W. Shields;
Willams and Wilkins, Baltimore, 1994; 986.
17. Hargis JL, Bone RC, Magilligan DJ, et al.
Lung infections and diffuse interstitial lung
disease. In Surgery of the Chest. Ed: Davyd C.
Sabyston. W.B: Saunders Company: 1995;
676.
18. Babatasi G, Massetti M, Chapelier A, et al.
Surgical treatment of pulmonary aspergilloma:
current outcome. J Thorac Cardiovasc Surg
2000; 119: 906-12.
19. Çitak N, Sayar A, Metin M, Pekçolaklar A ve
ark. Pulmoner aspergillomada alt› y›ll›k 26
olguluk cerrahi tedavi sonuçlar›: Tek cerrahi
servisinin deneyimi. Tüberküloz ve Toraks
Dergisi 2011; 59(1): 62-9.
20. Koflar A, K›ral H, Örki A ve ark. Pulmoner
Aspergillomada Cerrahi Yaklafl›m. Türk Toraks
Dergisi 2005; 6 (1): 001-007.
ASPERGILLOMA: A RARE CAUSE OF EOSINOPHILIA
Year 2012,
Volume: 26 Issue: 1, 51 - 55, 01.05.2012
Pulmonary infiltrates which associate with eosinophilia are known as ‘eosinophilic lung disease'. It occurs in many conditions such as athopia, parasitoses, drugs, vasculitis. Eoshinophilia of aspergilloma is a rare condition. We presented a case of aspergilloma. The patient was male and 37 years old. He has bronchiectasis, cavitary lesion and fungus ball and pulmonary infiltrates on HRCT scans; and blood eosinophilia. We could not find any cause for blood eosinophilia further investigations. After lobectomy blood eoshinophilia disappeared.
1. Rochester CL. The eosinophilic pneumonias.
In: Fishman AP. Fishman’s Pulmonary Diseases
and Disorders. Mc Graw-Hill Company, New
York 2002; 1133-1150.
2. Teo CG, Singh M, Ting WC, Ong YW and Seet
LC. Evaluation of the common conditions
associated with eosinophilia. J Clin Pathol
1985; 38: 305-8.
3. Cheng WH, Shih CL, Jen CC, Hong WG,
Yeung LC. Complex Pulmonary Aspergilloma: A
Case Report. J Med Sci 2001; 21(6): 301-4.
4. Sharma OP, Bethlem EP: The pulmonary
infiltration with eosinophilia syndrome. Curr
Opin Pulm Med 1996; 2: 380-9.
5. Weller PF. Causes of pulmonary eosinophilia.
In UpToDate. Rose BD (Ed). Wellesley, MA:
UpToDate, 2003.
6. Allen JN, Davis WB. Eosinophilic lung diseases.
Am J Respir Crit Care Med 1994; 150: 1423-38.
7. Weller PF. Parasitic pneumonias. In Respiratory
Infections: Diagnosis and Management, 3rd
ed. Pennington JE (Ed). New York: Raven
Press; 1994: 695.
8. Goetz EJ, Luce JM. Eosinophilic lung diseases.
In: Murray JF, Nadel JA; eds. Textbook of
Respiratory Medicine. 3td ed. Philadelphia:
W.B. Saunders Company; 2000: 1757-1773.
9. Goetzl EJ, Luce MJ. Eosinophilic lung diseases.
In: Murray JF, Nadel JA, Mason RJ, Boushey HA,
eds. Textbook of Respiratory Medicine. 3rd
ed. Philadelphia: WB Saunders Company,
2000; 1767.
10. Philit F, Etienne-Mastroianni B, Parrot A, et al.
Idiopathic acute eosinophilic pneumonia: A
study of 22 patients. Am J Respir Crit Care
Med 2002; 166: 1235-9.
14. Vlahakis N, Aksamit T. Diagnosis and treatment
of allergic bronchopulmonary aspergillosis.
Mayo Clin Proc 2001; 76: 930-8.
15. Scott SM, Takaro T. Thoracic Infections Caused
by Actinomycetes, Fungi, Opportunistic
Organisms, an Echinococcus. in Baue AA,
Geha AS, Hammond GL, et al (eds). Glenn's
Thoracic and Cardiovascular Surgery, 5th
ed, Prentice Hail International Inc, 1991:
273-275.
16. Scott SM, Takara T, Varkey B, et al. Thoracic
mycotic and actinomycotic infections in
General Thoracic Surgery: Ed: W. Shields;
Willams and Wilkins, Baltimore, 1994; 986.
17. Hargis JL, Bone RC, Magilligan DJ, et al.
Lung infections and diffuse interstitial lung
disease. In Surgery of the Chest. Ed: Davyd C.
Sabyston. W.B: Saunders Company: 1995;
676.
18. Babatasi G, Massetti M, Chapelier A, et al.
Surgical treatment of pulmonary aspergilloma:
current outcome. J Thorac Cardiovasc Surg
2000; 119: 906-12.
19. Çitak N, Sayar A, Metin M, Pekçolaklar A ve
ark. Pulmoner aspergillomada alt› y›ll›k 26
olguluk cerrahi tedavi sonuçlar›: Tek cerrahi
servisinin deneyimi. Tüberküloz ve Toraks
Dergisi 2011; 59(1): 62-9.
20. Koflar A, K›ral H, Örki A ve ark. Pulmoner
Aspergillomada Cerrahi Yaklafl›m. Türk Toraks
Dergisi 2005; 6 (1): 001-007.