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IMMUNSÜPRESIF TEDAVİ ALAN OLGUDA MORTAL SEYREDEN STAPHYLOCOCCUS AUREUS PNÖMONİSİ

Year 2012, Volume: 26 Issue: 3, 207 - 211, 01.12.2012

Abstract

İmmunsupresif hastalar başta bakteriyel enfeksiyonlar olmak üzere birçok enfeksiyona açık hale gelirler. İmmunsupresif hastaların önemli bir bölümünü de immun sistemi baskılayan ilaç kullananlar oluşturmaktadır. Bu hastalarda gelişen pnömoniler, hızlı ilerler ve yüksek mortaliteye sahiptir. Pemfigus vejetans tanısı ile üç ay boyunca immünsüpresif tedavi alan hastada gelişen ve mortal seyreden Stapfilococus aureus (S. aureus) pnömonisi olgusunu literatürler eşliğinde sunduk. Pemfigus vejetans tanısı ile takip edilen ve immunsupresif tedavi alan 37 yaşında kadın hasta pnömoni nedeniyle kliniğimize yatırıldı ve sepsis sonucu hasta kaybedildi. Hastamız immunsupresif tedavi almasına rağmen önerilen kontrollere gelmemiştir. Hasta ancak pnömoniye bağlı semptomlar ortaya çıktığında hastaneye başvurmuş fakat geç kalındığından hastada sepsis tablosu gelişmiş, yapılan agresif tedaviye rağmen hasta 4 saat içinde kaybedilmiştir. Olgumuzu sunmamızın amacı immunsupresif tedavi verilen hastaların takiplerinin düzenli yapılmaması sonucu ortaya ölümcül komplikasyonların çıkabileceğini göstermektir.

References

  • 1. Waite S, Jeudy J, White CS. Acute lung infections innormal and immunocompromised hosts. Radiol Clin North Am 2006; 44 (2): 295-315.
  • 2. Apisarnthanarag A, Mundy LM. Etilogy of community-acquired pneumonia. Clin Chest Med 2005; 26(1): 47-55.
  • 3. Gharip AM, Stern EJ. Radiology of pneumonia. Med Clin North Am 2001; 85(6): 1461-91.
  • 4. Giamarellou H, Antoniadou A. Infectious complications of febrile leukopenia. Infect Dis Clin North Am 2001; 15: 457-82.
  • 5. Cunha BA. Pneumonias in the immunucompromised host. Infect Dis Clin North Am 2001; 15: 591-612.
  • 6. Bystryn JC. How should pemphigus be treated? J Eur Acad Dermatol Venereol 2002; 16: 562-63.
  • 7. Datta R, Huang SS. Risk of infection and death due to methicilin-resistant Staphylococcus aureus in long-term carriers. Clin Infect Dis 2008; 47: 176-81.
  • 8. Nguyen ET, Kanne JP, Hoang LM, et al. Community-acquired methicillin-resistant Staphylococcus aureus pneumonia: Radiografic and computed tomography findings. J Thorac Imaging 2008; 23: 13-9.
  • 9. Hughes WT, Armstrong D, Bodey GP et al. 2002 IDSA Guidelines. Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. CID 2002; 34: 730-51.
  • 10. Jill C Roberts, Sam P Gulino, K Kealy Peak, Vicki A Luna, and Roger Sanderson Fatal necrotizing pneumonia due to a PantonValentine leukocidin positive communityassociated methicillin-sensitive Staphylococcus aureus and Influenza co-infection: a case report Ann Clin Microbiol Antimicrob 2008; 7: 5.
  • 11. Ada S-Z Cheung, Craig A Aboltins, John R Daffy and Peter A Stanley Necrotising pneumonia due to Panton–Valentine leukocidinpositive methicillin-sensitive Staphylococcus aureus MJA 2008; 188 (6): 373.
  • 12. George F. Murfhy, Skin. In. Kumar V, Cotran RS, Robbins SL, eds. Basic Pathology. 6th ed. Philadelphia: W.B. Saunders; 2000: 697- 712.
  • 13. Sydney E. Salmon, MD. Alan C. Sartorelli, PhD, Kanser Kemoterapisi. In. Katzung BG, eds. Temel ve Klinik Farmakoloji. 6th ed. San Francisco: CN: Appleton and Lange; 1995: 1109-1111.
  • 14. Agusti C, Rano A, Filalle X, et al. Pulmonary infiltrates in patients receiving long-term glucocorticotid treatment: Etiology, Prognostic Factors and Associated Inflammatory Response. Chest 2003; 123: 488-98.
  • 15. Toth GG, Jonkman MF. Therapy of pemphigus. Clin Dermatol 2001; 19: 761-7.

MORTAL STAPHYLOCOCCUS AUREUS PNEUMONIA IN A CASE WHO HAS IMMUNOSUPPRESSIVE TREATMENT

Year 2012, Volume: 26 Issue: 3, 207 - 211, 01.12.2012

Abstract

The immunosuppressive patients are exposed to many infections, especially bacterial infections. A significant part of immunosuppressive patients consist of those who use medicine which suppresses immune system. Pneumonia which develops in these patients develops rapidly and causes high rate of mortality. We have presented the case of Stapfilococus aureus (S. aureus) pneumonia which develops in the patients who had immunosuppressive treatment for three months and which causes mortality, in companion with literature. A 37-year-old woman who was followed up with the diagnosis of Pemfigus Vegetance and who had immunosuppressive treatment was admitted to our clinic and she died as a result of sepsis. Although our patient had immunosuppressive therapy, she did not come to the advised controls. The patient consulted to the hospital only after peumonia-based symptoms occurred; however, her sepsis table had developed because she was too late and the she died within 4 hours thereafter in spite of the aggressive treatment. The purpose of presenting this case is to show that lethal complications may come into being on the condition that the patient who have immunosuppressive treatment are not followedup regularly.

References

  • 1. Waite S, Jeudy J, White CS. Acute lung infections innormal and immunocompromised hosts. Radiol Clin North Am 2006; 44 (2): 295-315.
  • 2. Apisarnthanarag A, Mundy LM. Etilogy of community-acquired pneumonia. Clin Chest Med 2005; 26(1): 47-55.
  • 3. Gharip AM, Stern EJ. Radiology of pneumonia. Med Clin North Am 2001; 85(6): 1461-91.
  • 4. Giamarellou H, Antoniadou A. Infectious complications of febrile leukopenia. Infect Dis Clin North Am 2001; 15: 457-82.
  • 5. Cunha BA. Pneumonias in the immunucompromised host. Infect Dis Clin North Am 2001; 15: 591-612.
  • 6. Bystryn JC. How should pemphigus be treated? J Eur Acad Dermatol Venereol 2002; 16: 562-63.
  • 7. Datta R, Huang SS. Risk of infection and death due to methicilin-resistant Staphylococcus aureus in long-term carriers. Clin Infect Dis 2008; 47: 176-81.
  • 8. Nguyen ET, Kanne JP, Hoang LM, et al. Community-acquired methicillin-resistant Staphylococcus aureus pneumonia: Radiografic and computed tomography findings. J Thorac Imaging 2008; 23: 13-9.
  • 9. Hughes WT, Armstrong D, Bodey GP et al. 2002 IDSA Guidelines. Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. CID 2002; 34: 730-51.
  • 10. Jill C Roberts, Sam P Gulino, K Kealy Peak, Vicki A Luna, and Roger Sanderson Fatal necrotizing pneumonia due to a PantonValentine leukocidin positive communityassociated methicillin-sensitive Staphylococcus aureus and Influenza co-infection: a case report Ann Clin Microbiol Antimicrob 2008; 7: 5.
  • 11. Ada S-Z Cheung, Craig A Aboltins, John R Daffy and Peter A Stanley Necrotising pneumonia due to Panton–Valentine leukocidinpositive methicillin-sensitive Staphylococcus aureus MJA 2008; 188 (6): 373.
  • 12. George F. Murfhy, Skin. In. Kumar V, Cotran RS, Robbins SL, eds. Basic Pathology. 6th ed. Philadelphia: W.B. Saunders; 2000: 697- 712.
  • 13. Sydney E. Salmon, MD. Alan C. Sartorelli, PhD, Kanser Kemoterapisi. In. Katzung BG, eds. Temel ve Klinik Farmakoloji. 6th ed. San Francisco: CN: Appleton and Lange; 1995: 1109-1111.
  • 14. Agusti C, Rano A, Filalle X, et al. Pulmonary infiltrates in patients receiving long-term glucocorticotid treatment: Etiology, Prognostic Factors and Associated Inflammatory Response. Chest 2003; 123: 488-98.
  • 15. Toth GG, Jonkman MF. Therapy of pemphigus. Clin Dermatol 2001; 19: 761-7.
There are 15 citations in total.

Details

Other ID JA35SP33AP
Journal Section Case Report
Authors

Pınar Yıldız Gülhan This is me

Aydanur Ekici This is me

Mehmet Ekici This is me

Mukadder Koçak This is me

Publication Date December 1, 2012
Published in Issue Year 2012 Volume: 26 Issue: 3

Cite

APA Gülhan, P. Y., Ekici, A., Ekici, M., Koçak, M. (2012). IMMUNSÜPRESIF TEDAVİ ALAN OLGUDA MORTAL SEYREDEN STAPHYLOCOCCUS AUREUS PNÖMONİSİ. İzmir Göğüs Hastanesi Dergisi, 26(3), 207-211.