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AKTİF VE İNAKTİF TÜBERKÜLOZLU OLGULARDA 25(OH) VİTAMİN D SEVİYELERİ

Year 2014, Volume: 28 Issue: 2, 105 - 112, 01.10.2014

Abstract

Amaç: D vitamini, insan organizmasının birçok hayati fonksiyonlarında görev alır. Serum seviyesinin azaldığı durumlarda hastalıklar ortaya çıkabilir. Tüberküloz hastalığı ile güneş ışınları arasındaki ilişki yüzyıllardır fark edilmiş olmasına rağmen, bu ilişkinin bilimsel temellere dayandırılması amacı ile birçok çalışma yapılmıştır. Biz de, çalışmamızda, aktif tüberkülozlu, inaktif tüberkülozlu ve sağlıklılardan oluşan toplam 102 olgunun serum 25 (OH) vitamin D düzeylerini karşılaştırarak, literatürün ışığı altında tartışmak istedik. Yöntem ve Gereç: Çalışmaya 102 olgu alınmıştır. Aktif tüberkülozlu grupta, yaşları 20-79 arasında değişen, 27'si erkek, 10'u kadın 37 olgu, inaktif tüberkülozlu grupta, yaşları 18-79 arasında değişen, 27'si erkek, 6'sı kadın 33 olgu ve sağlıklı kişilerden oluşan grupta, yaşları 20-48 arasında değişen, 16'sı erkek, 16'sı kadın 32 olgu alındı. Aktif tüberkülozlu, inaktif tüberkülozlu ve sağlıklılardan oluşan toplam 102 olgunun serum 25 (OH) vitamin D düzeyleri karşılaştırıldı. Bulgular: 25(OH) vitamin D düzeyi, aktif tüberkülozlu grupta, sağlıklı bireylere göre, anlamlı olarak düşük bulunmuştur. İnaktif tüberkülozlu grupta ise aktif tüberkülozlu gruba göre anlamlı olarak arttığı, ancak halen sağlıklı kişilerdeki seviyelere ulaşmadığı gözlenmiştir. Sonuç: Sonuç olarak, şimdiye dek yapılan çalışmalar serum vitamin D düzeyi ile tüberküloz hastalığı arasında bir ilişki olduğunu göstermiştir. Ancak, bu ilişkinin, net bir şekilde ortaya konulması için daha fazla çalışmaya ihtiyaç vardır.

References

  • 1. Prentice A. Vitamin D deficiency: a global perspective. Nutr Rev 2008;66(10) : 153-64.
  • 2. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357(3): 266-81.
  • 3. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 2008; 29(6): 726-76.
  • 4. Bouillon R. Vitamin D. From photosentezis, metabolism and action, to clinical aplications. In: Endocrinology, De Groot, LJ, Jameson, JL (Eds), Elsevier Saunders, Philadelphia 2009. p: 91-8.
  • 5. Moller L, Gatherer A, Dara M. Barriers to implementation of effective tuberculosis control in prisons. Public Health 2009; 123(6): 419-21.
  • 6. Tezcan Fİ. Vitamin D ve immun sistem. Türkiye Klinikleri J Pediatr Sci 2012;8(2):66-8
  • 7. Kocabaş A. Akciğer Tüberkülozu. Willke Topçu A, Söyletir G, Doğanay M (ed): İnfeksiyon Hastalıkları ve Mikrobiyolojisi Kitabı. Nobel Tıp Kitabevi, İstanbul, 1. Baskı, 2002.p. 538-591.
  • 8. Haas DW. Mycobacterium tuberculosis. Mandell GL, Bennett JF, Dolin R (eds): In Principles and Practice of Infectious Diseases. Churchill Livingstone, Philedelphia, 5th edition, 2000. p. 2576-2607.
  • 9. Çalışkan T. Tüberküloz immunpatogenezi. Türkiye Klinikleri J Pulm-Med-Special Topics 2011; 4(2):7-14
  • 10. Kıyan M. Mikobakteriler. Ustaçelebi Ş (ed). Temel ve Klinik Mikrobiyoloji Kitabı. Güneş Kitabevi, Ankara, 1. Baskı, 1999.p. 419-455.
  • 11. Davies PD, Brown RC, Woodhead JS. Serum concentrations of vitamin D metabolities in untreated tuberculosis. Thorax 1985;40(3):187- 90.
  • 12. Wilkinson RJ, Llewelyn M, Toossi Z, Patel P, Pasvol G, Lalvani A et al. Influence of vitamin D deficiency and vitamin D receptor polimorphisyms on tuberculosis among Gujarati Asian in west London: a case control study. Lancet 2000;355(9204): 618-21.
  • 13. Sasidharan PK, Rajeev E, Vijayakumari V. Tuberculosis and vitamin D deficiency. J Assoc Physicians India 2002; 50(4):554-58.
  • 14. Alataş F,Alataş Ö,Çolak Ö,Erginel S,Metintaş M,Uslu S. [25(OH) vitamin D levels in sera of active pulmonary tuberculosis patients].Turk Klinik Biokimya Derg 2004;2(3):91-95.
  • 15. Roth DE, Soto G, et al. Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis. J Infect Dis 2004;190(5): 920-7.
  • 16. Davies PDO, Grange JM. Factor affecting susceptibility and resistance to tuberculosis. Thorax 2001;56(10) : 23-29.
  • 17. Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a doubleblind randomised controlled trial. Lancet 2011; 377 (9761): 242-50.
  • 18. Coussens AK, Wilkonson RJ, Hanifa Y, Nikolayevsky V,Elkington PT, Islam K et al. Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment.Proc Natl Acad Sci USA 2012;18;109(38):15449-54
  • 19. Ku YC, Liu ME, Ku CS, Liu TY, Lin SL. Relationship between vitamin D deficiency and cardiovascular disease .World J Cardiol. 2013 September 26; 5(9): 337–346.
  • 20. Wang C. Role of vitamin d in cardiometabolic diseases. J Diabetes Res. 2013; 2013: 243934. 21. Querfeld U. Vitamin D and inflammation. Pediatr Nephrol. 2013 Apr;28(4): 605-10

25 (OH) VITAMIN D LEVELS IN ACTIVE AND INACTIVE TUBERCULOSIS PATIENTS

Year 2014, Volume: 28 Issue: 2, 105 - 112, 01.10.2014

Abstract

Aim: Vitamin D plays an important role for many vital functions of the human organism. Decreases in the serum levels of vitamin D may cause diseases. The relationship between sun rays and TB disease has been noticed for centuries and many studies have been carried in order to base this relationship on scientific grounds. In our study, we aimed to compare in the light of the literature the serum 25 (OH) vitamin D levels a total of 102 cases with active tuberculisis, inactive tuberculosis and a healthy control group. Material and Methods: The study was carried with 102 cases. Breakdown was 27 males and 10 females with an age range of 20-79 in the active tuberculosis group, 27 males and 6 females with an age range of 18-79 in the inactive tuberculosis group and 16 males and 16 females with an age range of 20-48 in the healthy control group. Vitamin D levels of these 102 cases were compared. Results: Vitamin D levels were significantly lower in active tuberculosis group than in healthy individuals. Within the inactive tuberculosis group, vitamin D levels were significantly higher than the group with active tuberculosis, but still did not reach levels as high as healthy individuals. Conclusion: As a result, studies of serum vitamin D levels and tuberculosis disease have shown that there is a relationship between serum vitamin D levels and tuberculosis. However, in order to detect these relationships further research is necessary.

References

  • 1. Prentice A. Vitamin D deficiency: a global perspective. Nutr Rev 2008;66(10) : 153-64.
  • 2. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357(3): 266-81.
  • 3. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 2008; 29(6): 726-76.
  • 4. Bouillon R. Vitamin D. From photosentezis, metabolism and action, to clinical aplications. In: Endocrinology, De Groot, LJ, Jameson, JL (Eds), Elsevier Saunders, Philadelphia 2009. p: 91-8.
  • 5. Moller L, Gatherer A, Dara M. Barriers to implementation of effective tuberculosis control in prisons. Public Health 2009; 123(6): 419-21.
  • 6. Tezcan Fİ. Vitamin D ve immun sistem. Türkiye Klinikleri J Pediatr Sci 2012;8(2):66-8
  • 7. Kocabaş A. Akciğer Tüberkülozu. Willke Topçu A, Söyletir G, Doğanay M (ed): İnfeksiyon Hastalıkları ve Mikrobiyolojisi Kitabı. Nobel Tıp Kitabevi, İstanbul, 1. Baskı, 2002.p. 538-591.
  • 8. Haas DW. Mycobacterium tuberculosis. Mandell GL, Bennett JF, Dolin R (eds): In Principles and Practice of Infectious Diseases. Churchill Livingstone, Philedelphia, 5th edition, 2000. p. 2576-2607.
  • 9. Çalışkan T. Tüberküloz immunpatogenezi. Türkiye Klinikleri J Pulm-Med-Special Topics 2011; 4(2):7-14
  • 10. Kıyan M. Mikobakteriler. Ustaçelebi Ş (ed). Temel ve Klinik Mikrobiyoloji Kitabı. Güneş Kitabevi, Ankara, 1. Baskı, 1999.p. 419-455.
  • 11. Davies PD, Brown RC, Woodhead JS. Serum concentrations of vitamin D metabolities in untreated tuberculosis. Thorax 1985;40(3):187- 90.
  • 12. Wilkinson RJ, Llewelyn M, Toossi Z, Patel P, Pasvol G, Lalvani A et al. Influence of vitamin D deficiency and vitamin D receptor polimorphisyms on tuberculosis among Gujarati Asian in west London: a case control study. Lancet 2000;355(9204): 618-21.
  • 13. Sasidharan PK, Rajeev E, Vijayakumari V. Tuberculosis and vitamin D deficiency. J Assoc Physicians India 2002; 50(4):554-58.
  • 14. Alataş F,Alataş Ö,Çolak Ö,Erginel S,Metintaş M,Uslu S. [25(OH) vitamin D levels in sera of active pulmonary tuberculosis patients].Turk Klinik Biokimya Derg 2004;2(3):91-95.
  • 15. Roth DE, Soto G, et al. Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis. J Infect Dis 2004;190(5): 920-7.
  • 16. Davies PDO, Grange JM. Factor affecting susceptibility and resistance to tuberculosis. Thorax 2001;56(10) : 23-29.
  • 17. Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a doubleblind randomised controlled trial. Lancet 2011; 377 (9761): 242-50.
  • 18. Coussens AK, Wilkonson RJ, Hanifa Y, Nikolayevsky V,Elkington PT, Islam K et al. Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment.Proc Natl Acad Sci USA 2012;18;109(38):15449-54
  • 19. Ku YC, Liu ME, Ku CS, Liu TY, Lin SL. Relationship between vitamin D deficiency and cardiovascular disease .World J Cardiol. 2013 September 26; 5(9): 337–346.
  • 20. Wang C. Role of vitamin d in cardiometabolic diseases. J Diabetes Res. 2013; 2013: 243934. 21. Querfeld U. Vitamin D and inflammation. Pediatr Nephrol. 2013 Apr;28(4): 605-10
There are 20 citations in total.

Details

Other ID JA26TK67YJ
Journal Section Research Article
Authors

Fatma Emre Taşolar This is me

Özlem Saniye İçmeli This is me

Hatice Türker This is me

Baran Gündoğuş This is me

Pınar Günel Karadeniz This is me

Publication Date October 1, 2014
Published in Issue Year 2014 Volume: 28 Issue: 2

Cite

APA Taşolar, F. E., İçmeli, Ö. S., Türker, H., Gündoğuş, B., et al. (2014). AKTİF VE İNAKTİF TÜBERKÜLOZLU OLGULARDA 25(OH) VİTAMİN D SEVİYELERİ. İzmir Göğüs Hastanesi Dergisi, 28(2), 105-112.