Abstract
Antibiyotikler günümüzde birçok sistemin enfeksiyonlarında oldukça sık reçete edilen ilaçlardır. Bu ilaçların nerdeyse tüm sistemleri etkileyen sık ve nadir yan etkileri vardır. Bu yan etkilerden nöropsikiyatrik belirtiler giderek artan bir şekilde bildirilmeye başlanmıştır. Çeşitli yazarlar, antibiyotik sonrası gelişen manik atak olgularına antibiomani adını vermişlerdir. Bu durumu açıklamak için yazarlar tarafından merkezi sinir sisteminde prostaglandin ve kortizol düzeylerinin artışı ya da GABA konsantrasyonunun azalması gibi hipotezler öne sürülse de tanımlayıcı bir açıklama henüz elde edilememiştir. Biz de bu yazıda klaritromisin ve sefalosporin kullanımı sonrası ortaya çıkan iki mani olgusunu sunduk. Antibiyotiklerin daha dikkatli reçete edilmesi ve tedavi takibinde bu belirtilerinde akılda tutulması gerektiğini vurgulamak istedik.
Keywords
References
- 1. Sternbach H, State R. Antibiotics: neuropsychiatric effects and psychotropic interactions. Harvard Rev Pschiatry 1997; 5: 214-26.
- 2. Ortiz–Dominguez A, Berlanga C, GuetierrezMora D. A case of clarithromycin-induced manic episode (antibiomania). Int J Neuropsychopharmacol 2004; 7: 99-100.
- 3. Neff NE, Kuo G. Acute manic psychosis induced by triple therapy for H. Pylori. J Am Board Fam Pract 2002; 15: 66-8.
- 4. Abouesh A, Stone C, Hobbs WR. Antimicrobialinduced mania (antibiomania): a review of spontaneous reports. J Clin Psychopharmacol 2002; 22: 71-82.
- 5. Yeung J, Canning K, MacDonald JF, Orse BA, Blockade of tonic and synaptic GABAergic cuurent in murine neurons reveals two populations of GABA-A receptors. Anesthesiology, 2002; 96: A768.
- 6. Ahuja N, Lloyd A. Antibiomania and ciprofloxacin-induced mania. Psychosomatics, 2007; 48 :363.
- 7. Prime K, French P. Neuropsychiatric reaction induced by clarithromycin in a patient on highly active antiretroviral therapy (HAART) Sex Transm Infect, 2001; 77: 297–298.
Abstract
Antibiotics are the drugs which are frequently prescribed for many system infections currently. These drugs have frequent and rare side efects which affect almost all systems. Neuropsychiatric symptoms; which are rare but important adverse effects have been reported more frequently. Various authors gave the name of antibiomania to manic episode cases devoloped after antibiotic usage. Although many authors had proposed some hypothesis that increased levels of prostoglandins and cortisol or decreased GABA concentration in central nervous system causes this circumstances; yet a definitive explanation have not been reached. In this case report we have presented two manic cases after using claritromycine and cephalosporins. We wanted to take attention to necessity of the adverse effects of antibiotic drug the prescribing and the treatment.
Keywords
References
- 1. Sternbach H, State R. Antibiotics: neuropsychiatric effects and psychotropic interactions. Harvard Rev Pschiatry 1997; 5: 214-26.
- 2. Ortiz–Dominguez A, Berlanga C, GuetierrezMora D. A case of clarithromycin-induced manic episode (antibiomania). Int J Neuropsychopharmacol 2004; 7: 99-100.
- 3. Neff NE, Kuo G. Acute manic psychosis induced by triple therapy for H. Pylori. J Am Board Fam Pract 2002; 15: 66-8.
- 4. Abouesh A, Stone C, Hobbs WR. Antimicrobialinduced mania (antibiomania): a review of spontaneous reports. J Clin Psychopharmacol 2002; 22: 71-82.
- 5. Yeung J, Canning K, MacDonald JF, Orse BA, Blockade of tonic and synaptic GABAergic cuurent in murine neurons reveals two populations of GABA-A receptors. Anesthesiology, 2002; 96: A768.
- 6. Ahuja N, Lloyd A. Antibiomania and ciprofloxacin-induced mania. Psychosomatics, 2007; 48 :363.
- 7. Prime K, French P. Neuropsychiatric reaction induced by clarithromycin in a patient on highly active antiretroviral therapy (HAART) Sex Transm Infect, 2001; 77: 297–298.
Details
| Other ID | JA78VB88ZV |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | May 1, 2015 |
| Published in Issue | Year 2015 Volume: 29 Issue: 1 |